LOCUS       NM_015285               7295 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens WD repeat domain 7 (WDR7), transcript variant 1, mRNA.
ACCESSION   NM_015285
VERSION     NM_015285.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7295)
  AUTHORS   Course,M.M., Gudsnuk,K., Smukowski,S.N., Winston,K., Desai,N.,
            Ross,J.P., Sulovari,A., Bourassa,C.V., Spiegelman,D., Couthouis,J.,
            Yu,C.E., Tsuang,D.W., Jayadev,S., Kay,M.A., Gitler,A.D., Dupre,N.,
            Eichler,E.E., Dion,P.A., Rouleau,G.A. and Valdmanis,P.N.
  TITLE     Evolution of a Human-Specific Tandem Repeat Associated with ALS
  JOURNAL   Am J Hum Genet 107 (3), 445-460 (2020)
   PUBMED   32750315
  REMARK    GeneRIF: Evolution of a Human-Specific Tandem Repeat Associated
            with ALS.
REFERENCE   2  (bases 1 to 7295)
  AUTHORS   Yu,D., Mathews,C.A., Scharf,J.M., Neale,B.M., Davis,L.K.,
            Gamazon,E.R., Derks,E.M., Evans,P., Edlund,C.K., Crane,J.,
            Fagerness,J.A., Osiecki,L., Gallagher,P., Gerber,G., Haddad,S.,
            Illmann,C., McGrath,L.M., Mayerfeld,C., Arepalli,S., Barlassina,C.,
            Barr,C.L., Bellodi,L., Benarroch,F., Berrio,G.B., Bienvenu,O.J.,
            Black,D.W., Bloch,M.H., Brentani,H., Bruun,R.D., Budman,C.L.,
            Camarena,B., Campbell,D.D., Cappi,C., Silgado,J.C., Cavallini,M.C.,
            Chavira,D.A., Chouinard,S., Cook,E.H., Cookson,M.R., Coric,V.,
            Cullen,B., Cusi,D., Delorme,R., Denys,D., Dion,Y., Eapen,V.,
            Egberts,K., Falkai,P., Fernandez,T., Fournier,E., Garrido,H.,
            Geller,D., Gilbert,D.L., Girard,S.L., Grabe,H.J., Grados,M.A.,
            Greenberg,B.D., Gross-Tsur,V., Grunblatt,E., Hardy,J., Heiman,G.A.,
            Hemmings,S.M., Herrera,L.D., Hezel,D.M., Hoekstra,P.J.,
            Jankovic,J., Kennedy,J.L., King,R.A., Konkashbaev,A.I.,
            Kremeyer,B., Kurlan,R., Lanzagorta,N., Leboyer,M., Leckman,J.F.,
            Lennertz,L., Liu,C., Lochner,C., Lowe,T.L., Lupoli,S.,
            Macciardi,F., Maier,W., Manunta,P., Marconi,M., McCracken,J.T.,
            Mesa Restrepo,S.C., Moessner,R., Moorjani,P., Morgan,J., Muller,H.,
            Murphy,D.L., Naarden,A.L., Nurmi,E., Ochoa,W.C., Ophoff,R.A.,
            Pakstis,A.J., Pato,M.T., Pato,C.N., Piacentini,J., Pittenger,C.,
            Pollak,Y., Rauch,S.L., Renner,T., Reus,V.I., Richter,M.A.,
            Riddle,M.A., Robertson,M.M., Romero,R., Rosario,M.C., Rosenberg,D.,
            Ruhrmann,S., Sabatti,C., Salvi,E., Sampaio,A.S., Samuels,J.,
            Sandor,P., Service,S.K., Sheppard,B., Singer,H.S., Smit,J.H.,
            Stein,D.J., Strengman,E., Tischfield,J.A., Turiel,M., Valencia
            Duarte,A.V., Vallada,H., Veenstra-VanderWeele,J., Walitza,S.,
            Wang,Y., Weale,M., Weiss,R., Wendland,J.R., Westenberg,H.G.,
            Shugart,Y.Y., Hounie,A.G., Miguel,E.C., Nicolini,H., Wagner,M.,
            Ruiz-Linares,A., Cath,D.C., McMahon,W., Posthuma,D., Oostra,B.A.,
            Nestadt,G., Rouleau,G.A., Purcell,S., Jenike,M.A., Heutink,P.,
            Hanna,G.L., Conti,D.V., Arnold,P.D., Freimer,N.B., Stewart,S.E.,
            Knowles,J.A., Cox,N.J. and Pauls,D.L.
