LOCUS       NM_015131               3506 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens WD repeat domain 43 (WDR43), mRNA.
ACCESSION   NM_015131 XR_015598
VERSION     NM_015131.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3506)
  AUTHORS   Yang,X., Luo,T., Liu,Z., Liu,J. and Yang,Z.
  TITLE     WD repeat domain 43 as a new predictive indicator and its
            connection with tumor immune cell infiltration in pan-cancer
  JOURNAL   Medicine (Baltimore) 103 (31), e39153 (2024)
   PUBMED   39093744
  REMARK    GeneRIF: WD repeat domain 43 as a new predictive indicator and its
            connection with tumor immune cell infiltration in pan-cancer.
REFERENCE   2  (bases 1 to 3506)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3506)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   4  (bases 1 to 3506)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3506)
  AUTHORS   Bi,X., Xu,Y., Li,T., Li,X., Li,W., Shao,W., Wang,K., Zhan,G.,
            Wu,Z., Liu,W., Lu,J.Y., Wang,L., Zhao,J., Wu,J., Na,J., Li,G.,
            Li,P. and Shen,X.
  TITLE     RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription
            and Pluripotency Control
  JOURNAL   Mol Cell 75 (1), 102-116 (2019)
   PUBMED   31128943
  REMARK    GeneRIF: RNA targets ribogenesis Factor WDR43 to chromatin for
            transcription and pluripotency control.
REFERENCE   6  (bases 1 to 3506)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 3506)
  AUTHORS   Prieto,J.L. and McStay,B.
  TITLE     Recruitment of factors linking transcription and processing of
            pre-rRNA to NOR chromatin is UBF-dependent and occurs independent
            of transcription in human cells
  JOURNAL   Genes Dev 21 (16), 2041-2054 (2007)
   PUBMED   17699751
REFERENCE   8  (bases 1 to 3506)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   9  (bases 1 to 3506)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   10 (bases 1 to 3506)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA654485.1, D26488.1, AC097720.5 and AW593733.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015131.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.166644.1, D26488.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407426.8/ ENSP00000384302.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DA654485.1         25-27
            4-529               D26488.1           1-526
            530-530             AC097720.5         85319-85319
            531-2032            D26488.1           528-2029
            2033-2033           AC097720.5         119463-119463
            2034-3096           D26488.1           2031-3093
            3097-3176           AC097720.5         120527-120606
            3177-3501           D26488.1           3172-3496
            3502-3506           AW593733.1         13-17               c
FEATURES             Location/Qualifiers
     source          1..3506
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.2"
     gene            1..3506
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /note="WD repeat domain 43"
                     /db_xref="GeneID:23160"
                     /db_xref="HGNC:HGNC:28945"
                     /db_xref="MIM:616195"
     exon            1..257
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2066
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /note="UTP5, small subunit (SSU) processome component,
                     homolog; U3 small nucleolar RNA-associated protein 5
                     homolog"
