LOCUS       NM_001384415            3267 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens WD repeat domain 5 (WDR5), transcript variant 9, mRNA.
ACCESSION   NM_001384415
VERSION     NM_001384415.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3267)
  AUTHORS   Feng,W., Tang,Y., Jing,R., Ju,S. and Zong,W.
  TITLE     Highly expressed B3GALT5-AS1 contributes to gastric cancer
            progression by recruiting WDR5 to mediate B3GALT5 and regulating
            beta-catenin/ZEB1 axis
  JOURNAL   J Cell Mol Med 28 (17), e70061 (2024)
   PUBMED   39224045
  REMARK    GeneRIF: Highly expressed B3GALT5-AS1 contributes to gastric cancer
            progression by recruiting WDR5 to mediate B3GALT5 and regulating
            beta-catenin/ZEB1 axis.
REFERENCE   2  (bases 1 to 3267)
  AUTHORS   Yuan,X.N., Shao,Y.C., Guan,X.Q., Liu,Q., Chu,M.F., Yang,Z.L.,
            Li,H., Zhao,S., Tian,Y.H., Zhang,J.W. and Wei,L.
  TITLE     METTL3 orchestrates glycolysis by stabilizing the c-Myc/WDR5
            complex in triple-negative breast cancer
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (5), 119716 (2024)
   PUBMED   38547933
  REMARK    GeneRIF: METTL3 orchestrates glycolysis by stabilizing the
            c-Myc/WDR5 complex in triple-negative breast cancer.
REFERENCE   3  (bases 1 to 3267)
  AUTHORS   Huang,X., Zhang,C., Shang,X., Chen,Y., Xiao,Q., Wei,Z., Wang,G.,
            Zhen,X., Xu,G., Min,J., Shen,S. and Liu,Y.
  TITLE     The NTE domain of PTENalpha/beta promotes cancer progression by
            interacting with WDR5 via its SSSRRSS motif
  JOURNAL   Cell Death Dis 15 (5), 335 (2024)
   PUBMED   38744853
  REMARK    GeneRIF: The NTE domain of PTENalpha/beta promotes cancer
            progression by interacting with WDR5 via its SSSRRSS motif.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3267)
  AUTHORS   Streeter,S.A., Williams,A.G., Evans,J.R., Wang,J., Guarnaccia,A.D.,
            Florian,A.C., Al-Tobasei,R., Liu,Q., Tansey,W.P. and
            Weissmiller,A.M.
  TITLE     Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus
  JOURNAL   BMC Genomics 25 (1), 360 (2024)
   PUBMED   38605297
  REMARK    GeneRIF: Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3267)
  AUTHORS   Zhao,X., Su,F., Kong,F., Su,J., Yang,X., Li,L., Li,A. and Li,Q.
  TITLE     WD repeat domain 5 promotes the development of late-onset
            preeclampsia by activating nuclear factor kappa B
  JOURNAL   Acta Cir Bras 38, e386223 (2023)
   PUBMED   38055397
  REMARK    GeneRIF: WD repeat domain 5 promotes the development of late-onset
            preeclampsia by activating nuclear factor kappa B.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3267)
  AUTHORS   Wysocka,J., Swigut,T., Milne,T.A., Dou,Y., Zhang,X.,
            Burlingame,A.L., Roeder,R.G., Brivanlou,A.H. and Allis,C.D.
  TITLE     WDR5 associates with histone H3 methylated at K4 and is essential
            for H3 K4 methylation and vertebrate development
  JOURNAL   Cell 121 (6), 859-872 (2005)
   PUBMED   15960974
  REMARK    GeneRIF: The WDR5 is required for binding of the methyltransferase
            complex to the K4-dimethylated H3 tail as well as for global H3 K4
            trimethylation and HOX gene activation in human cells.
REFERENCE   7  (bases 1 to 3267)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   8  (bases 1 to 3267)
  AUTHORS   Gori,F. and Demay,M.B.
  TITLE     BIG-3, a novel WD-40 repeat protein, is expressed in the developing
            growth plate and accelerates chondrocyte differentiation in vitro
  JOURNAL   Endocrinology 145 (3), 1050-1054 (2004)
   PUBMED   14657013
REFERENCE   9  (bases 1 to 3267)
  AUTHORS   Wysocka,J., Myers,M.P., Laherty,C.D., Eisenman,R.N. and Herr,W.
  TITLE     Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone
            H3-K4 methyltransferase are tethered together selectively by the
            cell-proliferation factor HCF-1
  JOURNAL   Genes Dev 17 (7), 896-911 (2003)
   PUBMED   12670868
REFERENCE   10 (bases 1 to 3267)
  AUTHORS   Gori,F., Divieti,P. and Demay,M.B.
