LOCUS       NM_014023               5137 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens WD repeat domain 37 (WDR37), mRNA.
ACCESSION   NM_014023
VERSION     NM_014023.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5137)
  AUTHORS   Li,Q., Zhao,Y.H., Xu,C., Liang,Y.L., Zhao,Y., He,Q.M., Li,J.Y.,
            Chen,K.L., Qiao,H., Liu,N., Ma,J., Chen,L. and Li,Y.Q.
  TITLE     Chemotherapy-Induced Senescence Reprogramming Promotes
            Nasopharyngeal Carcinoma Metastasis by circRNA-Mediated PKR
            Activation
  JOURNAL   Adv Sci (Weinh) 10 (8), e2205668 (2023)
   PUBMED   36683218
  REMARK    GeneRIF: Chemotherapy-Induced Senescence Reprogramming Promotes
            Nasopharyngeal Carcinoma Metastasis by circRNA-Mediated PKR
            Activation.
REFERENCE   2  (bases 1 to 5137)
  AUTHORS   Sorokina,E.A., Reis,L.M., Thompson,S., Agre,K.,
            Babovic-Vuksanovic,D., Ellingson,M.S., Hasadsri,L., van Bever,Y.
            and Semina,E.V.
  TITLE     WDR37 syndrome: identification of a distinct new cluster of
            disease-associated variants and functional analyses of mutant
            proteins
  JOURNAL   Hum Genet 140 (12), 1775-1789 (2021)
   PUBMED   34642815
REFERENCE   3  (bases 1 to 5137)
  AUTHORS   Sakaguchi,Y., Yoshihashi,H., Uehara,T., Miyama,S., Kosaki,K. and
            Takenouchi,T.
  TITLE     Coloboma may be a shared feature in a spectrum of disorders caused
            by mutations in the WDR37-PACS1-PACS2 axis
  JOURNAL   Am J Med Genet A 185 (3), 884-888 (2021)
   PUBMED   33369122
  REMARK    GeneRIF: Coloboma may be a shared feature in a spectrum of
            disorders caused by mutations in the WDR37-PACS1-PACS2 axis.
            Review article
REFERENCE   4  (bases 1 to 5137)
  AUTHORS   Hay,E., Henderson,R.H., Mansour,S., Deshpande,C., Jones,R.,
            Nutan,S., Mankad,K., Young,R.M., Moosajee,M., Research
            Consortium,G.E. and Arno,G.
  TITLE     Expanding the phenotypic spectrum consequent upon de novo WDR37
            missense variants
  JOURNAL   Clin Genet 98 (2), 191-197 (2020)
   PUBMED   32530092
  REMARK    GeneRIF: Expanding the phenotypic spectrum consequent upon de novo
            WDR37 missense variants.
REFERENCE   5  (bases 1 to 5137)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5137)
  AUTHORS   Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
            Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
            Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
            Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
            Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
            Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
            Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
            Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
            Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
            Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
            Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
            Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
            Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
            Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
            Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
            Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
            Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
            Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
            Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
            Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
            Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
            Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
            Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
            Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
            Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
            Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
            Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
            Heid,I.M. and Fox,C.S.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
  REMARK    GeneRIF: Meta-analysis and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 5137)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of genetic variants with hemorrhagic stroke in Japanese
            individuals
  JOURNAL   Int J Mol Med 25 (4), 649-656 (2010)
   PUBMED   20198315
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5137)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 5137)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of gene polymorphisms with chronic kidney disease in
            Japanese individuals
  JOURNAL   Int J Mol Med 24 (4), 539-547 (2009)
   PUBMED   19724895
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 5137)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022536.13, AL136827.1,
            AB023199.1 and AL607085.8.