                     /codon_start=1
                     /product="WD repeat-containing protein 43"
                     /protein_id="NP_055946.1"
                     /db_xref="CCDS:CCDS46251.1"
                     /db_xref="GeneID:23160"
                     /db_xref="HGNC:HGNC:28945"
                     /db_xref="MIM:616195"
                     /translation="MAAGGGGSCDPLAPAGVPCAFSPHSQAYFALASTDGHLRVWETA
                     NNRLHQEYVPSAHLSGTCTCLAWAPARLQAKESPQRKKRKSEAVGMSNQTDLLALGTA
                     VGSILLYSTVKGELHSKLISGGHDNRVNCIQWHQDSGCLYSCSDDKHIVEWNVQTCKV
                     KCKWKGDNSSVSSLCISPDGKMLLSAGRTIKLWVLETKEVYRHFTGHATPVSSLMFTT
                     IRPPNESQPFDGITGLYFLSGAVHDRLLNVWQVRSENKEKSAVMSFTVTDEPVYIDLT
                     LSENKEEPVKLAVVCRDGQVHLFEHILNGYCKKPLTSNCTIQIATPGKGKKSTPKPIP
                     ILAAGFCSDKMSLLLVYGSWFQPTIERVALNSREPHMCLVRDISNCWAPKVETAITKV
                     RTPVMNSEAKVLVPGIPGHHAAIKPAPPQTEQVESKRKSGGNEVSIEERLGAMDIDTH
                     KKGKEDLQTNSFPVLLTQGLESNDFEMLNKVLQTRNVNLIKKTVLRMPLHTIIPLLQE
                     LTKRLQGHPNSAVLMVQWLKCVLTVHASYLSTLPDLVPQLGTLYQLMESRVKTFQKLS
                     HLHGKLILLITQVTASEKTKGATSPGQKAKLVYEEESSEEESDDEIADKDSEDNWDED
                     EEESESEKDEDVEEEDEDAEGKDEENGEDRDTASEKELNGDSDLDPENESEEE"
     exon            258..395
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            396..517
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            518..638
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            639..778
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            779..881
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            882..946
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1118
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1205
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1337
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1469
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1556
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1588
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1652
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1766
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1836
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1886
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..3506
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3485..3490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /note="hexamer: AATAAA"
     polyA_site      3506
                     /gene="WDR43"
                     /gene_synonym="NET12; UTP5"
                     /note="major polyA site"
ORIGIN      
        1 gaacacgtgg ctgcagcggg gccagagcag caatggcggc gggcggcggc ggtagctgcg
       61 accccctggc ccctgctggg gtcccttgcg ccttctcccc gcacagccag gcctacttcg
      121 ctttggcctc taccgacggt cacttacgag tatgggagac ggccaacaac cggctgcacc
      181 aggagtacgt gccttccgcg cacctcagtg gtacctgcac ctgtctggcc tgggcgccag
      241 cgcggctgca ggccaaggaa agtccccaga ggaaaaaaag gaaatcagaa gctgtaggaa
      301 tgagtaacca gactgactta ttggctcttg gcacagcagt tggtagcatt ttattataca
      361 gcacagtaaa aggagagtta cacagtaaat taataagtgg tggacatgac aacagagtca
      421 actgcataca gtggcatcaa gacagtggct gtttatatag ttgttcagat gataaacata
      481 ttgtggaatg gaacgtacag acatgcaaag taaagtgcaa atggaaaggc gacaatagca
      541 gtgtcagttc cctatgtatc agcccagatg gaaagatgtt gctttcagct ggtcgaacaa
      601 tcaaactatg ggttttggag accaaagaag tctacaggca tttcacagga catgcaacgc
      661 cagtttcgtc actgatgttc actaccatca gacctcctaa tgagagccag ccctttgatg
