LOCUS       NM_025222               4286 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens WD repeat domain 82 (WDR82), mRNA.
ACCESSION   NM_025222
VERSION     NM_025222.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4286)
  AUTHORS   Bao,S. and Xu,C.
  TITLE     Molecular insight into the SETD1A/B N-terminal region and its
            interaction with WDR82
  JOURNAL   Biochem Biophys Res Commun 658, 136-140 (2023)
   PUBMED   37030068
  REMARK    GeneRIF: Molecular insight into the SETD1A/B N-terminal region and
            its interaction with WDR82.
REFERENCE   2  (bases 1 to 4286)
  AUTHORS   Park,K., Zhong,J., Jang,J.S., Kim,J., Kim,H.J., Lee,J.H. and Kim,J.
  TITLE     ZWC complex-mediated SPT5 phosphorylation suppresses divergent
            antisense RNA transcription at active gene promoters
  JOURNAL   Nucleic Acids Res 50 (7), 3835-3851 (2022)
   PUBMED   35325203
  REMARK    GeneRIF: ZWC complex-mediated SPT5 phosphorylation suppresses
            divergent antisense RNA transcription at active gene promoters.
REFERENCE   3  (bases 1 to 4286)
  AUTHORS   Estell,C., Davidson,L., Steketee,P.C., Monier,A. and West,S.
  TITLE     ZC3H4 restricts non-coding transcription in human cells
  JOURNAL   Elife 10, e67305 (2021)
   PUBMED   33913806
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4286)
  AUTHORS   Austenaa,L.M.I., Piccolo,V., Russo,M., Prosperini,E., Polletti,S.,
            Polizzese,D., Ghisletti,S., Barozzi,I., Diaferia,G.R. and Natoli,G.
  TITLE     A first exon termination checkpoint preferentially suppresses
            extragenic transcription
  JOURNAL   Nat Struct Mol Biol 28 (4), 337-346 (2021)
   PUBMED   33767452
  REMARK    GeneRIF: A first exon termination checkpoint preferentially
            suppresses extragenic transcription.
            GeneRIF: By making a stoichiometric complex with the RNA-binding
            protein ZC3H4, WDR82 controls termination of extragenic
            transcription in human and mouse cells. Cells depleted of the
            WDR82-ZC3H4 complex show greatly enhanced synthesis of long and
            spliced extragenic transcripts.
REFERENCE   5  (bases 1 to 4286)
  AUTHORS   Li,Y., Han,J., Zhang,Y., Cao,F., Liu,Z., Li,S., Wu,J., Hu,C.,
            Wang,Y., Shuai,J., Chen,J., Cao,L., Li,D., Shi,P., Tian,C.,
            Zhang,J., Dou,Y., Li,G., Chen,Y. and Lei,M.
  TITLE     Structural basis for activity regulation of MLL family
            methyltransferases
  JOURNAL   Nature 530 (7591), 447-452 (2016)
   PUBMED   26886794
REFERENCE   6  (bases 1 to 4286)
  AUTHORS   Lee,J.H. and Skalnik,D.G.
  TITLE     Wdr82 is a C-terminal domain-binding protein that recruits the
            Setd1A Histone H3-Lys4 methyltransferase complex to transcription
            start sites of transcribed human genes
  JOURNAL   Mol Cell Biol 28 (2), 609-618 (2008)
   PUBMED   17998332
  REMARK    GeneRIF: suggest a model for how the mammalian RNA polymerase II
            machinery is linked with histone H3-Lys4 histone methyltransferase
            complexes at transcriptionally active genes
REFERENCE   7  (bases 1 to 4286)
  AUTHORS   Lee,J.H., Tate,C.M., You,J.S. and Skalnik,D.G.
  TITLE     Identification and characterization of the human Set1B histone
            H3-Lys4 methyltransferase complex
  JOURNAL   J Biol Chem 282 (18), 13419-13428 (2007)
   PUBMED   17355966
REFERENCE   8  (bases 1 to 4286)
  AUTHORS   Higa,L.A., Wu,M., Ye,T., Kobayashi,R., Sun,H. and Zhang,H.
