LOCUS       NM_139281               6416 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens WD repeat domain 36 (WDR36), mRNA.
ACCESSION   NM_139281
VERSION     NM_139281.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6416)
  AUTHORS   Meer,E., Aleman,T.S. and Ross,A.G.
  TITLE     WDR36-Associated Neurodegeneration: A Case Report Highlights
            Possible Mechanisms of Normal Tension Glaucoma
  JOURNAL   Genes (Basel) 12 (10), 1624 (2021)
   PUBMED   34681019
  REMARK    GeneRIF: WDR36-Associated Neurodegeneration: A Case Report
            Highlights Possible Mechanisms of Normal Tension Glaucoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6416)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 6416)
  AUTHORS   Su,H.A., Li,S.Y., Yang,J.J. and Yen,Y.C.
  TITLE     An Application of NGS for WDR36 Gene in Taiwanese Patients with
            Juvenile-Onset Open-Angle Glaucoma
  JOURNAL   Int J Med Sci 14 (12), 1251-1256 (2017)
   PUBMED   29104481
  REMARK    GeneRIF: Study suggests that WDR36 gene is involved in the
            pathogenesis of juvenile open-angle glaucoma in Taiwan population
            as a subordinate modifier gene.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6416)
  AUTHORS   Liu,K., He,W., Zhao,J., Zeng,Y. and Cheng,H.
  TITLE     Association of WDR36 polymorphisms with primary open angle
            glaucoma: A systematic review and meta-analysis
  JOURNAL   Medicine (Baltimore) 96 (26), e7291 (2017)
   PUBMED   28658128
  REMARK    GeneRIF: Meta-analysis does not support a significant role of WDR36
            in the genetic susceptibility of primary open angle glaucoma or its
            subtypes.
            Review article
REFERENCE   5  (bases 1 to 6416)
  AUTHORS   Zhou,T., Souzeau,E., Siggs,O.M., Landers,J., Mills,R., Goldberg,I.,
            Healey,P.R., Graham,S., Hewitt,A.W., Mackey,D.A., Galanopoulos,A.,
            Casson,R.J., Ruddle,J.B., Ellis,J., Leo,P., Brown,M.A.,
            MacGregor,S., Sharma,S., Burdon,K.P. and Craig,J.E.
  TITLE     Contribution of Mutations in Known Mendelian Glaucoma Genes to
            Advanced Early-Onset Primary Open-Angle Glaucoma
  JOURNAL   Invest Ophthalmol Vis Sci 58 (3), 1537-1544 (2017)
   PUBMED   28282485
  REMARK    GeneRIF: The association between WDR36 and POAG was not supported,
            and the majority of POAG cases did not harbor a potentially
            disease-causing variant in the remaining Mendelian genes.
REFERENCE   6  (bases 1 to 6416)
  AUTHORS   Pang,C.P., Fan,B.J., Canlas,O., Wang,D.Y., Dubois,S., Tam,P.O.,
            Lam,D.S., Raymond,V. and Ritch,R.
  TITLE     A genome-wide scan maps a novel juvenile-onset primary open angle
            glaucoma locus to chromosome 5q
  JOURNAL   Mol Vis 12, 85-92 (2006)
   PUBMED   16518310
  REMARK    GeneRIF: Our results provided mapping of a novel locus for
            juvenile-onset primary open angle glaucoma at 5q and excluded
            coding or splicing junctions mutations within the WDR36 gene.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6416)
  AUTHORS   Monemi,S., Spaeth,G., DaSilva,A., Popinchalk,S., Ilitchev,E.,
            Liebmann,J., Ritch,R., Heon,E., Crick,R.P., Child,A. and
            Sarfarazi,M.
  TITLE     Identification of a novel adult-onset primary open-angle glaucoma
            (POAG) gene on 5q22.1
  JOURNAL   Hum Mol Genet 14 (6), 725-733 (2005)
   PUBMED   15677485
  REMARK    GeneRIF: role in etiology of both high- and low-pressure glaucoma.
