LOCUS       NM_001367482            5042 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens WD repeat domain 64 (WDR64), mRNA.
ACCESSION   NM_001367482 XM_006711736
VERSION     NM_001367482.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5042)
  AUTHORS   McGue,M., Zhang,Y., Miller,M.B., Basu,S., Vrieze,S., Hicks,B.,
            Malone,S., Oetting,W.S. and Iacono,W.G.
  TITLE     A genome-wide association study of behavioral disinhibition
  JOURNAL   Behav Genet 43 (5), 363-373 (2013)
   PUBMED   23942779
REFERENCE   2  (bases 1 to 5042)
  AUTHORS   Niu,N., Qin,Y., Fridley,B.L., Hou,J., Kalari,K.R., Zhu,M., Wu,T.Y.,
            Jenkins,G.D., Batzler,A. and Wang,L.
  TITLE     Radiation pharmacogenomics: a genome-wide association approach to
            identify radiation response biomarkers using human lymphoblastoid
            cell lines
  JOURNAL   Genome Res 20 (11), 1482-1492 (2010)
   PUBMED   20923822
REFERENCE   3  (bases 1 to 5042)
  AUTHORS   McCauley,J.L., Zuvich,R.L., Bradford,Y., Kenealy,S.J.,
            Schnetz-Boutaud,N., Gregory,S.G., Hauser,S.L., Oksenberg,J.R.,
            Mortlock,D.P., Pericak-Vance,M.A. and Haines,J.L.
  TITLE     Follow-up examination of linkage and association to chromosome 1q43
            in multiple sclerosis
  JOURNAL   Genes Immun 10 (7), 624-630 (2009)
   PUBMED   19626040
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX322532.3, BX248405.4 and AL365366.20.
            
            On Dec 1, 2018 this sequence version replaced XM_006711736.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000437684.7/ ENSP00000402446.4
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               BX322532.3         6583-6931
            350-480             BX322532.3         14832-14962
            481-583             BX322532.3         25376-25478
            584-687             BX322532.3         28946-29049
            688-717             BX322532.3         32489-32518
            718-828             BX322532.3         33787-33897
            829-1043            BX322532.3         37789-38003
            1044-1178           BX322532.3         41763-41897
            1179-1258           BX248405.4         25531-25610
            1259-1398           BX248405.4         37026-37165
            1399-1525           BX248405.4         52092-52218
            1526-1674           BX248405.4         55245-55393
            1675-1798           BX248405.4         58122-58245
            1799-1974           BX248405.4         63276-63451
            1975-2151           BX248405.4         71012-71188
            2152-2285           BX248405.4         79947-80080
            2286-2387           BX248405.4         83133-83234
            2388-2457           BX248405.4         84350-84419
            2458-2494           BX248405.4         85390-85426
            2495-2634           AL365366.20        375-514
            2635-2740           AL365366.20        2688-2793
            2741-2799           AL365366.20        7587-7645
            2800-2909           AL365366.20        10855-10964
            2910-3095           AL365366.20        15432-15617
            3096-3201           AL365366.20        18174-18279
            3202-3282           AL365366.20        22790-22870
            3283-3396           AL365366.20        23840-23953
            3397-5042           AL365366.20        28715-30360
FEATURES             Location/Qualifiers
     source          1..5042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q43"
     gene            1..5042
