LOCUS       NM_001083961            4727 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens WD repeat domain 62 (WDR62), transcript variant 1,
            mRNA.
ACCESSION   NM_001083961
VERSION     NM_001083961.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4727)
  AUTHORS   Aslam,K., Saeed,A., Saeed,H.I., Bashir,R., Abid,H., Akhtar,R.,
            Habib,N., Khan,R., Asif,R., Rafiq,S., Asif,M., Makhdoom,E.U.H.,
            Hussain,M.S., Baig,S.M. and Anjum,I.
  TITLE     Molecular genetics, neuroimaging outcomes, and structural analyses
            of novel and recurrent variants of WDR62 gene in two consanguineous
            Pakistani families with autosomal recessive primary microcephaly
  JOURNAL   Mol Biol Rep 51 (1), 783 (2024)
   PUBMED   38926176
  REMARK    GeneRIF: Molecular genetics, neuroimaging outcomes, and structural
            analyses of novel and recurrent variants of WDR62 gene in two
            consanguineous Pakistani families with autosomal recessive primary
            microcephaly.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4727)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 4727)
  AUTHORS   Hao,L., Ma,J., Wu,F., Ma,X., Qian,M., Sheng,W., Yan,T., Tang,N.,
            Jiang,X., Zhang,B., Xiao,D., Qian,Y., Zhang,J., Jiang,N., Zhou,W.,
            Chen,W., Ma,D. and Huang,G.
  TITLE     WDR62 variants contribute to congenital heart disease by inhibiting
            cardiomyocyte proliferation
  JOURNAL   Clin Transl Med 12 (7), e941 (2022)
   PUBMED   35808830
  REMARK    GeneRIF: WDR62 variants contribute to congenital heart disease by
            inhibiting cardiomyocyte proliferation.
REFERENCE   4  (bases 1 to 4727)
  AUTHORS   Cai,J., Su,L. and Luo,W.
  TITLE     WD repeat domain 62 (WDR62) promotes resistance of colorectal
            cancer to oxaliplatin through modulating mitogen-activated protein
            kinase (MAPK) signaling
  JOURNAL   Bioengineered 13 (6), 14450-14459 (2022)
   PUBMED   35758246
  REMARK    GeneRIF: WD repeat domain 62 (WDR62) promotes resistance of
            colorectal cancer to oxaliplatin through modulating
            mitogen-activated protein kinase (MAPK) signaling.
REFERENCE   5  (bases 1 to 4727)
  AUTHORS   Wasserman,T., Katsenelson,K., Daniliuc,S., Hasin,T., Choder,M. and
            Aronheim,A.
  TITLE     A novel c-Jun N-terminal kinase (JNK)-binding protein WDR62 is
            recruited to stress granules and mediates a nonclassical JNK
            activation
  JOURNAL   Mol Biol Cell 21 (1), 117-130 (2010)
   PUBMED   19910486
  REMARK    GeneRIF: JNK and WDR62 may regulate the dynamic interplay between
            polysomes stress granule and processing bodies, thereby mediating
            mRNA fate after stress.
REFERENCE   6  (bases 1 to 4727)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   7  (bases 1 to 4727)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   8  (bases 1 to 4727)
  AUTHORS   Roberts,E., Jackson,A.P., Carradice,A.C., Deeble,V.J., Mannan,J.,
            Rashid,Y., Jafri,H., McHale,D.P., Markham,A.F., Lench,N.J. and
            Woods,C.G.
  TITLE     The second locus for autosomal recessive primary microcephaly
            (MCPH2) maps to chromosome 19q13.1-13.2
  JOURNAL   Eur J Hum Genet 7 (7), 815-820 (1999)
   PUBMED   10573015
REFERENCE   9  (bases 1 to 4727)
  AUTHORS   Verloes,A., Ruaud,L., Drunat,S. and Passemard,S.
  TITLE     WDR62 Primary Microcephaly
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   35188728
REFERENCE   10 (bases 1 to 4727)
  AUTHORS   Verloes,A., Drunat,S., Gressens,P. and Passemard,S.
  TITLE     Primary Autosomal Recessive Microcephalies and Seckel Syndrome
            Spectrum Disorders - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301772
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK090617.1, BC058939.1,
            AC004144.1 and AW029580.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001083961.1.
