LOCUS       NM_024102               2456 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens WD repeat domain 77 (WDR77), transcript variant 2,
            mRNA.
ACCESSION   NM_024102
VERSION     NM_024102.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2456)
  AUTHORS   Xu,W., Huang,Z., Xiao,Y., Li,W., Xu,M., Zhao,Q. and Yi,P.
  TITLE     HNRNPC promotes estrogen receptor-positive breast cancer cell cycle
            by stabilizing WDR77 mRNA in an m6A-dependent manner
  JOURNAL   Mol Carcinog 63 (5), 859-873 (2024)
   PUBMED   38353359
  REMARK    GeneRIF: HNRNPC promotes estrogen receptor-positive breast cancer
            cell cycle by stabilizing WDR77 mRNA in an m6A-dependent manner.
REFERENCE   2  (bases 1 to 2456)
  AUTHORS   Ichikawa,T., Suekane,A., Nakahata,S., Iha,H., Shimoda,K.,
            Murakami,T. and Morishita,K.
  TITLE     Inhibition of PRMT5/MEP50 Arginine Methyltransferase Activity
            Causes Cancer Vulnerability in NDRG2low Adult T-Cell
            Leukemia/Lymphoma
  JOURNAL   Int J Mol Sci 25 (5), 2842 (2024)
   PUBMED   38474089
  REMARK    GeneRIF: Inhibition of PRMT5/MEP50 Arginine Methyltransferase
            Activity Causes Cancer Vulnerability in NDRG2[low] Adult T-Cell
            Leukemia/Lymphoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2456)
  AUTHORS   Zhao,Y., Yu,T., Sun,J., Wang,F., Cheng,C., He,S., Chen,L., Xie,D.,
            Fu,L., Guan,X., Yan,A., Li,Y., Miao,G. and Zhu,X.
  TITLE     Germ-line mutations in WDR77 predispose to familial papillary
            thyroid cancer
  JOURNAL   Proc Natl Acad Sci U S A 118 (31) (2021)
   PUBMED   34326253
  REMARK    GeneRIF: Germ-line mutations in WDR77 predispose to familial
            papillary thyroid cancer.
REFERENCE   4  (bases 1 to 2456)
  AUTHORS   Yuan,H., Zhao,L., Yuan,Y., Yun,H., Zheng,W., Geng,Y., Yang,G.,
            Wang,Y., Zhao,M. and Zhang,X.
  TITLE     HBx represses WDR77 to enhance HBV replication by DDB1-mediated
            WDR77 degradation in the liver
  JOURNAL   Theranostics 11 (17), 8362-8378 (2021)
   PUBMED   34373747
  REMARK    GeneRIF: HBx represses WDR77 to enhance HBV replication by
            DDB1-mediated WDR77 degradation in the liver.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2456)
  AUTHORS   Krzyzanowski,A., Gasper,R., Adihou,H., Hart,P.'. and Waldmann,H.
  TITLE     Biochemical Investigation of the Interaction of pICln, RioK1 and
            COPR5 with the PRMT5-MEP50 Complex
  JOURNAL   Chembiochem 22 (11), 1908-1914 (2021)
   PUBMED   33624332
  REMARK    GeneRIF: Biochemical Investigation of the Interaction of pICln,
            RioK1 and COPR5 with the PRMT5-MEP50 Complex.
REFERENCE   6  (bases 1 to 2456)
  AUTHORS   Yamada,S., Ohira,M., Horie,H., Ando,K., Takayasu,H., Suzuki,Y.,
            Sugano,S., Hirata,T., Goto,T., Matsunaga,T., Hiyama,E., Hayashi,Y.,
            Ando,H., Suita,S., Kaneko,M., Sasaki,F., Hashizume,K., Ohnuma,N.
            and Nakagawara,A.
  TITLE     Expression profiling and differential screening between
            hepatoblastomas and the corresponding normal livers: identification
            of high expression of the PLK1 oncogene as a poor-prognostic
            indicator of hepatoblastomas
  JOURNAL   Oncogene 23 (35), 5901-5911 (2004)
   PUBMED   15221005
REFERENCE   7  (bases 1 to 2456)
  AUTHORS   Yong,J., Wan,L. and Dreyfuss,G.
  TITLE     Why do cells need an assembly machine for RNA-protein complexes?
  JOURNAL   Trends Cell Biol 14 (5), 226-232 (2004)
   PUBMED   15130578
  REMARK    Review article
REFERENCE   8  (bases 1 to 2456)
  AUTHORS   Hosohata,K., Li,P., Hosohata,Y., Qin,J., Roeder,R.G. and Wang,Z.
