LOCUS       NM_018031               4070 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens WD repeat domain 6 (WDR6), transcript variant 1, mRNA.
ACCESSION   NM_018031 NM_052825 NM_052826
VERSION     NM_018031.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4070)
  AUTHORS   Li,J., Wang,Y.N., Xu,B.S., Liu,Y.P., Zhou,M., Long,T., Li,H.,
            Dong,H., Nie,Y., Chen,P.R., Wang,E.D. and Liu,R.J.
  TITLE     Intellectual disability-associated gene ftsj1 is responsible for
            2'-O-methylation of specific tRNAs
  JOURNAL   EMBO Rep 21 (8), e50095 (2020)
   PUBMED   32558197
REFERENCE   2  (bases 1 to 4070)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4070)
  AUTHORS   Sivan,G., Ormanoglu,P., Buehler,E.C., Martin,S.E. and Moss,B.
  TITLE     Identification of Restriction Factors by Human Genome-Wide RNA
            Interference Screening of Viral Host Range Mutants Exemplified by
            Discovery of SAMD9 and WDR6 as Inhibitors of the Vaccinia Virus
            K1L-C7L- Mutant
  JOURNAL   mBio 6 (4), e01122 (2015)
   PUBMED   26242627
  REMARK    GeneRIF: Replication of the K1L(-)C7L(-) mutant vaccinia virus
            virus was enabled by multiple siRNAs to SAMD9 or WDR6.
            Erratum:[mBio. 2017 Oct 31;8(5):e01735-17. doi:
            10.1128/mBio.01735-17.. PMID: 29089434]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4070)
  AUTHORS   Guy,M.P. and Phizicky,E.M.
  TITLE     Conservation of an intricate circuit for crucial modifications of
            the tRNAPhe anticodon loop in eukaryotes
  JOURNAL   RNA 21 (1), 61-74 (2015)
   PUBMED   25404562
REFERENCE   5  (bases 1 to 4070)
  AUTHORS   Chiba,T., Inoue,D., Mizuno,A., Komatsu,T., Fujita,S., Kubota,H.,
            Luisa Tagliaro,M., Park,S., Trindade,L.S., Hayashida,T.,
            Hayashi,H., Yamaza,H., Higami,Y. and Shimokawa,I.
  TITLE     Identification and characterization of an insulin receptor
            substrate 4-interacting protein in rat brain: implications for
            longevity
  JOURNAL   Neurobiol Aging 30 (3), 474-482 (2009)
   PUBMED   17720279
  REMARK    GeneRIF: Transgenic rat gene WDR6 is expressed in the hypothalamus
            and interacts with insulin receptor substrate 4 (IRS-4) in the
            brain.
REFERENCE   6  (bases 1 to 4070)
  AUTHORS   Fang,L., Wang,X., Yamoah,K., Chen,P.L., Pan,Z.Q. and Huang,L.
  TITLE     Characterization of the human COP9 signalosome complex using
            affinity purification and mass spectrometry
  JOURNAL   J Proteome Res 7 (11), 4914-4925 (2008)
   PUBMED   18850735
REFERENCE   7  (bases 1 to 4070)
  AUTHORS   Xie,X., Wang,Z. and Chen,Y.
  TITLE     Association of LKB1 with a WD-repeat protein WDR6 is implicated in
            cell growth arrest and p27(Kip1) induction
  JOURNAL   Mol Cell Biochem 301 (1-2), 115-122 (2007)
   PUBMED   17216128
  REMARK    GeneRIF: Results suggest that WDR6 is implicated in the cell growth
            inhibitory pathway of LKB1 via regulation of p27(Kip1).
REFERENCE   8  (bases 1 to 4070)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   9  (bases 1 to 4070)
  AUTHORS   Li,D. and Roberts,R.
  TITLE     WD-repeat proteins: structure characteristics, biological function,
            and their involvement in human diseases
  JOURNAL   Cell Mol Life Sci 58 (14), 2085-2097 (2001)
   PUBMED   11814058
  REMARK    Review article
REFERENCE   10 (bases 1 to 4070)
  AUTHORS   Li,D., Burch,P., Gonzalez,O., Kashork,C.D., Shaffer,L.G.,
            Bachinski,L.L. and Roberts,R.