                     /gene="WDR64"
                     /note="WD repeat domain 64"
                     /db_xref="GeneID:128025"
                     /db_xref="HGNC:HGNC:26570"
     exon            1..349
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..3480
                     /gene="WDR64"
                     /codon_start=1
                     /product="WD repeat-containing protein 64"
                     /protein_id="NP_001354411.1"
                     /db_xref="CCDS:CCDS91185.1"
                     /db_xref="GeneID:128025"
                     /db_xref="HGNC:HGNC:26570"
                     /translation="MDIRKEKRLNMALQMSNFKKALNRFEKLVEQTAAQKRDERAGLF
                     IHKEDAIGYDKFYASVQKLFGPDVKNQDVKRFYRKLCNNTDASADWCEIFGYFSSEED
                     PIASQLDEENLVFFVSRKRRILISGSRRRDVIKSIVKIPHLDLLITATQKGLITVFNN
                     QMRVQTSTNVTDTSWITGCDYLLQLKRIVATTERTIIVWDYKAQGSSQENYFVIKPMD
                     HCLLCVCVVPLPDHLCRDDILLGDDGGFVNRFTVNSDDFGIKQAKSKRKLQNQVLDSK
                     NFKSVKRKLHNDWVMKIRYISALNCFGSCSLDSNHSLVLESLKRLEDNLPVREFSMPR
                     GANTFCYCVKANVIVTGGDDKVIRLWHPNISTKPVGKLVGHMFSIAEIVTNEKDQHVV
                     SLSSAKVFRVWDIQTLSLLQVFHDSQGGPGDMQIYSMIYDANHGMLITGSSVMDMYPL
                     TRMIQDTKQVPHTHEREINVMLYNKYFHQVLTICSESIIRVWELETGLQVYQILEPHG
                     FNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDWKEDEHCLRRLIF
                     LKAQEKHQQLVLALERNGTIKMIQGKEDDIYLMVIWELPDVVPFLQDGKHAVHLRMST
                     RDRNMAIPFPDVELIVERNFSQPTDNPTMDLLRVNCIDLLQVEGYNLIAAGTLNGVII
                     LWNFVTSTVKKVYRPEDCFTVNPDLHPKHFKINDILFLFRTPECARRSSQDSICSSSQ
                     CESSKGPQSSKGSKQSIHDSEVKGEQTDVMVGKQQPMDKKHPGIANLPEAQPPILVTA
                     HEDGHLRLWTLEGRLLKDMLPFTKHSAISLTSLYTDSCTRILLAGNVEGHVILCNISS
                     FLDPPHDEKKFKQLLSWRAHSLEIIQVIYVEEKQVVLTASIDGSVRLWHALNGHYCGY
                     FGQRRLFELSQTRDFILPCDVTEYPIEIKEESKFTEKQKYEYPLIFDREKWRKMSSVS
                     LLFKRTPPKAFEVEQDFKFFKSLSSPKIRRYPLEGFVTENREAGIVFGSLPIYSISSP
                     TSLRFLPLIGVEAQKDSSDGITGKKKGGHVQREKAPRRRSLKKNLVPQINLASSFFPA
                     IPK"
     exon            350..480
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            481..583
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            584..687
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            688..717
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            718..828
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1043
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1178
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1258
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1398
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1525
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1674
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1798
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1974
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2151
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2285
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2387
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2457
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2494
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2634
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2740
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2799
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2909
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3095
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..3201
