LOCUS       NM_182758               7310 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens WD repeat domain 72 (WDR72), transcript variant 1,
            mRNA.
ACCESSION   NM_182758 XM_170760
VERSION     NM_182758.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7310)
  AUTHORS   Xu,K., Li,Y.D., Ren,L.Y., Song,H.L., Yang,Q.Y. and Xu,D.L.
  TITLE     Long non-coding RNA X-Inactive Specific Transcript (XIST)
            interacting with USF2 promotes osteogenic differentiation of
            periodontal ligament stem cells through regulation of WDR72
            transcription
  JOURNAL   J Periodontal Res 58 (6), 1235-1247 (2023)
   PUBMED   37712743
  REMARK    GeneRIF: Long non-coding RNA X-Inactive Specific Transcript (XIST)
            interacting with USF2 promotes osteogenic differentiation of
            periodontal ligament stem cells through regulation of WDR72
            transcription.
REFERENCE   2  (bases 1 to 7310)
  AUTHORS   Husein,D., Alamoudi,A., Ohyama,Y., Mochida,H., Ritter,B. and
            Mochida,Y.
  TITLE     Identification of the C-terminal region in Amelogenesis Imperfecta
            causative protein WDR72 required for Golgi localization
  JOURNAL   Sci Rep 12 (1), 4640 (2022)
   PUBMED   35301423
  REMARK    GeneRIF: Identification of the C-terminal region in Amelogenesis
            Imperfecta causative protein WDR72 required for Golgi localization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7310)
  AUTHORS   Zhang,H., Koruyucu,M., Seymen,F., Kasimoglu,Y., Kim,J.W.,
            Tinawi,S., Zhang,C., Jacquemont,M.L., Vieira,A.R., Simmer,J.P. and
            Hu,J.C.C.
  TITLE     WDR72 Mutations Associated with Amelogenesis Imperfecta and
            Acidosis
  JOURNAL   J Dent Res 98 (5), 541-548 (2019)
   PUBMED   30779877
  REMARK    GeneRIF: WDR72 mutations cause a syndromic form of AI and improve
            our ability to diagnose AI caused by WDR72 defects
REFERENCE   4  (bases 1 to 7310)
  AUTHORS   Rungroj,N., Nettuwakul,C., Sawasdee,N., Sangnual,S., Deejai,N.,
            Misgar,R.A., Pasena,A., Khositseth,S., Kirdpon,S.,
            Sritippayawan,S., Vasuvattakul,S. and Yenchitsomanus,P.T.
  TITLE     Distal renal tubular acidosis caused by tryptophan-aspartate repeat
            domain 72 (WDR72) mutations
  JOURNAL   Clin Genet 94 (5), 409-418 (2018)
   PUBMED   30028003
  REMARK    GeneRIF: WDR72 mutations associated with dRTA have not been
            previously described. This is the first identification of
            pathogenic variations in WDR72 as a cause of hereditary dRTA.
REFERENCE   5  (bases 1 to 7310)
  AUTHORS   El-Sayed,W., Shore,R.C., Parry,D.A., Inglehearn,C.F. and
            Mighell,A.J.
  TITLE     Hypomaturation amelogenesis imperfecta due to WDR72 mutations: a
            novel mutation and ultrastructural analyses of deciduous teeth
  JOURNAL   Cells Tissues Organs 194 (1), 60-66 (2011)
   PUBMED   21196691
  REMARK    GeneRIF: Hypomaturation amelogenesis imperfecta due to WDR72
            mutations: a novel mutation and ultrastructural analyses of
            deciduous teeth
REFERENCE   6  (bases 1 to 7310)
  AUTHORS   Lee,S.K., Seymen,F., Lee,K.E., Kang,H.Y., Yildirim,M., Tuna,E.B.,
            Gencay,K., Hwang,Y.H., Nam,K.H., De La Garza,R.J., Hu,J.C.,
            Simmer,J.P. and Kim,J.W.
  TITLE     Novel WDR72 mutation and cytoplasmic localization
  JOURNAL   J Dent Res 89 (12), 1378-1382 (2010)
   PUBMED   20938048
  REMARK    GeneRIF: A novel WDR72 dinucleotide deletion mutation
            (g.57,426_57,427delAT; c.1467_ 1468delAT; p.V491fsX497) was
            identified in both alleles of probands from Mexico and Turkey.