            
            Summary: This gene is proposed to play a role in cerebral cortical
            development. Mutations in this gene have been associated with
            microencephaly, cortical malformations, and cognitive disability.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058939.1, SRR7346977.1910121.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000401500.7/ ENSP00000384792.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1183              AK090617.1         17-1199
            1184-1544           BC058939.1         1144-1504
            1545-1545           AC004144.1         14477-14477
            1546-2345           BC058939.1         1506-2305
            2346-2346           AC004144.1         24065-24065
            2347-2623           BC058939.1         2307-2583
            2624-2624           AC004144.1         30743-30743
            2625-3542           BC058939.1         2585-3502
            3543-3543           AC004144.1         34477-34477
            3544-4003           BC058939.1         3504-3963
            4004-4198           AC004144.1         35073-35267
            4199-4244           BC058939.1         4159-4204
            4245-4245           AC004144.1         35850-35850
            4246-4723           BC058939.1         4206-4683
            4724-4727           AW029580.1         4-7                 c
FEATURES             Location/Qualifiers
     source          1..4727
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..4727
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /note="WD repeat domain 62"
                     /db_xref="GeneID:284403"
                     /db_xref="HGNC:HGNC:24502"
                     /db_xref="MIM:613583"
     exon            1..252
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..4647
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     microcephaly, primary autosomal recessive 2; WD
                     repeat-containing protein 62"
                     /codon_start=1
                     /product="WD repeat-containing protein 62 isoform 1"
                     /protein_id="NP_001077430.1"
                     /db_xref="CCDS:CCDS46059.1"
                     /db_xref="GeneID:284403"
                     /db_xref="HGNC:HGNC:24502"
                     /db_xref="MIM:613583"
                     /translation="MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRR
                     RTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENK
                     QQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVAC
                     VAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGN
                     RHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSG
                     LLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKP
                     HYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDIN
                     RVGKVWSELFHSSYVWNVEVYPEFEDQRACLPSGSFLTCSSDNTIRFWNLDSSPDSHW
                     QKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDVKAGVRVMQVSPDGQHLA
                     SGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNV
                     EKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHH
                     VAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVD
                     PSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVF
                     IWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQT
                     EDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRLLGDDDVADGLAFHAKR
                     SYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSES
                     ESPQEAGRGHPSFLPQQKESSEASELILYSLEAEVTVTGTDSQYCRKEVEAGPGDQQG
                     DSYLRVSSDSPKDQSPPEDSGESEADLECSFAAIHSPAPPPDPAPRFATSLPHFPGCA
                     GPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTESPCRELFPAALGDVEASEA
                     EDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQPRAGTG
                     YASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLPTDRNLPTPTSAPTPG
                     LAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLG
                     QELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVT
