LOCUS       NM_018034               2877 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens WD repeat domain 70 (WDR70), transcript variant 1,
            mRNA.
ACCESSION   NM_018034
VERSION     NM_018034.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2877)
  AUTHORS   Mao,X., Wu,J., Zhang,Q., Zhang,S., Chen,X., Liu,X., Wei,M., Wan,X.,
            Qiu,L., Zeng,M., Lei,X., Liu,C. and Han,J.
  TITLE     Requirement of WDR70 for POLE3-mediated DNA double-strand breaks
            repair
  JOURNAL   Sci Adv 9 (36), eadh2358 (2023)
   PUBMED   37682991
  REMARK    GeneRIF: Requirement of WDR70 for POLE3-mediated DNA double-strand
            breaks repair.
REFERENCE   2  (bases 1 to 2877)
  AUTHORS   Tang,Z.Z., Wang,H.B., Zeng,M., Liu,C. and Li,D.H.
  TITLE     [DNA Repair Function and Mutation of an H2B Monoubiquitination
            Factor WDR70 in Ovarian Cancer]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 48 (5), 693-698 (2017)
   PUBMED   29130659
  REMARK    GeneRIF: Ovarian cancer had different expression of WDR70 and H2B
            monoubiquitination compared with normal tissue
REFERENCE   3  (bases 1 to 2877)
  AUTHORS   Guo,L.D., Wang,D., Yang,F., Liang,Y.J., Yang,X.Q., Qin,Y.Y.,
            Ren,L.F., Zeng,M., Tang,Z.Z., Wang,X.J., Wang,S., Liu,C., Lou,J.Y.
            and Chen,J.
  TITLE     [Functional Analysis of DNA Damage Repair Factor WDR70 and Its
            Mutation in Ovarian Cancer]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 47 (4), 501-506 (2016)
   PUBMED   28591950
REFERENCE   4  (bases 1 to 2877)
  AUTHORS   Zeng,M., Ren,L., Mizuno,K., Nestoras,K., Wang,H., Tang,Z., Guo,L.,
            Kong,D., Hu,Q., He,Q., Du,L., Carr,A.M. and Liu,C.
  TITLE     CRL4(Wdr70) regulates H2B monoubiquitination and facilitates
            Exo1-dependent resection
  JOURNAL   Nat Commun 7, 11364 (2016)
   PUBMED   27098497
  REMARK    GeneRIF: CRL4(Wdr70) regulates H2B monoubiquitination and
            facilitates Exo1-dependent DNA repair resection.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC009648.1 and AC093269.3.
            
            On May 17, 2019 this sequence version replaced NM_018034.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.247246.1,
                                           SRR1803613.219462.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265107.9/ ENSP00000265107.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2114              BC009648.1         9-2122
            2115-2877           AC093269.3         5931-6693           c
FEATURES             Location/Qualifiers
     source          1..2877
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.2"
     gene            1..2877
                     /gene="WDR70"
                     /note="WD repeat domain 70"
                     /db_xref="GeneID:55100"
                     /db_xref="HGNC:HGNC:25495"
                     /db_xref="MIM:617233"
     exon            1..75
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..2015
                     /gene="WDR70"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 70"
                     /codon_start=1
                     /product="WD repeat-containing protein 70 isoform 1"
                     /protein_id="NP_060504.1"
                     /db_xref="CCDS:CCDS34147.1"
                     /db_xref="GeneID:55100"
                     /db_xref="HGNC:HGNC:25495"
                     /db_xref="MIM:617233"
                     /translation="MERSGPSEVTGSDASGPDPQLAVTMGFTGFGKKARTFDLEAMFE
                     QTRRTAVERSRKTLEAREKEEEMNREKELRRQNEDIEPTSSRSNVVRDCSKSSSRDTS
                     SSESEQSSDSSDDELIGPPLPPKMVGKPVNFMEEDILGPLPPPLNEEEEEAEEEEEEE
                     EEEENPVHKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASF
                     KAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYIVDM
                     ANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVI
                     PTTCTYSRDGNLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDSGTDTSCVTFSYDGNV
                     LASRGGDDSLKLWDIRQFNKPLFSASGLPTMFPMTDCCFSPDDKLIVTGTSIQRGCGS
                     GKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGA
                     KLCVVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEP
                     PVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDSPYWVSPAY
                     SKTQPKTMFAQVESDDEEAKNEPEWKKRKI"
     exon            76..141
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     exon            142..225
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     exon            226..346
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     exon            347..542
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     exon            543..602
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     exon            603..736