            GeneRIF: First series of WDR36 mutations in subjects with high- and
            low-pressure adult-onset primary open angle glaucoma. First mRNA
            expression profiling of this gene in various ocular and non-ocular
            tissues for human and mouse.
REFERENCE   8  (bases 1 to 6416)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   9  (bases 1 to 6416)
  AUTHORS   Bernstein,K.A., Gallagher,J.E., Mitchell,B.M., Granneman,S. and
            Baserga,S.J.
  TITLE     The small-subunit processome is a ribosome assembly intermediate
  JOURNAL   Eukaryot Cell 3 (6), 1619-1626 (2004)
   PUBMED   15590835
REFERENCE   10 (bases 1 to 6416)
  AUTHORS   Mao,M., Biery,M.C., Kobayashi,S.V., Ward,T., Schimmack,G.,
            Burchard,J., Schelter,J.M., Dai,H., He,Y.D. and Linsley,P.S.
  TITLE     T lymphocyte activation gene identification by coregulated
            expression on DNA microarrays
  JOURNAL   Genomics 83 (6), 989-999 (2004)
   PUBMED   15177553
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF385437.1 and AC008572.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 24, 2020 this sequence version replaced NM_139281.2.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. Mutations in this
            gene have been associated with adult-onset primary open-angle
            glaucoma (POAG). [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2607944.1,
                                           SRR11853559.26239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000513710.4/ ENSP00000424628.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2873              AF385437.1         177-3049
            2874-6416           AC008572.6         147911-151453
FEATURES             Location/Qualifiers
     source          1..6416
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.1"
     gene            1..6416
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /note="WD repeat domain 36"
                     /db_xref="GeneID:134430"
                     /db_xref="HGNC:HGNC:30696"
                     /db_xref="MIM:609669"
     exon            1..271
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2797
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /note="T-cell activation WD repeat protein; T-cell
                     activation WD repeat-containing protein"
                     /codon_start=1
                     /product="WD repeat-containing protein 36"
                     /protein_id="NP_644810.2"
                     /db_xref="CCDS:CCDS4102.2"
                     /db_xref="GeneID:134430"
                     /db_xref="HGNC:HGNC:30696"
                     /db_xref="MIM:609669"
                     /translation="MERASERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTT
                     CVGKSFHTYDVQKLSLVAVSNSVPQDICCMAADGRLVFAAYGNVFSAFARNKEIVHTF
                     KGHKAEIHFLQPFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHPSTY
                     LNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIH
                     NIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAH
                     STAIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYGQ
                     NGQQILSASQDGTLQSFSTVHEKFNKSLGHGLINKKRVKRKGLQNTMSVRLPPITKFA
                     AEEARESDWDGIIACHQGKLSCSTWNYQKSTIGAYFLKPKELKKDDITATAVDITSCG
                     NFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLK
                     FWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQ
                     GQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLNVSMSPTGDFLAT
                     SHVDHLGIYLWSNISLYSVVSLRPLPADYVPSIVMLPGTCQTQDVEVSEETVEPSDEL
                     IEYDSPEQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPG
                     LVPRYAAPEQNNDPQQSKVVNLGVLAQKSDFCLKLEEGLVNNKYDTALNLLKESGPSG
                     IETELRSLSPDCGGSIEVMQSFLKMIGMMLDRKRDFELAQAYLALFLKLHLKMLPSEP
                     VLLEEITNLSSQVEENWTHLQSLFNQSMCILNYLKSALL"
     exon            272..299
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            300..400
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            401..518
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            519..651
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            652..706
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            707..839
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1015
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1136
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1202
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1289
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1435
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1550
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1716
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1825
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1905
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2013
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2111
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2257
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2377
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2459
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2647
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..6416
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4258..4263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /note="hexamer: AATAAA"
     polyA_site      4278
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /note="major polyA site"
     regulatory      5595..5600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /note="hexamer: AATAAA"
     polyA_site      5625
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
     regulatory      6396..6401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /note="hexamer: AATAAA"
     polyA_site      6416
                     /gene="WDR36"
                     /gene_synonym="GLC1G; TA-WDRP; TAWDRP; UTP21"
                     /note="major polyA site"
ORIGIN      
        1 gttgtgtctg cagctctggc agaggactgt tccactagac acgctgaagg gactgggtac
       61 gtgttttcct tcaggaccag agctgagagg agctgggatc gcggcggcaa tggaacgggc
      121 ctcagaaagg cgcacggcca gcgcgctttt tgcggggttc cgggccttgg gacttttcag
      181 caacgacatt ccacacgtgg tgcggttcag cgcgctcaag cgccggttct atgtaacaac
      241 ctgcgtgggc aagagtttcc acacctatga cgttcagaaa cttagtctgg ttgcagtaag
      301 taattctgtt ccacaggata tctgctgtat ggcagctgat ggcagattag tctttgctgc
      361 ttatggaaat gttttctctg catttgcccg taataaagag atagtacata cctttaaggg
      421 tcataaggca gaaatccatt tcttgcaacc ctttggagac cacattatct ctgttgatac
      481 tgatggcatt cttattattt ggcacatata ttcagaagaa gaatacctgc agttgacttt
      541 tgataaatca gtatttaaaa tttctgcaat tttgcatcca agtacctact tgaataaaat
      601 acttctgggc agtgaacaag gaagcctgca gttgtggaat gtaaaatcca ataaacttct
      661 atatacattt ccaggatgga aagttggagt gacagctctt cagcaggcac cagccgtgga
      721 tgttgttgct attggtctta tgtcaggtca agttatcatt cacaacatta aatttaatga
      781 aacattaatg aagtttcgtc aagactgggg acccattact tcaatttcat ttcgcacaga