  TITLE     Cloning and characterization of a novel WD-40 repeat protein that
            dramatically accelerates osteoblastic differentiation
  JOURNAL   J Biol Chem 276 (49), 46515-46522 (2001)
   PUBMED   11551928
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX649632.2.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. This protein contains
            7 WD repeats. Alternatively spliced transcript variants encoding
            the same protein have been identified. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1803611.214840.1, SRR1803616.173367.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2142348, SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                BX649632.2         7891-7955
            66-229              BX649632.2         8193-8356
            230-368             BX649632.2         12334-12472
            369-477             BX649632.2         13217-13325
            478-551             BX649632.2         14024-14097
            552-641             BX649632.2         14463-14552
            642-731             BX649632.2         14847-14936
            732-815             BX649632.2         15150-15233
            816-871             BX649632.2         20802-20857
            872-918             BX649632.2         24497-24543
            919-994             BX649632.2         26980-27055
            995-1028            BX649632.2         27854-27887
            1029-1103           BX649632.2         28207-28281
            1104-1191           BX649632.2         29020-29107
            1192-3267           BX649632.2         30407-32482
FEATURES             Location/Qualifiers
     source          1..3267
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..3267
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /note="WD repeat domain 5"
                     /db_xref="GeneID:11091"
                     /db_xref="HGNC:HGNC:12757"
                     /db_xref="MIM:609012"
     exon            1..65
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            66..229
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            230..368
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1292
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /note="isoform 1 is encoded by transcript variant 9; SWD3,
                     Set1c WD40 repeat protein, homolog; BMP2-induced 3-kb gene
                     protein; WD repeat-containing protein 5; cilia and
                     flagella associated protein 89; BMP-2-induced gene 3 kb"
                     /codon_start=1
                     /product="WD repeat-containing protein 5 isoform 1"
                     /protein_id="NP_001371344.1"
                     /db_xref="CCDS:CCDS6981.1"
                     /db_xref="GeneID:11091"
                     /db_xref="HGNC:HGNC:12757"
                     /db_xref="MIM:609012"
                     /translation="MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGH
                     TKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL
                     VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT
                     GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS
                     FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS
                     GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
                     "
     exon            369..477
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            478..551
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            552..641
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            642..731
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            732..815
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            816..871
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            872..918
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            919..994
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1028
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1103
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1191
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..3267
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1573..1578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /note="hexamer: ATTACA"
     polyA_site      1599
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /note="major polyA site"
     regulatory      1962..1967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /note="hexamer: AATAAA"
