LOCUS       NM_080666               3109 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens WD repeat domain 89 (WDR89), transcript variant 2,
            mRNA.
ACCESSION   NM_080666
VERSION     NM_080666.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3109)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA882425.1 and BC010698.1.
            
            On Jun 2, 2019 this sequence version replaced NM_080666.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.171491.1,
                                           SRR1660809.23882.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620954.2/ ENSP00000480112.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               DA882425.1         53-156
            105-3109            BC010698.1         49-3053
FEATURES             Location/Qualifiers
     source          1..3109
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.2"
     gene            1..3109
                     /gene="WDR89"
                     /gene_synonym="C14orf150; MSTP050"
                     /note="WD repeat domain 89"
                     /db_xref="GeneID:112840"
                     /db_xref="HGNC:HGNC:20489"
     exon            1..68
                     /gene="WDR89"
                     /gene_synonym="C14orf150; MSTP050"
                     /inference="alignment:Splign:2.1.0"
     exon            69..174
                     /gene="WDR89"
                     /gene_synonym="C14orf150; MSTP050"
                     /inference="alignment:Splign:2.1.0"
     exon            175..3109
                     /gene="WDR89"
                     /gene_synonym="C14orf150; MSTP050"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1369
                     /gene="WDR89"
                     /gene_synonym="C14orf150; MSTP050"
                     /codon_start=1
                     /product="WD repeat-containing protein 89"
                     /protein_id="NP_542397.1"
                     /db_xref="CCDS:CCDS9759.1"
                     /db_xref="GeneID:112840"
                     /db_xref="HGNC:HGNC:20489"
                     /translation="MEKIEEQFANLHIVKCSLGTKEPTYLLGIDTSKTVQAGKENLVA
                     VLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVA
                     REKPVQLFKGYPSNIFISFDINCNDHIICAGTEKVDDDALLVFWDARMNSQNLSTTKD
                     SLGAYSETHSDDVTQVRFHPSNPNMVVSGSSDGLVNVFDINIDNEEDALVTTCNSISS
                     VSCIGWSGKGYKQIYCMTHDEGFYWWDLNHLDTDEPVTRLNIQDVREVVNMKEDALDY
                     LIGGLYHEKTDTLHVIGGTNKGRIHLMNCSMSGLTHVTSLQGGHAATVRSFCWNVQDD
                     SLLTGGEDAQLLLWKPGAIEKTFTKKESMKIASSVHQRVRVHSNDSYKRRKKQ"
     regulatory      1684..1689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR89"
                     /gene_synonym="C14orf150; MSTP050"
                     /note="hexamer: AATAAA"
     polyA_site      1706
                     /gene="WDR89"
                     /gene_synonym="C14orf150; MSTP050"
     regulatory      3085..3090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR89"
                     /gene_synonym="C14orf150; MSTP050"
                     /note="hexamer: ATTAAA"
     polyA_site      3109
                     /gene="WDR89"
                     /gene_synonym="C14orf150; MSTP050"
                     /note="major polyA site"
ORIGIN      
        1 gttccacttg accgctctaa gccgccgcgc agcctgcgtt ttctccggta caggttgagg
       61 ctactaaggt atttggctat tataaataaa atagtgatga acacgtgtac aggtgtttgt
      121 acggacataa gttgtcattt ctcttgagta aatacctaaa agtgggcttg ctggagtttt
      181 actacccttg gatgctgctg ttgacatgga aaagattgag gaacaatttg ctaatctgca
