LOCUS       NM_001099737            1450 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens WD repeat domain 83 (WDR83), transcript variant 1,
            mRNA.
ACCESSION   NM_001099737
VERSION     NM_001099737.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1450)
  AUTHORS   Kournoutis,A., Lamark,T., Johansen,T. and Abudu,Y.P.
  TITLE     WDR83/MORG1 inhibits RRAG GTPase-MTORC1 signaling to facilitate
            basal autophagy
  JOURNAL   Autophagy 20 (7), 1687-1688 (2024)
   PUBMED   38450633
  REMARK    GeneRIF: WDR83/MORG1 inhibits RRAG GTPase-MTORC1 signaling to
            facilitate basal autophagy.
REFERENCE   2  (bases 1 to 1450)
  AUTHORS   Bondeva,T. and Wolf,G.
  TITLE     Cloning of the Human MORG1 Promoter: Differential Regulation by
            Hypoxia and Prolyl-Hydroxylase Inhibitors
  JOURNAL   Genes (Basel) 13 (3), 427 (2022)
   PUBMED   35327980
  REMARK    GeneRIF: Cloning of the Human MORG1 Promoter: Differential
            Regulation by Hypoxia and Prolyl-Hydroxylase Inhibitors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1450)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 1450)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1450)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1450)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   7  (bases 1 to 1450)
  AUTHORS   Hopfer,U., Hopfer,H., Jablonski,K., Stahl,R.A. and Wolf,G.
  TITLE     The novel WD-repeat protein Morg1 acts as a molecular scaffold for
            hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)
  JOURNAL   J Biol Chem 281 (13), 8645-8655 (2006)
   PUBMED   16407229
  REMARK    GeneRIF: Functional characterization of the homologous rat gene.
REFERENCE   8  (bases 1 to 1450)
  AUTHORS   Vomastek,T., Schaeffer,H.J., Tarcsafalvi,A., Smolkin,M.E.,
            Bissonette,E.A. and Weber,M.J.
  TITLE     Modular construction of a signaling scaffold: MORG1 interacts with
            components of the ERK cascade and links ERK signaling to specific
            agonists
  JOURNAL   Proc Natl Acad Sci U S A 101 (18), 6981-6986 (2004)
   PUBMED   15118098
  REMARK    GeneRIF: Component of a modular scaffold system that participates
            in the regulation of agonist-specific ERK signaling.
REFERENCE   9  (bases 1 to 1450)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
  REMARK    GeneRIF: Includes the identification of this protein in C complex
            spliceosomes.
REFERENCE   10 (bases 1 to 1450)
  AUTHORS   Auffray,C., Behar,G., Bois,F., Bouchier,C., Da Silva,C.,
            Devignes,M.D., Duprat,S., Houlgatte,R., Jumeau,M.N., Lamy,B. et al.
  TITLE     [IMAGE: molecular integration of the analysis of the human genome
            and its expression]
  JOURNAL   C R Acad Sci III 318 (2), 263-272 (1995)
   PUBMED   7757816
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z46189.1, AK314164.1 and
            BC005870.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001099737.2.
            
            Summary: This gene encodes a member of the WD-40 protein family.