     polyA_site      1984
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
     regulatory      3244..3249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /note="hexamer: AATAAA"
     polyA_site      3267
                     /gene="WDR5"
                     /gene_synonym="BIG-3; BIG3; CFAP89; SWD3"
                     /note="major polyA site"
ORIGIN      
        1 actgcggagc gggcgcgggt gactccagag cggccctgcc agtccgcggg gctggcgggg
       61 agcagcgatg atcaagaagg ggcctggtcg cccggggagg tgccccggcc cgaatcgact
      121 ccggagacaa cgccgggcga cgccacctgc gcaggtcccg gagggccgct ggtgtctgtg
      181 tacagggcgt gctgtctgtg gaaacgcgag ggcacactag cactttccta ctgcctctgt
      241 caccgggtcc ctccaccctt gtctcctgtg cggccagcgt cagagccatg gcgacggagg
      301 agaagaagcc cgagaccgag gccgccagag cacagccaac cccttcgtca tccgccactc
      361 agagcaagcc tacacctgtg aagccaaact atgctctaaa gttcaccctt gctggccaca
      421 ccaaagcagt gtcctccgtg aaattcagcc cgaatggaga gtggctggca agttcatctg
      481 ctgataaact tattaaaatt tggggcgcgt atgatgggaa atttgagaaa accatatctg
      541 gtcacaagct gggaatatcc gatgtagcct ggtcgtcaga ttctaacctt cttgtttctg
      601 cctcagatga caaaaccttg aagatatggg acgtgagctc gggcaagtgt ctgaaaaccc
      661 tgaagggaca cagtaattat gtcttttgct gcaacttcaa tccccagtcc aaccttattg
      721 tctcaggatc ctttgacgaa agcgtgagga tatgggatgt gaaaacaggg aagtgcctca
      781 agactttgcc agctcactcg gatccagtct cggccgttca ttttaatcgt gatggatcct
      841 tgatagtttc aagtagctat gatggtctct gtcgcatctg ggacaccgcc tcaggccagt
      901 gcctgaagac gctcatcgat gacgacaacc cccccgtgtc ttttgtgaag ttctccccga
      961 acggcaaata catcctggcc gccacgctgg acaacactct gaagctctgg gactacagca
     1021 aggggaagtg cctgaagacg tacactggcc acaagaatga gaaatactgc atatttgcca
     1081 atttctctgt tactggtggg aagtggattg tgtctggctc agaggataac cttgtttaca
     1141 tctggaacct tcagacgaaa gagattgtac agaaactaca aggccacaca gatgtcgtga
     1201 tctcaacagc ttgtcaccca acagaaaaca tcatcgcctc tgctgcgcta gaaaatgaca
     1261 aaacaattaa actgtggaag agtgactgct aagtcccttt gctcctgccc gcgagagact
     1321 gtcgggaagt tgacccggat tggcaagaaa cagggtgtct tggaggtggt cccccagatc
     1381 tgcgcctggg ggtcaggaca gggcctgatt tgagcctcct ctctgaagat gatttggccg
     1441 agcggaaggt gtggaccacc ggaaagttct taaaagttgc tggtgacatt tcttgccaat
     1501 tctaacactg tctagggaag agttcctagt ctattgtgtt caaacagagt caacaaaagt
     1561 ttttaatttt ttattacaga agggtgaagt tcaatttaac atgcgttgtg ttttttcagt
     1621 aaacgttctg tatctttttg atattccatg acccagtgca cgctgtggcc tgtcaccgcc
     1681 accgtggccc cgccagctgg cctccccttt ggcccacgcc ggccgccccc attctctgct
     1741 gcgtagatgc cctggcccag ggccctgact cctccattcc cgccagtagc tgttcctagt
     1801 gtattttcgt ctttctggaa aacagcattg agtggttgtt ttctgtgtaa agagccgttt
     1861 gtgtcttggg agtttgtggc ccacatgccg atagcacggt catcgcacat gactctcccg
     1921 tttgtctcag tgtccctgca acaagcagca ccgcagactg taataaaagg tggggttttg
     1981 tgaatggttg tggcaagtgc gtccttgtga agctcgtctc catgtggctt tcttggagaa
     2041 aggctcccct ggggcaagag ggtggaaggt ttctttggac aggaggtgct gaggctggct
     2101 gcacctgctc tctgaagacg ccttcctctc taggttcatt gttcagtgtt gctgggggcg
     2161 gggaacgggg gtggggaggt tcttagttgc gaaggagcca agctcctgat ggacttgcgt
     2221 tgggatgtgg gggacacctg tggcatggta aggctccctg agtcccttac tccaggtcag
     2281 atgccagtgg gactcatgcg ccctatgagg gctgcagggc cagtgctgcc cctcggactc
     2341 ctcgaggggt tgggtgctaa gcgcgagcct cgccgtccct gctggagccc tcgcctgcct
     2401 gcccctctgc ctgtgctcct ggcagtgtgg cttcccggtg ctcacctgca cagcagttaa
     2461 cagcagaggc cgagcgggag cctctgggga gcgaggctga aacctgaacc tgcccatgga
     2521 gacagttgtg gtgagggttg ccacacacag tgagggcgga gcagggtggc tgagggcaca
     2581 ggtgcctggg tctgtcccac ggggcagggc tttggggctg tgatgctctg ggaagccagc
     2641 ttgggtcctg ggtctacaga gggccctggc cccggagccc agccagctct gcctctctca
     2701 gggcctggag tcctggggga gctcagccag ctctgccttt ctcagggcct ggagtcctgg
     2761 atgaatcctg caggtttttg gttgcaccgg cccagggagg aagcgggggg tttgtcaggt
     2821 gggctctcct ggaggtcctc gagtggcagg ggtgaggagg ggattatctg aggcatctgg
     2881 agatgtatat cctgtggttt cccctgcccc tctgtttccg atgaggtgta cggatgagtg
     2941 acctgcacta agaagtgagt tgccacagtg aaaatgggtt ggtttttgtc ttcgacgctc
     3001 agggtctggg cgcctcgcat ttgcagtctg ttgtgacaga cacggggagc tccgcgtgcc
     3061 agcctgtggc tgccctgctg tgggggtcct ggggccggcg aggccccttc agtcttgttc
     3121 tggggggacg gcccactccg gggagggggt gtgctgtgct gagcgctgta tccctgaata
     3181 tagtttattt tttctacatt tgaattctgt tgtagattta tgtaaaaata cattcttttt
     3241 gaaaataaaa attttcatgt cttctaa
//
