LOCUS       NM_018383               9490 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens WD repeat domain 33 (WDR33), transcript variant 1,
            mRNA.
ACCESSION   NM_018383
VERSION     NM_018383.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9490)
  AUTHORS   Liu,L. and Manley,J.L.
  TITLE     Non-canonical isoforms of the mRNA polyadenylation factor WDR33
            regulate STING-mediated immune responses
  JOURNAL   Cell Rep 43 (3), 113886 (2024)
   PUBMED   38430516
  REMARK    GeneRIF: Non-canonical isoforms of the mRNA polyadenylation factor
            WDR33 regulate STING-mediated immune responses.
REFERENCE   2  (bases 1 to 9490)
  AUTHORS   Liu,L., Seimiya,T. and Manley,J.L.
  TITLE     WDR33 alternative polyadenylation is dependent on stochastic
            poly(a) site usage and splicing efficiencies
  JOURNAL   RNA Biol 21 (1), 25-35 (2024)
   PUBMED   39327832
  REMARK    GeneRIF: WDR33 alternative polyadenylation is dependent on
            stochastic poly(a) site usage and splicing efficiencies.
REFERENCE   3  (bases 1 to 9490)
  AUTHORS   Clerici,M., Faini,M., Aebersold,R. and Jinek,M.
  TITLE     Structural insights into the assembly and polyA signal recognition
            mechanism of the human CPSF complex
  JOURNAL   Elife 6, e33111 (2017)
   PUBMED   29274231
  REMARK    GeneRIF: The authors define the molecular architecture of the core
            human CPSF complex comprising CPSF160, WDR33, CPSF30 and Fip1 and
            identify specific domains involved in inter-subunit interactions.
            Together, these results shed light on the function of CPSF in
            mediating polyA signal-dependent RNA cleavage and polyadenylation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9490)
  AUTHORS   Schonemann,L., Kuhn,U., Martin,G., Schafer,P., Gruber,A.R.,
            Keller,W., Zavolan,M. and Wahle,E.
  TITLE     Reconstitution of CPSF active in polyadenylation: recognition of
            the polyadenylation signal by WDR33
  JOURNAL   Genes Dev 28 (21), 2381-2393 (2014)
   PUBMED   25301781
  REMARK    GeneRIF: showed that WDR33 binds in and very close to the AAUAAA
            signal in vivo with high specificity
REFERENCE   5  (bases 1 to 9490)
  AUTHORS   Chan,S.L., Huppertz,I., Yao,C., Weng,L., Moresco,J.J., Yates,J.R.
            3rd, Ule,J., Manley,J.L. and Shi,Y.
  TITLE     CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3'
            processing
  JOURNAL   Genes Dev 28 (21), 2370-2380 (2014)
   PUBMED   25301780
  REMARK    GeneRIF: unexpectedly found that CPSF subunits CPSF30 and Wdr33
            directly contact AAUAAA
REFERENCE   6  (bases 1 to 9490)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 9490)
  AUTHORS   Shi,Y., Di Giammartino,D.C., Taylor,D., Sarkeshik,A., Rice,W.J.,
            Yates,J.R. 3rd, Frank,J. and Manley,J.L.
  TITLE     Molecular architecture of the human pre-mRNA 3' processing complex
  JOURNAL   Mol Cell 33 (3), 365-376 (2009)
   PUBMED   19217410
REFERENCE   8  (bases 1 to 9490)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   9  (bases 1 to 9490)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   10 (bases 1 to 9490)
  AUTHORS   Ito,S., Sakai,A., Nomura,T., Miki,Y., Ouchida,M., Sasaki,J. and
            Shimizu,K.
  TITLE     A novel WD40 repeat protein, WDC146, highly expressed during
            spermatogenesis in a stage-specific manner
  JOURNAL   Biochem Biophys Res Commun 280 (3), 656-663 (2001)
   PUBMED   11162572
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA768238.1, AB044749.1,
            BQ896760.1, BC010283.1, AL834365.1 and AC006011.2.
            
            On Nov 22, 2018 this sequence version replaced NM_018383.4.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. This gene is highly
            expressed in testis and the protein is localized to the nucleus.
