LOCUS       NM_017588               3157 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens WD repeat domain 5 (WDR5), transcript variant 1, mRNA.
ACCESSION   NM_017588
VERSION     NM_017588.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3157)
  AUTHORS   Feng,W., Tang,Y., Jing,R., Ju,S. and Zong,W.
  TITLE     Highly expressed B3GALT5-AS1 contributes to gastric cancer
            progression by recruiting WDR5 to mediate B3GALT5 and regulating
            beta-catenin/ZEB1 axis
  JOURNAL   J Cell Mol Med 28 (17), e70061 (2024)
   PUBMED   39224045
  REMARK    GeneRIF: Highly expressed B3GALT5-AS1 contributes to gastric cancer
            progression by recruiting WDR5 to mediate B3GALT5 and regulating
            beta-catenin/ZEB1 axis.
REFERENCE   2  (bases 1 to 3157)
  AUTHORS   Yuan,X.N., Shao,Y.C., Guan,X.Q., Liu,Q., Chu,M.F., Yang,Z.L.,
            Li,H., Zhao,S., Tian,Y.H., Zhang,J.W. and Wei,L.
  TITLE     METTL3 orchestrates glycolysis by stabilizing the c-Myc/WDR5
            complex in triple-negative breast cancer
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (5), 119716 (2024)
   PUBMED   38547933
  REMARK    GeneRIF: METTL3 orchestrates glycolysis by stabilizing the
            c-Myc/WDR5 complex in triple-negative breast cancer.
REFERENCE   3  (bases 1 to 3157)
  AUTHORS   Huang,X., Zhang,C., Shang,X., Chen,Y., Xiao,Q., Wei,Z., Wang,G.,
            Zhen,X., Xu,G., Min,J., Shen,S. and Liu,Y.
  TITLE     The NTE domain of PTENalpha/beta promotes cancer progression by
            interacting with WDR5 via its SSSRRSS motif
  JOURNAL   Cell Death Dis 15 (5), 335 (2024)
   PUBMED   38744853
  REMARK    GeneRIF: The NTE domain of PTENalpha/beta promotes cancer
            progression by interacting with WDR5 via its SSSRRSS motif.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3157)
  AUTHORS   Streeter,S.A., Williams,A.G., Evans,J.R., Wang,J., Guarnaccia,A.D.,
            Florian,A.C., Al-Tobasei,R., Liu,Q., Tansey,W.P. and
            Weissmiller,A.M.
  TITLE     Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus
  JOURNAL   BMC Genomics 25 (1), 360 (2024)
   PUBMED   38605297
  REMARK    GeneRIF: Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3157)
  AUTHORS   Zhao,X., Su,F., Kong,F., Su,J., Yang,X., Li,L., Li,A. and Li,Q.
  TITLE     WD repeat domain 5 promotes the development of late-onset
            preeclampsia by activating nuclear factor kappa B
  JOURNAL   Acta Cir Bras 38, e386223 (2023)
   PUBMED   38055397
  REMARK    GeneRIF: WD repeat domain 5 promotes the development of late-onset
            preeclampsia by activating nuclear factor kappa B.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3157)
  AUTHORS   Wysocka,J., Swigut,T., Milne,T.A., Dou,Y., Zhang,X.,
            Burlingame,A.L., Roeder,R.G., Brivanlou,A.H. and Allis,C.D.
  TITLE     WDR5 associates with histone H3 methylated at K4 and is essential
            for H3 K4 methylation and vertebrate development
  JOURNAL   Cell 121 (6), 859-872 (2005)
   PUBMED   15960974
  REMARK    GeneRIF: The WDR5 is required for binding of the methyltransferase
            complex to the K4-dimethylated H3 tail as well as for global H3 K4
            trimethylation and HOX gene activation in human cells.
REFERENCE   7  (bases 1 to 3157)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   8  (bases 1 to 3157)
  AUTHORS   Gori,F. and Demay,M.B.
  TITLE     BIG-3, a novel WD-40 repeat protein, is expressed in the developing
            growth plate and accelerates chondrocyte differentiation in vitro
  JOURNAL   Endocrinology 145 (3), 1050-1054 (2004)
   PUBMED   14657013
REFERENCE   9  (bases 1 to 3157)
  AUTHORS   Wysocka,J., Myers,M.P., Laherty,C.D., Eisenman,R.N. and Herr,W.
