LOCUS       NM_020779               6898 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens WD repeat domain 35 (WDR35), transcript variant 2,
            mRNA.
ACCESSION   NM_020779
VERSION     NM_020779.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6898)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6898)
  AUTHORS   Sekiguchi,T., Ishii,T., Kobayashi,H. and Furuno,N.
  TITLE     WDR35 is involved in subcellular localization of acetylated tubulin
            in 293T cells
  JOURNAL   Biochem Biophys Res Commun 547, 169-175 (2021)
   PUBMED   33610917
  REMARK    GeneRIF: WDR35 is involved in subcellular localization of
            acetylated tubulin in 293T cells.
REFERENCE   3  (bases 1 to 6898)
  AUTHORS   Walczak-Sztulpa,J., Wawrocka,A., Stanczyk,M., Pesz,K.,
            Dudarewicz,L., Chrul,S., Bukowska-Olech,E., Wieczorek-Cichecka,N.,
            Arts,H.H., Oud,M.M., Smigiel,R., Grenda,R., Obersztyn,E.,
            Chrzanowska,K.H. and Latos-Bielenska,A.
  TITLE     Interfamilial clinical variability in four Polish families with
            cranioectodermal dysplasia and identical compound heterozygous
            variants in WDR35
  JOURNAL   Am J Med Genet A 185 (4), 1195-1203 (2021)
   PUBMED   33421337
  REMARK    GeneRIF: Interfamilial clinical variability in four Polish families
            with cranioectodermal dysplasia and identical compound heterozygous
            variants in WDR35.
REFERENCE   4  (bases 1 to 6898)
  AUTHORS   Xu,Y., Zhuo,Y., Ye,M., Li,M., Tang,X. and Zhou,L.
  TITLE     Association study of genetic variants at TTC32-WDR35 gene cluster
            with coronary artery disease in Chinese Han population
  JOURNAL   J Clin Lab Anal 35 (2), e23594 (2021)
   PUBMED   33009702
  REMARK    GeneRIF: Association study of genetic variants at TTC32-WDR35 gene
            cluster with coronary artery disease in Chinese Han population.
REFERENCE   5  (bases 1 to 6898)
  AUTHORS   Mill,P., Lockhart,P.J., Fitzpatrick,E., Mountford,H.S., Hall,E.A.,
            Reijns,M.A., Keighren,M., Bahlo,M., Bromhead,C.J., Budd,P.,
            Aftimos,S., Delatycki,M.B., Savarirayan,R., Jackson,I.J. and
            Amor,D.J.
  TITLE     Human and mouse mutations in WDR35 cause short-rib polydactyly
            syndromes due to abnormal ciliogenesis
  JOURNAL   Am J Hum Genet 88 (4), 508-515 (2011)
   PUBMED   21473986
  REMARK    GeneRIF: Through structural modeling, we show that WDR35 has strong
            homology to the COPI coatamers involved in vesicular trafficking
            and that short-rib polydactyly mutations affect key structural
            elements in WDR35.
REFERENCE   6  (bases 1 to 6898)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
REFERENCE   7  (bases 1 to 6898)
  AUTHORS   Gilissen,C., Arts,H.H., Hoischen,A., Spruijt,L., Mans,D.A.,
            Arts,P., van Lier,B., Steehouwer,M., van Reeuwijk,J., Kant,S.G.,
            Roepman,R., Knoers,N.V., Veltman,J.A. and Brunner,H.G.
  TITLE     Exome sequencing identifies WDR35 variants involved in
            Sensenbrenner syndrome
  JOURNAL   Am J Hum Genet 87 (3), 418-423 (2010)
   PUBMED   20817137
  REMARK    GeneRIF: WDR35 is homologous to TULP4 (from the Tubby superfamily)
            and has previously been characterized as an intraflagellar
            transport component, confirming that Sensenbrenner syndrome is a
            ciliary disorder.
REFERENCE   8  (bases 1 to 6898)
  AUTHORS   Feng,G.G., Li,C., Huang,L., Tsunekawa,K., Sato,Y., Fujiwara,Y.,
            Komatsu,T., Honda,T., Fan,J.H., Goto,H., Koide,T., Hasegawa,T. and
            Ishikawa,N.
