LOCUS       NM_032168               2647 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens WD repeat domain 75 (WDR75), transcript variant 1,
            mRNA.
ACCESSION   NM_032168
VERSION     NM_032168.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2647)
  AUTHORS   Moudry,P., Chroma,K., Bursac,S., Volarevic,S. and Bartek,J.
  TITLE     RNA-interference screen for p53 regulators unveils a role of WDR75
            in ribosome biogenesis
  JOURNAL   Cell Death Differ 29 (3), 687-696 (2022)
   PUBMED   34611297
  REMARK    GeneRIF: RNA-interference screen for p53 regulators unveils a role
            of WDR75 in ribosome biogenesis.
REFERENCE   2  (bases 1 to 2647)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 2647)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2647)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2647)
  AUTHORS   Benyamin,B., Esko,T., Ried,J.S., Radhakrishnan,A., Vermeulen,S.H.,
            Traglia,M., Gogele,M., Anderson,D., Broer,L., Podmore,C., Luan,J.,
            Kutalik,Z., Sanna,S., van der Meer,P., Tanaka,T., Wang,F.,
            Westra,H.J., Franke,L., Mihailov,E., Milani,L., Halldin,J.,
            Winkelmann,J., Meitinger,T., Thiery,J., Peters,A., Waldenberger,M.,
            Rendon,A., Jolley,J., Sambrook,J., Kiemeney,L.A., Sweep,F.C.,
            Sala,C.F., Schwienbacher,C., Pichler,I., Hui,J., Demirkan,A.,
            Isaacs,A., Amin,N., Steri,M., Waeber,G., Verweij,N., Powell,J.E.,
            Nyholt,D.R., Heath,A.C., Madden,P.A., Visscher,P.M., Wright,M.J.,
            Montgomery,G.W., Martin,N.G., Hernandez,D., Bandinelli,S., van der
            Harst,P., Uda,M., Vollenweider,P., Scott,R.A., Langenberg,C.,
            Wareham,N.J., van Duijn,C., Beilby,J., Pramstaller,P.P.,
            Hicks,A.A., Ouwehand,W.H., Oexle,K., Gieger,C., Metspalu,A.,
            Camaschella,C., Toniolo,D., Swinkels,D.W. and Whitfield,J.B.
  CONSRTM   InterAct Consortium
  TITLE     Novel loci affecting iron homeostasis and their effects in
            individuals at risk for hemochromatosis
  JOURNAL   Nat Commun 5, 4926 (2014)
   PUBMED   25352340
  REMARK    Erratum:[Nat Commun. 2015 Mar 30;6:6542. doi: 10.1038/ncomms7542..
            Haldin, Jonas [corrected to Halldin, Jonas]. PMID: 25817829]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2647)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 2647)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 2647)
  AUTHORS   Prieto,J.L. and McStay,B.
  TITLE     Recruitment of factors linking transcription and processing of
            pre-rRNA to NOR chromatin is UBF-dependent and occurs independent
            of transcription in human cells
  JOURNAL   Genes Dev 21 (16), 2041-2054 (2007)
   PUBMED   17699751
REFERENCE   9  (bases 1 to 2647)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   10 (bases 1 to 2647)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC040567.1, AK023276.1 and BU619995.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032168.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.13618.1,
                                           SRR1660805.104256.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314761.9/ ENSP00000314193.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-639               BC040567.1         42-680
            640-640             AK023276.1         320-320
            641-2633            BC040567.1         682-2674
            2634-2647           BU619995.1         29-42               c
FEATURES             Location/Qualifiers
     source          1..2647
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.2"
     gene            1..2647
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /note="WD repeat domain 75"
                     /db_xref="GeneID:84128"
                     /db_xref="HGNC:HGNC:25725"
                     /db_xref="MIM:620341"
     exon            1..105
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..2512
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 75; UTP17, small subunit (SSU)
                     processome component, homolog; U3 small nucleolar
                     RNA-associated protein 17 homolog"
                     /codon_start=1
                     /product="WD repeat-containing protein 75 isoform 1"
                     /protein_id="NP_115544.1"
                     /db_xref="CCDS:CCDS2298.1"
                     /db_xref="GeneID:84128"
                     /db_xref="HGNC:HGNC:25725"
                     /db_xref="MIM:620341"
                     /translation="MVEEENIRVVRCGGSELNFRRAVFSADSKYIFCVSGDFVKVYST
                     VTEECVHILHGHRNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKL
                     HALFTLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKC
                     IAFGNEGVYVAAVREFYLSVYFFKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCI
                     ASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWR
                     DATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDR
                     SIFTGLMIDPRTKALVLNGKPGHLQFYSLQSDKQLYNLDIIQQEYINDYGLIQIELTK
                     AAFGCFGNWLATVEQRQEKETELELQMKLWMYNKKTQGFILNTKINMPHEDCITALCF
                     CNAEKSEQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCFSE
                     DGSLLAVSFEEIVTIWDSVTWELKCTFCQRAGKIRHLCFGRLTCSKYLLGATENGILC