            WDR72 is a cytoplasmic protein that is critical for dental enamel
            formation.
REFERENCE   7  (bases 1 to 7310)
  AUTHORS   Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
            Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
            Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
            Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
            Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
            Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
            Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
            Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
            Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
            Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
            Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
            Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
            Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
            Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
            Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
            Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
            Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
            Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
            Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
            Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
            Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
            Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
            Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
            Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
            Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
            Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
            Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
            Heid,I.M. and Fox,C.S.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
  REMARK    GeneRIF: Meta-analysis and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 7310)
  AUTHORS   Paterson,A.D., Waggott,D., Boright,A.P., Hosseini,S.M., Shen,E.,
            Sylvestre,M.P., Wong,I., Bharaj,B., Cleary,P.A., Lachin,J.M.,
            Below,J.E., Nicolae,D., Cox,N.J., Canty,A.J., Sun,L. and Bull,S.B.
  CONSRTM   MAGIC (Meta-Analyses of Glucose and Insulin-related traits
            Consortium); Diabetes Control and Complications Trial/Epidemiology
            of Diabetes Interventions and Complications Research Group
  TITLE     A genome-wide association study identifies a novel major locus for
            glycemic control in type 1 diabetes, as measured by both A1C and
            glucose
  JOURNAL   Diabetes 59 (2), 539-549 (2010)
   PUBMED   19875614
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 7310)
  AUTHORS   El-Sayed,W., Parry,D.A., Shore,R.C., Ahmed,M., Jafri,H., Rashid,Y.,
            Al-Bahlani,S., Al Harasi,S., Kirkham,J., Inglehearn,C.F. and
            Mighell,A.J.
  TITLE     Mutations in the beta propeller WDR72 cause autosomal-recessive
            hypomaturation amelogenesis imperfecta
  JOURNAL   Am J Hum Genet 85 (5), 699-705 (2009)
   PUBMED   19853237
  REMARK    GeneRIF: investigation of autosomal-recessive hypomaturation
            amelogenesis imperfecta (AI) in a consanguineous Pakistani family;
            a locus on chromosome 15q21.3 was identified; sequencing revealed a
            point mutation in the WDR72 gene
REFERENCE   10 (bases 1 to 7310)
  AUTHORS   Alexander,R.T., Law,L., Gil-Pena,H., Greenbaum,L.A. and Santos,F.
  TITLE     Hereditary Distal Renal Tubular Acidosis
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31600044