            The protein is proposed to function as a molecular scaffold for
            various multimeric protein complexes. The protein associates with
            several components of the extracellular signal-regulated kinase
            (ERK) pathway, and promotes ERK activity in response to serum or
            other signals. The protein also interacts with egl nine homolog 3
            (EGLN3, also known as PHD3) and regulates expression of
            hypoxia-inducible factor 1, and has been purified as part of the
            spliceosome. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.680912.1,
                                           SRR3476690.661101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000418543.8/ ENSP00000402653.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                Z46189.1           23-43
            22-1290             AK314164.1         2-1270
            1291-1450           BC005870.2         970-1129
FEATURES             Location/Qualifiers
     source          1..1450
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..1450
                     /gene="WDR83"
                     /gene_synonym="MORG1"
                     /note="WD repeat domain 83"
                     /db_xref="GeneID:84292"
                     /db_xref="HGNC:HGNC:32672"
                     /db_xref="MIM:616850"
     exon            1..186
                     /gene="WDR83"
                     /gene_synonym="MORG1"
                     /inference="alignment:Splign:2.1.0"
     exon            187..306
                     /gene="WDR83"
                     /gene_synonym="MORG1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..445
                     /gene="WDR83"
                     /gene_synonym="MORG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..1290
                     /gene="WDR83"
                     /gene_synonym="MORG1"
                     /note="mitogen-activated protein kinase organizer 1; MAPK
                     organizer 1"
                     /codon_start=1
                     /product="WD repeat domain-containing protein 83"
                     /protein_id="NP_001093207.1"
                     /db_xref="CCDS:CCDS12275.1"
                     /db_xref="GeneID:84292"
                     /db_xref="HGNC:HGNC:32672"
                     /db_xref="MIM:616850"
                     /translation="MAFPEPKPRPPELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCG
                     SDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVV
                     RKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVK
                     VSDHEILAGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLL
                     DKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVG
                     SGVVQSLAYHPTEPCLLTAMGGSVQCWREEAYEAEDGAG"
     exon            446..566
                     /gene="WDR83"
                     /gene_synonym="MORG1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..672
                     /gene="WDR83"
                     /gene_synonym="MORG1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..721
                     /gene="WDR83"
                     /gene_synonym="MORG1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..848
                     /gene="WDR83"
                     /gene_synonym="MORG1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..916
                     /gene="WDR83"
                     /gene_synonym="MORG1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1025
                     /gene="WDR83"
                     /gene_synonym="MORG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1140
                     /gene="WDR83"
                     /gene_synonym="MORG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1450
                     /gene="WDR83"
                     /gene_synonym="MORG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1416..1421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR83"
                     /gene_synonym="MORG1"
                     /note="hexamer: AATAGA"
     polyA_site      1450
                     /gene="WDR83"
                     /gene_synonym="MORG1"
                     /note="major polyA site"
ORIGIN      
        1 gcggtctgga ggctcacggg agagaggctg tagccctggg caatcccggg ggtcgttaca
       61 ggaaggtagg aaaatgccac cctcagggca ctggttgggc taaaggtgac actggcgtct
      121 cacgggctat gaagacggaa tgcctcttaa tgccggaatt ccaagacgga atgcctctta
      181 atgccgggca agtctcacat gaagctactc atcatttgct tcgtgtcctc cgagctccga
      241 gagttggcaa agctgatgaa ggagcagtag acagcgaccc aagcacacca cttcagctag
      301 ggaaagaccg atttaaggct gcaaggaagg agtcctggga gcatggcttt ccctgagcca
      361 aagccgcggc ctccagagct gccgcagaaa cggttgaaga cgctggactg cgggcagggg
      421 gcagtgcgag ccgtacgatt taatgtggat ggcaattact gcctgacgtg cggcagtgac
      481 aagacgctga agctgtggaa cccgcttcgg gggacgctgc tgcggacgta cagcggccac
      541 ggctacgagg tgctggatgc ggccggctcc tttgacaaca gtagtctctg ctccggcggc
      601 ggggacaagg cggtggttct gtgggatgtg gcatcagggc aggtcgtgcg caaattccgg
      661 ggccacgcag ggaaggtgaa cacggtgcag tttaatgaag aggccacagt tatcctgtcc
      721 ggctctattg attccagtat ccgctgttgg gattgccgct cacggaggcc tgagccagtg
      781 cagacgctgg atgaggccag agatggcgtg tccagtgtga aggtgtcaga ccacgagatc
      841 ctggcaggct ccgtggatgg ccgcgtgaga cgctatgacc taaggatggg gcagctcttc
      901 tcagactacg tgggcagccc catcacctgc acctgcttca gccgggatgg gcagtgcacc
      961 ctggtgtcca gcctggactc cacattgcgg ctcctggaca aagacacagg ggagctgctg
     1021 ggcgagtaca agggccataa gaaccaggaa tacaagctgg actgctgcct gagcgagcgt
     1081 gacacacatg tggtcagctg ttctgaggac gggaaggtgt tcttctggga cctggtggag
     1141 ggtgcgctgg ctctggccct gcctgtgggt tccggtgtgg tgcagtcgct ggcctaccac
     1201 ccaacagagc cctgcctgct gaccgccatg ggaggcagcg tccagtgctg gcgagaggag
     1261 gcctatgagg cagaggatgg agcaggctga agccagggga cccaccaaca ggaccaagga
     1321 ccgagacaca gacatggaag gacttcagat accatcttat tctagagacg tagctgacca
     1381 aaaagtaggg gaggggctgg gtctgcaaat taataaatag aagagggggt aagaccttcc
     1441 tgggaccgca
//