  TITLE     CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat
            proteins and regulates histone methylation
  JOURNAL   Nat Cell Biol 8 (11), 1277-1283 (2006)
   PUBMED   17041588
REFERENCE   9  (bases 1 to 4286)
  AUTHORS   Lee,J.H. and Skalnik,D.G.
  TITLE     CpG-binding protein (CXXC finger protein 1) is a component of the
            mammalian Set1 histone H3-Lys4 methyltransferase complex, the
            analogue of the yeast Set1/COMPASS complex
  JOURNAL   J Biol Chem 280 (50), 41725-41731 (2005)
   PUBMED   16253997
REFERENCE   10 (bases 1 to 4286)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092045.2, DB500464.1, AY358264.1, AK098435.1 and AI478905.1.
            
            On Nov 23, 2018 this sequence version replaced NM_025222.3.
            
            Summary: TMEM113 (WDR82) is a component of the mammalian SET1A (MIM
            611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase
            complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al.,
            2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.137759.1,
                                           SRR1803612.169907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296490.8/ ENSP00000296490.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC092045.2         134209-134214
            7-271               DB500464.1         1-265
            272-1489            AY358264.1         1-1218
            1490-1964           AK098435.1         930-1404
            1965-4269           AC092045.2         156103-158407
            4270-4286           AI478905.1         13-29               c
FEATURES             Location/Qualifiers
     source          1..4286
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..4286
                     /gene="WDR82"
                     /gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
                     TMEM113; WDR82A"
                     /note="WD repeat domain 82"
                     /db_xref="GeneID:80335"
                     /db_xref="HGNC:HGNC:28826"
                     /db_xref="MIM:611059"
     exon            1..449
                     /gene="WDR82"
                     /gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
                     TMEM113; WDR82A"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..1230
                     /gene="WDR82"
                     /gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
                     TMEM113; WDR82A"
                     /note="transmembrane protein 113"
                     /codon_start=1
                     /product="WD repeat-containing protein 82"
                     /protein_id="NP_079498.2"
                     /db_xref="CCDS:CCDS2851.2"
                     /db_xref="GeneID:80335"
                     /db_xref="HGNC:HGNC:28826"
                     /db_xref="MIM:611059"
                     /translation="MKLTDSVLRSFRVAKVFRENSDKINCFDFSPNGETVISSSDDDS
                     IVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRY
                     FPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFDPEGL
                     IFAAGVNSEMVKLYDLRSFDKGPFATFKMQYDRTCEWTGLKFSNDGKLILISTNGSFI
                     RLIDAFKGVVMHTFGGYANSKAVTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAV
                     LDGKHTGPITCLQFNPKFMTFASACSNMAFWLPTIDD"
     exon            450..547
                     /gene="WDR82"
                     /gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
                     TMEM113; WDR82A"
                     /inference="alignment:Splign:2.1.0"
     exon            548..614
                     /gene="WDR82"
