LOCUS       NM_001366157            3527 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens WD repeat domain 49 (WDR49), transcript variant 3,
            mRNA.
ACCESSION   NM_001366157
VERSION     NM_001366157.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3527)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3527)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 3527)
  AUTHORS   Smith,T.F.
  TITLE     Diversity of WD-repeat proteins
  JOURNAL   Subcell Biochem 48, 20-30 (2008)
   PUBMED   18925368
  REMARK    Review article
REFERENCE   4  (bases 1 to 3527)
  AUTHORS   Hudson,A.M. and Cooley,L.
  TITLE     Phylogenetic, structural and functional relationships between WD-
            and Kelch-repeat proteins
  JOURNAL   Subcell Biochem 48, 6-19 (2008)
   PUBMED   18925367
  REMARK    Review article
REFERENCE   5  (bases 1 to 3527)
  AUTHORS   Li,D. and Roberts,R.
  TITLE     WD-repeat proteins: structure characteristics, biological function,
            and their involvement in human diseases
  JOURNAL   Cell Mol Life Sci 58 (14), 2085-2097 (2001)
   PUBMED   11814058
  REMARK    Review article
REFERENCE   6  (bases 1 to 3527)
  AUTHORS   Smith,T.F., Gaitatzes,C., Saxena,K. and Neer,E.J.
  TITLE     The WD repeat: a common architecture for diverse functions
  JOURNAL   Trends Biochem Sci 24 (5), 181-185 (1999)
   PUBMED   10322433
  REMARK    Review article
REFERENCE   7  (bases 1 to 3527)
  AUTHORS   Garcia-Higuera,I., Fenoglio,J., Li,Y., Lewis,C., Panchenko,M.P.,
            Reiner,O., Smith,T.F. and Neer,E.J.
  TITLE     Folding of proteins with WD-repeats: comparison of six members of
            the WD-repeat superfamily to the G protein beta subunit
  JOURNAL   Biochemistry 35 (44), 13985-13994 (1996)
   PUBMED   8909296
REFERENCE   8  (bases 1 to 3527)
  AUTHORS   Neer,E.J., Schmidt,C.J., Nambudripad,R. and Smith,T.F.
  TITLE     The ancient regulatory-protein family of WD-repeat proteins
  JOURNAL   Nature 371 (6495), 297-300 (1994)
   PUBMED   8090199
  REMARK    Review article
            Erratum:[Nature 1994 Oct 27;371(6500):812]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079822.13, AC117425.3 and
            AC069530.14.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of the WD repeat protein family
            with nine WD repeats. WD repeats are minimally conserved regions of
            approximately 40 amino acids typically bracketed by gly-his and
            trp-asp (GH-WD), which may facilitate formation of heterotrimeric
            or multiprotein complexes. Members of this family are involved in a
            variety of cellular processes, including cell cycle progression,
            signal transduction, apoptosis, and gene regulation. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Feb 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.104862.1,
                                           SRR1803612.137087.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682715.1/ ENSP00000507497.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC079822.13        26773-26881         c
            110-348             AC079822.13        26200-26438         c
            349-789             AC117425.3         141412-141852       c
            790-966             AC117425.3         136027-136203       c
            967-1141            AC117425.3         134989-135163       c
            1142-1309           AC117425.3         118861-119028       c
            1310-1458           AC117425.3         116687-116835       c
            1459-1692           AC117425.3         90478-90711         c
            1693-1857           AC117425.3         74624-74788         c
            1858-2006           AC117425.3         69210-69358         c
            2007-2137           AC117425.3         51430-51560         c
            2138-2236           AC117425.3         47439-47537         c
            2237-2401           AC117425.3         45675-45839         c
            2402-2589           AC117425.3         43612-43799         c
            2590-2787           AC117425.3         42380-42577         c
            2788-2957           AC117425.3         36875-37044         c
            2958-3067           AC117425.3         19867-19976         c
