LOCUS       NM_030581               5878 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens WD repeat domain 59 (WDR59), transcript variant 1,
            mRNA.
ACCESSION   NM_030581 NM_024673 XM_290704
VERSION     NM_030581.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5878)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 5878)
  AUTHORS   Jiang,C., Dai,X., He,S., Zhou,H., Fang,L., Guo,J., Liu,S.,
            Zhang,T., Pan,W., Yu,H., Fu,T., Li,D., Inuzuka,H., Wang,P., Xiao,J.
            and Wei,W.
  TITLE     Ring domains are essential for GATOR2-dependent mTORC1 activation
  JOURNAL   Mol Cell 83 (1), 74-89 (2023)
   PUBMED   36528027
REFERENCE   3  (bases 1 to 5878)
  AUTHORS   Valenstein,M.L., Rogala,K.B., Lalgudi,P.V., Brignole,E.J., Gu,X.,
            Saxton,R.A., Chantranupong,L., Kolibius,J., Quast,J.P. and
            Sabatini,D.M.
  TITLE     Structure of the nutrient-sensing hub GATOR2
  JOURNAL   Nature 607 (7919), 610-616 (2022)
   PUBMED   35831510
REFERENCE   4  (bases 1 to 5878)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5878)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 5878)
  AUTHORS   Bar-Peled,L., Chantranupong,L., Cherniack,A.D., Chen,W.W.,
            Ottina,K.A., Grabiner,B.C., Spear,E.D., Carter,S.L., Meyerson,M.
            and Sabatini,D.M.
  TITLE     A Tumor suppressor complex with GAP activity for the Rag GTPases
            that signal amino acid sufficiency to mTORC1
  JOURNAL   Science 340 (6136), 1100-1106 (2013)
   PUBMED   23723238
REFERENCE   7  (bases 1 to 5878)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   8  (bases 1 to 5878)
  AUTHORS   Dastani,Z., Pajukanta,P., Marcil,M., Rudzicz,N., Ruel,I.,
            Bailey,S.D., Lee,J.C., Lemire,M., Faith,J., Platko,J., Rioux,J.,
            Hudson,T.J., Gaudet,D., Engert,J.C. and Genest,J.
  TITLE     Fine mapping and association studies of a high-density lipoprotein
            cholesterol linkage region on chromosome 16 in French-Canadian
            subjects
  JOURNAL   Eur J Hum Genet 18 (3), 342-347 (2010)
   PUBMED   19844255
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 5878)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   10 (bases 1 to 5878)
  AUTHORS   Marinov,J., Koubek,K. and Stary,J.
  TITLE     Expression of CDw12 and CD17 cell surface antigens on leukemic
            cells from patients with blood malignancies
  JOURNAL   Folia Biol (Praha) 39 (3), 124-128 (1993)
   PUBMED   8157132
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092383.4, CA777098.1, BC004519.2, AF370390.1 and AC009132.9.
            
            On Nov 23, 2018 this sequence version replaced NM_030581.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.495290.1,
                                           SRR1660809.235298.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262144.11/ ENSP00000262144.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC092383.4         97765-97768
            5-451               CA777098.1         31-477
            452-1818            BC004519.2         412-1778
            1819-3667           AF370390.1         747-2595
            3668-5878           AC009132.9         79817-82027
FEATURES             Location/Qualifiers
     source          1..5878
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..5878
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /note="WD repeat domain 59"
                     /db_xref="GeneID:79726"
                     /db_xref="HGNC:HGNC:25706"
                     /db_xref="MIM:617418"
     exon            1..160
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..3031
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 59; CDw12 antigen; GATOR complex