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3282
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3396
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..5042
                     /gene="WDR64"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3903..3908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR64"
                     /note="hexamer: AAGAAA"
     polyA_site      3923
                     /gene="WDR64"
                     /note="major polyA site"
     regulatory      5021..5026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR64"
                     /note="hexamer: ATTAAA"
     polyA_site      5042
                     /gene="WDR64"
                     /note="major polyA site"
ORIGIN      
        1 agacctaaat cagctttcct ccctgctaac atcctagtgg caactcttac tcctacccgc
       61 actatgggat tttaagatca aaggaattag acctagggca aaaactgaga cagcagggag
      121 gcactgtaac aactggaaag ttttccaaat tggtaaactt gcagtattct ttctgtacag
      181 aagtaaaaga tcccctatgt ccctatggat atcaggaagg aaaagcgtct caacatggca
      241 cttcagatga gcaatttcaa aaaggctttg aacaggtttg aaaaattggt tgaacaaaca
      301 gcagcccaga aaagagatga aagagcaggc ttatttatcc ataaagaaga tgcaattggt
      361 tatgacaagt tttatgcatc ggtacagaag ctctttggtc cagatgtgaa gaatcaagat
      421 gtgaaacgct tttacaggaa actgtgcaac aacacggatg catctgcaga ctggtgtgag
      481 atctttggat acttctcctc tgaagaagat cctattgctt cccagttgga tgaagaaaat
      541 ttggttttct ttgtgtctag aaaaaggcga attttaattt caggtagtag aagacgagat
      601 gtgattaaga gcattgtcaa gatacctcac ctggatttac taataacagc tactcagaaa
      661 ggattaataa cagtttttaa taaccagatg agagttcaga ccagcaccaa tgttacagac
      721 acctcctgga ttacagggtg tgattacctc ttgcagctga aacgaatcgt agccacaacc
      781 gaaaggacca ttattgtctg ggattataaa gctcaaggga gcagccagga aaattatttt
      841 gtcataaaac caatggatca ctgcctcctg tgtgtgtgtg tggtgccttt gcctgaccat
      901 ctctgccgag atgacatcct cttgggggat gatgggggtt ttgtgaacag attcacagtc
      961 aacagtgatg actttggaat aaagcaggca aaatccaaaa gaaaattaca aaatcaggtc
     1021 ttagactcaa agaactttaa aagtgttaaa aggaagctac ataatgactg ggttatgaaa
     1081 attagatata tttcagccct aaattgtttt ggatcctgct ccttagacag taatcattca
     1141 ttagttttgg aatccttgaa gagactcgag gataatttgc ctgtcagaga gttttccatg
     1201 ccaagaggag ccaacacttt ttgctactgt gttaaggcaa atgtgattgt cactggagga
     1261 gatgataagg tcatccggtt gtggcacccc aatatcagca ccaagccagt agggaaactt
     1321 gtaggacaca tgttcagtat cgccgagatc gtaaccaatg aaaaagatca acatgtcgtc
     1381 agcctttcct ctgcaaaggt tttccgggtg tgggatatac aaactctttc actattacaa
     1441 gtcttccatg acagccaggg aggaccagga gacatgcaga tttactctat gatatatgat
     1501 gccaatcatg gcatgcttat tacgggatct agtgttatgg acatgtatcc tttgactagg
     1561 atgatacaag atacaaaaca ggttcctcac actcatgaac gagaaatcaa tgtcatgctt
     1621 tacaacaaat attttcatca agtactcact atctgctctg aatccataat tagggtatgg
     1681 gaactcgaga ctgggctcca agtataccag attttagaac ctcatggttt caatactgaa
     1741 gtgacttctg cagctgtcga tgaaagtgga tttctttttg ccacaggagc gtataatgga
     1801 acagtcagaa tctgggactt tggcagtggg caggagatga aggtgttgcc ggaggggaaa
     1861 gactggaagg aggacgagca ctgcctacga cgcctcattt tcctcaaagc ccaagaaaaa
     1921 caccagcagc tggtcctggc cttggagcgc aacgggacta tcaaaatgat ccagggtaag
     1981 gaagatgata tctacctcat ggtgatctgg gagctgcctg atgttgtgcc tttcctacaa
     2041 gatgggaaac atgctgtgca tctgagaatg tctactagag acaggaacat ggctattcct
     2101 ttcccagatg tcgagttgat agttgagagg aacttttctc aacctactga taatcccacc
     2161 atggatttat tacgagtgaa ctgcattgat ttactacaag tagaaggata taatttgata