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC066611.6, BX537884.1,
            BC101614.1, AK096055.1, AC066614.8 and CK299278.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_182758.3.
            
            Summary: This gene encodes a protein with eight WD-40 repeats.
            Mutations in this gene have been associated with amelogenesis
            imperfecta hypomaturation type 2A3. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Mar 2013].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537884.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360509.10/ ENSP00000353699.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC066611.6         116431-116431       c
            2-31                BX537884.1         1-30
            32-340              BC101614.1         10-318
            341-341             AC066611.6         73416-73416         c
            342-959             BC101614.1         320-937
            960-1449            AK096055.1         1170-1659
            1450-3378           BC101614.1         1428-3356
            3379-6821           AC066614.8         164375-167817       c
            6822-7310           CK299278.1         18-506              c
FEATURES             Location/Qualifiers
     source          1..7310
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..7310
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /note="WD repeat domain 72"
                     /db_xref="GeneID:256764"
                     /db_xref="HGNC:HGNC:26790"
                     /db_xref="MIM:613214"
     exon            1..31
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            32..196
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..3352
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /note="isoform a is encoded by transcript variant 1; WD
                     repeat-containing protein 72"
                     /codon_start=1
                     /product="WD repeat-containing protein 72 isoform a"
                     /protein_id="NP_877435.3"
                     /db_xref="CCDS:CCDS10151.1"
                     /db_xref="GeneID:256764"
                     /db_xref="HGNC:HGNC:26790"
                     /db_xref="MIM:613214"
                     /translation="MRTSLQAVALWGQKAPPHSITAIMITDDQRTIVTGSQEGQLCLW
                     NLSHELKISAKELLFGHSASVTCLARARDFSKQPYIVSAAENGEMCVWNVTNGQCMEK
                     ATLPYRHTAICYYHCSFRMTGEGWLLCCGEYQDVLIIDAKTLAVVHSFRSSQFPDWIN
                     CMCIVHSMRIQEDSLLVVSVAGELKVWDLSSSINSIQEKQDVYEKESKFLESLNCQTI
                     RFCTYTERLLLVVFSKCWKVYDYCDFSLLLTEVSRNGQFFAGGEVIAAHRILIWTEDG
                     HSYIYQLLNSGLSKSIYPADGRVLKETIYPHLLCSTSVQENKEQSRPFVMGYMNERKE
                     PFYKVLFSGEVSGRITLWHIPDVPVSKFDGSPREIPVTATWTLQDNFDKHDTMSQSII
                     DYFSGLKDGAGTAVVTSSEYIPSLDKLICGCEDGTIIITQALNAAKARLLEGGSLVKD
                     SPPHKVLKGHHQSVTSLLYPHGLSSKLDQSWMLSGDLDSCVILWDIFTEEILHKFFLE
                     AGPVTSLLMSPEKFKLRGEQIICCVCGDHSVALLHLEGKSCLLHARKHLFPVRMIKWH
                     PVENFLIVGCADDSVYIWEIETGTLERHETGERARIILNCCDDSQLVKSVLPIASETL
                     KHKSIEQRSSSPYQLGPLPCPGLQVESSCKVTDAKFCPRPFNVLPVKTKWSNVGFHIL
                     LFDLENLVELLLPTPLSDVDSSSSFYGGEVLRRAKSTVEKKTLTLRKSKTACGPLSAE
                     ALAKPITESLAQGDNTIKFSEENDGIKRQKKMKISKKMQPKPSRKVDASLTIDTAKLF
                     LSCLLPWGVDKDLDYLCIKHLNILKLQGPISLGISLNEDNFSLMLPGWDLCNSGMIKD
                     YSGVNLFSRKVLDLSDKYTATLPNQVGIPRGLENNCDSLRESDTIVYLLSRLFLVNKL
                     VNMPLELACRVGSSFRMESIHNKMRGAGNDILNMSSFYSCLRNGKNESHVPEADLSLL
                     KLISCWRDQSVQVTEAIQAVLLAEVQQHMKSLGKIPVNSQPVSMAENGNCEMKQMLPK