  TITLE     Purification and identification of a novel complex which is
            involved in androgen receptor-dependent transcription
  JOURNAL   Mol Cell Biol 23 (19), 7019-7029 (2003)
   PUBMED   12972618
REFERENCE   9  (bases 1 to 2456)
  AUTHORS   Licciardo,P., Amente,S., Ruggiero,L., Monti,M., Pucci,P., Lania,L.
            and Majello,B.
  TITLE     The FCP1 phosphatase interacts with RNA polymerase II and with
            MEP50 a component of the methylosome complex involved in the
            assembly of snRNP
  JOURNAL   Nucleic Acids Res 31 (3), 999-1005 (2003)
   PUBMED   12560496
REFERENCE   10 (bases 1 to 2456)
  AUTHORS   Friesen,W.J., Wyce,A., Paushkin,S., Abel,L., Rappsilber,J., Mann,M.
            and Dreyfuss,G.
  TITLE     A novel WD repeat protein component of the methylosome binds Sm
            proteins
  JOURNAL   J Biol Chem 277 (10), 8243-8247 (2002)
   PUBMED   11756452
  REMARK    GeneRIF: Here, we describe a novel component of the methylosome, a
            50-kilodalton WD repeat protein termed methylosome protein 50
            (MEP50).
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB105102.1 and BC016946.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024102.3.
            
            Summary: The protein encoded by this gene is an androgen receptor
            coactivator that forms a complex with protein arginine
            methyltransferase 5, which modifies specific arginines to
            dimethylarginines in several spliceosomal Sm proteins. The encoded
            protein may be involved in the early stages of prostate cancer,
            with most of the protein being nuclear-localized in benign cells
            but cytoplasmic in cancer cells. Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction in the 3' end compared to variant 1. The resulting
            isoform (2) has the same N- and C-termini but is shorter compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016946.1, SRR3476690.507710.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000235090.10/ ENSP00000235090.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                DB105102.1         56-103
            49-2456             BC016946.1         1-2408
FEATURES             Location/Qualifiers
     source          1..2456
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..2456
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /note="WD repeat domain 77"
                     /db_xref="GeneID:79084"
                     /db_xref="HGNC:HGNC:29652"
                     /db_xref="MIM:611734"
     exon            1..202
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1116
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /note="isoform 2 is encoded by transcript variant 2;
                     methylosome protein 50; androgen receptor cofactor p44; WD
                     repeat-containing protein 77; testis tissue sperm-binding
                     protein Li 44a; methylosome protein WDR77"
                     /codon_start=1
                     /product="methylosome protein WDR77 isoform 2"
                     /protein_id="NP_077007.1"
                     /db_xref="CCDS:CCDS835.1"
                     /db_xref="GeneID:79084"
                     /db_xref="HGNC:HGNC:29652"
                     /db_xref="MIM:611734"
                     /translation="MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLL
                     GASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGA
                     VELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVL
                     SSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSL
                     AWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSE
                     DCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPA
                     PGPASVTE"
     exon            203..388
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /inference="alignment:Splign:2.1.0"
     exon            389..530
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /inference="alignment:Splign:2.1.0"
     exon            531..580
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /inference="alignment:Splign:2.1.0"
     exon            581..651
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /inference="alignment:Splign:2.1.0"
     exon            652..706
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /inference="alignment:Splign:2.1.0"
     exon            707..778
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /inference="alignment:Splign:2.1.0"
