LOCUS       NM_001142551            4226 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens WD repeat domain 47 (WDR47), transcript variant 3,
            mRNA.
ACCESSION   NM_001142551 XM_005270636
VERSION     NM_001142551.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4226)
  AUTHORS   Guardia,C.M., Jain,A., Mattera,R., Friefeld,A., Li,Y. and
            Bonifacino,J.S.
  TITLE     RUSC2 and WDR47 oppositely regulate kinesin-1-dependent
            distribution of ATG9A to the cell periphery
  JOURNAL   Mol Biol Cell 32 (21), ar25 (2021)
   PUBMED   34432492
  REMARK    GeneRIF: RUSC2 and WDR47 oppositely regulate kinesin-1-dependent
            distribution of ATG9A to the cell periphery.
REFERENCE   2  (bases 1 to 4226)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4226)
  AUTHORS   Wang,W., Lundin,V.F., Millan,I., Zeng,A., Chen,X., Yang,J.,
            Allen,E., Chen,N., Bach,G., Hsu,A., Maloney,M.T., Kapur,M. and
            Yang,Y.
  TITLE     Nemitin, a novel Map8/Map1s interacting protein with Wd40 repeats
  JOURNAL   PLoS One 7 (4), e33094 (2012)
   PUBMED   22523538
REFERENCE   4  (bases 1 to 4226)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA221069.1, AB020700.1, BC039254.1, BM793705.1 and AK225781.1.
            
            On May 21, 2020 this sequence version replaced NM_001142551.1.
            
            Transcript Variant: This variant (3) uses several alternate
            in-frame splice sites in the 5' coding region, compared to variant
            1, resulting in a protein (isoform 3) with a shorter N-terminus,
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB020700.1, SRR1803615.187069.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369962.8/ ENSP00000358979.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DA221069.1         127-153
            28-2484             AB020700.1         1-2457
            2485-3389           BC039254.1         2407-3311
            3390-3716           BM793705.1         243-569
            3717-4226           AK225781.1         3627-4136
FEATURES             Location/Qualifiers
     source          1..4226
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..4226
                     /gene="WDR47"
                     /note="WD repeat domain 47"
                     /db_xref="GeneID:22911"
                     /db_xref="HGNC:HGNC:29141"
                     /db_xref="MIM:615734"
     exon            1..241
                     /gene="WDR47"
                     /inference="alignment:Splign:2.1.0"
     exon            242..408
                     /gene="WDR47"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..3010
                     /gene="WDR47"
                     /note="isoform 3 is encoded by transcript variant 3; WD
                     repeat-containing protein 47; nemitin; neuronal enriched
                     MAP-interacting protein"
                     /codon_start=1
                     /product="WD repeat-containing protein 47 isoform 3"
                     /protein_id="NP_001136023.1"
                     /db_xref="CCDS:CCDS44187.1"
                     /db_xref="GeneID:22911"
                     /db_xref="HGNC:HGNC:29141"
                     /db_xref="MIM:615734"
                     /translation="MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGL
                     FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS
                     AEDEPQHLEFTMQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTA
                     RVHCFEEACVMVAEFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGE
                     EITESEVLLGIDLLCGNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPT
                     KAAYADLLTPLISKLSPYPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDL
                     GNKTSPMSHSFANFHYPGVQNLSRSLMLENTECHSIYEESPERDTPVDAQRPIGSEIL