  TITLE     Cross-disorder genome-wide analyses suggest a complex genetic
            relationship between Tourette's syndrome and OCD
  JOURNAL   Am J Psychiatry 172 (1), 82-93 (2015)
   PUBMED   25158072
REFERENCE   3  (bases 1 to 7295)
  AUTHORS   Edwards,A.C., Aliev,F., Bierut,L.J., Bucholz,K.K., Edenberg,H.,
            Hesselbrock,V., Kramer,J., Kuperman,S., Nurnberger,J.I. Jr.,
            Schuckit,M.A., Porjesz,B. and Dick,D.M.
  TITLE     Genome-wide association study of comorbid depressive syndrome and
            alcohol dependence
  JOURNAL   Psychiatr Genet 22 (1), 31-41 (2012)
   PUBMED   22064162
REFERENCE   4  (bases 1 to 7295)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 7295)
  AUTHORS   Baranzini,S.E., Wang,J., Gibson,R.A., Galwey,N., Naegelin,Y.,
            Barkhof,F., Radue,E.W., Lindberg,R.L., Uitdehaag,B.M.,
            Johnson,M.R., Angelakopoulou,A., Hall,L., Richardson,J.C.,
            Prinjha,R.K., Gass,A., Geurts,J.J., Kragt,J., Sombekke,M.,
            Vrenken,H., Qualley,P., Lincoln,R.R., Gomez,R., Caillier,S.J.,
            George,M.F., Mousavi,H., Guerrero,R., Okuda,D.T., Cree,B.A.,
            Green,A.J., Waubant,E., Goodin,D.S., Pelletier,D., Matthews,P.M.,
            Hauser,S.L., Kappos,L., Polman,C.H. and Oksenberg,J.R.
  TITLE     Genome-wide association analysis of susceptibility and clinical
            phenotype in multiple sclerosis
  JOURNAL   Hum Mol Genet 18 (4), 767-778 (2009)
   PUBMED   19010793
REFERENCE   6  (bases 1 to 7295)
  AUTHORS   Kawabe,H., Sakisaka,T., Yasumi,M., Shingai,T., Izumi,G., Nagano,F.,
            Deguchi-Tawarada,M., Takeuchi,M., Nakanishi,H. and Takai,Y.
  TITLE     A novel rabconnectin-3-binding protein that directly binds a
            GDP/GTP exchange protein for Rab3A small G protein implicated in
            Ca(2+)-dependent exocytosis of neurotransmitter
  JOURNAL   Genes Cells 8 (6), 537-546 (2003)
   PUBMED   12786944
REFERENCE   7  (bases 1 to 7295)
  AUTHORS   Sanders,S., Keck-Waggoner,C.L., Zimonjic,D.B., Popescu,N.C. and
            Thorgeirsson,S.S.
  TITLE     Assignment of WDR7 (alias TRAG, TGF-beta resistance associated
            gene) to orthologous regions of human chromosome 18q21.1-->q22 and
            mouse chromosome 18D.1-E.3 by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 324-325 (2000)
   PUBMED   10828621
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007052.4, AC008006.10 and
            AC012301.5.
            
            On May 12, 2020 this sequence version replaced NM_015285.2.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD)
            that may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. The encoded protein
            forms the beta subunit of rabconnectin-3 and binds directly with
            Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP
            activating protein; these proteins are regulators of Rab3 small G
            protein family members involved in control of the calcium-dependant
            exocytosis of neurotransmitters. Alternatively spliced transcript
            variants encoding different isoforms have been described. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150282.1, AB011113.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2151741
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254442.8/ ENSP00000254442.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               AC007052.4         131520-131737
            219-396             AC007052.4         152658-152835
            397-503             AC007052.4         159493-159599
            504-582             AC007052.4         161474-161552
            583-757             AC007052.4         162840-163014
            758-834             AC007052.4         166117-166193
            835-954             AC007052.4         167016-167135
            955-1100            AC007052.4         171377-171522
            1101-1203           AC007052.4         171876-171978