  TITLE     Molecular cloning, expression analysis, and chromosome mapping of
            WDR6, a novel human WD-repeat gene
  JOURNAL   Biochem Biophys Res Commun 274 (1), 117-123 (2000)
   PUBMED   10903905
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC389885.1, BC113467.1,
            AK092079.1 and AK022719.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_018031.5.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. The encoded protein interacts with serine/threonine
            kinase 11, and is implicated in cell growth arrest. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.238599.1,
                                           SRR1803611.17394.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000608424.6/ ENSP00000477389.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DC389885.1         83-94
            13-3470             BC113467.1         1-3458
            3471-3904           AK092079.1         1125-1558
            3905-4070           AK022719.1         2139-2304
FEATURES             Location/Qualifiers
     source          1..4070
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..4070
                     /gene="WDR6"
                     /gene_synonym="Trm734"
                     /note="WD repeat domain 6"
                     /db_xref="GeneID:11180"
                     /db_xref="HGNC:HGNC:12758"
                     /db_xref="MIM:606031"
     exon            1..141
                     /gene="WDR6"
                     /gene_synonym="Trm734"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..3407
                     /gene="WDR6"
                     /gene_synonym="Trm734"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 6; Trm734 homolog; tRNA
                     (34-2'-O)-methyltransferase regulator WDR6"
                     /codon_start=1
                     /product="tRNA (34-2'-O)-methyltransferase regulator WDR6
                     isoform 1"
                     /protein_id="NP_060501.4"
                     /db_xref="CCDS:CCDS2782.3"
                     /db_xref="GeneID:11180"
                     /db_xref="HGNC:HGNC:12758"
                     /db_xref="MIM:606031"
                     /translation="MDALEDYVWPRATSELILLPVTGLECVGDRLLAGEGPDVLVYSL
                     DFGGHLRMIKRVQNLLGHYLIHGFRVRPEPNGDLDLEAMVAVFGSKGLRVVKISWGQG
                     HFWELWRSGLWNMSDWIWDARWLEGNIALALGHNSVVLYDPVVGCILQEVPCTDRCTL
                     SSACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYL
                     ESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGE
                     DCVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHLVGRGYRG
                     LGVSALCFKSRSRPGTLKAVTLAGSWRLLAVTDTGALYLYDVEVKCWEQLLEDKHFQS
                     YCLLEAAPGPEGFGLCAMANGEGRVKVVPINTPTAAVDQTLFPGKVHSLSWALRGYEE
                     LLLLASGPGGVVACLEISAAPSGKAIFVKERCRYLLPPSKQRWHTCSAFLPPGDFLVC
                     GDRRGSVLLFPSRPGLLKDPGVGGKARAGAGAPVVGSGSSGGGNAFTGLGPVSTLPSL
                     HGKQGVTSVTCHGGYVYTTGRDGAYYQLFVRDGQLQPVLRQKSCRGMNWLAGLRIVPD
                     GSMVILGFHANEFVVWNPRSHEKLHIVNCGGGHRSWAFSDTEAAMAFAYLKDGDVMLY
                     RALGGCTRPHVILREGLHGREITCVKRVGTITLGPEYGVPSFMQPDDLEPGSEGPDLT
                     DIVITCSEDTTVCVLALPTTTGSAHALTAVCNHISSVRAVAVWGIGTPGGPQDPQPGL
