LOCUS       NM_019069               4217 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens WD repeat domain 5B (WDR5B), mRNA.
ACCESSION   NM_019069
VERSION     NM_019069.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4217)
  AUTHORS   Bailey,J.K., Ma,D. and Clegg,D.O.
  TITLE     Initial Characterization of WDR5B Reveals a Role in the
            Proliferation of Retinal Pigment Epithelial Cells
  JOURNAL   Cells 13 (14), 1189 (2024)
   PUBMED   39056772
  REMARK    GeneRIF: Initial Characterization of WDR5B Reveals a Role in the
            Proliferation of Retinal Pigment Epithelial Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4217)
  AUTHORS   O'Seaghdha,C.M., Yang,Q., Glazer,N.L., Leak,T.S., Dehghan,A.,
            Smith,A.V., Kao,W.H., Lohman,K., Hwang,S.J., Johnson,A.D.,
            Hofman,A., Uitterlinden,A.G., Chen,Y.D., Brown,E.M.,
            Siscovick,D.S., Harris,T.B., Psaty,B.M., Coresh,J., Gudnason,V.,
            Witteman,J.C., Liu,Y.M., Kestenbaum,B.R., Fox,C.S. and Kottgen,A.
  CONSRTM   GEFOS Consortium
  TITLE     Common variants in the calcium-sensing receptor gene are associated
            with total serum calcium levels
  JOURNAL   Hum Mol Genet 19 (21), 4296-4303 (2010)
   PUBMED   20705733
REFERENCE   3  (bases 1 to 4217)
  AUTHORS   Gilley,J. and Fried,M.
  TITLE     Extensive gene order differences within regions of conserved
            synteny between the Fugu and human genomes: implications for
            chromosomal evolution and the cloning of disease genes
  JOURNAL   Hum Mol Genet 8 (7), 1313-1320 (1999)
   PUBMED   10369878
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC083798.14, BC025762.1,
            BC043494.1, AA310178.1, AA587370.1 and BU678251.1.
            
            On May 17, 2019 this sequence version replaced NM_019069.3.
            
            Summary: This intronless gene encodes a protein containing several
            WD40 repeats. WD repeats are approximately 30- to 40-amino acid
            domains containing several conserved residues, including a trp-asp
            at the C-terminal end. The encoded protein may mediate
            protein-protein interactions. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1803612.13213.1, SRR1803616.36101.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330689.6/ ENSP00000330381.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC083798.14        130855-130881       c
            28-984              BC025762.1         1-957
            985-1944            BC043494.1         547-1506
            1945-2036           BC025762.1         1917-2008
            2037-3132           BC043494.1         1599-2694
            3133-3171           AA310178.1         19-57
            3172-3731           BC043494.1         2734-3293
            3732-4149           AA587370.1         75-492              c
            4150-4210           BU678251.1         436-496
            4211-4217           AC083798.14        126665-126671       c
FEATURES             Location/Qualifiers
     source          1..4217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.1"
     gene            1..4217
                     /gene="WDR5B"
                     /note="WD repeat domain 5B"
                     /db_xref="GeneID:54554"
                     /db_xref="HGNC:HGNC:17826"
     exon            1..4217
                     /gene="WDR5B"
                     /inference="alignment:Splign:2.1.0"
     CDS             535..1527
                     /gene="WDR5B"