            1204-1345           AC007052.4         174780-174921
            1346-1594           AC007052.4         175111-175359
            1595-1815           AC007052.4         176403-176623
            1816-2011           AC008006.10        30877-31072
            2012-2226           AC008006.10        44296-44510
            2227-2996           AC008006.10        69496-70265
            2997-3085           AC008006.10        71778-71866
            3086-3184           AC008006.10        89695-89793
            3185-3303           AC008006.10        92344-92462
            3304-3427           AC008006.10        94446-94569
            3428-3541           AC008006.10        128944-129057
            3542-3763           AC012301.5         41909-42130
            3764-3950           AC012301.5         85887-86073
            3951-4068           AC012301.5         97753-97870
            4069-4218           AC012301.5         100498-100647
            4219-4301           AC012301.5         101276-101358
            4302-4401           AC012301.5         124395-124494
            4402-4506           AC012301.5         182710-182814
            4507-7295           AC012301.5         188969-191757
FEATURES             Location/Qualifiers
     source          1..7295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.31"
     gene            1..7295
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /note="WD repeat domain 7"
                     /db_xref="GeneID:23335"
                     /db_xref="HGNC:HGNC:13490"
                     /db_xref="MIM:613473"
     exon            1..218
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            219..396
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..4710
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 7; TGF-beta resistance
                     associated; rabconnectin-3 beta; TGF-beta
                     resistance-associated protein TRAG"
                     /codon_start=1
                     /product="WD repeat-containing protein 7 isoform 1"
                     /protein_id="NP_056100.2"
                     /db_xref="CCDS:CCDS11962.1"
                     /db_xref="GeneID:23335"
                     /db_xref="HGNC:HGNC:13490"
                     /db_xref="MIM:613473"
                     /translation="MAGNSLVLPIVLWGRKAPTHCISAVLLTDDGATIVTGCHDGQIC
                     LWDLSVELQINPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCLWDVSDGRCI
                     EFTKLACTHTGIQFYQFSVGNQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDW
                     ISSMSIIRSHRTQEDTVVALSVTGILKVWIVTSEISDMQDTEPIFEEESKPIYCQNCQ
                     SISFCAFTQRSLLVVCSKYWRVFDAGDYSLLCSGPSENGQTWTGGDFVSSDKVIIWTE
                     NGQSYIYKLPASCLPASDSFRSDVGKAVENLIPPVQHILLDRKDKELLICPPVTRFFY
                     GCREYFHKLLIQGDSSGRLNIWNISDTADKQGSEEGLAMTTSISLQEAFDKLNPCPAG
                     IIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGSIVIVPATQTAIVQLLQGEHML
                     RRGWPPHRTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIF
                     CVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVI
                     KWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITAVEILNACDEAVPAAVDSLSHP
                     AVNLKQAMTRRSLAALKNMAHHKLQTLATNLLASEASDKGNLPKYSHNSLMVQAIKTN
                     LTDPDIHVLFFDVEALIIQLLTEEASRPNTALISPENLQKASGSSDKGGSFLTGKRAA
                     VLFQQVKETIKENIKEHLLDDEEEDEEIMRQRREESDPEYRSSKSKPLTLLEYNLTMD
                     TAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSRGGHMSLMLPGYNQPAC
                     KLSHGKTEVGRKLPASEGVGKGTYGVSRAVTTQHLLSIISLANTLMSMTNATFIGDHM
                     KKGPTRPPRPSTPDLSKARGSPPTSSNIVQGQIKQVAAPVVSARSDADHSGSDPPSAP
                     ALHTCFLVNEGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRCLEVREAAQAL
                     LLAELRRIEQAGRKEAIDAWAPYLPQYIDHVISPGVTSEAAQTITTAPDASGPEAKVQ
