LOCUS       NM_024908               3932 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens WD repeat domain 76 (WDR76), transcript variant 1,
            mRNA.
ACCESSION   NM_024908
VERSION     NM_024908.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3932)
  AUTHORS   Kwon,M., Oh,T., Jang,M., Kim,G.H., Kim,J.H., Ryu,H.W., Oh,S.R.,
            Jang,J.H., Ahn,J.S. and Ko,S.K.
  TITLE     Kurarinone induced p53-independent G0/G1 cell cycle arrest by
            degradation of K-RAS via WDR76 in human colorectal cancer cells
  JOURNAL   Eur J Pharmacol 923, 174938 (2022)
   PUBMED   35381263
  REMARK    GeneRIF: Kurarinone induced p53-independent G0/G1 cell cycle arrest
            by degradation of K-RAS via WDR76 in human colorectal cancer cells.
REFERENCE   2  (bases 1 to 3932)
  AUTHORS   Yang,J., Wang,F. and Chen,B.
  TITLE     The role of WDR76 protein in human diseases
  JOURNAL   Bosn J Basic Med Sci 21 (5), 528-534 (2021)
   PUBMED   33714259
  REMARK    GeneRIF: The role of WDR76 protein in human diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3932)
  AUTHORS   Dayebgadoh,G., Sardiu,M.E., Florens,L. and Washburn,M.P.
  TITLE     Biochemical Reduction of the Topology of the Diverse WDR76 Protein
            Interactome
  JOURNAL   J Proteome Res 18 (9), 3479-3491 (2019)
   PUBMED   31353912
  REMARK    GeneRIF: Biochemical Reduction of the Topology of the Diverse WDR76
            Protein Interactome.
REFERENCE   4  (bases 1 to 3932)
  AUTHORS   Ro,E.J., Cho,Y.H., Jeong,W.J., Park,J.C., Min,D.S. and Choi,K.Y.
  TITLE     WDR76 degrades RAS and suppresses cancer stem cell activation in
            colorectal cancer
  JOURNAL   Cell Commun Signal 17 (1), 88 (2019)
   PUBMED   31362761
  REMARK    GeneRIF: destabilization of RAS by WDR76 is a potential strategy
            for targeting malignant CRC involving CSC activation
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3932)
  AUTHORS   Jeong,W.J., Park,J.C., Kim,W.S., Ro,E.J., Jeon,S.H., Lee,S.K.,
            Park,Y.N., Min,D.S. and Choi,K.Y.
  TITLE     WDR76 is a RAS binding protein that functions as a tumor suppressor
            via RAS degradation
  JOURNAL   Nat Commun 10 (1), 295 (2019)
   PUBMED   30655611
  REMARK    GeneRIF: Study identifies WD40-repeat protein 76 (WDR76) as one of
            the HRAS binding proteins using proteomic analyses of
            hepatocellular carcinomas tissue form human patients and mouse
            diethylnitrosamine-induced liver carcinogenesis model and
            demonstrates that WDR76 functions as a tumor suppressor via RAS
            degradation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3932)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 3932)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3932)
  AUTHORS   Higa,L.A., Wu,M., Ye,T., Kobayashi,R., Sun,H. and Zhang,H.
  TITLE     CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat
            proteins and regulates histone methylation
  JOURNAL   Nat Cell Biol 8 (11), 1277-1283 (2006)
   PUBMED   17041588
REFERENCE   9  (bases 1 to 3932)
  AUTHORS   Fleischmann,C., Bevan,S., Neil,J.C., Terry,A. and Houlston,R.S.
  TITLE     Mutations in the candidate tumour suppressor gene FLJ12973 on
            chromosome 15q15 are rare in colorectal cancer
  JOURNAL   Cancer Lett 196 (1), 65-67 (2003)
   PUBMED   12860291
  REMARK    GeneRIF: To examine the proposition that FLJ12973 is involved in
            colorectal cancer we analysed 31 tumours for sequence variation. No
            missense changes or pathogenic mutations--truncating or splice
            site--were detected in any of the tumours.
REFERENCE   10 (bases 1 to 3932)
  AUTHORS   Beatty,J., Terry,A., MacDonald,J., Gault,E., Cevario,S.,
            O'Brien,S.J., Cameron,E. and Neil,J.C.