                     /codon_start=1
                     /product="WD repeat-containing protein 5B"
                     /protein_id="NP_061942.2"
                     /db_xref="CCDS:CCDS3012.1"
                     /db_xref="GeneID:54554"
                     /db_xref="HGNC:HGNC:17826"
                     /translation="MATKESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAV
                     SSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSAS
                     DDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCL
                     KTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF
                     SPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED
                     NLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMSNH"
     polyA_site      2036
                     /gene="WDR5B"
                     /note="major polyA site"
     regulatory      3682..3687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR5B"
                     /note="hexamer: AATAAA"
     polyA_site      3699
                     /gene="WDR5B"
     regulatory      3714..3719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR5B"
                     /note="hexamer: AATAAA"
     polyA_site      3736
                     /gene="WDR5B"
     regulatory      3754..3759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR5B"
                     /note="hexamer: AACAAA"
     polyA_site      3790
                     /gene="WDR5B"
     regulatory      4196..4201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR5B"
                     /note="hexamer: AATAAA"
     polyA_site      4217
                     /gene="WDR5B"
ORIGIN      
        1 agtgcacacc tgctggtacg agcaaaagta gccgacaggc cagagtttcc agtttcggtg
       61 gcttcgtagg cttttagctt ctgaaatccg ctaaaagcgg cggttcattc atcttcaagt
      121 acctagcctg actggtaggg ctgctcagca ttccgaaaca tttcgacctg gggagggggg
      181 cggcggtgaa agaatacttt ctgtagagag tgcccctcgc gtcgcccctg ctttgaaggc
      241 tttatgtatt aacggaatgc cgaacatttg tgtcctactt gctgacagcg cacaggatcc
      301 ttctaacagt atttctcaag tacttaacaa aaagatgaaa acttgaagtc caagccgtgc
      361 tgctgattcc gtctcacagt ttaaagactg tccagaaact ttaagctttc aaaactgtac
      421 attttaaaat cctgtgcgtt tatcttcatt ttgctgggca gaaagccaaa gtactggact
      481 gcctggttca gggctgaacg cctagtacac ctgctaactt ggagcttcag agccatggca
      541 accaaggagt caagagacgc caaagcacag ttggccctct cctcatcggc caatcagagc
      601 aaggaagtgc ctgaaaaccc aaactatgct ctcaaatgta ctcttgtggg acacacggaa
      661 gcagtgtcat cagttaagtt tagtcctaat ggagaatggc tagcaagttc ttctgctgat
      721 aggctaatca taatttgggg agcatatgat ggaaaatatg agaaaacact ctatggtcat
      781 aatttggaaa tatcggatgt tgcctggtca tcagattcca gtcgtcttgt ttctgcctca
      841 gatgataaaa ctctaaaatt atgggatgtg agatctggaa aatgtttgaa aacactgaag
      901 gggcacagta attatgtctt ttgttgtaac ttcaatccgc catccaacct tataatctcg
      961 ggatcttttg atgagactgt aaaaatatgg gaggtgaaaa caggaaagtg tctcaagact
     1021 ttgtctgctc attctgaccc agtttctgct gttcatttta attgtagtgg gtccttgata
     1081 gtgtcaggta gctatgatgg cctctgtaga atctgggatg ctgcatcagg tcagtgttta
     1141 aaaacgctcg ttgatgacga taaccctcct gtctcttttg taaaattttc tccaaatggt
     1201 aaatacattc tcactgcaac tttggacaac actcttaaac tatgggatta tagcagaggc
     1261 aggtgcctga aaacatacac tggtcataag aatgagaaat attgcatatt tgccaatttt
     1321 tcagttactg gtggaaagtg gattgtgtct ggttccgagg ataacctggt ttacatttgg
     1381 aaccttcaga ctaaagagat tgtgcagaaa ttacaaggcc atacagatgt tgtgatctca