                     protein WDR59; GATOR2 complex protein WDR59"
                     /codon_start=1
                     /product="GATOR2 complex protein WDR59 isoform 1"
                     /protein_id="NP_085058.3"
                     /db_xref="CCDS:CCDS32488.1"
                     /db_xref="GeneID:79726"
                     /db_xref="HGNC:HGNC:25706"
                     /db_xref="MIM:617418"
                     /translation="MAARWSSENVVVEFRDSQATAMSVDCLGQHAVLSGRRFLYIVNL
                     DAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQ
                     GHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKN
                     ANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKF
                     WDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVH
                     TFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRVDSQMQRLCANDILDGVDE
                     FIESISLLPEPEKTLHTEDTDHQHTASHGEEEALKEDPPRNLLEERKSDQLGLPQTLQ
                     QEFSLINVQIRNVNVEMDAADRSCTVSVHCSNHRVKMLVKFPAQYPNNAAPSFQFINP
                     TTITSTMKAKLLKILKDTALQKVKRGQSCLEPCLRQLVSCLESFVNQEDSASSNPFAL
                     PNSVTPPLPTFARVTTAYGSYQDANIPFPRTSGARFCGAGYLVYFTRPMTMHRAVSPT
                     EPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERKS
                     RRWKSKREGSDSGNRQIKAAGKVIIQDIACLLPVHKSLGELYILNVNDIQETCQKNAA
                     SALLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWARHPFGRQLLESLLAHYCRLR
                     DVQTLAMLCSVFEAQSRPQGLPNPFGPFPNRSSNLVVSHSRYPSFTSSGSCSSMSDPG
                     LNTGGWNIAGREAEHLSSPWGESSPEELRFGSLTYSDPRERERDQHDKNKRLLDPANT
                     QQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGVYCSHCRSEVRGTQC
                     AICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEWFRTQEVCPTGCGCHCLLES
                     TF"
     exon            161..210
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            211..346
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            347..432
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            433..513
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            514..551
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            552..640
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            641..757
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            758..835
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            836..992
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1072
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1205
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1330
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1495
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1591
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1748
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1818
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1972
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2106
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2188
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2301
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2452
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2525
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2652
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2795
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..5878
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3672
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /note="major polyA site"
     regulatory      5856..5861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
                     /note="hexamer: AATAGA"
     polyA_site      5878
                     /gene="WDR59"