                     /gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
                     TMEM113; WDR82A"
                     /inference="alignment:Splign:2.1.0"
     exon            615..714
                     /gene="WDR82"
                     /gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
                     TMEM113; WDR82A"
                     /inference="alignment:Splign:2.1.0"
     exon            715..831
                     /gene="WDR82"
                     /gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
                     TMEM113; WDR82A"
                     /inference="alignment:Splign:2.1.0"
     exon            832..987
                     /gene="WDR82"
                     /gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
                     TMEM113; WDR82A"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1057
                     /gene="WDR82"
                     /gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
                     TMEM113; WDR82A"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1200
                     /gene="WDR82"
                     /gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
                     TMEM113; WDR82A"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..4286
                     /gene="WDR82"
                     /gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
                     TMEM113; WDR82A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4250..4255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR82"
                     /gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
                     TMEM113; WDR82A"
                     /note="hexamer: TATAAA"
     polyA_site      4286
                     /gene="WDR82"
                     /gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
                     TMEM113; WDR82A"
                     /note="major polyA site"
ORIGIN      
        1 ctcagcttct gcctgtcgcc ccaaaatggc ggacacaatg agccggcgac gcgccggttg
       61 tccgtgaggt ggctgtgagg acgaacggtc ggcgaggctc cacagtccag gcagaagacc
      121 ctcgaccaag caggaagaag aggaggaggc ggcccaactg ttggccgact tcccgctagc
      181 cgccggcgcg gcgcccgccc cgcctgggtt ggcccctcgg cagcccgccc gctcgccgcc
      241 gggccccgcc ccggccctgc gccgccgctg ccttccccag ccgccgccat gaagctgacc
      301 gacagcgtgt tgcggagctt ccgcgtcgct aaggtgttcc gcgaaaactc ggacaagatt
      361 aactgcttcg atttcagccc caacggcgag acggtcatct cgagtagcga cgacgactcc
      421 atcgtgctct atgactgcca ggagggcaaa ccaaagagaa ccctgtacag taagaaatat
      481 ggtgtggacc tcatcagata cactcatgca gcaaacacag ttgtttacag ctctaacaaa
      541 atagacgata ctattcgtta cttgtccttg catgacaaca aatacatcag atactttcct
      601 ggacatagca aaagggtggt ggccttgtcc atgtcacctg tggatgacac tttcatttct
      661 gggtctcttg ataagaccat tcgactctgg gatctccggt ctcctaactg ccagggcctc
      721 atgcatctgc aggggaagcc agtttgttct tttgatccag aagggttaat tttcgctgca
      781 ggtgtcaact ctgaaatggt caagctttat gaccttcgtt cttttgataa ggggccattt
      841 gctaccttta agatgcagta tgatcgaact tgtgagtgga caggacttaa attcagcaat
      901 gatggcaagc tcatcctcat ttccaccaac ggcagcttca ttcgtctgat tgatgcattc
      961 aaaggagtgg tgatgcacac atttgggggt tatgccaaca gcaaagctgt cacactggag
     1021 gcttcattta ctccagactc tcagtttatt atgattggtt cagaggatgg caagatccat
     1081 gtctggaatg gagagagcgg tataaaagta gctgtgttgg atggtaaaca cacaggcccg
     1141 attacctgtt tgcaattcaa ccccaagttc atgacttttg ccagtgcgtg ttccaacatg
     1201 gccttttggt tgcccaccat tgatgactga ccctgttgct gcttggctat ttctgtatag
     1261 tgagggcggc cagcaggaag aaactcagag ggaactgaga taatagtggg attggatcat
     1321 ttgactgggc tggagaacat ccttttacat ggccttccca tggatgtgct gtacatctgc