                     CWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQSSVGSDLFVFKPSEPRPLYIQKGI
                     SREKVQWGVFVPRDVPESFTSEAYQWLNRSQFYFLTKSQSLLTFSTKSPEEKLTPTSK
                     QLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQLPLTENIPAISELLHTPAHV
                     LPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESEDSDEENDFTEKVQDTSNT
                     GLGEDIIHQLSKSEEKELRKFRKIDYSWIAAL"
     exon            106..235
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            236..301
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            302..392
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            393..517
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            518..588
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            589..708
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            709..797
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            798..956
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1016
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1132
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1308
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1466
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1647
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1742
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1838
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2008
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2068
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2215
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2307
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2647
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2624..2629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /note="hexamer: AACAAA"
     polyA_site      2647
                     /gene="WDR75"
                     /gene_synonym="NET16; UTP17"
                     /note="major polyA site"
ORIGIN      
        1 attccgctac tgcgcaaaga tggtggagga ggagaacatc cgcgtggttc gttgtggcgg
       61 cagcgagttg aactttagga gagctgtgtt ctctgcagat tctaagtata tcttctgtgt
      121 ctctggagac tttgttaaag tttacagcac agttacagaa gagtgtgtac acatactgca
      181 tggacacaga aatctggtga ctggaatcca gcttaacccc aacaaccatc tacagctgta
      241 ttcttgttcc cttgatggca caattaaact gtgggactat atagatggca tcttaataaa
      301 gactttcata gttggatgta aacttcatgc cctctttact cttgcccaag ctgaggattc
      361 tgtctttgtt atagtgaata aagaaaaacc agatatattt cagctggttt cagtgaaact
      421 gccaaaatcc tcaagccagg aagtagaagc caaggagctg tcctttgttt tggattacat
      481 aaaccagtca cccaagtgca ttgcctttgg aaacgaggga gtatatgttg ctgcagtacg
      541 ggaattttac ttgtctgttt attttttcaa aaagaaaaca acatcaaggt ttactttatc
      601 atcatcaaga aataagaagc atgctaaaaa caattttaca tgtgtagcat gtcacccaac
      661 ggaagactgc atcgcatctg gtcacatgga tggcaaaatt cgtctttgga ggaattttta
      721 tgatgataag aaatatacgt acacatgttt acattggcac catgatatgg ttatggattt
      781 ggctttttca gtgacaggca ccagtctgct gagtggcggt cgtgaatctg tacttgtaga
      841 gtggcgcgat gcaacagaga agaataagga gtttctcccg cgtttaggag ctactattga
      901 acatatctca gtctcgcctg caggagattt attctgcact tctcactctg ataataagat
      961 aataattatt caccgaaacc ttgaagcatc cgcagtaatt caaggcctag tgaaagatag
     1021 gagtatcttc actggtttga tgattgatcc aagaactaaa gctttggttt tgaatggaaa
     1081 acctggccac ctgcagtttt attctctcca gagtgataaa cagttataca atttagatat
     1141 tatacagcaa gaatatatta atgattatgg tctgatccaa attgaactaa caaaggctgc
     1201 atttggctgc tttggtaact ggcttgcaac agtggaacag cggcaagaaa aggaaactga
     1261 gcttgaattg caaatgaaac tgtggatgta taataagaaa acacaagggt ttattcttaa
     1321 cactaaaatt aacatgccac acgaagactg cattacagct ctctgtttct gtaatgcaga
     1381 aaaatctgaa cagcccacct tggttacagc tagcaaagat ggttacttca aagtatggat
     1441 attaacagat gactctgaca tatacaaaaa agctgttggc tggacctgtg actttgttgg
     1501 tagttatcac aagtatcaag caactaactg ttgtttctcc gaagatggtt ctttactagc
     1561 agttagtttt gaggaaatag tcacaatatg ggattctgta acatgggaac ttaaatgtac
     1621 attttgccaa cgagctggga aaataaggca cctttgcttt gggagattga cgtgttcaaa
     1681 gtatctactt ggtgctactg aaaatggcat tctttgctgt tggaatctgc tgagctgtgc
     1741 attggagtgg aatgcaaaat taaatgttag agttatggaa cccgatccta attcagagaa
     1801 tattgctgca atctctcagt cttcagtggg ttcagacttg tttgtattta aacctagtga
     1861 gccaaggcca ttgtatattc aaaagggtat ctccagagag aaagtccagt ggggagtgtt
     1921 tgttccacga gatgtccctg aatccttcac ctcagaagct taccagtggc taaatagatc
     1981 ccagttttac ttcctaacaa aatcacagag tttattgaca ttcagtacaa agtctccaga
     2041 agaaaaactc acaccaacaa gcaaacagct gctagcagaa gaaagtcttc ccacaacccc
     2101 attttatttc atattgggaa aacacaggca acagcaggat gaaaaactaa acgaaacttt
     2161 agagaatgag ctggtacaac tacccttaac agaaaacata cccgcaatta gtgagcttct
     2221 tcacactcca gcccatgtcc tgccatctgc tgctttcctg tgctccatgt ttgtaaattc
     2281 attgctgctg tctaaagaga ctaagagtgc taaggaaatt cctgaagatg tagatatgga
     2341 agaagaaaaa gaaagtgaag attcagatga agaaaatgat tttaccgaaa aagtccagga
     2401 tacaagtaac acaggtttag gagaagacat tatacatcag ttgtcaaaat ctgaagaaaa
     2461 agaactgaga aaatttagga aaatagacta cagctggata gctgcccttt aagccttgga
     2521 gatggggagg atccttggac tttgtgtttt tgattgtatg ttgatattct aaaaacatct
     2581 attttaatgt tatttctgtt ctaaaaataa gataataaat attaacaaac tttgcttttt
     2641 taaaaaa
//