  TITLE     Feline immunodeficiency virus integration in B-cell lymphoma
            identifies a candidate tumor suppressor gene on human chromosome
            15q15
  JOURNAL   Cancer Res 62 (24), 7175-7180 (2002)
   PUBMED   12499253
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA439086.1, AK023035.1, BC025247.1, AC023356.8 and AA743653.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024908.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.1698.1,
                                           SRR1803612.274830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263795.11/ ENSP00000263795.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 DA439086.1         89-96
            9-487               AK023035.1         2-480
            488-488             BC025247.1         507-507
            489-1101            AK023035.1         482-1094
            1102-1102           BC025247.1         1121-1121
            1103-2532           AK023035.1         1096-2525
            2533-3496           AC023356.8         68857-69820
            3497-3932           AA743653.1         18-453              c
FEATURES             Location/Qualifiers
     source          1..3932
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.3"
     gene            1..3932
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /note="WD repeat domain 76"
                     /db_xref="GeneID:79968"
                     /db_xref="HGNC:HGNC:25773"
                     /db_xref="MIM:620302"
     exon            1..91
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1912
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 76"
                     /codon_start=1
                     /product="WD repeat-containing protein 76 isoform 1"
                     /protein_id="NP_079184.2"
                     /db_xref="CCDS:CCDS10106.1"
                     /db_xref="GeneID:79968"
                     /db_xref="HGNC:HGNC:25773"
                     /db_xref="MIM:620302"
                     /translation="MSRSGAAAEKADSRQRPQMKVNEYKENQNIAYVSLRPAQTTVLI
                     KTAKVYLAPFSLSNYQLDQLMCPKSLSEKNSNNEVACKKTKIKKTCRRIIPPKMKNTS
                     SKAESTLQNSSSAVHTESNKLQPKRTADAMNLSVDVESSQDGDSDEDTTPSLDFSGLS
                     PYERKRLKNISENADFFASLQLSESAARLREMIEKRQPPKSKRKKPKRENGIGCRRSM
                     RLLKVDPSGVSLPAAPTPPTLVADETPLLPPGPLEMTSENQEDNNERFKGFLHTWAGM
                     SKPSSKNTEKGLSSIKSYKANLNGMVISEDTVYKVTTGPIFSMALHPSETRTLVAVGA
                     KFGQVGLCDLTQQPKEDGVYVFHPHSQPVSCLYFSPANPAHILSLSYDGTLRCGDFSR
                     AIFEEVYRNERSSFSSFDFLAEDASTLIVGHWDGNMSLVDRRTPGTSYEKLTSSSMGK
                     IRTVHVHPVHRQYFITAGLRDTHIYDARRLNSRRSQPLISLTEHTKSIASAYFSPLTG
                     NRVVTTCADCNLRIFDSSCISSKIPLLTTIRHNTFTGRWLTRFQAMWDPKQEDCVIVG
                     SMAHPRRVEIFHETGKRVHSFGGEYLVSVCSINAMHPTRYILAGGNSSGKIHVFMNEK
                     SC"
     exon            92..493
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..583
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..639
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..763
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..865
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..909
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1063
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1222
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1440
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1593
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1647
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..3932
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2514..2519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /note="hexamer: ATTAAA"
     polyA_site      2537
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /note="major polyA site"
     regulatory      3912..3917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /note="hexamer: AATAAA"
     polyA_site      3932
                     /gene="WDR76"
                     /gene_synonym="CDW14; CMR1"
                     /note="major polyA site"
ORIGIN      
        1 gggaaggcgc cggccgctaa gaagccgaaa gatgtccagg tcgggcgcgg cggctgagaa
       61 ggcggactcc agacagcgac cccagatgaa ggtaaatgaa tataaagaaa atcaaaacat
      121 cgcttatgtg tctctgagac cagcacagac tacagtttta ataaaaacag ctaaggtcta
      181 tcttgccccc ttttcactca gtaattacca gctagaccag cttatgtgcc ccaaatccct
      241 atcagaaaag aattctaaca atgaagtggc gtgtaagaag actaaaataa agaaaacttg
      301 cagaaggatt atacctccaa agatgaaaaa cacatcttcc aaggcagaat ccacgctgca