                     GQSSVSEKEPANGAQNPGPAKQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQIY
                     QQMLLEGGVNQEDGPDQQQNLTEQFLNRSIQKLGELNIGMDGLGNEVSALNQQCNGSK
                     GNGSNGSSVTSFTTPPQDSSQRLTHDASNIHTSTPRNPGSTNHIPFLEESPCGSQISS
                     EHSVIKPPLGDSPGSLSRSKGEEDDKSKKQFVCINILEDTQAVRAVAFHPAGGLYAVG
                     SNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSND
                     KYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTT
                     DCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHG
                     TGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHY
                     LLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTL
                     WTYNG"
     exon            409..492
                     /gene="WDR47"
                     /inference="alignment:Splign:2.1.0"
     exon            493..577
                     /gene="WDR47"
                     /inference="alignment:Splign:2.1.0"
     exon            578..1380
                     /gene="WDR47"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1504
                     /gene="WDR47"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1683
                     /gene="WDR47"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1941
                     /gene="WDR47"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2017
                     /gene="WDR47"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2175
                     /gene="WDR47"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2345
                     /gene="WDR47"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2516
                     /gene="WDR47"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2648
                     /gene="WDR47"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2867
                     /gene="WDR47"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..4226
                     /gene="WDR47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4202..4207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR47"
                     /note="hexamer: AATAAA"
     polyA_site      4226
                     /gene="WDR47"
                     /note="major polyA site"
ORIGIN      
        1 gcagtctgca agaggctgag ctgaggagtc gctgggccgg gaggggcgga cgtgagaagg
       61 acggattgac gaactgatgg attgacgcgc gggcggtagg agggaggacc gacgccaaac
      121 ccagaccgcc gccgtcgtgc tcctgccgca gcccggagcc ggccgcttcg gggccctggc
      181 cgccggcctc ccagccgcgt tctcctccgc cgctcctccg ggcttgccct ggagccctca
      241 ggctatcaat atgacggctg aagaaacagt gaatgtaaaa gaggttgaaa tcattaagct
      301 aattttggac ttcctgaatt caaagaagct tcacattagt atgctggccc tggagaagga
      361 aagtggagtc ataaatggcc tgttttcaga tgatatgctt ttcctgaggc agctaatact
      421 tgatggtcaa tgggatgaag ttcttcagtt cattcagcct ctagaatgta tggaaaaatt
      481 tgacaaaaaa aggtttcgtt atattatcct gaagcagaag tttttagaag ctttatgtgt
      541 taacaacgcg atgtcagcag aagatgagcc ccagcatctg gaatttacca tgcaagaagc
      601 tgtgcaatgt ttacatgctc tagaagaata ctgtccttct aaagatgact atagtaagct
      661 ctgtttgctt ttgactttgc ctcgtctgac caatcatgcc gagtttaagg actggaatcc
      721 cagcaccgca cgagttcact gttttgaaga ggcttgtgtc atggttgcag aattcatccc
      781 tgctgatagg aagctaagtg aagctggttt taaggctagt aacaatcgtt tatttcagct
      841 tgtaatgaaa ggcctgcttt atgaatgctg tgtagaattt tgtcagagta aagcaactgg
      901 agaagaaatt acagaaagcg aagtgcttct tggcatcgac ctcttatgtg gtaatggttg
      961 tgatgatttg gatctgagtt tactgtcatg gcttcagaat cttccatctt ctgtcttctc
     1021 ttgtgctttt gaacagaaaa tgcttaatat tcatgttgac aaacttctga aacctacaaa
     1081 agctgcatat gctgatcttt tgactcctct tatcagcaaa ctctctccct atccatcatc
     1141 cccaatgaga agacctcaat cagctgatgc ctatatgacc cgctctctga atcctgcttt