            
            On May 17, 2019 this sequence version replaced NM_014023.3.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.104792.1,
                                           SRR1660809.120623.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263150.9/ ENSP00000263150.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-451               AC022536.13        66827-67277         c
            452-473             AC022536.13        66805-66826         c
            474-1712            AL136827.1         1-1239
            1713-2467           AB023199.1         1233-1987
            2468-5062           AL607085.8         8042-10636
            5063-5137           AL607085.8         10637-10711
FEATURES             Location/Qualifiers
     source          1..5137
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.3"
     gene            1..5137
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /note="WD repeat domain 37"
                     /db_xref="GeneID:22884"
                     /db_xref="HGNC:HGNC:31406"
                     /db_xref="MIM:618586"
     exon            1..584
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /inference="alignment:Splign:2.1.0"
     exon            585..762
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /inference="alignment:Splign:2.1.0"
     CDS             625..2109
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /codon_start=1
                     /product="WD repeat-containing protein 37"
                     /protein_id="NP_054742.2"
                     /db_xref="CCDS:CCDS7057.1"
                     /db_xref="GeneID:22884"
                     /db_xref="HGNC:HGNC:31406"
                     /db_xref="MIM:618586"
                     /translation="MPTESASCSTARQTKQKRKSHSLSIRRTNSSEQERTGLPRDMLE
                     GQDSKLPSSVRSTLLELFGQIEREFENLYIENLELRREIDTLNERLAAEGQAIDGAEL
                     SKGQLKTKASHSTSQLSQKLKTTYKASTSKIVSSFKTTTSRAACQLVKEYIGHRDGIW
                     DVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTAS
                     GDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTS
                     LKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPT
                     QRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKV
                     WDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPRSSR
                     QGHRRMVCCSAWSEDHPVCNLFTCGFDRQAIGWNINIPALLQEK"
     exon            763..859
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /inference="alignment:Splign:2.1.0"
     exon            860..955
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1020
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1156
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1228
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1273
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1350
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1585
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1727
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1862
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1977
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..5137
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4899..4904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /note="hexamer: ATTAAA"
     regulatory      4929..4934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /note="hexamer: TATAAA"
     polyA_site      4935
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /note="major polyA site"