                     EEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAEIEPPKL
                     LTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRTAIDL
                     IGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALSLI
                     ATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTD
                     VVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVA
                     LYDIRTGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNTSLLGSIGMLN
                     SAPQLRCIKTYQVPPVQPASPGSHNALKLARLIWTSNRNVILMAHDGKEHRFMV"
     exon            397..503
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            504..582
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            583..757
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            758..834
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            835..954
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1100
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1203
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1345
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1594
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1815
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..2011
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2226
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2996
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3085
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3184
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3303
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3427
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..3541
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            3542..3763
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            3764..3950
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..4068
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            4069..4218
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            4219..4301
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            4302..4401
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            4402..4506
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            4507..7295
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      7121
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /note="major polyA site"
     regulatory      7276..7281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /note="hexamer: AATAAA"
     polyA_site      7295
                     /gene="WDR7"
                     /gene_synonym="TRAG"
                     /note="major polyA site"
ORIGIN      
        1 agctgattta ctgcagtggc ggcggcggcg gcaccggcac cttgcagtat cactggggag
       61 acggcggctg tatagcgctt gccgccccac ggattatccc agcaggatct acgcaccccg
      121 catcctccgt agttccgccc tatccttgtc ctccttggct ggggcgccca ccggcggtct
      181 gataggctac atcgcggcat gagatgaagc tgtgacaggt ttgaaaacac aaacacaatg
      241 gcaggaaaca gccttgttct acccattgtt ctttggggtc gaaaagcgcc cacacattgc
      301 atctcagccg tacttttaac agatgatggg gccacgatcg taacaggatg tcacgacgga
      361 caaatatgtc tctgggatct ttcagtagaa ctgcaaatta atcctcgagc actgttgttt
      421 ggtcatacag catcaatcac ttgtttgtct aaagcttgtg cttccagtga caaacagtat
      481 attgtgagtg catctgaaag tggagagatg tgcctctggg atgtgagtga tggcagatgt
      541 attgaattta caaaattagc ttgcacacat actggcatac agttctacca gttctctgtt
      601 gggaatcagc gagaaggaag gcttttatgc cacggacatt accctgaaat ccttgttgtg
      661 gatgctacca gccttgaagt attatactcc ttagtatcaa agatatcacc agactggatt
      721 agctccatga gtattattcg atcccaccga acacaagagg acacagtggt agcactctcg
      781 gtgactggca tcctgaaggt ctggattgtt acctcggaaa taagtgacat gcaggatact
      841 gagccaatat ttgaggagga atccaaacca atttattgtc agaattgcca aagcatctct
      901 ttttgtgcat ttacacaaag gtcacttttg gttgtgtgtt ccaaatattg gagggtgttc
      961 gatgccggag actattcctt gttgtgttca ggtcctagtg aaaatggaca gacatggacc