      361 aaattcatcc tcagctgttc atactgaaag taacaagcta caacccaaga gaacggcaga
      421 tgcgatgaat ctcagtgttg atgtggaaag tagtcaggat ggagacagtg atgaagatac
      481 cacaccatcc ctggattttt cgggattgtc accctacgaa aggaagagac tgaagaacat
      541 atcagaaaac gcagactttt ttgcttctct tcagttgtct gagtctgctg caagactccg
      601 tgaaatgata gagaagagac agcctcctaa atccaaaaga aagaagccta agagagaaaa
      661 tgggattgga tgtagaaggt caatgcgatt actaaaagtt gatccttcgg gagtttcatt
      721 accagcagct ccaacaccgc cgacattagt agcagatgaa actcctttgt tacctcctgg
      781 gcctttagaa atgacttctg aaaatcaaga agacaacaat gaacgattta aaggatttct
      841 gcacacatgg gcaggaatga gcaagccaag tagtaagaac actgagaagg gattatctag
      901 cattaaaagc tacaaagcca atttaaatgg catggtcatt agtgaagata ccgtttacaa
      961 agttaccaca ggcccaatat tctctatggc tctccatcca tcagaaacta gaactttggt
     1021 agcagttggg gccaaatttg ggcaagttgg actttgtgat ttgacccagc aacctaaaga
     1081 agatggagtt tatgtttttc atccccatag tcagccagtt agctgtcttt acttctcacc
     1141 cgccaatccg gcccacatac tgtcactgag ctatgatggc acgttacgct gtggggattt
     1201 ttccagggct atttttgaag aggtgtatag aaatgaaaga agtagctttt cctccttcga
     1261 cttcttggca gaagatgcct ccactttaat agtaggacac tgggatggaa atatgtcact
     1321 ggtggataga cggacacctg gaacttctta tgagaaactt accagttctt ctatgggaaa
     1381 aataagaact gttcatgtcc acccagtgca tagacagtat tttatcactg ccggattgag
     1441 ggatactcat atttatgatg caaggcgatt gaattccagg agaagtcagc ctttgatttc
     1501 tttgactgaa catacaaaga gcattgcttc cgcctatttt tcacctctta ctggtaacag
     1561 agtggtgacc acatgtgctg attgtaatct gagaattttt gacagcagct gtatatcttc
     1621 taagattccg ctcctcacca ccatcaggca caacactttc actgggcgat ggctgaccag
     1681 gttccaagcc atgtgggatc ctaaacaaga agactgtgtc atagttggca gcatggccca
     1741 tccacgacgg gtagaaatct tccatgagac aggaaagagg gtgcattcgt ttggtggaga
     1801 ataccttgtc tctgtgtgtt ccatcaatgc catgcaccca actcggtata ttttggctgg
     1861 aggtaattcc agcgggaaga tacatgtttt tatgaatgaa aaaagctgct gagtttttgg
     1921 tttaggaaca tcaatttgtt caaattgacc actgtctaag gagcctagta atcggcgtgc
     1981 cttagtgtgt ttatgtggta atgtgttaca tttagcaatt ataacattgt tttattaata
     2041 agactataag aagagtgtac ttttagtaag ggagaagtct tggagggttg cttctgcagg
     2101 acggggaggg aatttgaggg gaggctgagg tgccgtcagg actttttttt tttttttttt
     2161 tttgagatgg agttttgctc ttgttgccca ggctggagtg caatagcgcg atcttggctc
     2221 accgcaacct ccgcctccca ggttcaagcg attctcctgc ctcagactcc taagtagctg
     2281 ggattacagg cacctgccac cacgcctggc tatttttttg tatttttagt agagatgggg
     2341 tttcatcatg ttggccaggc tggtctcgag ctcctgacct caggtgatct gcccgcctcg
     2401 gcctccaaaa gtgctggaat tacaggcgtg agccaccatg cctggccatc agaacttgta
     2461 atcaagacag tatgttgaga aattctaaca ttataaatta caaagctttg actattaaag
     2521 tttttgtgat ctaatgatac agttttgatt ctatagtaat ttgtggctta ttttatagtt
     2581 tataatgaat acttatttct agactcatac actggaaggg gacccggaaa ggtaatgtaa
     2641 ctcagtgatt ttaaaacttg atttttttaa ctgagaactt tttttgcccc ctgcctgtag
     2701 gttaagtctt acgtgaaatg ccaagataat tgctgagcag ctttggttac ccagggcggg
     2761 gtctgggtct gtctgtactt tgcctttact ctagatggct cctgagacac aggcaggact
     2821 cccaagcacc gggttgggat ctgccctggt cccggcattc cagtataaga ttgcctcaga
     2881 cctgtgtttt tcagactggg tttttgctct tcacatgaaa tcaagttaga tgacaatgac
     2941 tggtgttgaa aaaaatgaaa aggaaagaat ttgtaaagaa cagaaaatat atttgagtaa
     3001 gtattgtttg gtaaaactta gttacatatg catatatatt tgttaggtat atatgtttat
     3061 gtgtattctg atgtaaaata tatatatata tatattttat tactatagta ccatgggtaa
     3121 tggataaaga agttaaagct actgcttaga atgaagaagg ccccaggctt acctgtcccg
     3181 atctttaaac tgtccgaagg aaattcaata gcctgttaag tgaatacctt cattcttact
     3241 tgtatttggg ggaatattat gaaatactca ccacttttgg tattttatga aaatgttttc
     3301 ttttcagaag ttatggtaat ttcaatgtgt ttgttgttgg gaggggagct gccaaatcag
     3361 ttactaatat tactgtgtga catctatcca acttttttca ttattcttca ttgccaaata
     3421 ctgaaagact tgtaaatggc tttggcaata tgtttgaatt ctaagaggaa atattttccc
     3481 ataattgtat atcagagaaa tatagtgata tacaatttcc ttgaaaacca atttctaaat
     3541 aattttcttc tctgtaatct aagtgtaaaa aggtttagtt ttttaatagg tttaggtgtt
     3601 tataagcaat agttctctat tttctagttg atataagtag aagaattgac aagtgagatg
     3661 gaaatgttaa tttataaagg gaaagaaaag ctaggtgagg ttgagttata attaaactgt
     3721 tcaggaaaca tcgtaaaggc tttaggctcc ctttttcatt tctataccaa ttaatctcat
     3781 gggttctaga gtggttagtt ctacgggaat tgtttttgtt tttgttttta aagatgctga
     3841 aaactactct caatcaaatt agtaccatca tttaagcttt gaatacttgg cagtaattgc
     3901 ctgggctcgt caataaatgt tagcaaattc tt
//