  TITLE     Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor
            necrosis factor-induced apoptosis
  JOURNAL   Biochem Biophys Res Commun 394 (1), 153-157 (2010)
   PUBMED   20193664
  REMARK    GeneRIF: These results indicated that naofen may function as a
            novel modulator activating caspase-3, and promoting
            TNF-alpha-stimulated apoptosis.
REFERENCE   9  (bases 1 to 6898)
  AUTHORS   Da Silva,J.D., Tkachenko,N. and Soares,A.R.
  TITLE     Ellis-van Creveld Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37903214
REFERENCE   10 (bases 1 to 6898)
  AUTHORS   Tan,W., Lin,A. and Keppler-Noreuil,K.
  TITLE     Cranioectodermal Dysplasia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24027799
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC036659.2, AB037757.2,
            BX476609.1 and BC033951.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_020779.3.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. Multiple
            alternatively spliced transcript variants encoding distinct
            isoforms have been found for this gene. Two patients with
            Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were
            identified with mutations in this gene, consistent with a possible
            ciliary function.[provided by RefSeq, Sep 2010].
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            coding region, as compared to variant 1. The encoded isoform 2 thus
            lacks an internal segment, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.1972141.1,
                                           SRR14038193.1859896.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281405.9/ ENSP00000281405.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2688              BC036659.2         18-2705
            2689-3833           AB037757.2         2748-3892
            3834-3917           BC036659.2         3851-3934
            3918-4125           AB037757.2         3977-4184
            4126-4133           BX476609.1         574-581
            4134-6891           AB037757.2         4193-6950
            6892-6898           BC033951.1         1035-1041
FEATURES             Location/Qualifiers
     source          1..6898
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.1"
     gene            1..6898
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /note="WD repeat domain 35"
                     /db_xref="GeneID:57539"
                     /db_xref="HGNC:HGNC:29250"
                     /db_xref="MIM:613602"
     exon            1..114
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..3603
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /note="isoform 2 is encoded by transcript variant 2;
                     naofen; WD repeat-containing protein 35; intraflagellar
                     transport protein 121 homolog"
                     /codon_start=1
                     /product="WD repeat-containing protein 35 isoform 2"
                     /protein_id="NP_065830.2"
                     /db_xref="CCDS:CCDS1695.1"
                     /db_xref="GeneID:57539"
                     /db_xref="HGNC:HGNC:29250"
                     /db_xref="MIM:613602"
                     /translation="MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLE
                     TQTDDAKLRGLAAPSNLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYK
                     GSWIEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLS
                     HVTWSADSKVLLFGMANGEIHIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYHGTEG
                     YVEPDCPCLAVCFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQKA
                     AMQDKDVNIVQFYTPFGEHLGTLKVPGKEISALSWEGGGLKIALAVDSFIYFANIRPN
                     YKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNNEKYVKYVKGLISITTCGDFCILATKA
                     DENHPQFVLVLCNSIGTPLDPKYIDIVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLT
                     ALEINQITRSRKEGRERIYHVDDTPSGSMDGVLDYSKTIQGTRDPICAITASDKILIV
                     GRESGTIQRYSLPNVGLIQKYSLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVT
                     DSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYI
                     CNFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDN
                     PHPRLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFVKRLGKLLSESMKQAEVVGYF
                     GRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGDY
                     FADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPENHKLLPEIAQMFV
                     RVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLL
                     EKNKTLDAIELYRKANYFFDAAKLMFKIADEEAKKGSKPLRVKKLYVLSALLIEQYHE
                     QMKNAQRGKVKGKSSEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLY
                     EGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACASRAFGTCSKAFIKLKSLETLSS
                     EQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTCVATGSPITEYQFWMCSV
                     CKHGVLAQEISHYSFCPLCHSPVG"
     exon            115..232
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            233..304
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            305..397
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            398..526
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            527..660
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            661..826
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            827..972
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1098
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1284
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1345
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1490
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1560
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1614
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1724
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1935
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2016
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2153
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2357
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2504
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2637
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2748
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2913
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3054
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3211
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            3212..3452
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..6898
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3896..3901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /note="hexamer: AATAAA"
     polyA_site      3921
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /note="major polyA site"
     regulatory      6878..6883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
                     /note="hexamer: AATAAA"
     polyA_site      6898
                     /gene="WDR35"
                     /gene_synonym="CED2; CFAP118; FAP118; IFT121; IFTA1;
                     SRTD7"
ORIGIN      
        1 ccggagctgc tggtactccc gattggagac gtagaaccgt tacttgtcga gggccttagc
       61 ggccgccgtg accctctcgg ggatcccacg atgttcttct acctgagcaa gaaaatttcc
      121 attcccaata acgtgaagct gcagtgtgta tcctggaaca aggaacaagg gttcatagca
      181 tgcggtggtg aagatggatt actgaaagtt ttgaaattag agacgcagac agatgatgca
      241 aaattgaggg gccttgcagc ccccagtaac ctttctatga atcagactct tgaaggtcat
      301 agtggttctg ttcaagttgt aacatggaat gagcagtatc agaagttgac taccagtgat
      361 gaaaacgggc ttatcattgt gtggatgtta tataaaggct cttggattga ggagatgatc
      421 aacaatcgaa ataaatcagt tgttcgcagt atgagctgga atgctgacgg acagaagatc
      481 tgcattgtat atgaagatgg ggctgtgata gttggttcag tggatggcaa tcgtatttgg
      541 ggaaaagacc tgaagggtat acagctatcc catgtaacat ggtctgcgga cagtaaagtc