                     LEWTEELELQCVRNTLPLQTPVSPVKHDSNSNSANFQDVEDMPDRCALEESESPGEPR
                     HHSWIAKVCPCKVS"
     exon            197..303
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            304..382
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            383..557
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            558..634
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            635..754
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            755..900
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            901..997
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1145
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1391
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1612
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1808
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..2005
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2823
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2915
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..2995
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3191
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            3192..3296
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..7310
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3711..3716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /note="hexamer: AATAAA"
     polyA_site      3731
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
     regulatory      5868..5873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /note="hexamer: AATAAA"
     polyA_site      5888
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /note="major polyA site"
     regulatory      7290..7295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /note="hexamer: ATTAAA"
     polyA_site      7310
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
ORIGIN      
        1 gcctctgccg ctcctccgcc ccacggctca ggattcgccc aaaatgagga cttccctgca
       61 ggcagtggca ctctggggac agaaggcccc tccccacagc atcactgcca tcatgatcac
      121 tgatgaccag cgaacgattg tgactggaag tcaagagggt cagctctgtc tctggaatct
      181 ctcacatgaa ctaaagattt cagcgaaaga actcctattt ggtcattcag cttcggtaac
      241 atgtttggca agagcaaggg acttctctaa acagccctac attgttagtg ctgctgaaaa
      301 tggggagatg tgtgtttgga atgtcaccaa tggacagtgc atggagaagg ctacacttcc
      361 ttacaggcac actgcaatct gttattacca ctgctcattc cggatgacag gagaaggctg
      421 gcttctttgt tgtggagaat atcaagatgt ccttataatt gatgccaaaa ctttggctgt
      481 tgttcacagt tttagatcat ctcagtttcc tgactggatc aactgcatgt gcattgttca
      541 ctccatgaga attcaagaag attctctctt ggtggtatca gtagctggtg agctcaaagt
      601 atgggatctt tcctcatcta tcaacagcat tcaggaaaag caagatgtct atgaaaaaga
      661 atccaagttt cttgagtcct tgaactgcca gacaattcga ttttgcacat atactgagag
      721 acttctattg gtggtatttt ctaaatgttg gaaggtttat gattattgtg atttttccct
      781 tctgctgact gaagttagta gaaatgggca gttctttgct ggtggagaag tgattgctgc
      841 tcacagaatc ctcatctgga cagaagatgg tcacagttac atctatcagc tgctgaacag
      901 tgggctttca aaaagcatat accctgctga tggaagagtg cttaaagaga ccatttatcc
      961 tcatttactg tgctctactt ctgtgcagga aaataaggaa cagagccgtc cctttgttat
     1021 gggctacatg aatgaaagga aagagccttt ttacaaggta cttttctctg gagaagtctc
     1081 aggaagaatt actttgtggc acatccctga tgttcctgta tccaagtttg atggttctcc
     1141 tagagagata ccagtaactg ccacctggac tcttcaagat aattttgata agcatgatac
     1201 tatgtcacaa agtattattg actatttctc tgggcttaaa gatggggcag gaactgctgt
     1261 agtcacttca tcagagtata ttccaagtct tgataaacta atatgtggct gtgaagatgg
     1321 gacaattatc attacccagg ctttgaatgc tgccaaagca agacttctgg aaggtggttc
     1381 tttagtaaaa gattctcccc ctcataaagt tcttaaaggc caccaccaaa gtgtcacttc
