LOCUS       NM_017706               3852 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens WD repeat domain 55 (WDR55), mRNA.
ACCESSION   NM_017706
VERSION     NM_017706.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3852)
  AUTHORS   Luke,M.M., O'Meara,E.S., Rowland,C.M., Shiffman,D., Bare,L.A.,
            Arellano,A.R., Longstreth,W.T. Jr., Lumley,T., Rice,K., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Gene variants associated with ischemic stroke: the cardiovascular
            health study
  JOURNAL   Stroke 40 (2), 363-368 (2009)
   PUBMED   19023099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 3852)
  AUTHORS   Iwanami,N., Higuchi,T., Sasano,Y., Fujiwara,T., Hoa,V.Q., Okada,M.,
            Talukder,S.R., Kunimatsu,S., Li,J., Saito,F., Bhattacharya,C.,
            Matin,A., Sasaki,T., Shimizu,N., Mitani,H., Himmelbauer,H.,
            Momoi,A., Kondoh,H., Furutani-Seiki,M. and Takahama,Y.
  TITLE     WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell
            cycle progression, and teleost organ development
  JOURNAL   PLoS Genet 4 (8), e1000171 (2008)
   PUBMED   18769712
  REMARK    Erratum:[PLoS Genet. 2008 Sep;4(9). doi:
            10.1371/annotation/6683988c-4647-4550-88e3-e8ba052f7916]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3852)
  AUTHORS   Shiffman,D., O'Meara,E.S., Bare,L.A., Rowland,C.M., Louie,J.Z.,
            Arellano,A.R., Lumley,T., Rice,K., Iakoubova,O., Luke,M.M.,
            Young,B.A., Malloy,M.J., Kane,J.P., Ellis,S.G., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Association of gene variants with incident myocardial infarction in
            the Cardiovascular Health Study
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (1), 173-179 (2008)
   PUBMED   17975119
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116353.2.
            
            On Nov 18, 2020 this sequence version replaced NM_017706.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1575525.1,
                                           SRR18074967.2370680.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358337.10/ ENSP00000351100.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AC116353.2         120615-120814
            201-301             AC116353.2         123945-124045
            302-389             AC116353.2         124126-124213
            390-569             AC116353.2         124323-124502
            570-669             AC116353.2         124602-124701
            670-839             AC116353.2         124790-124959
            840-3852            AC116353.2         125044-128056
FEATURES             Location/Qualifiers
     source          1..3852
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..3852
                     /gene="WDR55"
                     /note="WD repeat domain 55"
                     /db_xref="GeneID:54853"
                     /db_xref="HGNC:HGNC:25971"
                     /db_xref="MIM:620832"
     exon            1..200
                     /gene="WDR55"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1161
                     /gene="WDR55"
                     /codon_start=1
                     /product="WD repeat-containing protein 55"
                     /protein_id="NP_060176.3"
                     /db_xref="CCDS:CCDS4235.1"