      841 tggtcatcca gtaatggcag ctggaagccc atgtggccat attggactct gggatctaga
      901 agacaaaaaa ttaatcaacc aaatgagaaa tgcacactct acagcaattg ccggactgac
      961 atttctccat agagagccac ttcttgtcac aaatggcgct gacaatgctc ttaggatatg
     1021 gatatttgat ggtcctacag gtgaaggccg acttttgaga ttcagaatgg gtcatagtgc
     1081 tcctcttacc aatatcagat attatggaca gaatggacag cagattctaa gtgcaagtca
     1141 agatggaact cttcagtcat tttccacggt acatgaaaaa ttcaataaga gcttgggaca
     1201 tggattaata aataaaaaga gagttaaacg taaaggactt cagaatacca tgtcagtgag
     1261 acttccaccc atcacaaagt ttgcagcaga ggaagctcgt gaaagtgact gggatggtat
     1321 cattgcttgc catcaaggta agctatcttg ctcaacctgg aattatcaga aatctacaat
     1381 aggcgcttac tttctcaagc caaaagagtt gaagaaagat gacataactg caacagcagt
     1441 ggatataact tcttgtggaa actttgctgt aattggcctc tcatcaggaa ctgtagatgt
     1501 atataacatg cagtctggca tacatcgagg aagttttggc aaggatcaag ctcacaaggg
     1561 atctgttaga ggtgtcgcag tggatggatt aaaccagttg acagttacaa ctggtagtga
     1621 aggattactc aaattctgga actttaaaaa caaaatttta atccattctg tgagcctcag
     1681 ttcatctcca aatatcatgt tgctacatag ggacagtggc attctgggac tcgccttgga
     1741 tgacttctcc attagtgttc tggacataga aactaggaag attgtcagag agttttctgg
     1801 acaccaaggc caaataaatg acatggcttt tagtcctgat ggtcgttggt taataagtgc
     1861 tgcgatggat tgctctatta ggacttggga ccttccttct gggtgcctta tagactgctt
     1921 tttgttggac tcggctcctc tcaatgtttc tatgtctcct actggagact ttctggcaac
     1981 ttcccatgtg gaccaccttg gaatttatct atggtccaat atttccctgt attcagttgt
     2041 ttcattacgg ccacttcctg cagattatgt cccttcaata gtcatgcttc ctggtacttg
     2101 tcaaacccaa gatgtagaag tatcagaaga aacagtagaa ccaagtgatg aattgataga
     2161 atatgattcg ccagaacagt tgaatgagca attggtgact ctttcacttc ttcctgaatc
     2221 acgatggaaa aaccttctta accttgatgt tattaagaaa aagaataaac caaaggaacc
     2281 acccaaagta cccaaatcag caccattttt cattccaaca attcctggcc ttgtacccag
     2341 atatgctgca cctgaacaaa ataatgatcc ccagcagtct aaagtggtaa atcttggagt
     2401 tttggctcaa aaatcagatt tctgcttgaa acttgaagaa ggactggtaa ataataagta
     2461 tgacactgct ctcaaccttc tgaaagaatc aggcccatca ggaattgaaa cagagctgcg
     2521 aagcttgtct cctgattgtg gtgggtccat agaagttatg cagagcttct tgaaaatgat
     2581 tgggatgatg ctggacagaa agcgtgattt tgagttagcc caggcatacc ttgcattgtt
     2641 tctaaagtta caccttaaaa tgcttccttc agagccagta ctcctagaag aaataacaaa
     2701 tttgtcatcc caggtggaag aaaactggac ccatttgcaa tcactcttca atcaaagcat
     2761 gtgtatttta aattatctca aaagtgcttt gttgtaaaaa taaatttgtg actaaacaaa
     2821 gactttcata ttaaatgggt tcaattgaac tcatttctta ttttccaagt gtcaatgtga
     2881 aaagaaaata aatgctagca ctactgacta gtcagtatat ctccacttta aatgctaaat
     2941 actttcttga aataaaatcg cacctcccgg ccaggcatga tggataatgc ctgtaattcc
     3001 agcactttca gaggccaaag cgggaggatt gcttgaagcc aggaatttga gcccagcctg
     3061 ggcaacatag caagcaagat cccatctcta caaaaagtta aaaaaataaa ttacacctgc
     3121 cttttgtttt gaagacttaa agaatctgct caaatgattt attttctgag tctcttcaca
     3181 ttaactttta tatgattttt aaaaaattat tacctgctta tattttttga gtatctgttt
     3241 catataaaga gatgctgcat gttcactgtg aagtattgct gaattaaatt gaaaatgtca
     3301 gataaaactg atacatgatg tagttataaa aatgctgtta tgaagaaaaa aggaatgctt
     3361 ttttcctcgg tggcctttga taaaaatatg aatgattgac tctcagagtt ggaggataaa
     3421 ctaatcatct tctagcacag ccctgttgtg ttgcaggaga ggaatcaggc taaagtctgc
     3481 tggtatttca gtgacagatt aaaactttct aacagtggcc tagtgctttc tccattgtaa
     3541 tgtactgaaa ggaagttgtt catggatcag aaatgtggga ggcccttcct tgcccaaggc