                     TAHVVSAGGRAEMHCFSIMVTPDPSTPSRLACHVMHLSSHRLDEYWDRQRNRHRMVKV
                     DPETRYMSLAVCELDQPGLGPLVAAACSDGAVRLFLLQDSGRILQLLAETFHHKRCVL
                     KVHSFTHEAPNQRRRLLLCSAATDGSLAFWDLTTMLDHDSTVLEPPVDPGLPYRLGTP
                     SLTLQAHSCGINSLHTLPTREGHHLVASGSEDGSLHVFVLAVEMLQLEEAVGEAGLVP
                     QLRVLEEYSVPCAHAAHVTGLKILSPSIMVSASIDQRLTFWRLGHGEPTFMNSTVFHV
                     PDVADMDCWPVSPEFGHRCALGGQGLEVYNWYD"
     exon            142..2623
                     /gene="WDR6"
                     /gene_synonym="Trm734"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2707
                     /gene="WDR6"
                     /gene_synonym="Trm734"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2824
                     /gene="WDR6"
                     /gene_synonym="Trm734"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2943
                     /gene="WDR6"
                     /gene_synonym="Trm734"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..4070
                     /gene="WDR6"
                     /gene_synonym="Trm734"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4048..4053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR6"
                     /gene_synonym="Trm734"
                     /note="hexamer: AATAAA"
     polyA_site      4070
                     /gene="WDR6"
                     /gene_synonym="Trm734"
                     /note="major polyA site"
ORIGIN      
        1 cccttcttag ccgtggctgc ctcagcacct cgaggatcga catggacgct ctcgaggact
       61 acgtttggcc gcgggcaacc tcggagctta tactcctccc agtgacgggt ctggagtgcg
      121 tgggggaccg gctgttggcg ggtgagggtc ccgatgtcct ggtgtacagc ttggactttg
      181 gtgggcatct gcggatgata aagcgagtgc agaacctgct tggccactat cttatccatg
      241 gcttccgggt acggccagag cctaatggag accttgactt ggaggccatg gtggctgtgt
      301 ttggaagcaa gggactccga gttgtgaaaa ttagctgggg acagggccac ttctgggagc
      361 tttggcgctc tggcctgtgg aacatgtctg actggatttg ggatgcacgc tggcttgagg
      421 gaaatatagc cttggccctg ggccacaact cagtggtgct atatgaccct gtagtagggt
      481 gcatcctgca agaggtgccc tgcacagaca ggtgcaccct ctcttcagcc tgcctgattg
      541 gagacgcctg gaaggagctg accatagtgg caggtgctgt ttccaaccag ctcttggtct
      601 ggtacccagc aactgcctta gcagacaaca aacctgtagc acctgaccga cgaatcagtg
      661 ggcatgtggg catcatcttc agcatgtcat acctggaaag caagggattg ctggctacag
      721 cttcagaaga ccgaagcgtt cgtatctgga aggtgggcga cctgcgagtg cctgggggtc
      781 gggtgcagaa tattgggcac tgctttgggc acagcgcccg tgtgtggcag gtcaagcttc
      841 tagagaatta ccttatcagt gcaggagagg attgtgtctg cttggtgtgg agccatgaag
      901 gtgagatcct ccaggccttt cggggacacc agggacgtgg gatccgggcc atagctgccc
      961 atgagaggca ggcctgggtg atcactgggg gtgatgactc aggcattcgg ctgtggcact
     1021 tggtagggcg tgggtaccgg ggattggggg tctcggctct ctgcttcaag tcccgtagta
     1081 ggccaggtac actcaaggct gtgactctgg ctggctcttg gcgactgctg gcagtgactg
     1141 atacaggggc cctgtatctc tatgacgtcg aggtcaagtg ctgggagcag ctgctagagg
     1201 ataaacattt ccagtcctac tgcctgctgg aggcagctcc tggtcccgag ggcttcggat
     1261 tgtgtgctat ggccaatggg gaaggtcgtg tcaaggttgt ccccatcaac actccaactg
     1321 ctgctgtgga ccagaccctg tttcctggga aggtgcacag cttgagctgg gccctgcgtg
     1381 gttatgagga gctcctgttg ctggcatcgg gccctggcgg ggtagtagct tgcctagaga