      601 ttactttttg gaatggcaaa tggggaaata cacatttacg ataatcaagg aaattttatg
      661 ataaaaatga aactgagttg tttggtgaat gtcactggag ctatcagcat tgctggaatt
      721 cattggtacc atggcacaga aggctacgtg gagcctgatt gcccttgcct tgctgtttgc
      781 tttgataatg gaagatgcca aataatgaga catgagaatg accaaaatcc cgttttgatt
      841 gacactggca tgtacgtagt aggcatccag tggaaccaca tgggcagcgt gttagctgtg
      901 gcaggcttcc agaaggcagc catgcaggac aaagatgtga acattgtgca gttttacact
      961 ccgtttggtg agcatctggg tactttgaaa gttcctggaa aggaaatatc tgcactatct
     1021 tgggaaggag gtggactgaa aattgcacta gctgttgatt cctttatata ttttgcaaac
     1081 attcgaccta attataagtg gggttattgc tcaaacactg tagtttatgc atataccaga
     1141 cctgatcgtc cagaatattg tgttgtcttc tgggatacga aaaacaatga aaaatatgtt
     1201 aaatatgtga agggtctcat ttctattact acctgtggag atttctgcat tttggctaca
     1261 aaagctgatg aaaatcatcc tcagtttgta ctagttcttt gtaattctat tggtacaccc
     1321 ttggatccca aatacattga tattgtacca ttgtttgttg caatgaccaa aacccatgtg
     1381 atagcagcct cgaaagaagc attttatacc tggcaatatc gtgtggcaaa gaagctcaca
     1441 gcattggaaa ttaatcagat cacacggtct cgaaaagaag ggagagaaag aatttatcat
     1501 gttgatgata ccccttctgg atcaatggat ggtgtgcttg attatagtaa aaccattcaa
     1561 ggcacaaggg atccaatttg tgccataact gcatcagata agatattgat tgtgggtcgt
     1621 gaatctggca ccattcagag atacagtcta cctaatgttg gtttgattca aaaatattcc
     1681 cttaattgtc gagcctacca gttatccttg aattgcaact ctagccgtct tgctatcata
     1741 gacatctcag gagttctgac tttctttgac ttggatgctc gagtaacgga cagtacggga
     1801 cagcaagtag ttggagagtt gttaaaattg gaacgaagag atgtctggga tatgaagtgg
     1861 gccaaagata atcctgattt gtttgcaatg atggagaaga caagaatgta tgttttcaga
     1921 aacttggatc ctgaggaacc cattcagacc tctggatata tttgtaattt tgaggattta
     1981 gaaattaaat ctgttctttt ggatgagata ttaaaggatc cagaacatcc aaacaaggat
     2041 tacctaatta actttgagat tcggtctctg cgagatagcc gagcactgat tgagaaggtt
     2101 ggaattaaag atgcatctca gttcatagag gacaatccac acccccgact ttggcgccta
     2161 ctggctgaag cagctcttca gaaactggat ctatacactg cagagcaagc atttgtgcgc
     2221 tgcaaagatt accaaggcat taagtttgtg aagcgcttgg gcaaactact gagtgagtca
     2281 atgaaacagg ctgaagttgt tggctacttc ggcaggtttg aagaggctga aagaacgtat
     2341 ctcgagatgg acagaaggga tcttgctatt ggcctccggc tgaaattggg ggattggttt
     2401 agagtactcc agctcctgaa aactggatct ggtgatgcag atgacagtct cctggaacaa
     2461 gccaacaatg ccattggaga ctactttgct gatcgacaaa agtggttgaa tgctgtacaa
     2521 tattatgtac aaggacggaa ccaggaacgc ttagctgaat gttactatat gttagaggat
     2581 tatgaagggt tagagaacct tgccatttca cttccagaaa accacaagtt acttccagaa
     2641 atagcacaaa tgtttgtcag agttggaatg tgtgaacaag cagtgactgc atttttgaaa
     2701 tgtagtcaac caaaggcagc agtagatacc tgcgtacatc tcaaccaatg gaacaaagct
     2761 gttgaattgg ctaaaaatca tagtatgaaa gaaattggat ctctgttagc taggtatgca
     2821 tctcatttac tggaaaagaa taaaactctt gatgccatag aactctatcg gaaagccaat
     2881 tacttttttg atgcagctaa actgatgttt aagattgcag atgaagaggc aaagaaagga
     2941 agtaaacctt tacgtgtcaa gaagctctat gtactgtcag ccttacttat agagcaatac
     3001 catgaacaga tgaagaatgc ccagcgagga aaagttaaag gaaaaagttc agaggccact
     3061 tctgccttgg ctggtttgct ggaagaagaa gttctgtcta caacagatcg tttcacagat
     3121 aatgcatgga gaggggcaga ggcttaccac ttctttatac ttgcacagag gcagctctat
     3181 gagggatgtg tggacactgc actgaagaca gctcttcacc tgaaagacta tgaagacatc
     3241 atccctcctg tggagatcta ctctctgcta gcactctgcg catgcgccag cagagccttt
     3301 gggacttgtt caaaagcttt cattaaactt aaatctttag agaccctcag ttcagaacag
     3361 aaacagcagt atgaagacct tgctttagaa atcttcacca aacatacttc aaaagataac
     3421 agaaaacctg aattggacag ccttatggaa ggtggagaag ggaaactgcc aacatgcgtt
     3481 gccacaggaa gcccaatcac tgagtatcaa ttctggatgt gcagtgtatg caaacacggt
     3541 gtccttgctc aggaaataag ccactacagc ttctgcccct tatgccatag tccagtggga
     3601 taaaggaatg ataaactgta tataactgta aaatatatgt agcatatata catggctata
     3661 tgctgtatat gtaataaggt ttatttctgt gagttttgta tgaaaatcag cctcattatt
     3721 tatagttgaa tttttgcaca aaatatatgt taataaaata atttttatgg caatacaact