      241 cattgttaaa tgttccttag gaaccaaaga gcccacttac cttcttggta tagacacatc
      301 aaagactgtc caagcaggaa aggaaaactt ggttgctgtt ttatgttcta atggatcaat
      361 cagaatatat gataaagaaa ggttaaatgt actacgagaa tttagtggat atcctggact
      421 tcttaatgga gtcagatttg caaattcctg tgacagtgta tattcagcat gtactgatgg
      481 cactgtgaaa tgctgggatg ctcgagtagc cagagaaaaa cctgttcagc tcttcaaggg
      541 ttacccttcc aatattttta tcagttttga tattaattgt aatgatcata ttatttgtgc
      601 tggtacagaa aaagttgatg atgatgcatt gttggtgttt tgggatgcaa ggatgaattc
      661 tcagaattta tctacaacta aagactcact tggtgcatat tcagagacac atagtgatga
      721 tgtcactcaa gtacgtttcc atcccagcaa tcccaacatg gtagtctcag gttcatctga
      781 tggcctggta aatgtatttg atattaatat tgataatgag gaggatgcac tggttacaac
      841 ctgtaactca atttcatcag taagctgtat tggttggtct gggaaaggtt ataaacagat
      901 ttactgcatg acacatgatg aaggatttta ttggtgggat cttaatcatc tggacactga
      961 tgaaccagtt acacgtttga acatccagga tgtcagagaa gtagttaaca tgaaagaaga
     1021 tgctttggac tatttgattg gtggcctata tcatgaaaag acagacacat tgcatgttat
     1081 tggaggaaca aacaaaggaa ggattcattt gatgaactgc agcatgtcag gactgaccca
     1141 tgtgactagc cttcagggag ggcatgctgc tacagtccgt tctttctgtt ggaatgtgca
     1201 agatgattct ttgttgactg gaggagaaga tgcacagttg ttactttgga aacctggagc
     1261 tatagagaag acctttacaa agaaagagag tatgaaaata gcatcctctg tgcaccaacg
     1321 agtacgagtt catagtaatg attcttataa aagaaggaaa aagcagtgat aatgcatttg
     1381 gcactttgtt tggtaggttt tatagtttca aatagtcctt cttgtttact acccatggta
     1441 gacatgttta aagctttatg taaaaacaag ccagttagca aacagtcctg gaaaaatatg
     1501 gtgagaatgg tttaattccg gtcttcacat attctaaaaa attttaaagc ctctaagtat
     1561 aaaatcagtg agttgaaagt aaaatttctt atttaaagaa cccatctgtt aatgtagtaa
     1621 atgttggctt taaagaaata gctccgataa ggacttttta gaaggaaata cttggtaaaa
     1681 cttaataaaa caggtggttg gctgcatttt ttaagcccag ttttttacat tttaaattgt
     1741 ctttattgtg tataaaacca gattagacta tattcttcat ctgaggagca tctatatgtt
     1801 taatacacct aatgtattat gctggagtat ttaaatgtaa gtattttaat gagtaaatag
     1861 aattaacctt ttttacaaat gaaatgatag gcatctatgt aaagtgagaa aaatatgttt
     1921 cgtaaatatt tgcatcttta atattgttag taagtagtaa acaggtgttt tgctgattga
     1981 aaggaagtta tcttggtaaa ttgagactca aagtgaaata caaaaatgaa aatatttata
     2041 ataggactcg acttggagaa attgctattc ttcctgttgt ccaaaccata aatctgagga
     2101 taacctgggc ttttctcttt cctcttctcc taaccagttt ttcaccaagt cctgtgccat
     2161 ttcacctcct aacgtctgtc agctatcctt ttgcctttac ctcaccacta ttaccctaga
     2221 gaagactttc attatttctc atctggatta ccagctcgat ctctaatctg cttcagttca
     2281 tccttcttgc tacttctagg ctaaacatca aaaacagatc tggtaggggc ggggaaatga
     2341 gggggaagaa acaaaaacgt gatggtgcct catgctgctt aaaatcttca gtacattgat
     2401 gttttgatgg cggactacat aagcgttaaa aattgtgttt ttcagaatct ttaaaatata
     2461 agacagtgct atctagtgaa taaaaaaatt agtttgaaag atatctggag aaatcgcatt
     2521 cataaaacaa ttggaagtga aactattaaa acaatagggc tttttaaaat taaaaatatt
     2581 taaaattcaa aagtaattaa tagtgttgga agatgtaggt gagaaaatat tcctgaaagt
     2641 agaactgaaa gagacaaaga gaaaagatga aagccacaga agataaatac aggggtcaaa
     2701 accagactaa cagttttaga aagtgaaaaa agttaaaaaa gaaatggggg cagtgggtta
     2761 ttagaaataa cataaatggc tggtatggtt tgtctgtgtc ctcacccaaa tttcatctcg
     2821 aattgtaatc cccataatcc ccatgtgtct agggagagac ctggtgggag gtgattggat
     2881 catgggggtg gtttccccta cgatgttctc ctgatagtgg gtgagttctc acaagatctg
     2941 atggttttat aaagggctct gcccctttaa ctcctcactc tttctcctga agccttgtga
     3001 agaaggtgct ttgcttcccc tttgcgttcc cccatgattg taagtttctt gaggcctccc
     3061 tggccatgct gaactcttca gtcaattaaa cactttcctt tataaatta
//