     2221 gcagctggaa ccttaaatgg tgtgatcatc ttatggaatt ttgtgacgtc tactgtcaaa
     2281 aaagtgtacc gacctgaaga ttgcttcact gtaaaccctg acttgcatcc caagcacttt
     2341 aaaattaatg acatactgtt cctctttcgt acccctgaat gtgcaaggag atcaagtcag
     2401 gattccatat gttcttcatc ccagtgtgaa tccagcaaag gtccacagag cagtaaggga
     2461 agcaagcaaa gcatacatga cagtgaggtt aaaggtgaac aaacagatgt aatggtggga
     2521 aagcaacagc caatggacaa aaaacaccct ggaattgcca atttaccaga agcccagcca
     2581 cctatccttg tcactgctca tgaggatgga cacctccgct tgtggactct ggagggaaga
     2641 ctactgaaag atatgctacc tttcacaaaa cattctgcca tttctctgac atcgctgtat
     2701 actgattcat gtacgaggat actactggct ggaaatgtgg aaggacatgt tatcctttgc
     2761 aatattagct ctttcctgga tccacctcat gatgaaaaga aattcaagca gctgctttcc
     2821 tggcgtgctc attctttgga aattattcaa gtaatctatg tagaagaaaa acaagtggta
     2881 cttactgcct ccatcgatgg ctcagtaagg ctctggcatg ccctcaatgg acattattgt
     2941 ggatattttg gacagcgaag gctctttgaa ttatcacaga caagagattt cattttgcct
     3001 tgtgatgtta ctgaatatcc catagaaata aaagaagaaa gcaagttcac agagaagcaa
     3061 aaatatgaat atcctctgat atttgaccgg gaaaaatgga gaaaaatgag ctcagtgtct
     3121 ctacttttca aacgcacacc tcccaaggcc tttgaagtgg aacaggattt caagtttttc
     3181 aagtctcttt cttctcctaa gattcgaaga tatcccttgg aaggtttcgt gactgaaaac
     3241 agagaggcag ggattgtttt cggctctctg cctatataca gtatatcaag ccccactagt
     3301 ctaagatttc ttccactgat tggcgtagaa gcccaaaagg actcttcaga tggcattaca
     3361 ggaaagaaga agggaggtca tgttcaacgt gaaaaagcac cacgaagaag aagtttgaaa
     3421 aaaaatttag tcccacaaat aaatctggct tcttccttct tcccagctat acccaagtaa
     3481 ggagaaaaaa tcagaaatgg ctgctgcaca taaaatggca acgtttggat gatacctgct
     3541 ctttatttca ggatgagagg gagaaaccac cagacactat cagtcatctc tggtgtcagg
     3601 ccatcctatt gatgggaaag attgcttagg gagttctggt gaccttaact ctgaatacca
     3661 agcaagcagc aagcagccag aagtttaggc ggtgtttctt atttactgtc agcaaactga
     3721 cacataagaa aacaaatgaa atcaacagca ttagtaggtc taaaataata tggttatcaa
     3781 tgtttagctt tccacttcct cccattggtc accttactcc acagcaagaa tgactgtcag
     3841 aacatgtgca gtaaaaggca ctttcaagtc atgctatgtg ttgtacaaaa agaattatta
     3901 aaaagaaaaa tgtaccagtc agatctctag atgtttgtct tcttcattta gagaaatatt
     3961 atctggaaga aaatgtccta agtttctcaa agtcagaaat tatttctatg tagtccagac
     4021 ctgactccag ataaatataa aagacggcaa agaaaggaag aaaaatgggt catagaaata
     4081 gaaaaagcat agtaacatgg tagatttaac cttaaatata tcaataatta tgaaaccttt
     4141 aataggttaa agtatgcaag tttaaaaggt tgtcagaatg gattaaaaaa acaaaatcca
     4201 actatatgtt gtttacaaga aacacatcta acatacaagg acaccaaact cttaaagata
     4261 aaagaatgaa aaaagatgta tgatgcaaaa actaacctaa agaaaatcaa tatagccata
     4321 ttaatattaa aatacacttt aagaaaataa acaagaatct ttataaaagt tttataaagt
     4381 tattaataat aactcaaaaa aggaaaaagc ctagtttcca caacagaaga atgactaaac
     4441 aaactatggt agggtaggac aatggaatcc tcagcaatta aagggaataa aatgctaatg
     4501 catgcattaa catagaccaa tctcaagaat atgttaagtc aaaaaaactt tacagaaaga
     4561 atacatgttg tatgattcca cgtttataaa attctacaac aggaaagact aacactcagt
     4621 ttaaaaaatt aaaacaatgg tggcctctgg aagagagggc aaatatcaca gagagattta
     4681 gagatttaga aggggtatga aagaactttc tggggtgaat ggtaatgtta tcttaataaa
     4741 gtttgggtta tacagctagg tgtgcatttc aaaatttatt ggatgatatt tctgcatttc
     4801 gttgtatgtg aattttttca aaaaattaag aattgtaaac taatattctc attgatatgc
     4861 atgctaatag gattactagt gtcttccact tactttgaaa tgaatcaaaa aaataagatg
     4921 aactaatgga tagagggatg gactgataga tggatatgtg ttagagcata tctaaaacca
     4981 cattaattat ggaatctagg tggtaggaat acaggtattc attaaagaac tctttcaaat
     5041 tc
//