                     /db_xref="GeneID:54853"
                     /db_xref="HGNC:HGNC:25971"
                     /db_xref="MIM:620832"
                     /translation="MDRTCEERPAEDGSDEEDPDSMEAPTRIRDTPEDIVLEAPASGL
                     AFHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITV
                     SKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGICLWDQRKEGP
                     LMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTL
                     MKWGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCMVPVTESLLCTGSTDGVI
                     RAVNILPNRVVGSVGQHTGEPVEELALSHCGRFLASSGHDQRLKFWDMAQLRAVVVDD
                     YRRRKKKGGPLRALSSKTWSTDDFFAGLREEGEDSMAQEEKEETGDDSD"
     exon            201..301
                     /gene="WDR55"
                     /inference="alignment:Splign:2.1.0"
     exon            302..389
                     /gene="WDR55"
                     /inference="alignment:Splign:2.1.0"
     exon            390..569
                     /gene="WDR55"
                     /inference="alignment:Splign:2.1.0"
     exon            570..669
                     /gene="WDR55"
                     /inference="alignment:Splign:2.1.0"
     exon            670..839
                     /gene="WDR55"
                     /inference="alignment:Splign:2.1.0"
     exon            840..3852
                     /gene="WDR55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3829..3834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR55"
                     /note="hexamer: AGTAAA"
     polyA_site      3852
                     /gene="WDR55"
                     /note="major polyA site"
ORIGIN      
        1 cttctcagca tggaccgcac ttgtgaggag aggcccgctg aggatgggag cgacgaggag
       61 gacccagact ccatggaagc cccaacccgg atccgggaca ctccggaaga catcgtgctg
      121 gaagctccgg ctagtgggct ggcgttccat ccggcccgtg acctactggc tgcaggggac
      181 gtggacgggg acgtgttcgt cttttcctac tcttgccaag agggagaaac caaggagctc
      241 tggtcatcag gtcaccatct caaggcctgc cgagctgtgg ccttctctga agatgggcag
      301 aagctcatta ctgtctccaa ggacaaagcc atccatgttc tagatgtgga gcagggccaa
      361 ctggaaagac gtgtttccaa ggctcatggt gcccccatca atagtcttct gctggtggat
      421 gagaatgttc tggccactgg ggatgacaca ggtggtatct gtctctggga ccagcggaag
      481 gagggcccct taatggatat gaggcaacat gaagagtaca tcgcagacat ggctctggat
      541 ccagccaaaa agctgctgct gacagccagc ggggatggct gccttggcat cttcaacatt
      601 aagaggcgtc ggtttgagct gctctcagaa cctcagtctg gggacctgac ctctgtcact
      661 ctcatgaaat gggggaagaa ggtagcctgt ggctccagtg aaggtaccat ctacctcttc
      721 aattggaatg gctttggggc cacaagtgac cgctttgccc tgagagctga atctatcgac
      781 tgcatggttc cagtcaccga gagtctgctg tgtactggct ccactgatgg agtcatcagg
      841 gctgtgaaca tcctaccgaa ccgagtggtg ggcagtgtgg gccagcacac tggggagcct
      901 gtggaggagc tggccctctc ccactgtggc cgcttcctgg ccagtagtgg ccatgaccag
      961 cgcctcaagt tttgggacat ggcccagctg cgagctgtgg tggtggatga ctaccgtcgg
     1021 cgcaaaaaaa agggaggacc actgcgggct ctgagcagca agacttggag caccgatgac
     1081 ttcttcgcag gactgaggga agagggagaa gactccatgg ctcaggaaga aaaggaggag
     1141 actggggatg acagtgactg aaggaatgaa ttgaatcttg agacgggtcc tcaccaggca
     1201 agagtcttgc ttattgggct gcatccccag agaggatatg aattattttt tgaaaagaca