     polyA_site      4952
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
     regulatory      5043..5048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /note="hexamer: AATATA"
     polyA_site      5067
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
     regulatory      5119..5124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
                     /note="hexamer: ATTAAA"
     polyA_site      5137
                     /gene="WDR37"
                     /gene_synonym="NOCGUS"
ORIGIN      
        1 actgcggagg agccgaacac tgaccgcgcc gtccccgcca ggctcccgcg cggccggcac
       61 cgcggccctg agcgcaggcg gccccgggtc tcaggcctca ggcggaccgc gccccgggct
      121 cgcagccctc ccgccccggc tgccgggcta cggggcagat ggactcggag cgccccgccg
      181 gtgagtagct acgacccccg aggccacctc ccgcgaaccg ctcggcggca ggagtacgtg
      241 accaagggtg ggggcgttgg cccagcagcc gaaggggtct tcagcgcgcc cagacccctc
      301 ggggctgcgg ggcggaagcc ggggcgtgac ttccggcgcc gccgggtgtg gggcggaggt
      361 gtggggcggc ttccggagaa cccagcggcg cgggactggg gcgggacttc cggcgacacc
      421 ggaagtgcat tagcgccagg ttggggttgt ggggtcgcgt cagtgcggag acagcggtgt
      481 cctgcgcgtc ttcgggtcag tacggggggc cgcgtcgtag ggactcactg gcggtgcgcg
      541 acctgggctg gctccggggg tggcgggcgc agctgctgtg acagcttatt gcaggagtga
      601 ccaggacact acctcctaga agtaatgccc acagaaagcg caagttgttc gactgctcgc
      661 caaacaaaac agaagcgcaa atcccatagc ctttctatac gaagaactaa cagctcggag
      721 caggagagga cgggactgcc aagagacatg ttagaaggac aagattctaa actgccttcc
      781 tcggttcgca gtacacttct ggaactgttt ggtcaaatag aaagagaatt tgaaaacctt
      841 tatatcgaaa acttagaatt acgtagagaa atcgacactc ttaatgaacg tttagctgct
      901 gaaggacaag cgattgatgg agcagagctg agtaagggcc aactcaaaac aaaagccagt
      961 cacagcacca gccagctctc ccagaaactg aagaccactt acaaggcttc caccagcaag
     1021 attgtctcca gctttaagac cacgacatcg agagctgcct gccagctcgt gaaggagtac
     1081 atcggccacc gggacggcat ctgggatgtc agcgtggcca agacacagcc agtggtgctc
     1141 gggactgcat cagccgatca cacggctttg ctgtggagca tagagacagg gaagtgccta
     1201 gtcaagtacg caggccacgt gggctcagta aattctatca aatttcatcc ctcagagcag
     1261 ttggctctca ctgcttctgg agatcagact gctcatatct ggagatacgc ggtgcagctg
     1321 ccgacacccc agcctgttgc tgacactagt atatctgggg aagatgaagt agagtgctct
     1381 gacaaggacg agcccgacct cgatggggat gtgtccagcg actgccccac catccgcgtc
     1441 ccactgacat ccctcaagag ccaccagggc gtggtcatcg cctccgactg gctggttggg
     1501 gggaagcagg ctgtgactgc ctcctgggac cggacggcaa acctgtacga cgtggagacg
     1561 tccgagctcg ttcactctct gacagggcac gaccaggagt tgacgcactg ctgcacacac
     1621 cccacccagc ggctcgtggt gacctcctcc cgtgacacga ctttccgcct ctgggatttc
     1681 agggacccct ccatccactc ggtgaatgtt ttccagggac acacggacac tgtgacttct
     1741 gccgtgttca ccgtgggaga caacgtggtt tcaggcagcg atgaccgcac ggtgaaagtc
     1801 tgggacttga aaaatatgag atcccccatt gcaactattc gcacggactc tgccattaac
     1861 aggatcaatg tatgtgtcgg ccaaaaaatc atagccctcc cccatgacaa ccgacaagtg
     1921 agactgtttg atatgtcagg agtgcgcctg gcgcggcttc cccggagcag ccgacagggc
     1981 cacaggagaa tggtatgctg ctcggcatgg agtgaagacc accccgtgtg caatctgttc
     2041 acctgtgggt ttgaccggca agccattggt tggaacatca acatccctgc attgctacaa
     2101 gaaaaataag gacaccggca gcccttagtt tcactgtttg ccagcacaga cctttgatgg
     2161 gtgcaggctt ttctgcgtat taatcagcca tttttgtgag agtttgaccc tggaaagggt
     2221 gctttgtata tgttcttttc acatagtgcc cagcttgcat gaaatgtaca gagaaatgtg
     2281 tggtcgtatt ttttactttt gtcttgtata tgtatgtata ttgggtcctc tgggcagtag