     1201 agatggcctc acctgtggac taaccagtca tgataagaga atttcagacc ttggaaacaa
     1261 aacttctcca atgtcacact cctttgctaa cttccattat ccaggggtac aaaacctcag
     1321 tagaagtctc atgcttgaga atacagaatg tcacagtatt tacgaagaat cccctgagcg
     1381 tgatacacct gttgatgcac agaggcctat cggcagtgaa atcttgggcc agagttcagt
     1441 ttcagaaaaa gagcctgcaa atggagcaca gaatccagga ccagctaaac aagaaaaaaa
     1501 tgagcttcga gattcaacag aacaatttca agaatattat aggcaaagat tacgctatca
     1561 acagcattta gaacagaagg agcaacagcg gcagatatac caacagatgt tgcttgaagg
     1621 aggcgtgaat caggaggatg gtcctgatca gcagcagaat cttactgaac agttccttaa
     1681 taggtccatt caaaagcttg gtgaattaaa tattggaatg gatggccttg gtaatgaggt
     1741 atcagcactc aaccagcaat gtaatgggag caaaggcaat ggatctaatg gttcttctgt
     1801 gactagtttt actacaccac cccaagactc tagtcagaga ttaacacatg atgcttcaaa
     1861 tattcataca agcactcctc gtaatcctgg atcaacaaat cacatacctt ttctggagga
     1921 atcaccttgt ggaagccaaa tctcttcaga acattcggtc attaagccac ctcttggaga
     1981 ttctccaggg agtctttcaa ggtcgaaagg ggaagaggat gacaaatcaa aaaagcagtt
     2041 tgtttgtatt aatatcctag aagacacaca agctgttaga gcagtggctt ttcatccagc
     2101 tggaggttta tatgctgttg gttcaaattc aaaaactctg agagtatgtg cctatccaga
     2161 tgtaattgat ccaagtgcac atgagactcc taagcagccg gtggtacgtt ttaaaaggaa
     2221 taaacatcat aaaggatcca tttactgtgt ggcctggagt ccttgtgggc agttattagc
     2281 aacaggatca aatgacaaat acgtcaaagt gctgcccttc aatgcagaga cttgtaacgc
     2341 aacaggacca gatctggaat ttagtatgca tgatggaaca attagagact tggcatttat
     2401 ggaaggccca gaaagcggag gagctatttt aataagtgct ggagcagggg attgtaacat
     2461 ttatacaacc gattgtcaaa gaggacaggg cctccatgct ttgagtggac atactgggca
     2521 tattttagca ctttatacct ggagtggctg gatgattgca tctggttccc aagataagac
     2581 tgttagattt tgggatcttc gagtaccaag ttgtgttcgt gttgttggca caacatttca
     2641 tggaactggc agtgcagtgg catctgtagc tgtagatccc agtggtcgtc tcttagccac
     2701 aggtcaagaa gattctagct gcatgttgta tgacataaga ggaggaagaa tggtacaaag
     2761 ttatcatcct cattccagtg atgttcgctc tgttcgattc tcccctggag ctcactactt
     2821 gctaacaggc tcttatgata tgaaaataaa ggtgacagac ctacaagggg acctcaccaa
     2881 gcagcttcct atcatggtgg tgggggagca caaggacaaa gtgattcagt gcagatggca
     2941 cacccaggat ctttccttcc tgtcatcctc tgcagataga actgtcaccc tctggactta
     3001 caatgggtag agcacaccgc atgtcagtct atgcagcaaa agcacagaga cttaagacta
     3061 ctgagttgtg aaaattacaa atctgaagaa catagtgtcc aggaaagtgg tttagcacga
     3121 agaggcccct tattaccatg tatcccactg ataggaggtg ttgggtggtg ttattccgca
     3181 gtgctttcag tcttccatgt gagctcgtgc tgctgtgacc tgctatatgt agtctcgttg
     3241 ccaaagtctg cagaagagct cttcagttgt tggtgtgcac tccaagtcag gatggacaat
     3301 gtgtttacgg tttagtattc aatgcattcc ttggtctttg cctaaataac agttttatat
     3361 gcacattgaa atggaattat acttcaacta tattattaaa tgtaatgcaa ccaagttcct
     3421 cccagattaa acttcccagg tgttcagaat tacttttgct cttctcacga tcccatattg
     3481 tattatcact tgtcttctag aggtcagaat tccataatat atgtcactca aaagttacat
     3541 ggttgctttc acttaaggat cattgtggag tttaaagatg aatgaaaaac tgcttcttag
     3601 tttactacat ggtataggcc cttttttctt aaacccaggg atatgattat tttgtcatat
     3661 aattttgttt caggctaaaa ggtaaatgtg tttgcttcag aaacttgtta acttcagttt
     3721 tttgaatgca acaggatacc tcccttccaa actgaactgt agaagcagag cagcagcagt
     3781 tatgtgatgc aacacttgat ggtacagtaa atttactggc atttttctcc ttaaaaatta
     3841 aaatccttga catagaccat agcatggctt gaaatgctat gtctgcatga taatttaaaa
     3901 tggaagattt aaactttgca ctccaaaagc ttatttggat ttttttcttg cactgttttg
     3961 tgtaatgcag aataatgatt ttatttctac agctttgtag attctaacat ttatgtatct
     4021 ttattttcat attgtacagt aattttactt taaattattt aaataggcta ttttatttat
     4081 ttcaaatgca gttgtattag ttctcattat tgaactgtct gtgcactgta tgtagcaagc
     4141 atttttcatc tgttgtatac aagtggaaag ggtattagaa gtgtaactgt gctattattt
     4201 caataaagac ctcttgacat ttaaaa
//