                     /gene_synonym="CDW12; FP977; p90-120"
ORIGIN      
        1 gtgtcggggc tgattctctg gctgtgtggg gcgcacggtc ccgggatact ggggacggcg
       61 gggtgggagg gcgccgtcct ggggccgcgg cggccgggcg ggggagatgg cggcgcgatg
      121 gagcagcgaa aacgtggttg tagagttccg tgactcccag gcaactgcga tgtctgtgga
      181 ctgtcttggg cagcatgcag tgctttctgg ccgcagattc ttatacatcg tcaatctaga
      241 tgcccctttc gaaggtcacc gaaagatctc tcgccagagc aaatgggaca ttggagctgt
      301 gcagtggaat cctcatgaca gctttgcaca ctattttgcg gcttcgagta accaacgagt
      361 agacctttac aagtggaaag acggcagtgg ggaagttggc acaaccttac aaggccacac
      421 tcgtgtcatc agcgacttgg actgggcggt gtttgagcct gacctcctgg ttaccagctc
      481 tgtggacacc tacatctaca tttgggatat caaagacaca aggaaaccta ctgttgcact
      541 gtctgctgtt gcgggtgcct cccaggtcaa atggaataaa aaaaatgcta actgccttgc
      601 caccagccat gacggcgatg tgcggatatg ggataagagg aaacccagta cagcagtgga
      661 atatctagcc gcccacctct ccaaaatcca tggcctggac tggcacccag acagcgagca
      721 cattcttgct acctccagtc aagacaattc tgtgaagttc tgggattacc gccagcctcg
      781 gaaatacctc aatattcttc cttgccaggt gcctgtctgg aaggccagat acacaccttt
      841 cagcaatgga ttggtgactg tgatggttcc ccagctgcgg agggaaaaca gccttctcct
      901 gtggaatgtc tttgacttga acaccccagt ccacaccttc gtggggcatg atgatgtggt
      961 cctggagttc cagtggagga agcagaagga agggtccaag gactatcaac tggtgacgtg
     1021 gtcccgggat cagaccttga gaatgtggcg ggtggattcc cagatgcaga ggctttgtgc
     1081 aaatgacata ttagatggtg ttgatgagtt cattgagagt atttcccttc tgccggaacc
     1141 tgagaagacc ctgcacactg aagatacaga tcaccagcac actgcaagcc atggggagga
     1201 agaagcccta aaagaagatc cccctagaaa tctcctggaa gagaggaaat cagatcaact
     1261 ggggctgcct cagaccttgc agcaggaatt ctccctgatc aatgtgcaaa tccggaatgt
     1321 caatgtggag atggatgcgg cagacaggag ctgcacagtg tctgtgcact gcagcaacca
     1381 tcgtgtcaag atgctggtga agttccctgc acagtaccca aacaacgccg ccccttcctt
     1441 ccagtttatt aaccccacaa ccatcacatc caccatgaaa gctaagctgc tgaagatcct
     1501 gaaggacaca gccctgcaga aagtgaagcg tggccagagc tgcctggagc cctgcctgcg
     1561 ccagctcgtc tcctgccttg agtcctttgt gaaccaggaa gacagcgctt ccagcaaccc
     1621 gtttgcactc cccaactctg tcactccccc cttaccgacg tttgcgcggg tgaccacggc
     1681 ttacgggtcg taccaggacg ccaacattcc ctttcctagg acttctgggg ccaggttctg
     1741 cggagcaggt tacctggtat atttcacaag gcccatgaca atgcatcggg cggtgtctcc
     1801 cacagagcct actccgagat ctctctcagc cttgtctgct tatcacactg gcttgatcgc
     1861 gcccatgaag atccgcacag aggcccctgg gaaccttcgt ttatacagtg ggagccccac
     1921 tcgcagcgag aaagagcagg tctccatcag ctccttctac tacaaggagc ggaaatcaag
     1981 acgatggaaa agtaagcgtg agggatcaga ctctggcaat cgacagatca aggctgctgg
     2041 gaaagtcatc atccaggata ttgcttgcct cctgcctgtt cacaaatcgc tgggagagct
     2101 gtacatattg aatgtgaatg atattcagga aacatgtcag aagaatgccg cctctgcctt
     2161 gctcgttgga agaaaggatc ttgtccaggt ttggtcgctg gctacggtag ctacagatct
     2221 ttgccttggt ccgaaatctg acccagattt ggaaacaccc tgggctcgac atccatttgg
     2281 gcggcagctg ctggagtccc tgttggctca ctattgccgg ctccgggatg ttcagacact
     2341 ggcgatgctc tgtagcgtgt ttgaagccca gtctcggcct caggggctac caaacccctt
     2401 tgggcctttt cctaaccgtt cttctaatct tgtggtgtcc catagtcgat atcctagctt
     2461 tacctcttct ggttcctgct ccagtatgtc agacccaggg ctcaacactg gcggctggaa
     2521 catagcggga agagaggcag agcacttgtc ctccccttgg ggagaatcct caccagaaga
     2581 gctccgcttt gggagtctga cctacagtga tccccgtgag cgagaacgcg accagcatga
     2641 taaaaataaa aggctcctgg accccgccaa tacccagcaa tttgatgact ttaagaaatg
     2701 ctatggggaa atcctctacc gttggggtct gagagagaag cgagctgaag tgttgaagtt
     2761 tgtctcctgt cctcctgacc ctcacaaagg gatcgagttc ggcgtgtact gcagccactg
     2821 ccggagtgag gtccgtggca cgcagtgtgc catctgcaaa ggcttcacgt tccagtgtgc
     2881 catctgtcac gtggctgtgc ggggatcgtc caatttctgc ctgacctgtg ggcacggtgg