     3601 aagtcgctgt agatggttaa actgatacca aggataggta agggaaattc caaattccat
     3661 tggaagatgg ccttttactg acactgcaga catgtagata acaatagttt aatgtcctct
     3721 gaaaaggtaa aaattccata aatccttgca aacaattttt agcaatattg tttattgcta
     3781 ccacagccaa gaatgggtat ttcaaagcca gggttttttt tattttgttt tgttttgttt
     3841 tttttttttt ttttttggct acactttttt gggggggacc ttttaatttg ggaagaaaat
     3901 gctgagtata cttttctttc acaaccattg caaacccagg tagccctgga gttttctttt
     3961 tttctcatca tcattgtttt gtttttttta tggttcaaga cttttgcaat acatgaatta
     4021 aaaataagca gttctttaaa gcatagcgct ctaaaaacta ttcttagttt ataccctcaa
     4081 aagttgggtc tttcatgaaa cacagtggtt tgaatatgaa caccagtagc attctcgttc
     4141 gttgttaggg taagagagtt ttgtagaatg atctccaaaa gaagcagtcc tcaaaaggca
     4201 tttaccagtg atatctttta atattcatgt ttttatttaa tgatgtaaga tagaattaat
     4261 aaactactaa ggaaataagc caatgtggtt attgtactca atttcgtttt tcttttagaa
     4321 atgtgtattg acttattaaa gccactgaca gaaatgttaa tcatgactta agttctaatt
     4381 taaaaaacta ttttcctctt tcctaaatac tatattctaa attggaatat ggcaaaatcc
     4441 caatatataa ttctatacct agtaaagatt gtaaataact aaaacaaaat gataagagct
     4501 gtgaactgaa attgtattgc ttacagaaat catgaaccga attttcttct ctttttaaag
     4561 tgagcataaa gacttaagtg tattgttacc agagatatat ttagatagaa tacatcattt
     4621 tggcaggtaa tcttctagaa cctttcatgt actgtttcca tcaagggagg gaaagaaata
     4681 gaaaatataa ttttatctat attttcctta aaatatatca atctgtgcac actctttcag
     4741 ttttttaatt actcatgtaa tatatgacta cattttgctt gtgtgctttt tgaaaaccat
     4801 cttcagtccc aatatcctct gtagaagtaa tagttttaac tctcctagat cttcttttag
     4861 agtgttttta tgagtgttta atgtaggaat gtgtatatat tatctacagc cacaggaaat
     4921 gtatagttac gatttttaca tacgtgtatg tatattattg tacaacttgc tatttctact
     4981 tgggagtttt ttattttggt acattcacat ttacctaatc tcttgtgcac tgtccaacag
     5041 tactttgcct ataatagaca cttaaggaag ttttccttct ttttattcct ttataattac
     5101 aaacaatgct gaaaggaaca tcatcctaca tgagcccttt ttgtacatat aaggctctct
     5161 ctgtggtata tgcttaggat ttgaatttca ggccagagta taaccatttt taatttgaag
     5221 agatacttcc atttgggttc cagaatggct gtatcaagtt acagttcccc tgagcaagat
     5281 atgagcatct gcttccccat gtaattaatg acacttgcta ttggattttt gtaatttaat
     5341 tactctgaaa aaattatttt ggttttaaat cagaaatttc tcactagtga agatggacat
     5401 atttttgtat gtttatttta gaacatataa acatttgtta attttctttt tcctctcatt
     5461 tttctattga atgatttgtc cttttatctc atggatttgt taggagttct cttgtatttt
     5521 ctgtatttta tgtctgttgc caatgttttc tcctacttag ccatttggct ttaattttac
     5581 atggtgtctg tttaaataaa tgttttatat ttgtatacaa tcaaattgat taattttcat
     5641 gacttatttc aggatataaa gcaaattatt ttctaagaca tttacagtgt atgttttcct
     5701 atgtttacat gtgctcattt cacgtcatgt attttcctct acgacatgtt tctgtgtgag
     5761 tagttaacat gtagatcttt agaattgatt tttctgaaga gtgaaacagc gctgcttcca
     5821 atatctgttc aaaattcatt tattgaaaag tccactcata tgtctgattt gaaatgctgt
     5881 ttcattatgt gttaaattct ttcactgagc tcttccatat tcctagtaaa tgatgcatta
     5941 ctttggtatg ttctcagatt tgggtaaagc cttcctcatg ttctataaaa attggttaac
     6001 tgctggtgag cacatctctt gaagttttga tatgggttgc acaacattta taggactgat
     6061 ttggagagac cgacaatacc gagtgcagtc ctcccttggt atctagttcc aggacccctg
     6121 tggataccaa aatccaagca atgccctgca gatcatggga cctatgcata tgaaaagtcg
     6181 gtccttgtat ttgagggttt tgcatccctc aaataccata tgttttattt gtgtttggtt
     6241 gaaaaaagtt tgcatataag tgaaacttag catttcaaac ctgtgttgtt caaagatcat
     6301 ttgtatttct cttcaagaac aatgaatgtc ttcattaaat catcttttgt gggagagctt
     6361 ttggtttcat agattttcat atatatatat gatataataa acactttttg acattc
//