            3068-3214           AC117425.3         14713-14859         c
            3215-3527           AC069530.14        2970-3282           c
FEATURES             Location/Qualifiers
     source          1..3527
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.1"
     gene            1..3527
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /note="WD repeat domain 49"
                     /db_xref="GeneID:151790"
                     /db_xref="HGNC:HGNC:26587"
     exon            1..109
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            110..348
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..3333
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /note="isoform 2 is encoded by transcript variant 3; WD
                     repeat-containing protein 49; cilia- and
                     flagella-associated protein 337"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 337
                     isoform 2"
                     /protein_id="NP_001353086.1"
                     /db_xref="CCDS:CCDS93422.1"
                     /db_xref="GeneID:151790"
                     /db_xref="HGNC:HGNC:26587"
                     /translation="MSCQKAVLELNIGSQLGPKSPERTEGVTAFEDYGTGLLENQLSV
                     GDFVKIQKAFESPQPRKIICMSREDFTQKMTEIVGWGTKEEYGELFDKVDVAQDGFIN
                     WDKLTSFILLELYEQDERAKATVVPQWKDLEFLPVKHKDTIQKVIFLKNSSHYLTISK
                     EGLLAIWGEHLKLQETFPITSDATKLKHLWVTSLVSLENVNKIAVAFTSKEVCFYDLL
                     SKEEFACQYKLQGLKGTPICMDYWYDPLDANESILSFGDITGKVQAIAFTAALISLFE
                     RPASACEDGEATMTINWAELLSGCHKCCHILEHKLHQGDWVRQVTYNASLDAIISSTT
                     SNTNSVVMAWREKSKKRLNMTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPYVV
                     SKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIACSFPKSQD
                     FRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVISSD
                     TGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDANETRLLTGSTDGTVKIWDFNGYC
                     HHTLNVGQDGAVDISQILILKKKILVTGWERYDYASWKTIGRAITVFRPQNFNQFFIQ
                     PEEWKGGIQHHDDILCAAFLPPQTLVTGSYDGEIVLWNNSTENAHHVLHPDYQRLLKS
                     KLDTKPQKLLSAGRSQPSHPMADHSTTGVRNFEIDTEGKNAVMRLCFLKARKNTAVTG
                     GANLVSCGGSGYVRFWDIYKKQLLAEFLAHSGVGSIIMSTDKMNRYLTTGDLDGWLKI
                     WNIEEYCLNSSKNKITKAPTLIRSFQPHEDRISSLEMCEPGGQLLIISSSADCSICVT
                     GVCNAPVWIFGQAKHWHIENCLFLPKRDTNLVESEIQKEISLFSKEESCLDPTEHSLL
                     NKKNKDDSTYNVRPSEDINLDIKYKERSTCMKETQKPYYGEVIKKSFSTFRSLNIGAL
                     EELPEVNKPAFLLDPEKYFRKEPEEERPQILEAPSLFKTLKAVFDEKNLFPKEILHHE
                     RKAKQLCQEKSCEVKKNKK"
     exon            349..789
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            790..966
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1141
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1309
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1458
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1692
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1857
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..2006
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2137
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2236
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2401
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2589
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2787
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2957
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3067
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3214
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3527
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3510..3515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /note="hexamer: AATAAA"
     polyA_site      3527
                     /gene="WDR49"
                     /gene_synonym="CFAP337"
                     /note="major polyA site"
ORIGIN      
        1 gcattcagag tcaagtactt cattggtagg gaaactctgc agctttgtca tctaactctt
       61 ccagacaaga aagtggaatt gaaaactaca acatgttaat ggaagcaagg cacctgttga
      121 aggaaaaaga agatccatcc ttatagaaat agttgaaggc aactgagaaa aggtgaagcc