     1261 gggttttgcc atcgtccagg ctggagtgcg ctggcttgat cttggctcac tgcagcctca
     1321 atgtccccag gctcagattg tccttccacc ttagcctctg gagcagctgg gactacaggt
     1381 gtgcactacc acaccaggcc aatttttgtt tttttttttt ggtagaaacg ggtctgtttt
     1441 gcccaggctg gtcttcaact cctggactca aatgatccac ctgcctctgc ttcccaaagt
     1501 gctgggatta caggcacgag ccaccacacc tggccaaaaa aatttatatt ttttgagaca
     1561 aggtctcact ctgtcaccca ggctggagta cagtgggttg atcatggctc actgcatcct
     1621 tgacttcctg ggctcaagtg atccacctca gcctgcctgg tagctgagac ttaacaggca
     1681 tctgccacca tgcttgacta atttttgtga tttttttttg gtagagacca ggggtttcac
     1741 tatgttgacc aagctggtct tggaactcct gggctcaagt gatcctcctg ccttggcctc
     1801 ccaaaatgct gggattacag gcatgagcca ctgtgcctgg ctggatatga aatttttttt
     1861 tttttttttt ttgagacagg gtttcgctct tgttgccagg gctggagtgc aatggcgtga
     1921 tcttggctca ctgcaacctc cgcctcccgg gttcaagcaa ttctcctgcc tcagcctccc
     1981 aagtagctgg gattacaggt gtctgccacc atgccaggct aatttttgta ttttcagtag
     2041 agacggggtt tctccatgct ggccaggctg gtctcgaact cctgacctca ggtgatccac
     2101 ccgcctcagc ctcccaaagt gctgggatta caggcaaaag ccaacacacc cggcctggat
     2161 atgaatttat aataccctac agtgcaacac aagaagatgc actcaaagca ctgatgtgag
     2221 gaagtacttg ccccgtagca gctattcact ctaccagtgt aaacaaactc taagctaggg
     2281 caagacagca cagacacaag tatatactaa ccaggggttt aatataaata caaccagcat
     2341 agaaagaccc aaaactatac agaaaccaaa accagaatgc catgtggtgg aggcaaaggg
     2401 cagaatttct gacccctttg gctcagctgc ccttccccac aaataaaaac caacaaagag
     2461 gacaaatcag gacaataaag aagattcatg ctaagctgtg gcagaggggg gaaggtatga
     2521 tcgggtgggg gtgggacaag gaacggccat ggaagatcac tgggtcaggt tggaccctgg
     2581 gctgggagcg ggagggcaag gcccctcacc acaacttaac ccaaacctaa gctgccccca
     2641 ggtgccatag gtccctgtcc cagcagggag gctgatgggc ctgggcccat gcccctcccc
     2701 acctttgggg gtcagaaagt ggccacccag gcctgctggg atggggcctg acacaggctc
     2761 tgcatgccca ttcagggtgc ctgtggagaa agaatggagt cactgtttaa ccatggtacc
     2821 tgcctcagcc ccagcagacc acaggaggtt ggccccagac tcactgagtg cctgcagcag
     2881 ccgtacagac acagcatcct tggccacctc atgcccatcc cggccatcta gggtcagcac
     2941 aacccagatg aggccgctga agggcaccgg atgcccagga atcaccacct ggtaccagaa
     3001 gcggtgccag ccagcaggtc ctatgcccaa acacttggtg aggaacacag ggctgcccag
     3061 cttcattcgt tggcacagca actgcagggt agcccgagcc ccttggaacc ctaacttgtc
     3121 ccttgccaaa gccaactggc tgccctctgg ctgtggggac cgcaagaagg gacccacaag
     3181 ctgctggcga agtcgctgct tcaggtctgg cttgagccac tccacagcca cctgctctcc
     3241 acagaggtgt gactgccctg taggaaaaat gcaaagacaa gggcaggtct aaaccctggg
     3301 cccaagcctc caggtggtga gccctttgga gctacacagt cctgttattt gtagccttcc
     3361 catttcctgg tagtgtgacc atgggtaaga aaagacaatg aagccttcag cctccattat
     3421 ttgcaaaggg agtataacac actgctacct tacaagtttc cttggagaag tactggttaa
     3481 ttgcaggctt tgtctgcctc ataaccatca taatggctaa tctttactgg gaaaacttgc
     3541 tgtaagtcag tcagtgtgct aagtaccgta cacccattat gttacttaat tctcataaca
     3601 gtctgaggaa acagattcta tagtagtaaa aagctcagtt ggattccctt gagcaaatca
     3661 atttctctaa cagtttcctc atagcttgag ggtcctgtgc ctattttgcg gtgtgggggt
     3721 gggggaaggt tgagaattaa gtcaggaggt aatgctcggg aagtgtcaca aatttaggta
     3781 agcggtggtg gtagcaccat tggaagtttt aaaaatctga gatcaaatag taaaaggttg
     3841 caaattctgg ca
//