                     VPAVSFPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTAS
                     LLEPTSGALGLLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYR
                     VLVSSGQVDTGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLY
                     PLASPDLQALLEHYSELLVQAVRRKARGH"
     exon            253..344
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            345..407
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            408..465
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            466..636
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            637..774
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            775..957
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1118
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1308
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1446
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1625
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1717
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1843
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1911
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2033
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2109
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2221
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2285
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2408
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2542
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2595
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2814
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2942
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3046
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3157
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3295
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3410
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3411..3537
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3589
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            3590..4228
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            4229..4386
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            4387..4727
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4705..4710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /note="hexamer: AATAAA"
     polyA_site      4727
                     /gene="WDR62"
                     /gene_synonym="C19orf14; MCPH2"
                     /note="major polyA site"
ORIGIN      
        1 gctgttccag tgggtcgtgg cggtggcggc agcggcggtt aggggatgta acggtcgccc
       61 gcctccggcg tgacgatggc ggccgtaggg tccggaggct atgcgcggaa cgatgcaggg
      121 gagaagctgc cctctgtcat ggcgggagtt ccggcgcgga ggggccagtc ctccccgccc
      181 cccgccccac caatctgcct acggcggcgg acgcgactct cgacggcctc cgaggagacg
      241 gtgcagaacc gggtgtcact cgagaaggtg cttggcatca cagcccagaa cagcagtggc
      301 ctaacctgtg accccggcac aggccatgtg gcctacctgg caggctgtgt ggtggtgatt
      361 ttggacccca aggagaacaa gcagcagcac atctttaaca ccgccaggaa gtctctcagt
      421 gctctggcct tctcccctga tgggaagtac atagtgacag gggagaatgg gcataggcct
      481 gctgtgcgca tctgggatgt ggaggagaag aatcaggtgg cggagatgct aggccacaag
      541 tatggtgtgg cgtgtgtggc cttctcaccc aatatgaagc acatcgtgtc catgggctac
      601 caacatgaca tggtgctcaa cgtctgggac tggaagaaag acatcgtagt ggcctccaac
      661 aaggtatctt gtagagtcat tgccctctcc ttctcagagg acagcagcta ttttgtcact
      721 gttgggaacc gccatgtgag gttctggttc ttggaagtct ccactgagac aaaggtgacg
      781 agcacagtgc cccttgtagg gcgctcgggc atcctgggcg agctgcacaa caacatcttc
      841 tgtggtgtgg cctgcggtcg gggccggatg gcgggcagta ccttctgtgt gtcctactcg
      901 ggcctcctct gccagttcaa tgagaagagg gtgctggaga agtggatcaa cctgaaggtc
      961 tccctgtctt cctgcctctg tgtcagccag gagctcatct tctgtggctg cacagatggg
     1021 atagtccgca tcttccaggc ccatagcctg cactacctcg ccaacctgcc caagccacac
     1081 taccttgggg tagacgtggc acagggcctg gagcccagct tcctcttcca caggaaggcg
     1141 gaagcagtct acccagatac agtggcactg accttcgacc ccatccacca gtggctgtcc
     1201 tgcgtgtata aggaccacag catctacatc tgggatgtca aggacatcaa cagagtgggc
     1261 aaggtgtggt cagagctctt ccacagctcc tacgtttgga acgtggaggt gtatcctgag
     1321 tttgaagacc agagagcttg tttgccatca ggatcctttc tgacttgttc ttcagacaac