      181 attatgagtt gccagaaagc tgtacttgag ttaaacatag ggtcacagct tgggccaaag
      241 agtcctgaga gaacagaagg tgtaactgca tttgaagact atggcacagg cctgcttgaa
      301 aaccaactca gcgtgggtga ctttgtaaaa atacagaagg cctttgagtc cccacagcca
      361 aggaaaatca tttgtatgtc cagagaagac ttcacgcaga agatgacaga gattgttggt
      421 tggggcacga aggaagaata tggggagctc tttgacaaag tggatgtggc ccaagatggc
      481 ttcattaatt gggacaagct gacttcattt atactgctag agctttatga gcaagatgaa
      541 cgagcaaagg caactgtggt gccccagtgg aaggaccttg aattcctccc agtaaaacac
      601 aaggacacca ttcaaaaagt aattttctta aaaaattcaa gtcattatct gacaattagt
      661 aaagaaggtt tattggcaat ctggggagag catttaaagc tgcaagaaac attccccatc
      721 acttcagatg ccaccaagct caaacacctg tgggtgacaa gtctggtttc tctggaaaat
      781 gtaaacaaga tagcagtggc ttttacaagt aaagaggttt gtttctatga tctgctgtcc
      841 aaagaagaat ttgcttgcca atacaaactc caaggcctga aaggaacacc aatttgcatg
      901 gattattggt atgatcctct tgatgccaat gaatcaattc tttcttttgg ggatataact
      961 ggaaaggttc aagcaattgc tttcaccgca gccttgattt ccctgtttga acggcctgct
     1021 agtgcatgtg aagatggaga agccactatg accattaact gggcagagct gctctctgga
     1081 tgtcacaaat gttgccatat attagagcat aaacttcatc aaggagattg ggtcaggcaa
     1141 gttacttaca atgcatcttt agacgctatc atttccagta caaccagcaa tacaaatagt
     1201 gtggtgatgg cttggagaga gaaatcaaaa aagcgtctta atatgacatc cttcaacatt
     1261 gcccagggca ttcatgcttt tgattatcac tctcggctca atttaattgc aactgctggc
     1321 attaacaata aagtttgcct ttggaatccc tatgttgtct ctaaaccagt gggtgtcctt
     1381 tggggccact cagccagtgt aatagccgtc caattctttg tggaaagaaa acaacttttc
     1441 agcttctcca aggataaagt tttgagactc tgggatattc aacaccagct gtccatccag
     1501 aggatagctt gttctttccc caaaagtcag gacttcagat gtctcttcca ctttgatgaa
     1561 gcccatggac gacttttcat ctcgtttaat aaccagctag cattgttggc aatgaaaagt
     1621 gaagccagca agagggtgaa aagccatgag aaagcagtca cttgtgttct ttacaattct
     1681 atcttgaagc aggtaatcag ctctgataca gggtctactg tttccttctg gatgatagac
     1741 actgggcaga aaatcaaaca gtttactggt tgccacggca acgcagaaat cagcactatg
     1801 gcccttgatg caaatgagac tcggcttttg actggcagca cagatgggac tgtaaagata
     1861 tgggacttca atggatattg tcaccataca ctaaatgttg ggcaagatgg agctgtggat
     1921 atttcacaaa tcctcattct taagaagaaa atactggtta caggctggga gaggtatgat
     1981 tatgcctcat ggaaaactat aggaagggct attactgtgt ttcgacccca aaacttcaat
     2041 caatttttca tccagcctga agaatggaaa ggaggtatac agcaccatga tgacatcttg
     2101 tgtgctgcgt ttttacctcc acaaactctt gttacgggga gttatgatgg agaaattgtt
     2161 ctatggaaca atagcacaga gaatgctcac catgttcttc accctgatta ccagaggttg
     2221 ctaaagtcaa aattagatac aaaacctcaa aaacttctca gtgctgggag aagccaaccc
     2281 tcccacccca tggcagacca ttctaccacg ggagtccgca actttgagat tgacactgag
     2341 ggcaaaaatg ctgttatgag actttgcttt cttaaagcaa gaaaaaacac tgcagtgaca
     2401 ggaggagcta acctggtatc atgtggagga tctggttatg tcagattttg ggatatatat
     2461 aagaagcaac ttctggctga atttttggct catagtggag ttggatcgat tattatgtct
     2521 actgataaga tgaatcgata ccttaccaca ggagatcttg atggatggtt gaaaatctgg
     2581 aatatagagg agtactgtct taactccagt aagaacaaaa tcaccaaggc cccaactctg
     2641 ataagatcat tccaacctca tgaggaccga ataagttcct tagagatgtg tgagccaggt
     2701 ggtcagttac tgattatctc ctcctctgca gactgcagta tttgtgtgac tggtgtctgc
     2761 aatgctcctg tttggatctt tggtcaggca aagcactggc atattgaaaa ctgccttttc
     2821 cttcctaaaa gagatactaa tttagtggaa agtgagattc aaaaggaaat ttctttattt
     2881 tctaaggagg aatcttgttt agacccaaca gaacattctc tacttaataa gaaaaacaaa
     2941 gatgactcaa catacaatgt cagaccatca gaagatataa atttagatat aaaatataag
     3001 gaaagaagta cctgcatgaa agaaacacaa aaaccttatt atggtgaagt tataaaaaaa
     3061 tcattcagta catttaggtc attaaacatt ggagccctgg aagagctgcc tgaagtgaat
     3121 aaacctgctt tccttctaga ccctgagaaa tactttagga aagaaccaga ggaagagcgt
     3181 ccccaaattc tggaggcccc gtcacttttt aaaactttga aagctgtatt tgatgagaaa
     3241 aacctgtttc ccaaggaaat tctgcatcat gaacgaaaag ccaagcaatt atgccaagaa
     3301 aaaagttgtg aagtgaagaa aaataagaag taattacaac agaaaaacct tcactgttac
     3361 ataaggtaca gatataaaat gcagaaaaag catcaagaat tctgcctttt attttatttt
     3421 atatttaaac ttcaggaagt tttctcttca tgggataatt tagtactgct tttatctatc
     3481 atctgtcaat ttctctgtat tcttaataaa ataaatattg aactaaa
//