     1441 attactctat ccacatggtc tctcttcgaa attagaccaa agttggatgt tgtctgggga
     1501 cctggactca tgtgtgatct tgtgggatat ctttactgaa gaaattttgc ataaattctt
     1561 tttggaagct ggtccagtaa caagtctttt gatgtcacca gagaagttta aactaagggg
     1621 tgagcagata atttgctgtg tgtgcggtga ccattccgtg gctctccttc accttgaggg
     1681 aaagagttgc ctcctgcatg cccggaagca cctttttcct gtgaggatga taaaatggca
     1741 cccggttgag aattttttaa ttgttggatg tgcagatgac tcagtttata tctgggaaat
     1801 tgaaacaggc actttggaaa gacatgagac aggagaaaga gcacgaatta ttcttaattg
     1861 ttgtgatgat tcacagcttg tgaagtctgt acttcccatt gcctcagaga cacttaagca
     1921 caaaagtata gaacagagat cctccagccc ctaccagctt gggccattac cttgccctgg
     1981 tctgcaggtg gagtcttcat gtaaggttac tgatgccaaa ttttgcccaa gaccttttaa
     2041 tgtcttgcct gtgaagacaa aatggagtaa cgttggcttt catattcttc tatttgatct
     2101 ggaaaacctt gttgaacttt tgctaccaac tccactcagt gatgttgact cttccagttc
     2161 attctatggt ggtgaggtcc tgagaagagc caagagcaca gtggagaaga agacactgac
     2221 actgagaaaa agtaaaactg cctgtggtcc tctttcagca gaggcactag ccaagcctat
     2281 tactgaaagc ctggcccaag gagataatac catcaaattc tcagaagaaa atgatggcat
     2341 taaaaggcag aagaaaatga agatctccaa aaaaatgcag cctaagccat caagaaaagt
     2401 agatgccagt ctcacaatag acacagcaaa attgtttctg tcttgccttt tgccatgggg
     2461 agtggataaa gatttagatt atctttgcat taagcacctc aatattttaa agcttcaggg
     2521 tcctatttct ttgggaattt ctttgaatga agataatttc tcactgatgt tgccaggttg
     2581 ggatttatgc aatagtggaa tgataaaaga ctattcagga gtaaatttat tttccaggaa
     2641 agttttggac ttgtcagata aatacacagc cactcttcca aatcaggttg gaattccaag
     2701 aggattggaa aataattgtg attctttgcg agagtcagat actatagttt atttgttgag
     2761 cagactattt ttagttaata aattagttaa catgccttta gaattggcat gtagagttgg
     2821 cagttctttc agaatggaaa gtatacataa taagatgaga ggtgctggga atgacatttt
     2881 aaatatgtca agcttctaca gttgcttacg aaatggtaag aatgaatccc atgtacctga
     2941 ggctgacctt tcacttttga agctaatttc ctgttggaga gaccagtctg tgcaggtaac
     3001 tgaagcaata caagctgttc tcttggcgga agttcaacaa cacatgaaga gtttgggaaa
     3061 gatacccgtc aatagtcaac cagtgtccat ggcagagaat ggtaactgtg agatgaagca
     3121 gatgctgcca aagctggaat ggacagaaga actagagtta cagtgtgtta gaaacacttt
     3181 gcctctgcaa actccagtca gcccggtcaa gcatgacagc aactcaaact cggcaaactt
     3241 ccaagacgtg gaggacatgc ctgacagatg tgccttggaa gagtctgaga gtccaggtga
     3301 gccaaggcat cattcatgga tagcaaaggt ctgcccctgc aaggtgtctt aaatggaatc
     3361 tcatcagtag gagctgaatt tggacaaatt aagaaatcca aaagatgcca tttgtttatt
     3421 actgtataaa agcattgttg ttattggtca agttattagg ctgtagtgga tttgctaata
     3481 ctttagccaa catgtattaa agtgatttta atacatgctg attacaatgc aatacatact
     3541 gattgaaaat attcatattc atctaatttt agaaaaatat tgcctagatc attctctatt
     3601 cctgtttctt actttttctg ttaatatttc caacagggaa tgccagtcca cagacacaaa
     3661 tttaatactg ctttaaattt tctcctatcc ttttagtccc tgaattatat aataaacaat
     3721 gttaaaacca atgtagtaca caatacttac ttacaaattt aatactgctt caaggtattt
     3781 aatctaaaat tttaccaact ttgatttgtc tggttaggat attttgtttt agtggatatg
     3841 ctttaattcg gatcaattac tgcagtaaat ctcatcccta agcatgaaat gttgtcaaca
     3901 aatacccagt tccatttagt tatcaattag cccaaataag agatacaaag tataacagtg
     3961 accaaccttg tactgttgag ttaatttgaa cttctaatga cattgaggct aatgtcttta
     4021 gctcaaggtt gatcttgttg gccatataga tgtgaactag ggaaggggaa tcaacttaca
     4081 gcatatcaca attgatcctt attaagtata aactcttgta ggtcttttcc cagaaagaag
     4141 cttgactagc aggaattcta aaactgaaat atatcaaaca gcataaatag gaatagacat
     4201 aaagtgctct tctattaaag cctttggtga tctatttact atgatttata ttgtacagtt
     4261 cctcgattta cagaaaatca tcaaaattat taatctacat atcttatgta tataaatatt
     4321 gcctaatcca tagaaaaaag gatataaagt attaaatatg tgatatatag ctatatctat