     1381 tcaaaagaaa ataattactt tgatgagcgt cttcaaaagg actcttggtg caacagactc
     1441 aattggaact cagcttttct aactgtcact gcaccaagct ctgctggagg agtgaccaga
     1501 ctcacgattt ggtatagtgg ggctctcaag catcttcaat ttgaatgtac atgctgctga
     1561 ggagccggtg aagtcatcag ttccgcacat cccttctacc ctccaactgc atgggaagcc
     1621 aaagtcctgg ttttgaaatg cttgggcagc tcagccgctt gccctcaccc tgcatgtctt
     1681 gttactgggt ctccctgtgt acttgtggca ttatccacaa ccatcatgtt tcttaggtgc
     1741 caaacattta cagaaacatt ttcatatatc ttggggtcag agaaagggac agatacagaa
     1801 ggaccttgct tgcaggaagc catgcagtta gtttctgcag ttagtcgtgt gaggctaggt
     1861 ggttgggcag gcctcgggct gtaggtgttg ggtgggaaaa agacccaagg gcctgaaagg
     1921 gagggaaagg ggagggtagc gggagggtag caggtgagtt cctagggctg gaaggtttag
     1981 cagcagcctg gtgcagtgcc ctgtcatcaa gacaaaccca cggtcctcct gggtgcctac
     2041 caagcttggt ttgtacaaaa gcaaggtggg agtctatttt tgtacatgag atacatcaca
     2101 cttacctgtg ggccagtatt gtgaagtgag tctgagttgt ttacactgat gccttccctg
     2161 cccaccacaa attgtgtaca tagtcttcag atgataccac ccctttcccc agctcccaac
     2221 caagagctgg ttctaggcct gtgttatatg tcatatttag cgtttttata tatgaccttt
     2281 gatttctgtt gtttgtattt tagcacagtg tatgcacctt catttaaata catctgtgtg
     2341 catacagata cgcatatatg tgtgtgcgta tgcatatatc tctcatctgt agtttccaag
     2401 agttcagctg aagcagatgg agtcctgcag cccaggagac accctgcatc cctgctaata
     2461 gtgtttgcca caagtattag tgagtcttcc ttattaatat tttcatttca gaagactgaa
     2521 gcaaagctga tagtgtttgc tgtttctttg gcagctaagt gagggtcttg ggatgacttg
     2581 ctgtgttcct caagctgcac tttggggcca tctctgcagt attagccccc tttttgcttg
     2641 gtggtactct gtctgtgcct gtgtgtgtgt gtgatagtca ctcttgcatg gcttccatgt
     2701 ctggtttgtg gcatttgggg ataaggtgct gaagccagag catttgcagt ttgtttgagg
     2761 cctcgttgcc aatgatagat cactcctgtt gacctggtat gtctgcttgc ttgctgcttt
     2821 tccttgcttt ctcttggaag aggaaaggac tctggtcagg cccaggctga gtgagatgag
     2881 ctgcagctgg ctcatggcct tcttagagca gagagaggag tatgtcattt tactaagttc
     2941 ctaaacaaac atttatgcag gcaacactcc ttgcagatcc agaaactgag gcacaatagg
     3001 gttatgactt gctcaagaat atgtagctgc tagggggtaa atcaaggcat cacaatttct
     3061 gttcagcggg caggaatagg ctgtgaattg ctagcacttt ttttttttaa gcaattactt
     3121 tttgacttgt tcctctgaaa gtgcaagagg cgtacacctt tcccaaatgt agactagaat
     3181 ctgcaggatg ccacccactg tatagttctg ctttcccaga gaggaagaac ttttagaaac
     3241 caaatgatct taattgttat tgcccacccc tggcttttcc gggtagaaaa ttcacagtag
     3301 gaatgattgt taagagagag tgcttggaac catgggttaa caggaaaggc tacctaactt
     3361 cacatatctg caaccagagc agccaccaag cattacttag cagcaggaaa atgattgtat
     3421 ttgagttcct gtgtgtccaa aactgagcac catgttcttt gaaaacatgc cacctcaagg
     3481 ctgggcgcgg tggctcacac ctgtaatccc agcactttgg gaggccgagg cgggcggatc
     3541 accggaggtc gggagtttga gaccagcctg accaacatgg agaaacccca tctctactaa
     3601 aaatacaaaa ttagccgggc gtggtggcat gcgcctataa tctcagctac ttgggaggct
     3661 gaggcaggag aattgcttga acccaggagg cggaggttgc ggtgagttga gatcgtgcca
     3721 ttgcactccg gcctgggcaa caacagcaaa actccgtctc aaaaaaaaaa aaaaaaaaat
     3781 gccacctcac agtctctatc gttgggccct gtggttgcaa agctgcctcc tgaattaaga
     3841 aggaaaggga aaagatatag ctggaagcga gtggaagaga tgctgagggc tggggctgca
     3901 cagacgtgct cagcagggct acaggtgctc aagccctatt ggggatgggt ggggagtggg
     3961 gcagcggcgt ttgccacctt aagaattggg gccaaagcca ctgatgttta tttgacagtg
     4021 acactgcact gggtacttaa agaaattatt tcccgttgta attataatta ctgcttatta
     4081 aggaaaatat gggaatttta gaaagaatca agtttgccac ccaaatgcta ccactgttaa
     4141 tcttttggtg ttaaatgttc cccctagaca tttctgtgca tagatttttg gtgtgtttac
     4201 atagtcgtta ttctgtatat acaattttat gtcccttttg tacttaacgt ataaacattt
     4261 tttccatgtt acagtcttaa acagaa
//