     1381 accattcgct tctggaactt ggacagcagc cctgattctc actggcagaa aaacatcttc
     1441 agcaataccc tgctgaaggt cgtgtacgtg gagaatgaca tccagcacct gcaggacatg
     1501 tcacacttcc cagaccgggg gagcgagaat gggacaccca tggacgtgaa agccggggtg
     1561 cgggtcatgc aggtcagtcc tgacggccag catttggctt caggcgaccg aagtggaaat
     1621 ctgaggatcc acgagctgca cttcatggac gagctggtca aggtggaggc ccatgatgct
     1681 gaggtgctgt gcctggagta ctccaagcca gagacggggc tgaccttgct ggcctcagcc
     1741 agtcgggacc ggctgatcca tgtgctgaac gtggagaaga actacaacct ggagcagacg
     1801 ctggatgacc actcctcctc catcaccgcc atcaagttcg ctggcaacag agacatccag
     1861 atgatcagct gtggggctga caagagcatc tactttcgca gtgcccagca gggttcggat
     1921 ggactacact ttgtccgtac ccaccacgta gcagagaaaa ccaccttgta tgacatggac
     1981 attgacatca cccagaagta cgtggccgtg gcctgccagg accgcaatgt gagagtctac
     2041 aacactgtga acgggaagca gaagaagtgc tacaagggct cccagggtga cgaagggtcc
     2101 ttgctgaagg tccatgtgga cccctcaggc accttcctgg ccaccagctg ctctgacaaa
     2161 agcatctcag tgattgactt ttactcgggc gagtgcattg ccaagatgtt tggccattca
     2221 gaaattatta ccagcatgaa gttcacctat gactgtcatc acttgatcac agtatctgga
     2281 gacagctgcg tgttcatctg gcacctgggc ccggagatca ccaactgcat gaagcagcac
     2341 ttgctggaga ttgaccaccg gcagcagcag cagcacacaa atgacaagaa gcggagtggc
     2401 caccccaggc aggatacgta tgtgtccaca cctagtgaga ttcactccct gagccctgga
     2461 gagcaaacag aggatgatct ggaggaagag tgtgagccag aagagatgct gaagacacca
     2521 tccaaagata gcttggatcc agatcctcgt tgcctgctaa ccaacggcaa gctgccactg
     2581 tgggcaaagc ggctgctagg ggacgatgat gtggcagatg gcttggcctt ccacgccaag
     2641 cgcagctacc agccccacgg ccgctgggca gagcgggccg gccaagagcc cctcaagacc
     2701 atcctggatg cccaggacct ggattgctac tttaccccca tgaagcccga gagtctggag
     2761 aactccattc tggattcact ggagccacag agcctggcca gcctgctgag tgagtcagag
     2821 agtccccagg aagctggccg cgggcacccc tccttcctgc cccagcagaa ggaatcatct
     2881 gaggccagtg agctcatcct ctactctctg gaggcagaag tgacagtcac agggacagac
     2941 agccagtatt gcaggaagga ggtggaggcc gggcctggag accagcaggg cgactcctac
     3001 ctcagggtgt cctccgacag cccaaaggac cagagcccgc ctgaggactc gggggagtca
     3061 gaggccgacc tggagtgcag cttcgcagcc atccactccc cagctccgcc tcctgaccct
     3121 gcccctcggt ttgccacgtc gctgccccat ttcccaggat gcgcaggtcc cacagaagat
     3181 gagctgtccc tgcccgaggg acccagcgtc cccagcagct ccctacccca gactccggag
     3241 caggagaagt tcctccgcca ccactttgag acactgactg agtccccctg cagagagctc
     3301 ttccccgcag ctctgggaga cgtggaggcc tctgaagctg aagaccactt cttcaaccca
     3361 cgcctgagta tctccacgca gttcctctca agcctccaga aggcatccag gttcacccat
     3421 accttccctc cccgggcaac ccagtgcctt gtgaagtctc cagaggtcaa gctcatggac
     3481 cgaggcggaa gccagcccag agcaggtact ggctacgcct ccccagacag gacccacgtc
     3541 ctcgctgcag ggaaggctga agagaccctg gaggcctggc gcccaccacc tccctgcctt
     3601 acgagcctgg cgtcctgtgt ccctgcttcc tccgtgctgc ccacagacag gaatctccca
     3661 acgcccacat ctgcacccac cccaggcctg gctcagggtg tccatgcccc ctccacctgt
     3721 tcctacatgg aggccactgc cagctcccgt gccaggatat cacgcagcat ctccctcggt
     3781 gacagtgagg gccctatcgt ggccacactg gcccagcccc tccgtaggcc atcgtccgtt
     3841 ggggagctgg cctccttggg ccaggagctt caggccatca ccaccgcgac aacacccagt
     3901 ttggacagtg agggccaaga gcctgccctg cgttcctggg gcaaccacga ggcccgggcc
     3961 aacctgagac tgaccctgtc aagtgcctgt gatgggctcc tgcagccccc cgtggatacc
     4021 cagcctggcg tcaccgtccc tgcagtgagc ttcccagccc ctagccctgt ggaagagagc
     4081 gccctgaggc tccacggctc tgcctttcgc ccaagtctcc cagctcctga gtcccctggc
     4141 cttcctgccc accccagtaa cccccagctt ccagaggccc ggcctggcat ccctggcggc
     4201 actgcctccc tcctggagcc cacctccggt gcacttggtc tgttacaggg cagccctgcc
     4261 cgctggagtg agccctgggt gccggttgaa gccctgcccc catctcccct tgagctgagc
     4321 agggtgggga acatcttgca caggctgcag accaccttcc aagaagccct cgacctttac
     4381 cgtgtgttgg tctccagtgg ccaggtggac accgggcagc agcaggcacg gactgagctg
     4441 gtctccacct tcctgtggat ccacagccag ctggaggctg aatgcctggt ggggactagt
     4501 gtggccccag cccaggctct gcccagccca ggacccccgt ccccaccgac gctgtacccc
     4561 ctggccagcc cagacctgca ggccctgctg gaacactact cggagctgct ggtgcaggcc
     4621 gtgcggagga aggcacgggg gcactgaggg cgcagcccct ccaccgcagc cctgctgctt
     4681 ctgaggactt aggtatttta agcgaataaa ctgacagctt tgaggaa
//