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     exon            737..890
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     exon            891..967
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1142
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1242
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1327
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1466
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1567
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1647
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1764
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1927
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2877
                     /gene="WDR70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2093..2098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR70"
                     /note="hexamer: ATTAAA"
     polyA_site      2114
                     /gene="WDR70"
                     /note="major polyA site"
     regulatory      2204..2209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR70"
                     /note="hexamer: ATTAAA"
     polyA_site      2227
                     /gene="WDR70"
ORIGIN      
        1 gcagttgttt gggctgtccc tgtggctggt tctggggtgt gcggccagcc atggagcgct
       61 ctgggcccag cgaagtgaca ggctcagacg cgtcgggacc ggacccgcag cttgcggtca
      121 ccatgggctt cacggggttc ggtaaaaaag ctcgcacatt tgacttggaa gcaatgtttg
      181 aacaaactcg aaggacagct gtggaaagaa gtcgcaaaac actggaagca agagaaaaag
      241 aggaagaaat gaacagagag aaagaattaa gaagacaaaa tgaagatatt gagccaacat
      301 cctcaagatc aaatgtggtc agagattgct ccaaatcatc ttccagggat acgagcagca
      361 gtgaaagtga acagagttct gactcttctg atgatgagtt aattggccct cctttacccc
      421 ctaaaatggt aggaaaacca gttaatttta tggaggaaga tatcctcggt cctttacctc
      481 cacctcttaa tgaagaagaa gaagaagcag aggaagaaga agaggaagag gaggaagagg
      541 aaaatcctgt tcacaagatt cctgactcgc atgagataac gctgaagcat ggcactaaaa
      601 cagtgtctgc tttgggtctg gatccctcag gtgcccgttt ggtgacagga ggatatgact
      661 atgatgttaa gttttgggat tttgctggaa tggatgcttc ttttaaggca tttcgatccc
      721 ttcagccctg tgagtgccat cagatcaagt cattacagta tagtaacaca ggagacatga
      781 ttcttgttgt atctggaagc tctcaggcca aggtgattga cagagatggt tttgaagtaa
      841 tggaatgtat aaaaggagac cagtatattg tggacatggc caacaccaag ggtcatacag
      901 caatgcttca tactggctca tggcatccca aaataaaggg agaatttatg acttgctcaa
      961 atgatgcgac tgtgaggacg tgggaagttg aaaatccaaa gaagcaaaaa agtgtgttta
     1021 aaccacggac gatgcaaggc aaaaaagtca ttcccactac gtgcacatat agtagagatg
     1081 gaaacctcat agcagctgcc tgccagaatg gaagcataca gatctgggac cgaaatttga
     1141 ctgttcatcc taagttccac tataaacagg ctcatgactc gggcacagac acttcttgcg
     1201 tgactttttc ctatgatggt aatgtccttg cctctcgtgg aggtgacgat tcattaaaat
     1261 tatgggacat ccgacaattt aataaaccac ttttttcagc ctcgggtctt cccaccatgt
     1321 tcccaatgac tgactgctgt ttcagtccag atgataagct catagtcact ggtacatcta
     1381 ttcaaagagg atgtggcagc ggcaaacttg ttttctttga gcgtaggact ttccaaaggg
     1441 tgtatgaaat agacatcaca gatgcgagtg ttgttcgctg cctgtggcat ccaaagctga
     1501 accagatcat ggttggaact ggaaatggat tggctaaagt ctattacgac cccaacaaga
     1561 gtcagagggg agcaaaatta tgtgtggtta aaacccagcg gaaggcaaaa caagctgaga
     1621 ctctaactca ggactacatc atcacccctc atgccttgcc tatgttccgt gagccccgcc
     1681 aacggagtac aaggaaacag ctggagaagg acagactgga tcccctgaag tcgcataaac
     1741 ctgaacctcc tgtagcaggc ccaggtcgtg gtggccgagt tggaacccac gggggcactc
     1801 tctcttccta tattgtgaag aacattgctt tggacaagac cgatgacagt aatcctcggg
     1861 aagccatttt gcgtcatgcc aaagcagcag aagacagccc atattgggtt tctccagcat
     1921 attccaagac tcagcccaaa accatgtttg cccaagttga atctgatgat gaggaagcaa
     1981 agaatgagcc agaatggaaa aaacgtaaaa tttgaagaat ctcatttgag agctgtttgc
     2041 atgagtggga ggggtatggg acaggtttgg gttttttttt tatgctcatg aaattaaaaa
     2101 ttcattttta tgaacaggtt ttgtcctttg cattattgaa ctggtcaaaa gtttggtggc
     2161 taggcttcac taaaattgtg cttaaatttt cttacctgca actattaaac tgattacaga
     2221 taaacaagaa acagattctt agtctattac caagtacttt aggtatttgg aaactttatt
     2281 caacaattat tggtcttgtc cagattctca taaccttaga gaggaaaatg tacattaaga
     2341 tgtgcatctg tctctagcaa ttctaggaac ataatataga aatagagatc aaaaagttta
     2401 atgtttctgt ataatttcac aacagttgtt tacatgactg taattaatta ggctgagttc
     2461 aaaccaaata cattgccata ctgggaaaga gcattatctc attatccttc aatagcagaa
     2521 tacagtggtt aagagttagg agtgggcttt gaagtcagac tcatgtggat tcaagtcctg
     2581 gctttgctct ttacttctgg gtcatcttaa gagagttatt taacttttct tttctagcct
     2641 cagatgatga aatagtacgt actttgcagg ttcgtcagaa gaattaaatg ggacatgcct
     2701 cacagagcat ttagtacagt acctggaaca cagtaaatgt ataccaaata tttgctattt
     2761 taaaataggg ctaatattta ctttgcttgg tttttatcag tattaaatta gaaaggtata
     2821 gaattgcttt gtaaatgtaa agactaaaca gaagacatta aaaattattc taaaaaa
//