     1021 gggggggact ttgtctcatc agataaagtc atcatttgga cagaaaatgg gcaaagttat
     1081 atttacaaac tacctgccag ttgccttcca gctagtgatt cattccgcag tgatgtgggg
     1141 aaggcagttg aaaatttaat tcctcctgta caacatatcc tcttggatcg aaaagataaa
     1201 gagttgctaa tttgtcctcc tgttactcgg ttcttctatg gatgcagaga atatttccat
     1261 aaactgttaa ttcagggtga ttcttctgga aggttgaata tttggaacat atcagacaca
     1321 gctgataaac agggaagtga agaagggctg gcaatgacaa cttctattag tttgcaagag
     1381 gcatttgata aactgaatcc ttgtcctgct ggaattatag atcagctgag tgtgattccc
     1441 aatagtaatg aacctcttaa agtaactgca agtgtgtaca taccagcaca tggacgactt
     1501 gtttgtggtc gtgaagatgg aagcatagtt attgtacctg ccacacagac ggccatagta
     1561 cagctgttgc aaggggaaca catgctcaga agaggttggc cacctcacag aacactccgt
     1621 ggtcatcgga acaaagtcac atgtttgcta tatcctcatc aggtctcagc tcggtatgat
     1681 caaagatacc tgatatctgg aggtgtggat ttttcagtca taatttggga catattttct
     1741 ggagaaatga aacatatctt ctgtgttcat ggtggtgaga ttactcaact tctagttcca
     1801 cctgaaaact gtagtgcaag agtacagcac tgcatctgct ctgtagccag tgaccactca
     1861 gtaggacttc taagtttgcg agagaaaaaa tgcataatgt tggcatctcg tcaccttttt
     1921 cctattcaag taatcaaatg gaggccttct gatgattacc tggtggtggg gtgttcagat
     1981 ggttctgtgt acgtctggca aatggatact ggtgcattgg atcgttgtgt gatggggata
     2041 acagcagttg agattctaaa cgcttgtgat gaagctgttc ctgctgctgt tgattcactt
     2101 agtcatccag cagtcaacct aaaacaagct atgacgagac gtagtcttgc tgctcttaaa
     2161 aatatggccc atcataagct acaaaccctt gcaactaacc tcttggcttc tgaggcatct
     2221 gacaagggaa atttacctaa atattctcat aactccctga tggttcaagc aataaagaca
     2281 aacctaacag acccggacat acatgtgcta ttctttgatg tggaagcgtt gattattcaa
     2341 ctcctgactg aagaagcctc taggccgaat actgctctta tttccccaga gaatttgcaa
     2401 aaagcatctg gcagttcaga caaagggggc tcttttttaa ctggaaaacg agcagcagtt
     2461 ctcttccaac aagtgaaaga aacgatcaaa gagaacatca aggaacacct ccttgatgat
     2521 gaagaggagg atgaggagat aatgaggcag agaagggaag aaagtgatcc tgaatatcgg
     2581 tccagcaaat caaagccatt gaccctatta gaatataatt taactatgga cactgcaaag
     2641 ctgtttatgt cctgccttca cgcctggggt ttgaatgaag tactggatga agtttgcctg
     2701 gatcgccttg gaatgctgaa accccactgc accgtatcgt ttggcctctt gtcaagagga
     2761 ggccatatgt cactgatgct gccgggttat aatcagcctg cttgtaaact gtcacatggg
     2821 aaaacagaag taggaaggaa gctgccagcg tctgagggag taggaaaggg aacttacgga
     2881 gtgtcccgtg ccgtcaccac acagcatctc ctgtctatca tttctttggc aaatacttta
     2941 atgagtatga ccaatgcaac ttttattggt gatcatatga agaagggtcc taccaggcca
     3001 cctagaccaa gcaccccaga cctttctaag gcaaggggtt cccctccaac ttccagtaat
     3061 attgtgcaag gacagattaa acaagttgct gcacctgtcg tttccgctcg gtctgatgct
     3121 gatcactctg gctctgaccc tccttctgct cctgctttac atacctgttt cttagtaaat
     3181 gaaggttgga gtcagttagc tgctatgcac tgtgttatgc tgccagacct actgggattg
     3241 gataaattta ggcctcccct tctggagatg ctggcccgaa gatggcaaga tcgatgcttg
     3301 gaggtgagag aagccgcgca ggccctgctt ctggcggaac tgagaagaat tgagcaggca
     3361 ggcaggaagg aagccattga tgcctgggct ccttacttac ctcagtacat agaccacgtc
     3421 atatcacctg gagtcacatc agaagccgcg cagactatca ccacggctcc tgatgcctca
     3481 gggcctgaag caaaagtcca ggaggaagag catgaccttg ttgacgatga catcaccact
     3541 ggttgcttat caagtgtccc acaaatgaaa aaaatttcta catcttacga ggaaagacgg
     3601 aagcaagcta ccgctattgt tttacttgga gtaataggag ctgaatttgg tgctgaaatt
     3661 gaacctccta aactattgac cagacctcga agctctagcc aaattcctga gggattcggg
     3721 ttgactagtg gtggatccaa ctactcgctg gccagacata cttgcaaggc actgacgttt
     3781 cttctgctac agcctccaag ccccaaactt cctccacaca gcactatccg aagaacagcc
     3841 attgatctga ttggacgtgg gttcactgtt tgggagcctt acatggatgt gtccgctgtt
     3901 ctgatggggc ttctcgaact ttgtgccgat gccgagaaac aacttgccaa catcacaatg
     3961 gggttgcctc tgagcccagc agctgactcg gcccgctctg cgaggcatgc cctctcgctc
     4021 attgccaccg ccagaccacc cgccttcatc accaccatag ccaaagaggt acacagacat
     4081 acggctcttg cagcaaatac ccaatcacag cagaatatgc acacaacaac tcttgcacga
     4141 gctaaagggg aaattttgag agtcattgaa attcttattg aaaagatgcc cacagatgtt
