LOCUS       NM_001045476            1265 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens WD repeat domain 38 (WDR38), transcript variant 2,
            mRNA.
ACCESSION   NM_001045476
VERSION     NM_001045476.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1265)
  AUTHORS   Gao,Q., Liu,G., Huang,L., Zhang,Y., Zhang,X., Song,X. and Xing,X.
  TITLE     WDR38, a novel equatorial segment protein, interacts with the
            GTPase protein RAB19 and Golgi protein GM130 to play roles in
            acrosome biogenesis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1561-1570 (2023)
   PUBMED   37635409
  REMARK    GeneRIF: WDR38, a novel equatorial segment protein, interacts with
            the GTPase protein RAB19 and Golgi protein GM130 to play roles in
            acrosome biogenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC150645.1, AL354928.9 and AA867995.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001045476.2.
            
            Transcript Variant: This variant (2) has an alternate splice site
            in the 3' coding region, compared to variant 1. The resulting
            isoform (2) lacks an internal aa, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373574.2/ ENSP00000362677.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-586               BC150645.1         44-629
            587-690             AL354928.9         116365-116468
            691-1029            BC150645.1         734-1072
            1030-1109           AL354928.9         117511-117590
            1110-1265           AA867995.1         18-173              c
FEATURES             Location/Qualifiers
     source          1..1265
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     gene            1..1265
                     /gene="WDR38"
                     /note="WD repeat domain 38"
                     /db_xref="GeneID:401551"
                     /db_xref="HGNC:HGNC:23745"
     exon            1..141
                     /gene="WDR38"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1017
                     /gene="WDR38"
                     /note="isoform 2 is encoded by transcript variant 2; WD
                     repeat-containing protein 38"
                     /codon_start=1
                     /product="WD repeat-containing protein 38 isoform 2"
                     /protein_id="NP_001038941.1"
                     /db_xref="CCDS:CCDS43876.1"
                     /db_xref="GeneID:401551"
                     /db_xref="HGNC:HGNC:23745"
                     /translation="MNSGVPATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGC
                     VYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLK
                     GHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVN
                     CLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIW
                     KPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLD
                     VAHTCAFTPDGKILVSGAADQTRRQISRTSKSPRDPQT"
     exon            142..262
                     /gene="WDR38"
                     /inference="alignment:Splign:2.1.0"
     exon            263..379
                     /gene="WDR38"
                     /inference="alignment:Splign:2.1.0"
     exon            380..477
                     /gene="WDR38"
                     /inference="alignment:Splign:2.1.0"
     exon            478..558
                     /gene="WDR38"
                     /inference="alignment:Splign:2.1.0"
     exon            559..690
                     /gene="WDR38"
                     /inference="alignment:Splign:2.1.0"
     exon            691..840
                     /gene="WDR38"
                     /inference="alignment:Splign:2.1.0"
     exon            841..888
                     /gene="WDR38"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1265
                     /gene="WDR38"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1265
                     /gene="WDR38"
                     /note="major polyA site"
ORIGIN      
        1 cctctgccca gtcctggggt cccgcggccg cctaggaggg agcccgccgg ggcggggcgg
       61 ggccgggtgc ccatgaacag cggggtcccg gccacgctgg ccgtgcggag agtgaaattc
      121 ttcggccagc acggcgggga ggtcaactct tctgccttct cccctgatgg ccagatgctg
      181 ctcacaggct cagaagatgg ctgcgtgtat ggctgggaga cccggagtgg gcagctgctg
      241 tggaggctgg gtggccacac aggccccgtg aagttctgcc gcttctcccc tgatggccac
      301 ctcttcgcca gcgcctcctg tgactgcact gtccgcctgt gggatgtggc aagagcgaag
      361 tgtctgcggg tcctgaaggg tcaccaacgg agtgtggaga cggtcagctt cagccctgac
      421 tcgagacagc tggcatcagg tggctgggac aagcgggtga tgctctggga tgtgcagtcc
      481 ggccagatgc tgcgcctctt agttgggcac cgtgactcca tccagagcag cgacttctca
      541 cccacggtga actgcctggc caccggctcc tgggactcca ccgtacacat ctgggacctg
      601 cggatggtga ccccagcagt ctcccaccag gcgctagagg gacacagtgc caacatcagc
      661 tgcctgtgct attcagcatc cggcctcctg gcatccggct cctgggacaa gaccatccac
      721 atctggaagc ccacaaccag cagcctgctt atccaactga agggccatgt cacctgggtg
      781 aagagcatag ccttctctcc cgacgagctg tggctggcca gcgccggcta ttcccgcatg
      841 gtcaaagtct gggactgcaa cacaggaaag tgccttgaga ccctgaaggg agtcctggat
      901 gtggcccaca cctgtgcctt caccccagat gggaaaatct tagtgtctgg agctgccgat
      961 cagactagac gtcaaatatc ccgcacgtcc aaatcaccca gggaccctca aacctaacac
     1021 caaccacctt agatggtgcc gacctcaccc gctcccctca gtggcgcaca ggcatgccgc
     1081 ttctccccac agacgcaaag tgactgtgct ggcatccagc agatccccat ggccaggact
     1141 ctccaggccc caccagagca gacaactgtg gtgggcagga cgcttgctgg aacccatcag
     1201 acacctggtc cccaaaacca gacccaccca cctccaccca atcagtggaa gtgccaggaa
     1261 acaaa
//