     exon            779..887
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /inference="alignment:Splign:2.1.0"
     exon            888..956
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /inference="alignment:Splign:2.1.0"
     exon            957..2456
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1375..1380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /note="hexamer: AATAAA"
     polyA_site      1394
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /note="major polyA site"
     regulatory      2051..2056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /note="hexamer: AATAAA"
     polyA_site      2072
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /note="major polyA site"
     regulatory      2292..2297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /note="hexamer: AATATA"
     polyA_site      2309
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
     regulatory      2395..2400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /note="hexamer: AGTAAA"
     polyA_site      2421
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
     regulatory      2436..2441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
                     /note="hexamer: AGTAAA"
     polyA_site      2456
                     /gene="WDR77"
                     /gene_synonym="HKMT1069; MEP-50; MEP50; Nbla10071; p44;
                     p44/Mep50"
ORIGIN      
        1 agaggtgcac cacgtggggt ttgctgccgg agcggagtct ccggccggcg tccagtttga
       61 gtctaggttg gagttggaac cgtggagatg cggaaggaaa ccccaccccc cctagtgccc
      121 ccggcggccc gggagtggaa tcttccccca aatgcgcccg cctgcatgga acggcagttg
      181 gaggctgcgc ggtaccggtc cgatggggcg cttctcctcg gggcctccag cctgagtggg
      241 cgctgctggg ccggctccct ctggcttttt aaggacccct gtgccgcccc caacgaaggc
      301 ttctgctccg ccggagtcca aacggaggct ggagtggctg acctcacttg ggttggggag
      361 agaggtattc tagtggcctc cgattcaggt gctgttgaat tgtgggaact agatgagaat
      421 gagacactta ttgtcagcaa gttctgcaag tatgagcatg atgacattgt gtctacagtc
      481 agtgtcttga gctctggcac acaagctgtc agtggtagca aagacatctg catcaaggtt
      541 tgggaccttg ctcagcaggt ggtactgagt tcataccgag ctcatgctgc tcaggtcact
      601 tgtgttgctg cctctcctca caaggactct gtgtttcttt catgcagcga ggacaataga
      661 attttactct gggatacccg ctgtcccaag ccagcatcac agattggctg cagtgcgcct
      721 ggctaccttc ctacctcgct ggcttggcat cctcagcaaa gtgaagtctt tgtctttggt
      781 gatgagaatg ggacagtctc ccttgtggac accaagagta caagctgtgt cctgagctca
      841 gctgtacact cccagtgtgt cactgggctg gtgttctccc cacacagtgt tcccttcctg
      901 gcctctctca gtgaagactg ctcacttgct gtgctggact caagcctttc tgagttgttt
      961 agaagccaag cccacagaga ctttgtgaga gatgcgactt ggtccccgct caatcactcc
     1021 ctgcttacca cagtgggctg ggaccatcag gtcgtccacc acgttgtgcc cacagaacct
     1081 ctcccagccc ctggacctgc aagtgttact gagtagattg gatttaagac aaaaagcaag
     1141 tcccccatga gtgtccactt ctttgccctg ccctctcagc ttgtgagaca acacaggagc
     1201 cttctatagt atgttgatat gctagatctg tgccgttaat aggcatcgtc tctcagcctg
     1261 agggaggctg gattctgggt tcctgtagtc acagggagga aaagctttct taaaaatgga
     1321 catgtatgtg cgtgtgagtg tgtgtgtaga tttatagttt ttggtagtgg caggaataaa
     1381 aaaaatccat cctacatctt ccctaagcac tgcctctctc tcacccccca aaacaagttg
     1441 acgaaagggt tttatgtagc tgtctatgag gaattggccg tgtctgggtg ggttatggga
     1501 tgtgggcatc cctgggttct tggaagcagc tcttatgcta ctcatagaga tgggattgac
     1561 tttatttttt tatagtgctt aattcaccat tatgagaaat gcttccagtc acaaaaatgc
     1621 agcccagctc actctgagga agaagcagga cttggtacgg ttttacacaa ctccttacca
     1681 ttaaactgaa tcagaaatcc attttctggc tgaataaaaa gtttggcttg cctgtgtaat
     1741 gcccactccc ttccccctgg ctccctagtg atgggacata tatgagagag aagtgttttt
     1801 ctatcataga caccataggg gaaagtttgg ggatgaagga gagcttaaag gtgtttcaat
     1861 taagttagaa aactgacaca ggctgttgag aattctttgc cacttttccc accccaaaac
     1921 agcatggggc ctgacatctt ctgccctggt cccctttctc ttgatgtgga aagtctgaat
     1981 gcagtattta tagacttcta aggttttaaa atccagtatc aagaagaaaa tcagaaatac
     2041 tggttggtga aataaagagt ttaggcattg ttggcctgtc ttttttgaag catgtgtgtt
     2101 atgtgtagtt agatatattt cacttatgtg agtcatcatg gtgttggtct tgtagcccat
     2161 tatttttcct gtgcttcccc agcttcccaa agtagctagt tagaacttaa ggtaaatatt
     2221 tattcttggg ttggtggagt ggatattgcc agttaggagt catggatcaa ttactgatta
     2281 tattgaaagt aaatataatc aattatgtac ttttgagctt tgcaggttca atttaggtaa
     2341 aaatcacatt atgaaactgg gaaagtctga aggaatatgg gcaaaatatt tctcagtaaa
     2401 gcttccatgc ttcacccttg acatgattac ccttgagtaa aacatgggaa tttgta
//