     4201 gtggatcttc tcgtggaggt tatggacatc attatgtact gccttgaagg atctttagtt
     4261 aaaaagaaag gtcttcaaga atgtttccca gccatctgca ggttctacat ggtcagctat
     4321 tatgagcgga atcacagaat agcagttgga gctcgccatg gttcagtggc cctgtacgac
     4381 atccggactg gaaaatgtca gacaatccat ggacacaagg gaccaatcac tgcagtggct
     4441 tttgctcctg atggaagata tcttgccacc tactcaaaca ctgacagcca catttctttt
     4501 tggcagatga acacgtcact gctgggaagc atcggcatgc tgaactcggc acctcagctg
     4561 cgctgcatta aaacctacca ggtgccccct gtgcagcccg cgtcccccgg ctcccacaat
     4621 gccctcaagc tggcccggct catctggact tccaaccgca acgtcatcct catggcccat
     4681 gacgggaagg agcaccgctt catggtctaa tgctgctgcc tgccgccgtg actgcgtttt
     4741 agttctctaa attatccaag ccgatgttgc tctgtccttc ctcacaccag attgttccca
     4801 ggggcctgcc caccccagtg ccatccagtg gcacggccgg gtcttgtcac ttgtgcatgc
     4861 ttctcagggg cagaacccgc tcgtgccatc tgtcgattca gaggcacgca cacatgctct
     4921 gcaggatgtg gccatcctgt caccaggtag tttttccctg ccagagatgg caggggaaag
     4981 ccagtggttc ctgggaacgc tcttgttgct tggtgcaaca gaagcacaaa aatcaataaa
     5041 cactgtgatt gcactcccag cccagatcag catttttagc catctcaacc gcacctctga
     5101 agtgctgctt gaatctggcc gttctgacac tgggtgttga ggtcatgtgg cagtcctcac
     5161 gattgaaatt attgcccttt gaattaccta aaatattgtt taccaaaaag attctgtgtt
     5221 tacatgttct tttcttctgg tgattgctag gaaattactc aatccaattt cctagggttt
     5281 agctaccacc ttctttatca acagctaacc aatttgagat tcatgattaa ttatgtacac
     5341 aaaaatattt tccttgtaga aaatagtttt ccagacactt agccttctga agtgctcatc
     5401 tcttgcttaa atgatagtct atttagtagt ttaaaataaa aataatcact ccctatgatc
     5461 tagttaatgt aattatccag tcactgtaac taatctcttg aagggacttt tgtgataaag
     5521 agccaagttc agaagcatag cgtgtaccga aaatgaagac tctcctatct actgctacag
     5581 atcctgttga agaaagagct tacccctttc ccccggaaaa cttgcaatcc tgtagttccc
     5641 atatgtgtgg catatgtcag ttatgaaatt attataattc agccttcaaa ctactactga
     5701 tcaactaaag gaaagctaat aaggtatttc ttttaaacaa gtattctgga aaagtaataa
     5761 ctatggcaca aatgttcagg agtgtatata aaaatatgtg ggctctcgat ttatttgagc
     5821 aaacattgca atgagggtgt tcattatgct tctaagtaag ctttaactag accactttct
     5881 tcttatgtca gattgtgctg gttctagctc ataataatga aaaaaataga attatatttt
     5941 gtatgaattg tttctaacaa accttgatct gtatatactt gtgaggggtt gtttggttgc
     6001 ctaattgttg attggttggt tagttgggca aaatcattta ttacatgcaa aaatagaaaa
     6061 ttatttgtta aattcagaga aaatatgtga agtttacaaa ggaaccaaaa tgataatggg
     6121 agaatttagt cttaaaagtt taggttgtca gagtttatct gatatacaaa aaagtaggat
     6181 caaagtctag gaacaaacat tggttatttc actgaaacag atttttaaag agcatattaa
     6241 gaaattaaga ccattagatc atctctttca taatgatatg atgttatttc cattgacggc
     6301 aaatctatac tgttccttgg ttttagagtt gggtattctt tcaaaagtga atttaggcac
     6361 atgcatgtac attgtattta taaagattat atatgtagtt tccaaggaag aaacaaagac
     6421 ctatacagtt tagactttat ttgtttggtg aacgtgctgt tgtgtttggc atagctagag
     6481 aaatgtaagg taaaaggctc actttgtttt ccagtgggtc cagagtcttc tctataccca
     6541 acatatgttt actttatgaa cttaaatgga aattaattta ttgtagacta catctctatt
     6601 tggaatgatg aggtaaatgt ataccttagc attttcttta acaaaaatgt tctgtgtgtc
     6661 aggaaagagg tgtgagagtg gtaggcagcc tgccgcaaac acacggatgg ctccccccgc
     6721 cacgaaggtt gagaacaaag ccagggggcc cagaggagca atagccctgg gccacaagcg
     6781 tgggtaggcc tttcacgtat tccgtctgca caggcaacca aggccagtag aaagctatgg
     6841 ctgcaaaacc ctggggtgga cgatgtttga tgattagacg gtcatctcta actactaaac
     6901 taatatctgc attcttgtta acataaatct ctccttggct attttaatag ccacagtccc
     6961 aaacttcatc ccagcttaga tttctcagca ctgaggtaaa ctctgcattg tcatcccagc
     7021 gtacaccttt aatgttttat tgatttcact ggcactgtat ttggacctgt ccttgtatat
     7081 gtagagacat atgtggcttc attggtaatt tacaagcaaa agatgacatg acgtgacacc
     7141 tgtatgaaaa tgtgatgatt gaactccctg tgtacagcga gtgaattaaa atgtctgcct
     7201 ctccagacat ttcttaatga ttccacttaa tagactctat gtgtgctgaa tgttcctgtg
     7261 tacatatgtg tgttaaataa aacaattgta ttgaa
//