  TITLE     Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone
            H3-K4 methyltransferase are tethered together selectively by the
            cell-proliferation factor HCF-1
  JOURNAL   Genes Dev 17 (7), 896-911 (2003)
   PUBMED   12670868
REFERENCE   10 (bases 1 to 3157)
  AUTHORS   Gori,F., Divieti,P. and Demay,M.B.
  TITLE     Cloning and characterization of a novel WD-40 repeat protein that
            dramatically accelerates osteoblastic differentiation
  JOURNAL   J Biol Chem 276 (49), 46515-46522 (2001)
   PUBMED   11551928
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX649632.2, BG773451.1,
            AK000552.1, BC029769.1 and AA490313.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_017588.2.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. This protein contains
            7 WD repeats. Alternatively spliced transcript variants encoding
            the same protein have been identified. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.144406.1,
                                           SRR1803616.101591.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358625.4/ ENSP00000351446.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BX649632.2         8596-8601
            7-40                BG773451.1         7-40
            41-1874             AK000552.1         1-1834
            1875-3155           BC029769.1         169-1449
            3156-3157           AA490313.1         13-14               c
FEATURES             Location/Qualifiers
     source          1..3157
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..3157
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /note="WD repeat domain 5"
                     /db_xref="GeneID:11091"
                     /db_xref="HGNC:HGNC:12757"
                     /db_xref="MIM:609012"
     exon            1..119
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            120..258
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1182
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /note="isoform 1 is encoded by transcript variant 1; SWD3,
                     Set1c WD40 repeat protein, homolog; BMP2-induced 3-kb gene
                     protein; WD repeat-containing protein 5; cilia and
                     flagella associated protein 89; BMP-2-induced gene 3 kb"
                     /codon_start=1
                     /product="WD repeat-containing protein 5 isoform 1"
                     /protein_id="NP_060058.1"
                     /db_xref="CCDS:CCDS6981.1"
                     /db_xref="GeneID:11091"
                     /db_xref="HGNC:HGNC:12757"
                     /db_xref="MIM:609012"
                     /translation="MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGH
                     TKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL
                     VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT
                     GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS
                     FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS
                     GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
                     "
     exon            259..367
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            368..441
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            442..531
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            532..621
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            622..705
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            706..761
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            762..808
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            809..884
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            885..918
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            919..993
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1081
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..3157
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1463..1468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /note="hexamer: ATTACA"
     polyA_site      1489
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /note="major polyA site"
     regulatory      1852..1857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /note="hexamer: AATAAA"
