LOCUS       NM_182627               1594 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens WD repeat domain 53 (WDR53), transcript variant 1,
            mRNA.
ACCESSION   NM_182627
VERSION     NM_182627.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1594)
  AUTHORS   Higa,L.A., Wu,M., Ye,T., Kobayashi,R., Sun,H. and Zhang,H.
  TITLE     CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat
            proteins and regulates histone methylation
  JOURNAL   Nat Cell Biol 8 (11), 1277-1283 (2006)
   PUBMED   17041588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU186444.1, BC054030.1 and AI803796.1.
            
            On Nov 23, 2018 this sequence version replaced NM_182627.2.
            
            Summary: This gene encodes a protein containing WD domains. The
            function of this gene is unknown. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1-6 all encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.218520.1,
                                           SRR5189667.151345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332629.7/ ENSP00000328079.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BU186444.1         131-142
            13-1583             BC054030.1         1-1571
            1584-1594           AI803796.1         13-23               c
FEATURES             Location/Qualifiers
     source          1..1594
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..1594
                     /gene="WDR53"
                     /note="WD repeat domain 53"
                     /db_xref="GeneID:348793"
                     /db_xref="HGNC:HGNC:28786"
                     /db_xref="MIM:615110"
     exon            1..36
                     /gene="WDR53"
                     /inference="alignment:Splign:2.1.0"
     exon            37..467
                     /gene="WDR53"
                     /inference="alignment:Splign:2.1.0"
     exon            468..963
                     /gene="WDR53"
                     /inference="alignment:Splign:2.1.0"
     CDS             484..1560
                     /gene="WDR53"
                     /note="isoform a is encoded by transcript variant 1; WD
                     repeat-containing protein 53; WD domain, G-beta
                     repeat-containing protein"
                     /codon_start=1
                     /product="WD repeat-containing protein 53 isoform a"
                     /protein_id="NP_872433.1"
                     /db_xref="CCDS:CCDS3318.1"
                     /db_xref="GeneID:348793"
                     /db_xref="HGNC:HGNC:28786"
                     /db_xref="MIM:615110"
                     /translation="MAVKWTGGHSSPVLCLNASKEGLLASGAEGGDLTAWGEDGTPLG
                     HTRFQGADDVTSVLFSPSCPTKLYASHGETISVLDVRSLKDSLDHFHVNEEEINCLSL
                     NQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQ
                     VMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAED
                     GKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANSEVEK
                     KQKSPTKRTHRKKPKRGTCTKQGGNTNASVTDEEEHGNILPKLNIEHGEKVNWLLGTK
                     IKGHQNILVADQTSCISVYPLNEF"
     exon            964..1594
                     /gene="WDR53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1565..1570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR53"
                     /note="hexamer: AATAAA"
     polyA_site      1594
                     /gene="WDR53"
                     /note="major polyA site"
ORIGIN      
        1 atcactaggc gccgaggagg ggagcgggaa gcgcagtgcc agcgccacag cccttcaatc
       61 attttggttg ctatccagct tctccacatc aagtccaact tcagaaaccc caagcctgta
      121 gagaaaagtt gacctgtgct gactctggtg atggtgactg tctctcacta atttctttga
      181 agtcttcaag gataagcaga gttgatccat ctgagaaagg gatcatgaac tagacagaat
      241 gaacagcctt agaggcacag actcttgaac gggacggtgg tggtatgact agtgcagagt
      301 gtttagagat cactcagttt ttaaagactg gcctttatcg tgtctcagtg cagccgaggc
      361 agagcctttg aaggatgcga tgttgtcatt cttactaatc tagtccagcc gctgaggtga
      421 ctttcaacgg cagaccgtct cctgagcgcc ccaggtagaa tttcaaaagt ctccgggacc
      481 attatggcag tcaagtggac gggtgggcat tcttctcctg tcctctgcct gaatgcaagt
      541 aaagaagggc tgctggcttc tggagcagag ggcggagatc tcacggcttg gggtgaagat
      601 ggaactccat taggacacac gcggttccaa ggggctgatg atgttaccag tgtcttattt
      661 tctccctcct gtcccaccaa gctctatgcc tcacatggag aaaccattag tgtactggat
      721 gtcaggtccc tcaaagattc cttggaccat tttcatgtga atgaagaaga aatcaattgt
      781 ctttcattga atcaaacgga aaacctgctg gcttctgctg acgactctgg ggcaatcaaa
      841 atcctagact tggaaaacaa gaaagttatc agatccttga agagacattc caatatctgc
      901 tcctcagtgg cttttcggcc tcagaggcct cagagcctgg tgtcatgtgg actggatatg
      961 caggtgatgc tgtggagtct tcaaaaagcc cgaccactct ggattacaaa tttacaggag
     1021 gatgaaacag aagaaatgga aggcccacag tcacctggtc agctcttaaa ccctgcccta
     1081 gcccattcta tctctgtggc ttcgtgtggt aatattttta gttgtggtgc agaagatggt
     1141 aaggttcgaa tctttcgggt gatgggagtt aagtgtgaac aggaactggg atttaagggc
     1201 cacacttcag gggtatccca ggtctgcttt ctcccagaat cctatttgct gcttactgga
     1261 gggaatgatg ggaagatcac gttgtgggat gcaaacagtg aagttgagaa aaaacagaag
     1321 agtcccacaa aacgtaccca caggaagaaa cctaaaagag gaacttgcac caagcagggt
     1381 ggaaatacta acgcttcagt aacagatgag gaagaacatg gcaacatttt accaaagcta
     1441 aatattgaac atggagaaaa agtgaactgg ctcttgggta caaaaataaa gggacaccaa
     1501 aatatattag tagctgatca aactagttgt atatctgtat accccttaaa tgaattttaa
     1561 atccaataaa aacatttgaa gaattgtggc aaaa
//