     2341 aggcaaagct cacctcccat gtagcacatg aaatgcttgt gagttgttga cattggacag
     2401 gtgaacagta gggcattaca tttgtgtgaa ttaaatgtga acttctgtat tacgttgcgg
     2461 cgtcggcagt cctgcgttcc ctggagtaac tgtacgtatc tgcctttgct gggaagactg
     2521 tggggctgcc tgtgttggct ggcgaccagc aggattgctc caggattttg tgtttacctc
     2581 gcgtgaagtt cagcacgtgc tgtcgtgtag tcagcttcta ctctaatttc tgttacagtt
     2641 ctgcaaaggt aacctggagt ttagaagtta aaaaaaagca tgggatgttg gatttgcacc
     2701 atttggagtt tctttaggaa agaaaagttt tctgcttttt tatagaaaat catttcagtc
     2761 tcccgaggtc tcatgctagc aaattttgaa ataggattct aatcactgat ttcaaatatt
     2821 aagcaaaatg taaagcactt taatttatag ctatggttat aaacaggttt tagatgtttc
     2881 aaatgacttg tccactgaat gtcacttgac cttgataaga ggccgcctgc acacagagcc
     2941 cagttaattc tccgcacctc ggttgtgtgc ttccgaatgg gctcactccc gtggtggtgt
     3001 ttgagagcca acaacactac ctcagagacg ggtctttggg aaactttggg tctcactgtt
     3061 gcctggctgg agcactttgg tttatagctg gaatactgag ttcagttcag aaggcaggaa
     3121 agacagtcac accgacgtgt cctgaaggtg taggctctcc acttaggcgc acaagctgac
     3181 ggctgcagcc agcaggcccc ggtgacgaga cacttccagg tcttgtggtg gggacgcctc
     3241 tcagtgccag tcccgccact gctgagtgag cctggtgttc ttgccttctt ggaaattact
     3301 gctcacctgg tatctgtacg ttaatgtttc ttgctgagtt acagttttga taaagaggct
     3361 ctcatttcct gtgtcttgta tattcagtcc tttcaatacg tccacctgga ggctcaccac
     3421 ttggagagac acaggaaggt aatatttaca gctgtcatgt gacatcccca ggtctttgtg
     3481 ttttgccctg ttttacggtg aggtaggagg gaacccatct ggggaccggt aggtgcaggt
     3541 gcagtaggac gtgggacttt tggacccgtc ctttggtgca gctcgccagg gatgagaggc
     3601 acctccctac ttgggtcttc aggagctggt ccaaggagct tcgaatctaa gtcatctaga
     3661 atgaccctga aatgactgac agccccgggc ccaagaaaaa cccataacca cctcagatgg
     3721 atctgacgtg gctaagggac aaacagcaaa tatttcagtc attttgattt tacaaataaa
     3781 aaatgtgttg tgtttttgtc cgacattatt tcctgactgc actgttctga gaatggagtc
     3841 cacctggtcc ctctggttga ttagaatctc aggtttcagc tcctgctgtc ctgagcgaac
     3901 ttgcctgatg cagggctgtg ctgtgtccag atgttgctgg ggcctcactt tttctcttgg
     3961 ctggaggtcc aattgccaga gcctcccaca ctgcacatac aaaggtctga gcccagggca
     4021 gcttctgggg ccactgcaca ggccacctgc ttgggttcct cggagtttaa tttgaaagtc
     4081 tgggtgtctt aggatgatgg ttaggaacat tgaaaaatgg ctgcaaatag ccaaatcaaa
     4141 cttaagaacc agatctctgc cagattaaac atttttgaag cttttaaaag tcaatattcc
     4201 tagtggccac tgagttccag gcacactggt gccctttact gccacagctg ctcaccttgt
     4261 ctggcaaact ggagggacct cagaaactgg actcctgcat gtccttgggg gcgcagccct
     4321 gtggtgctca ggcagagctc tcaggagccg gggcaccttg ctgttcgctg ctgtgtcgtc
     4381 ttctaatgtg agctcatcca ctgctgctgc agcgtggtga tcaggagtca cagacaagat
     4441 cggggatggt gtgtgtgtgt gtgtgtgtgt gtgtgtgcac gtgtgtgtgg ctaaattaag
     4501 tcatactgtc aaccacacgt gatctcgtct gaaacagtgt ttggaagtgg gaacagtttt
     4561 gtcctgtatg ctgatgtgtc cagaatttca tttaatgata gacggaaaat gtgtggttac
     4621 tgaaaactgt atatgataca gaatttcata agagccatgc tgttgggcaa agcaactctt
     4681 tttcaaccac tgctcatcag tttctgtaga gacaaaaact ctgtacatat tttggaatct
     4741 gaagaatcct atgtaaatca tttgttactt aagtctgtga aaaacatatt tctttggagg
     4801 aaaatgtatg catttataag tgttccatgg aatcagtttt tattgtatcg atataattgt
     4861 ctctaagtgt tgactgtctt cattgcaata tgaaattcat taaaatgtcc atgttccata
     4921 attactatta taaaagcttt gtgttattgg gagtcttatt atttttatag tttttcatgt
     4981 tttgctttgg tgaaacattg tgaatgacta tataaacatc acgatgagct agaaattgaa
     5041 caaatataat actggtcact cgaaaaattt ttagacttaa aaagtcagtt gtgttttgtg
     5101 tctgtctctt atgctaacat taaacaatac ataatta
//