      721 gaattacagg tctttatttc ttatctggag cagtacatga ccggttactt aatgtctggc
      781 aggtccgatc agaaaacaaa gaaaagagtg cagtgatgtc atttacagtt accgatgaac
      841 ctgtctatat tgacttaact ttgtcagaaa acaaagaaga gcctgtcaag ttggctgttg
      901 tttgcagaga tggtcaagtc catctttttg aacacatatt aaatgggtac tgcaaaaagc
      961 ctttgacttc aaactgcaca attcagatag caacacctgg gaaaggcaag aagtcaacac
     1021 caaaacccat ccctattcta gctgctggtt tttgctcaga caaaatgtca ttgttgcttg
     1081 tatatggcag ttggtttcag cctactattg agcgagtggc tttaaactcc agagaacctc
     1141 atatgtgttt agtaagagat atttcaaact gctgggcccc caaagtagaa acagctataa
     1201 caaaggtgag gacaccagtg atgaattctg aagcaaaagt tctggtgcct gggattcctg
     1261 gtcatcatgc agctatcaag cccgctcctc cacaaaccga gcaagtagag agcaagagga
     1321 agtcaggggg aaatgaggtt agcattgaag aacgtctggg agcaatggat atagacacac
     1381 acaaaaaagg aaaggaagac ctccagacga atagctttcc agttcttctt acccagggct
     1441 tagaaagtaa cgattttgaa atgctaaata aagtacttca aactaggaat gtaaacctta
     1501 taaagaagac tgtattaagg atgcccctgc atactattat tccgttgtta caagagctta
     1561 caaagaggtt acaaggacat cctaatagtg ctgtgctaat ggttcagtgg ctaaaatgtg
     1621 tgttaacagt tcatgcatca tacctgtcca cgttgcctga cctggtaccc cagctgggga
     1681 cactctacca gttaatggaa agcagagtca aaacttttca gaaactttca caccttcatg
     1741 gaaagcttat tcttctaatt acacaagtaa cagcatcaga gaagacaaag ggagcaactt
     1801 cccctggaca gaaggcaaag ttggtgtatg aagaagagtc ttctgaagag gagtctgatg
     1861 atgaaatagc agataaggat tctgaagata attgggatga agatgaggag gagagtgaaa
     1921 gtgaaaaaga tgaggacgtt gaagaggaag atgaggatgc cgaaggaaaa gatgaagaaa
     1981 atggcgagga cagagataca gcaagtgaaa aagaattaaa tggagattct gatttagatc
     2041 ctgaaaatga aagtgaagaa gaatgaagac agcaaagcaa gccggtcaaa ctatataaac
     2101 tctggctcac cttgcccagt ggtgagggct gcctctgtgc caggatgcca aggaccgctg
     2161 cacatttcca aattcacagc agtggatccc atgccacttt gctgtcctga gcaccccaga
     2221 cttgactgtg taaataagag tgtttcattc aaatgttaat aaactttaca cagtatatag
     2281 acacattttc tgcaatgtac tgacatcagt gtccaatata tggtatattt ttataatata
     2341 atatcctagt atgattggtt atatcaagaa ttgacaagtg cagataaaga cctttcccat
     2401 aggagttcaa gaactggact gttgtgaaga agtcagctct tatctcaggt tggtatcttt
     2461 catcaaatcc agatgcaaag cagcactagt gaaaattttt ttaatttagt acatttaatt
     2521 tggtacattt tcataaaata tgaagggata actacaaact ggagtaaaaa tgatggtaat
     2581 taaaaaaaat cctcagtatc cctagcttgt ctattaactg tgataatctg acttgagtca
     2641 gattgaatat ttggagtgct tccccagaat aaccacttat ttttgaagct atcatgtgaa
     2701 gtattttttt aaaacaaaac aaaaattatg gtcattaaaa aactagagaa ttagccatat
     2761 taaggatttt tcttgactgc aaattacttc taaagaatca tcagtgtata gattagaagt
     2821 gctcattacc tgcaactttt aaaaaaaatt cagttatagc tgcttttgaa gaggtttcca
     2881 tttttattta aattactaat ggatcaaaga acaattgttt attttttctc tttggtttta
     2941 gatattaatg ataaccttgt tggaattttt tttccaaaga aaatattttt ataattaaat
     3001 aatttaatgt ttttcttcct tttcattacc tactcttggc agtgttaggg tatctgttta
     3061 cctttaaaat gataagtctc actcaagatt ttttatgtat gtataaatat tttggtgtgc
     3121 tacaaaagcc tttgcaaatt atcagtagta gttttttttt tttttttttt ttttttaaag
     3181 aatgagccga tattggctta gtgctcacta ggggacatgc acatggaagc tcacctctaa
     3241 gaaagggctg ggcagatgga tttatttttt cccacctgtg aatatgtaaa acaaaaccat
     3301 tatctttgag ggagttttta ataccaatga cagaacagag atttgtgtgc tcatcttaag
     3361 agccagagcc atataagcat cttgggaaag caagtttgaa ccagctgctg gtgtaatgta
     3421 cagttatatt tgtctataaa tggagctgtt tatggcaatt taataccatt ctctttgtaa
     3481 agtgaataaa tattcatctt taccca
//