     2941 ccacaccagc cacatgatgg agtggtttcg gacccaggag gtgtgtccca ccgggtgtgg
     3001 gtgccactgc ctgcttgaaa gcactttctg aacctacaga agttgggtat tgtctgaaat
     3061 cccagaggac ccataagtgc cggtgacaag ctgtctgtca ggggagaggc tccagaacct
     3121 gggttcgtcc ccagtgagac cggaggatga tcccccaagg actgcgcagc atcagctctt
     3181 ggtgggcctc tgccttctct tctgtttggc cacctggtgt ggatgtcact gtgtgaagat
     3241 aaggacagaa gtgcagagct gcgctttgtg tgttgtctat gtcggctgag ctaccaaggt
     3301 ggaagttttc atggagaaaa gcacctggct ccagggccag tgttacagtg ttaccctgta
     3361 aggtgttagc cttaaaccac cgagcagcgt tctcttgatg ccagtgcaga gaccagagtc
     3421 agatgcccga ggacagtggg taggaatttc atcaacaaat ggacctatgg catcatggct
     3481 ttagaagctg gtacatttac tgagctgatg gacagtggcc ttctaaaata tgacacttaa
     3541 attgtaaata tgcactgtac ttaaggattc ttaagatgta tttttttgtt atttctcctc
     3601 cagctgctat cccttggcta ataaaattct agtaatttga aaaaaaaaaa aaagagagaa
     3661 agttaaacaa cattatggtg aatcattttt taccctaatt ctaattgaag gtagctattt
     3721 tgaataggac caaagtcagt gctccgattt ttaaaggaaa tgctgattta cttttgtcat
     3781 ctgacaagag aaaatggaat ttgacattta aggttcttcc tagccccaag agtcttattt
     3841 cttctagcaa aaggaggaca agattgccgt gcagcatgga tagaaaagtc tccctggcca
     3901 ggccccatgg ctcatgcctg taatcccaca ctttagaagg caaaagtgag gggatcacct
     3961 gagctcagga gttcgagacc agcctgggca acataaggag atcccatctc tgcaaaaaat
     4021 ttaaaaaata ggccgggcac ggtggctcat gcctgtaatc ccagcacttt gggaggctga
     4081 ggtgggagga ttacctgagg tcaggagttc gagactagcc tggccaacat ggtgaaaccc
     4141 catctctact aaaaatagaa aaattagccg ggcatggtgg cgggcgcctg taatcccagg
     4201 tactggggag gctgagacag gagaatcgct tgaacttggg aagcagaggt tgcagcgagc
     4261 tgagattatg ccattgcact ccagcctggg tgacaagagt gagactctgt ctcaaaaaaa
     4321 gaaaaaaaaa attaaaaaaa tagccgggtg tggtggcaca tgcctgtggt cccagctact
     4381 tgaggggccg aggtgggagg atcacttgag tccaggaggt tgaggctgca gtgagccttg
     4441 attgcaccgc tgcactccag cctgggcaac agagtgagac cctgtcaata aaccaaagtc
     4501 ttccttgcct ctgttcagat gggctgggtt ccagtgagtg ccctcactct tcctttaggc
     4561 tccctcgcaa actgcctgtg tttgcctgtg ttctgagtag ttataacatc tgtgtccacc
     4621 aattcttcag aatgattttc ttttttaaag ttaaattttt tttttttttt tttagagaga
     4681 gagacagggt ctcactctgt cacccagact ggagagtggt gatgcaatca tagctcactg
     4741 tagcctctat cacctgagct caagtgatcc tcccacctca gcctcccgag tagctgggac
     4801 tacaggtgtg caccaccatg cctggctaat ttcagaatga ttttcaactt cacattttgt
     4861 atgtgccagt gaaaagaaat cttttttatt atttctactg aaatatctat ttctgtttct
     4921 tagaatttta cagttccaag tagattagct tagggactag gacatgtctc ataatgggag
     4981 agcattgcat attcatgtgt ttcaaactcc aggtcaggac ccattagtgg attgtgacat
     5041 tgatctagtg cggaaaacca gcatttaaaa aaatgaaatg gtgtaagaga aaaatgatca
     5101 caatgtacca tacatagcta aggaaaatgt tttgtgtaac ttgtttacgt gtgtgcagca
     5161 catgtgtgca caggtgtata ccggatcata gcgtaaattc atttcttact gaaagttgta
     5221 gtcaaaacat tttcacaaca ctgttttgga tgaagcttat acctcgtccc ctgtgttact
     5281 gggcacaaaa cttcaggatg taagaaagaa ctgagatcct gtgcagtgga accagaggtt
     5341 tagtgctggg ctctggtctg aggtaaggtg ccagtgtctc agtagcgtga gcagggcggg
     5401 ggagccgctg ggaggatgac aggagaaggc ccagccggga atttgcatac acaaattctg
     5461 ttgtaatggt gatcacagaa taggttggct gatttacaca gagagaaagg atctgttgtg
     5521 ttcctcagtg aaatcacacc atttgcagag agcaatcttt tcctgttccc cactgctcaa
     5581 gttagtgtaa aaacctgtcc ctatctgtcc ccatcaagaa tgagatgttt ttcttgtttt
     5641 attgttggag gaacattgac tttcaaaatt gaaaaacctt aatggtgtga agaaatttcg
     5701 agtttaaaat attacataat gtcatccttc aatacggaaa ttccttttga atttccaagt
     5761 taccagaaca aaagtctaat attttaaaat attcatgttt ggaaacaggt tggttgtctg
     5821 gttgcgggcc atggccgata ttctctcagc cgcagaatag atgattacaa gcacctga
//