     polyA_site      1874
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
     regulatory      3134..3139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /note="hexamer: AATAAA"
     polyA_site      3157
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /note="major polyA site"
ORIGIN      
        1 gcccccgccg cctggcgccc gcccgagctg ccgccttgtc gagctgagtc cgcgctcccg
       61 cccaggcggc ggccgacgcg acgccccgag cgcccggccc cgccgccgcg gcccggcaga
      121 ctgcctctgt caccgggtcc ctccaccctt gtctcctgtg cggccagcgt cagagccatg
      181 gcgacggagg agaagaagcc cgagaccgag gccgccagag cacagccaac cccttcgtca
      241 tccgccactc agagcaagcc tacacctgtg aagccaaact atgctctaaa gttcaccctt
      301 gctggccaca ccaaagcagt gtcctccgtg aaattcagcc cgaatggaga gtggctggca
      361 agttcatctg ctgataaact tattaaaatt tggggcgcgt atgatgggaa atttgagaaa
      421 accatatctg gtcacaagct gggaatatcc gatgtagcct ggtcgtcaga ttctaacctt
      481 cttgtttctg cctcagatga caaaaccttg aagatatggg acgtgagctc gggcaagtgt
      541 ctgaaaaccc tgaagggaca cagtaattat gtcttttgct gcaacttcaa tccccagtcc
      601 aaccttattg tctcaggatc ctttgacgaa agcgtgagga tatgggatgt gaaaacaggg
      661 aagtgcctca agactttgcc agctcactcg gatccagtct cggccgttca ttttaatcgt
      721 gatggatcct tgatagtttc aagtagctat gatggtctct gtcgcatctg ggacaccgcc
      781 tcaggccagt gcctgaagac gctcatcgat gacgacaacc cccccgtgtc ttttgtgaag
      841 ttctccccga acggcaaata catcctggcc gccacgctgg acaacactct gaagctctgg
      901 gactacagca aggggaagtg cctgaagacg tacactggcc acaagaatga gaaatactgc
      961 atatttgcca atttctctgt tactggtggg aagtggattg tgtctggctc agaggataac
     1021 cttgtttaca tctggaacct tcagacgaaa gagattgtac agaaactaca aggccacaca
     1081 gatgtcgtga tctcaacagc ttgtcaccca acagaaaaca tcatcgcctc tgctgcgcta
     1141 gaaaatgaca aaacaattaa actgtggaag agtgactgct aagtcccttt gctcctgccc
     1201 gcgagagact gtcgggaagt tgacccggat tggcaagaaa cagggtgtct tggaggtggt
     1261 cccccagatc tgcgcctggg ggtcaggaca gggcctgatt tgagcctcct ctctgaagat
     1321 gatttggccg agcggaaggt gtggaccacc ggaaagttct taaaagttgc tggtgacatt
     1381 tcttgccaat tctaacactg tctagggaag agttcctagt ctattgtgtt caaacagagt
     1441 caacaaaagt ttttaatttt ttattacaga agggtgaagt tcaatttaac atgcgttgtg
     1501 ttttttcagt aaacgttctg tatctttttg atattccatg acccagtgca cgctgtggcc
     1561 tgtcaccgcc accgtggccc cgccagctgg cctccccttt ggcccacgcc ggccgccccc
     1621 attctctgct gcgtagatgc cctggcccag ggccctgact cctccattcc cgccagtagc
     1681 tgttcctagt gtattttcgt ctttctggaa aacagcattg agtggttgtt ttctgtgtaa
     1741 agagccgttt gtgtcttggg agtttgtggc ccacatgccg atagcacggt catcgcacat
     1801 gactctcccg tttgtctcag tgtccctgca acaagcagca ccgcagactg taataaaagg
     1861 tggggttttg tgaatggttg tggcaagtgc gtccttgtga agctcgtctc catgtggctt
     1921 tcttggagaa aggctcccct ggggcaagag ggtggaaggt ttctttggac aggaggtgct
     1981 gaggctggct gcacctgctc tctgaagacg ccttcctctc taggttcatt gttcagtgtt
     2041 gctgggggcg gggaacgggg gtggggaggt tcttagttgc gaaggagcca agctcctgat
     2101 ggacttgcgt tgggatgtgg gggacacctg tggcatggta aggctccctg agtcccttac
     2161 tccaggtcag atgccagtgg gactcatgcg ccctatgagg gctgcagggc cagtgctgcc
     2221 cctcggactc ctcgaggggt tgggtgctaa gcgcgagcct cgccgtccct gctggagccc
     2281 tcgcctgcct gcccctctgc ctgtgctcct ggcagtgtgg cttcccggtg ctcacctgca
     2341 cagcagttaa cagcagaggc cgagcgggag cctctgggga gcgaggctga aacctgaacc
     2401 tgcccatgga gacagttgtg gtgagggttg ccacacacag tgagggcgga gcagggtggc
     2461 tgagggcaca ggtgcctggg tctgtcccac ggggcagggc tttggggctg tgatgctctg
     2521 ggaagccagc ttgggtcctg ggtctacaga gggccctggc cccggagccc agccagctct
     2581 gcctctctca gggcctggag tcctggggga gctcagccag ctctgccttt ctcagggcct
     2641 ggagtcctgg atgaatcctg caggtttttg gttgcaccgg cccagggagg aagcgggggg
     2701 tttgtcaggt gggctctcct ggaggtcctc gagtggcagg ggtgaggagg ggattatctg
     2761 aggcatctgg agatgtatat cctgtggttt cccctgcccc tctgtttccg atgaggtgta
     2821 cggatgagtg acctgcacta agaagtgagt tgccacagtg aaaatgggtt ggtttttgtc
     2881 ttcgacgctc agggtctggg cgcctcgcat ttgcagtctg ttgtgacaga cacggggagc
     2941 tccgcgtgcc agcctgtggc tgccctgctg tgggggtcct ggggccggcg aggccccttc
     3001 agtcttgttc tggggggacg gcccactccg gggagggggt gtgctgtgct gagcgctgta
     3061 tccctgaata tagtttattt tttctacatt tgaattctgt tgtagattta tgtaaaaata
     3121 cattcttttt gaaaataaaa attttcatgt cttctaa
//