     4381 ctatctatgt atctaatagg gaagtccaag tcacttcaat tgaagaaaca tatctctgag
     4441 cataggagca gcctcaggtc ctatggtggg atgcagtgga caggagaggg ggaaattaga
     4501 aaagagaact atataattga aaaagggata taaagcatta aatatatgat atatagctat
     4561 atctatgtat gtatctaaca gagaagttca agtcacttca attaaagaaa catttttgag
     4621 catgggacca gcctcaggtc ttatgctggg atgcagtaga caggagatgg ggaaattaga
     4681 aaagagaact gtgtaattga aatgacgtgg gctgcaccct taaggaactt ataattaatg
     4741 atgatctgaa taaacatacc aggataaaga tgtcaaatga gtgtgactcc cttaaagtag
     4801 attaaagtgt gcattctttg tttcctaaaa tatgatttta ctgcttgaaa ttacatttga
     4861 gttgaagttt agaaactaac atagcattaa tatgaataat catggaaaat tattatcctt
     4921 tgaaaactga ttgataaata tattccccct cctttagaaa cagtcaaaag ccacttcaaa
     4981 caagtttcaa aataaaggaa ggtagcaagt taggcgatgg attatatttt cttgcttgtt
     5041 gtataccagt tgtcaaggac attataagga ctcccaaaag cattttgaag gatggcaata
     5101 tcaaataagt gtatgtcctc tcaaatgagg catttttaat tgttaaaatc tatttggacg
     5161 ctcaggttat gatatgttta tgaaaaataa gcttcattat ttttatagct acatcctatt
     5221 attccctttt agaaacaaga ataacaatag gttttaatag ttgccatact tagcatttat
     5281 cagttctaat gaaaccaata ttgaatctct gataaatatt ttctgatgtt actagctatg
     5341 ggaaattaga actggcacaa ccctgacatt actaagtgga aatgttagga tttttcggca
     5401 tcgcatgtta gaatctctaa aatttaaaca ttcctgttaa atgactaagg tttgctttta
     5461 tcaatatgaa ttctgaaggc caatatcata ccattaacta tgaaagcttt taattcctaa
     5521 aaatagtttt agagatattc aagcaatgct ctcctaatat ccatacgcaa gtgtgtttat
     5581 gacacaaatt cactagtctg tttaaaaatg aattctttat attgactggt gttccacata
     5641 tttcagtaat ttctgttatg agaggacttg aaatagcaaa ttgccacaca gttaactgga
     5701 tagaccacgt acgtggtgat cataaccact tggtactaca cccagaaact caaaattgtc
     5761 tttctcctga tgagatatgg gtgtcctttt gtacgtctag gcctaggtaa ccagtggagt
     5821 gattatatta gcaaatgtgt ttgtatccgg agtcttcctg tcattgtaat aaaaaattta
     5881 tttaaaaatt ttgtcttgtg tttctttttt ggtaatcatc ttggtgatat ttatgaatgt
     5941 atttgtgtgt gtgtgtgtgt gtgtatacat acatatatat gtgtgtatat atatacacac
     6001 atatatatac acatatatat gtgtgtatat atatatatat atggcatatc ccccaaagga
     6061 atatcatatt ttcatttgca agccttgatt ctttgacttg ctgttgagtt tcacattggc
     6121 tccattgtat attgcaggaa aaagtacctg gaaagcctgg agggttaaaa gcagaggctc
     6181 ctcggcagcg tgtccaggcc gtgtgtgctt gctgtgcttg tcagagcctc attccctccc
     6241 ctgtgttgga gagctttctc acagggctca tccagaggtg ctagaaagca atgtgagcac
     6301 tattaaacac ttcaaatata aggaaaaatg tataatgtta gaaacacaca gttaaaaagt
     6361 agccccaggt atcaaacatt ctgttactat tttagaaact aaattaaggc tgctttgaac
     6421 atgatggtat tagaaaaatg gtagaataca gtttgttaaa tattaatatt ctatctttag
     6481 atgatagcat ttggtgactt ttatttcttt tctcatacat tttttccagt gttctgtatt
     6541 tttaaaatcc tttcataatt attataatga acactttaga aaagatacta tttctcttcc
     6601 atccttagag ggcacattat aataattgag tattttaaaa ttaaatttta tgccatgtat
     6661 ttaaaatgaa agttcaggtt acattaattc caactgattt taaagcctta ttttcacaga
     6721 gtggactcat tcaatttttt aaattttata ttcatacatt ttgattgctc agttatataa
     6781 aagcggtgtt atagactcct ttattctcca caaaatgttg tcttatatgt aaagtgccaa
     6841 aagttgtgtt taatttccta agaaagtcat tgctttgtaa acatttgcat aatacttagt
     6901 gttttttgta attttaaaaa attagcttaa ccaaaagagt tgcaaaatta aaacttactt
     6961 gagtaggtat ctttcagaca aagctgcatg gcttcatgta caatagtccc cagatcacct
     7021 cgcactgtag tttgctcaag aaggagccta cagatggcag gtaggagaag gtaaactgga
     7081 aattaacagg tctgtctgta agagcatgcc actggaaaca cccatccaat ttgggacccc
     7141 tggaagacag catgtgtcta atgggaggcc tgtcctagta caactccttt actcttttca
     7201 ccttcatctt gaccttctca gataccatct ttatgtaaaa tgttgatgtt gtggagtttt
     7261 tgcagtaatt taatttttat aaatattgta ttaaaatata tttatcttga
//