     3781 gtgaaataat aaggccgatt ttcatataaa tgtatgaaaa tcaaccatgt tttctctcac
     3841 cctctctctt ttgtttatct tgtttttggt tacatgatac catggaaata ttccaaataa
     3901 atttttttct cacagtgtca aggtaactga attcattaaa aaatcttgaa gggagtaggg
     3961 agtgggggaa gcatgggagt ggggcaaagt tgaatttaga gaatttttat aacccatgtt
     4021 acaaggaagt taaacaattg taataatgaa atgagctttc tctatagcca tatttaatta
     4081 aataagtgtc gaatgtcttc tttattgtat tttcagaagt gaggcgatgg cattttaaga
     4141 cattttttac aatctgaatt gtttctaata gccctattct tctattttaa aacctgtcct
     4201 tttagtctca tttaagagat ggcatttgga atttacactt tcatatgatt gtgcagaaaa
     4261 cttgcctcta tttataatga agataactta aacagaaata tccattttgt agttatagct
     4321 tctgttgaaa cattgtcact aagttggacc gtttatttac acaagtattg ttgagggagt
     4381 gattttttct tgatatgcgt ctgttttcat ttattattaa tttgaaagat aaacagttgt
     4441 gatccataat ggatcatttc ttatgtcttt tacatagcta ataatgttct ctgtttattt
     4501 ctcatgaatt cccattttgt ggctaaagac cagacctttg cactatttca tcaagattat
     4561 tttattgagg tttggcttac atatagtaga ggcaatacat agagatacgc aactttgttt
     4621 ttgcagctac aatacacttt ctcaatctca tatgtttttg tcttgtagag acagagacaa
     4681 gttcagcatg ttgcagattg ggaatagtga gctatgagaa gagatttaga gcctagatga
     4741 gcttaggata gagagtgggc tcattggcct aaataaaaag agaagaccag aagtctttga
     4801 ggtctctgtc tctattcatg cgcctcgtgg aaaattacct tggtacaatg gtagcctcta
     4861 aatagactgc ctcgcaagct attccagagg tcatggaaca gaaagcctta taaaccaaat
     4921 aaaaattctc aaaatacatt ggtttattga accaatttgc aatacacagt gaggaacaag
     4981 gagaaagcaa tgatagatta acactgttag tgtaacgtgc cagtggagtg gaaagaccgc
     5041 aacacctgaa tcctgggttt tgtaatgttt ttatgtcctg actcacattc tgtcacatac
     5101 gctttcccct aatagtcggg ttacaaaaag gaccagagtg gccgcttgag ccagatgact
     5161 caatcagatg aaatgtgcct gaggccaacg atgtacactt gctctataga agggtgtcag
     5221 gggcaagtac acttcaccac agcaatagct tgcctattag tctgctgagc agtcatgaat
     5281 tttattgtat ttcttgggta aggacaggcc agaatgagtg tcaccagtgg gtaattgaat
     5341 caacttctca cacatactga aggctttata tgtctcatgc atacttagtg tatcatgaat
     5401 atttggtatc tttgtggctt ttcatatttt tagtgcttca tgaatatttg gtatctcttg
     5461 ctcctttcta tctgtggtca cacatacacg ctctattaac tttgcctaat aagtctccta
     5521 ggttactaac ttacttacct aaatgtaaca caatgaattc cagctttctc atttgttcta
     5581 taccagaatg ggaaatttcc ccaaatcaga aaatcacatc ctaacaaaga agtctgtcta
     5641 agacagtaca tctcctgttg aacttgcatc tttccacagg actttctgtt tttagggatg
     5701 agactattct ctgcttcatc aaggaaagag aaatgttcag ggttgtaggg atggcacact
     5761 tattagttct gcctgtctga aaggttcctg caggacagtt tggtcagagc tgcaattctt
     5821 agtccatggt ctaatgcttg agtatctctt ctttcccttt cctgtctcag gaatcagctg
     5881 agaattcatt cgattgtcat gcctctagcc ccttactgtg atttgttggt tgcactttca
     5941 tttgctttag ttctagaatc acctgttgac tcctcagact tcacctaact ttggaaactc
     6001 tcttttggag gcttctcatt tccccctaat tctgtgctgc ctgagcccta gaattttccc
     6061 accaacgaat tattccaggt agatcctaag ttgctggatc tagttgatat ttaaacaata
     6121 tctagttgat atttctcatt cagttggatc cagaaaccag tatctctaaa aacaacctct
     6181 cataccttgt ggacctaatt ttgtgtgcgt gtgtgtgtgc gcgcatatgt atatagacag
     6241 gcacatcttt tttacttttg taaaagctta tgcctctttg gtatctatat ctgtgaaagt
     6301 tttaatgatc tgccataatg tcttggggac ctttgtcttc tgtgtaaatg gtactagaga
     6361 aaacacctat attatgagtc aatctagttg gttttattcg acatgaagga aatttccaga
     6421 taacaacact aacaaactct cccttgacta gggggacaaa gaaaagcaaa actgaccata
     6481 aaaaacaatt acctggtgag aagttgcata aacagaatta ggtagtatat tgaagacagc
     6541 atcattaaac agttatgttg ttctccttgc aaaaaacatg tactgacttc ccgttgagta
     6601 atgccaagtt gtttttttta ttataaaact tgcccttcat tacatgtttc aaagtggtgt
     6661 ggtgggccaa aatattgaaa tgatggaact gactgataaa gctgtacaaa taagcagtgt
     6721 gcctaacaag caacacagta atgttgacat gcttaattca caaatgctaa tttcattata
     6781 aattgttttg ctaaaataca ctttgaaact atttttctgt attccaagag ctgagatctt
     6841 agattttatg tagtattaag tgaaaaaata cgaaaataat aaacattgaa gaaaaaaa
//
