LOCUS       NM_198285               2038 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens WD repeat domain 86 (WDR86), transcript variant 2,
            mRNA.
ACCESSION   NM_198285 XM_351761 XM_353710
VERSION     NM_198285.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2038)
  AUTHORS   Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R,
            Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T,
            Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K,
            Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T,
            Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T
            and Sugano S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res. 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   2  (bases 1 to 2038)
  AUTHORS   Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R,
            Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine
            M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J,
            Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K,
            Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T,
            Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi
            T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato
            K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H,
            Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S,
            Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta
            T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO,
            Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N,
            Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y,
            Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H,
            Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A,
            Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T,
            Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai
            A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H,
            Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M,
            Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y,
            Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K,
            Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M,
            Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano
            J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T,
            Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T,
            Nakamura Y, Ohara O, Isogai T and Sugano S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat. Genet. 36 (1), 40-45 (2004)
   PUBMED   14702039
REFERENCE   3  (bases 1 to 2038)
  AUTHORS   Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD,
            Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg
            B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T,
            Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin
            GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL,
            Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P,
            Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy
            SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH,
            Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW,
            Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J,
            Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M,
            Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW,
            Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J,
            Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U,
            Smailus DE, Schnerch A, Schein JE, Jones SJ and Marra MA.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA267732.1, BI757623.1, BX338490.2, AC005996.2, BX390499.1,
            BC107125.2 and BC047921.1.
            
            On Jun 2, 2019 this sequence version replaced NM_198285.2.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, which results in a frameshift, compared to
            variant 1. It encodes isoform 2, which has a shorter and distinct
            C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000334493.11/ ENSP00000335522.7
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               DA267732.1         1-163
            164-585             BI757623.1         145-566
            586-616             BX338490.2         509-539
            617-617             AC005996.2         120656-120656
            618-638             BX338490.2         541-561
            639-729             BI757623.1         620-710
            730-973             BX338490.2         653-896
            974-1360            BX390499.1         81-467
            1361-1996           BC107125.2         758-1393
            1997-2038           BC047921.1         2110-2151
FEATURES             Location/Qualifiers
     source          1..2038
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..2038
                     /gene="WDR86"
                     /note="WD repeat domain 86"
                     /db_xref="GeneID:349136"
                     /db_xref="HGNC:HGNC:28020"
     exon            1..612
                     /gene="WDR86"
                     /inference="alignment:Splign:2.1.0"
     CDS             450..1580
                     /gene="WDR86"
                     /note="isoform 2 is encoded by transcript variant 2; WD
                     repeat-containing protein 86"
                     /codon_start=1
                     /product="WD repeat-containing protein 86 isoform 2"
                     /protein_id="NP_938026.2"
                     /db_xref="CCDS:CCDS5925.2"
                     /db_xref="GeneID:349136"
                     /db_xref="HGNC:HGNC:28020"
                     /translation="MGGGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWST
                     ADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNR
                     ILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEA
                     AAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIR
                     AWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRR
                     NVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHD
                     GALRLWDVRGLRGAPRPPPPMRSLSRLFSNKVGCAAAPLQPA"
     exon            613..754
                     /gene="WDR86"
                     /inference="alignment:Splign:2.1.0"
     exon            755..1175
                     /gene="WDR86"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1311
                     /gene="WDR86"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1415
                     /gene="WDR86"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..2038
                     /gene="WDR86"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2016..2021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR86"
                     /note="hexamer: AATATA"
     polyA_site      2038
                     /gene="WDR86"
                     /note="major polyA site"
ORIGIN      
        1 accgtattgt tccgcgctcg gccggggagg gcgcggggcg ctcggcttcc cgtgttcctc
       61 tccccgcccc agccccgtgg gcgcgagagg aggcgggggg ctccttgtgc accagagacg
      121 cagctgcctt gttcgcccgg tggggtgtgg atcctccgag cggtgctggg aagggggttc
      181 tctctgcccg cgcgcccagg actctaccca gggcggaggt cccgagtggg ccgccccccg
      241 cagcgccctg ggttcgcggg cccagaggct ggaggcagcg gggagctagg gtccttcacc
      301 ctcccctcgc cgcgtgcctc cgcaggagtc gggctccccg ttccccgcga tggccgcggg
      361 ccgcagtcgt acggagccgc cgcgcggacc ccggggcgcc cctccctagc ggggcgcagc
      421 tccttcttgt tccccgccct gccagcggga tggggggcgg cgggtcggcc ctgagggtct
      481 gcgccgacca ccgcgggggc atcaactggc tgagcctgag ccccgacggg cagcgcctgc
      541 tgacgggcag cgaggacggc acggcccggc tctggagcac cgcggacggc cagtgctgcg
      601 cgctcctgca aggacatgaa agctatgtga ccttctgcca gctggaggat gaggctgcct
      661 tcacatgcag cgccgactgc accatcagga ggtgggacgt gctgaccggg cagtgtctgc
      721 aggtgtaccg aggacacacg tccatcgtga acaggatcct ggttgccaac aaccagctct
      781 tcagcagctc ctatgaccgg acagctcggg tctggagtgt ggacaagggg cagatgtccc
      841 gggagttccg gggccaccgc aactgcgtgc tgaccctagc ctactctgcc ccgtgggacc
      901 tccccagcac tccctgcgcg gaggaggccg cggccggggg gcttctggtg accggcagca
      961 cagatggcac agccaaggtg tggcaggtgg ccagcggctg ctgccaccag acgctgcggg
     1021 gccacacggg tgcagtgctg tgcctagtgc tagacacgcc cggccacacg gccttcacag
     1081 gcagcaccga cgccaccatc cgtgcctggg acatcctgag tggggagcag ctgcgggtgt
     1141 tccgggagca ccggggctcc gtcatctgtc tggagctggt gaaccgactc gtgtactctg
     1201 gcagcgcgga caggaccgtc aagtgctggc tggcagacac aggggagtgt gtgcgcacgt
     1261 tcacggccca cagacgcaac gtgagcgccc tcaagtacca cgcgggcacc ttgttcacgg
     1321 gcagcgggga cgcttgcgcc cgggccttcg acgcgcagtc tggagagctg cggagggtgt
     1381 tccggggcca cacattcatc atcaactgca tccaggtgca cggccaggtg ctctacaccg
     1441 cctcgcacga cggcgccctg cgcctctggg acgtgcgcgg gctccgaggt gccccgcggc
     1501 cccctccgcc catgcgcagc ctctcgcggc tcttcagcaa caaggtgggc tgcgccgccg
     1561 cgcccctgca gccggcctga tcccgcgggg cccctgcaga cgccagccca gacacccagc
     1621 ggctcccaga gcgccccgcc ctgctacccg cggtggtggc gcccgatggc cggcgagggg
     1681 cgaggagcga ggaagcccgg gcgggaggag agcccgtcgc aggcgtctgg tttttctttg
     1741 gtggccagga ggcgctggga gcgggagtgc tcgccctggg gaccgccccc ttttcccttt
     1801 tagggtggct cctgtcctcc ctccccatcc ctgacctggc gaaaggccta gtcctgggga
     1861 ccctcccacc tcaggggctg caggcggact gccccagctc ccccagcccc acgaaactgg
     1921 gcctttcctg ctgagaggaa gtgacttttt acagaagcca ctgaacctgg ttattttggc
     1981 aaatcgtccg tctcgagggc cttgggggga actgaaatat acagcctgaa cgttaaaa
//