     1441 gcagcttgtc atcctacaga aaacctcatc gcatcagcag cattagaaaa tgacaaaaca
     1501 attaaactgt ggatgagtaa ccactaatcc ctttgaaaat caagtagtag agccaagttg
     1561 gccaaaaaac ttggatattt aaaaagacgg tttcttttaa ttttggcagt ttggtatttt
     1621 aaaaattgtc tattgttaaa ttttgagatt catacactac atttacaaaa tgagatagtt
     1681 gaaaaagcac atctagaatt cagcttctga ctaccaatct tttttgagca actttttgta
     1741 atttttatgg atttatgtca cttttattac agggatatat tgcatagtgg tgaaatctgg
     1801 gcttagtata ccctcaccca aatagtatac attgtaccta gtaaatactt tcccatctct
     1861 caccccactc ccacctttga aggctctagt gtctatgatt ctgctctcca cgtccaggtg
     1921 tacacattgt ttatctccca cttacgagaa catgtggttt ttgactttct gtatcattac
     1981 ttcacttaat ggcctccagg tccatccatg ttgttgcaaa agataagatt tcattatttt
     2041 tttttggctg agtagtattc tgtggtgtgt atgtgtgtgt gtgtatgcat atatgtgtat
     2101 gtgtatgtat ataagtatat acaccacatt atccagtcat ctggatatgt atataagtat
     2161 atacaccaca ttttctttat ccagtcatct cttgatggac ccttaggttg gttccataac
     2221 tttgctatta cgaatagtgc tgcgataaac agcactatta tgaatagtgc tgcgataaac
     2281 agtgcaggtg attttaaaat ataatttcct ttgggtagat acctactagt gggattgctg
     2341 gatcgaatgg tagtttttag ttggaaaatc tccatactgt tttccagagg ttgtaaaatg
     2401 tacattcctc cccacagtgt ataagctgtg cctttactct gcatctttgc catgattctt
     2461 tttgagacag agtctctggt gcccaggctg gagtgcagtg gcacaatctt ggctcactgc
     2521 aacctctgcc tcccgggttc aagcagttct catgtctcaa catcccaggt agctaggatt
     2581 acaggcgtgc caccatgcct ggctaatgtt tctattttta gtagagacag ggtttcacca
     2641 tgttcgaggc tggtcttgaa ctcctggcct caagtgatcc acctgcctcg gcctcccaaa
     2701 gtgctgggat tacaggcatg agccactgta cccagccatt ttttgacttt ttaataatag
     2761 ccattctaac tggtttaaga gagtatctca ttgtggttat attttgtatt cctctgatga
     2821 ttagtgatgt tgagcatttt tttgtgtgtg tttgttggcc acttgtatgt cttctttgaa
     2881 aactgacttc taatcttgag gcctattaat aatttcattt gtctgtcact ggacaatttc
     2941 tcattcctct cagtgactat cctagaggat cagtgtattt gagaaatatt tagaagtaaa
     3001 gttgacagga caggatgatt gattaaaaga ggggagcaag ggaatttgaa ataattccag
     3061 ggtttctggt ttgggagatc agatgaacaa gtgcataagc ctgggatgct ggtggaggac
     3121 tggagagaca tggcagatgc tacctgcaca cttttggtaa tattctgtgt gatgggatat
     3181 gaaatggtcc atagaaaaaa accggaaaaa tacgccaagg ttaggttcat tctaagagtc
     3241 taaaaatttc aaaaaccaaa acaacattat aaatggtgtt tctcaaggac ctttcactac
     3301 ctttttagat tgtgcttgtg attttcaggc aagctaaatg tctgatgaag actgctcttc
     3361 ttttgttctg tgtctgacct actaattcct gcccatgctt caaactcagt tcagaaatca
     3421 ctgaaggaac catccactgc cggcctgcct gcaaccacag ctgacagctg agttagttag
     3481 gttttcctgt ccctattatt taccagtttg tactgaaatg ctttcatggg ctgtgcttcc
     3541 agattatgag ttctgtggaa tcaggaagta tgtctctgta ttcttgtatt ctttggcttt
     3601 tttgtgtagt aaagggactc aagtaatgtt tgacagtgaa ggatacaact tcattccttg
     3661 cctgctttga taaattttag taataaattc ccaaaactat catgttgatt aaaaataaaa
     3721 agtaaccgta acctcacaca ttaactttat tcaaacaaac agcacttaca ggaaatgtaa
     3781 agtagaaaaa gatttctgcc cactttacct acggagacat gataaacacg caaaaaaaac
     3841 ctagaaatta agcaaaaaat agcacaataa tttaactgaa agcaacaagg gcaaaactgt
     3901 ctccttttgt agtttgtggt accttatagt agtgctcatt cagtttcgtt tgcttgataa
     3961 atctgaggac tatgagatat cagagttact agtagggtag gagtgctgta agggtactgg
     4021 gagaagtagg attagttagg ggcagatctt gaattctggc caagaaactg atatttaacc
     4081 cataaagaga tagtcactat atgttatcaa ataggagaat aacacaaatg agaaatgact
     4141 gttaattcct gatgcataat aacagttgtg agctttagtt taatgtaata tttgtaataa
     4201 aaacgtttgg ccaggca
//