     1441 tctcagccgc accctctggc aaggccatct ttgtcaagga acgttgtcgg tacctgctgc
     1501 ccccaagcaa gcagagatgg cacacatgca gtgccttcct acccccaggt gacttcctgg
     1561 tgtgtggtga ccgccggggc tctgtgctgc tattcccctc cagaccaggt ctgctcaagg
     1621 accctggggt gggaggcaag gctcgggctg gtgctggggc acctgtagtg ggtagtggta
     1681 gtagtggggg tgggaatgct ttcactgggt tgggcccagt gtctaccctg ccctctctgc
     1741 acgggaagca gggtgtgacc tcagtcacat gccatggtgg ctatgtgtat accacagggc
     1801 gtgatggagc ctactaccag ctgtttgtac gagacggcca gctccagcca gtcctaaggc
     1861 agaagtcctg tcgaggcatg aactggctag ctgggctccg tatagtgccc gatgggagca
     1921 tggttatcct gggtttccat gccaatgagt ttgtggtgtg gaaccctcgg tcacacgaga
     1981 agctgcacat cgtcaactgt ggtggagggc accgttcgtg ggcattctct gatactgagg
     2041 cggccatggc ctttgcttac ctcaaggatg gggatgtcat gctgtacagg gctctgggtg
     2101 gctgcacccg gccacacgtg attctccggg agggtctgca tggccgtgag atcacttgtg
     2161 taaagcgtgt gggcaccatt accctggggc ctgaatatgg agtgcccagc ttcatgcagc
     2221 ctgatgacct ggagcctggc agtgaggggc ccgacttgac tgacattgtg atcacatgta
     2281 gtgaggacac tactgtctgt gtcctagcac tccctacaac cacaggctca gcccacgcac
     2341 tcacagctgt ttgtaaccat atctcctcgg tacgtgctgt ggctgtgtgg ggcattggca
     2401 ccccaggtgg ccctcaggat cctcagccag gcctgactgc ccatgtggtg tctgcggggg
     2461 ggcgggctga gatgcactgc ttcagcatca tggttactcc ggaccccagc accccaagcc
     2521 gcctcgcctg ccatgtcatg cacctttcgt cccaccggct agatgagtat tgggaccggc
     2581 aacgcaatcg gcatcggatg gttaaggtag acccagagac caggtacatg tcccttgctg
     2641 tgtgtgaact tgaccagccc ggccttggcc cccttgtggc tgcagcctgt agtgatgggg
     2701 ccgtaaggct ctttcttttg caggattctg ggcggattct gcagctcctt gctgaaacct
     2761 tccaccataa gcgatgtgtc ctcaaggtcc actcctttac acacgaggca cccaaccaga
     2821 ggcggaggct cctcctgtgc agcgcagcta ctgatggcag cctggctttc tgggatctca
     2881 ccaccatgct agaccatgac tccactgtcc tggagcctcc agtggatcct gggcttccct
     2941 accggcttgg caccccctcc ctgactctcc aggcccacag ctgtggtatc aacagcctgc
     3001 acaccttgcc cacccgtgag ggccaccatc tcgtggccag tggcagtgaa gatggatccc
     3061 tccatgtctt cgtgcttgct gtggagatgc tacagctaga agaggctgtg ggagaggctg
     3121 ggctggtacc ccagctgcgt gtgctagagg aatactctgt cccctgtgca catgctgccc
     3181 atgtgacagg cctcaagatc ctaagcccaa gcatcatggt ctcagcctcc attgatcaac
     3241 ggctgacctt ctggcgtctg gggcatggtg aacccacctt catgaatagc actgtgttcc
     3301 atgtgcctga tgtggctgac atggactgct ggcctgtgag ccctgagttt ggccaccgtt
     3361 gtgcccttgg gggtcagggg cttgaggttt acaactggta tgactgaggt atcctgcggt
     3421 ggctggcgtg ctgggcatgg ggcctgctca cagacagcat ggagcaggga tgggctgtct
     3481 gtgcccatgc tcagcatgcc ttgaggggag gaggtggtgg ccgtgggttc ctgatgtcgg
     3541 tgcaggagct gaaggtgagt ggagtgctgc caagaatatg cccgactccc catgacaaga
     3601 cagaactttg taacaaacag taccaattta ttttggccgt gggtttttgc tttttttcca
     3661 gttgatgact ttgtgaacat tcccaggtat tggagcctct gtggccttaa atgtggctca
     3721 gtggagggag acccagcata gccaggccag tatggagcac ctcacgcaca gctctcagaa
     3781 gctgcaggcg gacgaacatc tgaccaaaga ggtgtggtcg aggctcctga aagagaaagg
     3841 gcctgctggt ctcatcctct gcttcctttg cctttaccct atacctctct gcacgtccca
     3901 ccccattttg ctgtgtgctc acccccagga tgtgtacccg gttgtagtag gagctgaaat
     3961 ccatgctgag ctgtaccagg aacttgcata tctagagaca gagactgagt cactggccca
     4021 tctctttgct cttgtgcccc aggccagaat aaagaataga gtgtagagtg
//
