LOCUS       NM_173479               1702 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens WD repeat domain 88 (WDR88), transcript variant 1,
            mRNA.
ACCESSION   NM_173479
VERSION     NM_173479.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1702)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1702)
  AUTHORS   Richards,A.L., Leonenko,G., Walters,J.T., Kavanagh,D.H., Rees,E.G.,
            Evans,A., Chambert,K.D., Moran,J.L., Goldstein,J., Neale,B.M.,
            McCarroll,S.A., Pocklington,A.J., Holmans,P.A., Owen,M.J. and
            O'Donovan,M.C.
  TITLE     Exome arrays capture polygenic rare variant contributions to
            schizophrenia
  JOURNAL   Hum Mol Genet 25 (5), 1001-1007 (2016)
   PUBMED   26740555
  REMARK    GeneRIF: Genome-wide significant support for contributing to
            schizophrenia has been found for the WDR88 (WD repeat-containing
            protein 88), a gene of unknown function.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC031227.1 and AI982942.1.
            
            On May 17, 2019 this sequence version replaced NM_173479.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131444.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355868.4/ ENSP00000348129.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1298              BC031227.1         23-1320
            1299-1702           AI982942.1         2-405               c
FEATURES             Location/Qualifiers
     source          1..1702
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..1702
                     /gene="WDR88"
                     /gene_synonym="PQWD"
                     /note="WD repeat domain 88"
                     /db_xref="GeneID:126248"
                     /db_xref="HGNC:HGNC:26999"
     exon            1..332
                     /gene="WDR88"
                     /gene_synonym="PQWD"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1475
                     /gene="WDR88"
                     /gene_synonym="PQWD"
                     /note="PQQ repeat and WD repeat domain containing; PQQ
                     repeat and WD repeat-containing protein"
                     /codon_start=1
                     /product="WD repeat-containing protein 88"
                     /protein_id="NP_775750.3"
                     /db_xref="CCDS:CCDS12429.1"
                     /db_xref="GeneID:126248"
                     /db_xref="HGNC:HGNC:26999"
                     /translation="MASPPRCSPTAHDRECKLPPPSAPASEYCPGKLSWGTMARALGR
                     FKLSIPHTHLLATLDPLALDREPPPHLLPEKHQVPEKLIWGDQDPLSKIPFKILSGHE
                     HAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRV
                     IAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAEN
                     ITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI
                     SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSS
                     FLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNI
                     EEIDEIPLVIKYKKAVGLKLKQCERCDRPFSIFKSDTSSEMFTQCVFCRIDTRGLPAD
                     TSSSSSSSERENSPPPRGSKDD"
     exon            333..443
                     /gene="WDR88"
                     /gene_synonym="PQWD"
                     /inference="alignment:Splign:2.1.0"
     exon            444..532
                     /gene="WDR88"
                     /gene_synonym="PQWD"
                     /inference="alignment:Splign:2.1.0"
     exon            533..596
                     /gene="WDR88"
                     /gene_synonym="PQWD"
                     /inference="alignment:Splign:2.1.0"
     exon            597..735
                     /gene="WDR88"
                     /gene_synonym="PQWD"
                     /inference="alignment:Splign:2.1.0"
     exon            736..865
                     /gene="WDR88"
                     /gene_synonym="PQWD"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1053
                     /gene="WDR88"
                     /gene_synonym="PQWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1136
                     /gene="WDR88"
                     /gene_synonym="PQWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1205
                     /gene="WDR88"
                     /gene_synonym="PQWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1298
                     /gene="WDR88"
                     /gene_synonym="PQWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1702
                     /gene="WDR88"
                     /gene_synonym="PQWD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1679..1684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR88"
                     /gene_synonym="PQWD"
                     /note="hexamer: AATAAA"
     polyA_site      1702
                     /gene="WDR88"
                     /gene_synonym="PQWD"
                     /note="major polyA site"
ORIGIN      
        1 ggcgccaccg ttcccatcca ggcttgtcgg cggccaccgg cggaccgggc ttcgagatgg
       61 cctccccgcc gcggtgctcc ccgacagccc atgacaggga atgcaagttg ccgccaccct
      121 ccgcccccgc cagcgagtat tgtcccggca agctgtcctg ggggaccatg gcgagggcct
      181 taggccgctt caagctgtcg atcccgcaca cgcacctgct ggccaccctc gaccccctgg
      241 ccttggacag ggaaccacca ccgcatctgt tgcctgagaa gcaccaggtg ccggagaaat
      301 tgatctgggg cgaccaggac cctctctcca agatcccatt taaaattctg agtgggcacg
      361 agcacgctgt gagcacctgc cacttctgtg tggatgacac aaagctcctc agtggctcct
      421 atgactgcac tgtgaagctg tgggatccgg tggacggttc tgtggttcgc gattttgagc
      481 acaggcccaa agctcctgtt gtagagtgca gcatcaccgg cgacagcagc agagtcattg
      541 ccgcatccta tgataagaca gtgagggcct gggacctgga gacaggcaag ctgctgtgga
      601 aggtcaggta tgataccttc atcgtctcct gtaagttttc tcctgatggt aaatacgtgg
      661 tctcaggctt cgacgtggat catggaatct gcataatgga cgccgagaac atcaccaccg
      721 tttccgtcat caaagatcat cacacaaggt ccatcacgtc atgctgcttt gaccccgaca
      781 gccagagggt ggcttctgtc tcattggaca ggtgcatcaa gatctgggat gttacatccc
      841 aggccacgct gctcaccatc actaaggcac attccaatgc aatctcaaac tgctgtttta
      901 ccttcagtgg ccatttcctg tgtacaagct cctgggataa aaacttaaaa atatggaacg
      961 tccacacagg ggagtttcga aactgtggag cctgtgtgac tctgatgcag ggccatgaag
     1021 gttctgtcag ttcctgtcac tttgccagag acagctcttt tctcatttct ggagggtttg
     1081 ataggactgt ggctatttgg gatgtagcag aaggctaccg gaagctctct ttgaagggcc
     1141 ataatgactg ggtgatggat gttgccatta gcaacaacaa gaaatggatc ctgtctgctt
     1201 ccaaggatag gaccatgaga ctgtggaata ttgaagaaat tgatgaaatt cctttggtaa
     1261 tcaagtacaa aaaggccgtg ggcttaaagt tgaaacagtg cgaaagatgt gacaggcctt
     1321 tctccatctt caagagtgac acctcttctg aaatgttcac ccaatgcgtg ttctgccgga
     1381 tagatacaag gggcttgcca gcagatactt catcgtcatc atcatcatcg gaaagggaga
     1441 actcaccgcc gccaagggga agcaaggatg actgacagcc acaggcccct ttgagtgact
     1501 ccagcacagg ctacctagca tgtaggtttc ggggctttgc aggggctttc tcttgggccc
     1561 ctcccaggct cagcaggcct gtcagactgg ggcaggaccc aagccctggc tggactcagc
     1621 acagtgccac ctcctcagct ctcagcttgg ggagtgaaca ctttccgttt tcatgcagaa
     1681 taaatctaat tcctttggaa aa
//