            This gene may play important roles in the mechanisms of
            cytodifferentiation and/or DNA recombination. Multiple
            alternatively spliced transcript variants encoding distinct
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1) with eight WD
            repeats, a collagen-like domain, and a GPR (Gly, Pro and Arg)-rich
            domain at the N-terminal, central, and C-terminal portion,
            respectively.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.41719.1,
                                           SRR1660805.86834.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322313.9/ ENSP00000325377.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DA768238.1         17-40
            25-2325             AB044749.1         1-2301
            2326-2652           BQ896760.1         272-598
            2653-3974           BC010283.1         14-1335
            3975-4596           AL834365.1         236-857
            4597-6283           BC010283.1         1958-3644
            6284-9490           AC006011.2         708-3914            c
FEATURES             Location/Qualifiers
     source          1..9490
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.3"
     gene            1..9490
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /note="WD repeat domain 33"
                     /db_xref="GeneID:55339"
                     /db_xref="HGNC:HGNC:25651"
                     /db_xref="MIM:618082"
     exon            1..160
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            161..387
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..4194
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 33; WD repeat-containing protein
                     WDC146; pre-mRNA 3' end processing protein WDR33; WD
                     repeat-containing protein of 146 kDa"
                     /codon_start=1
                     /product="pre-mRNA 3' end processing protein WDR33 isoform
                     1"
                     /protein_id="NP_060853.3"
                     /db_xref="CCDS:CCDS2150.1"
                     /db_xref="GeneID:55339"
                     /db_xref="HGNC:HGNC:25651"
                     /db_xref="MIM:618082"
                     /translation="MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFD
                     GKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNP
                     MNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAH
                     DSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFA
                     TCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPK
                     TGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEA
                     TAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCS
                     GSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLEPNSLAVIPGMGIPEQL
                     KLAMEQEQMGKDESNEIEMTIPGLDWGMEEVMQKDQKKVPQKKVPYAKPIPAQFQQAW
                     MQNKVPIPAPNEVLNDRKEDIKLEEKKKTQAEIEQEMATLQYTNPQLLEQLKIERLAQ
                     KQVEQIQPPPSSGTPLLGPQPFPGQGPMSQIPQGFQQPHPSQQMPMNMAQMGPPGPQG
                     QFRPPGPQGQMGPQGPPLHQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQRHPG
                     PHGPLGPQGPPGPQGSSGPQGHMGPQGPPGPQGHIGPQGPPGPQGHLGPQGPPGTQGM
                     QGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMGLNPRGMQGPPGPRENQGPAP
                     QGMIMGHPPQEMRGPHPPGGLLGHGPQEMRGPQEIRGMQGPPPQGSMLGPPQELRGPP
                     GSQSQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKTPLLGDGP
                     RAPFNQEGQSTGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDSRGPPNHHMGPMSE
                     RRHEQSGGPEHGPERGPFRGGQDCRGPPDRRGPHPDFPDDFSRPDDFHPDKRFGHRLR
                     EFEGRGGPLPQEEKWRRGGPGPPFPPDHREFSEGDGRGAARGPPGAWEGRRPGDERFP
                     RDPEDPRFRGRREESFRRGAPPRHEGRAPPRGRDGFPGPEDFGPEENFDASEEAARGR
                     DLRGRGRGTPRGGRKGLLPTPDEFPRFEGGRKPDSWDGNREPGPGHEHFRDTPRPDHP
                     PHDGHSPASRERSSSLQGMDMASLPPRKRPWHDGPGTSEHREMEAPGGPSEDRGGKGR
                     GGPGPAQRVPKSGRSSSLDGEHHDGYHRDEPFGGPPGSGTPSRGGRSGSNWGRGSNMN
                     SGPPRRGASRGGGRGR"
     exon            388..456
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            457..561
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            562..657
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            658..809
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            810..907
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1034
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1189
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1268
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1379
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1474
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1561
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1701
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1854
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2943
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3052
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3491
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            3492..3655
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            3656..3748
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            3749..3964
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            3965..9490
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4567..4572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /note="hexamer: AATACA"
     polyA_site      4603
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /note="major polyA site"
     regulatory      5208..5213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /note="hexamer: AATAAA"
     polyA_site      5229
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /note="major polyA site"
     regulatory      9467..9472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /note="hexamer: AATAAA"
     polyA_site      9490
                     /gene="WDR33"
                     /gene_synonym="NET14; WDC146"
                     /note="major polyA site"
ORIGIN      
        1 agagcgtgcg ttcggtggcc cataggggaa gatggcggct gctcctttgg aggagcggga
       61 ttgagaggat cggggtgggg agaccaaaca agagagacat ttctggctct gaaggcgaac
      121 gcttcgctgg ccatttagga gctctgctca aagccagacg tatcctagaa ggaaaacatc
      181 accatggcta cagaaattgg ttctcctcct cgttttttcc atatgccaag gttccagcac
      241 caggcacctc gacagctgtt ttataagcga cctgattttg cacaacagca agcaatgcaa
      301 cagcttactt ttgatggaaa acgaatgaga aaagctgtga accgaaaaac catagactac
      361 aatccatctg taattaagta tttggagaac agaatatggc aaagagacca gagagatatg
      421 cgggcaattc agcctgatgc aggttattac aatgatctgg tcccacctat aggaatgttg
      481 aataatccta tgaatgcagt aacaacaaaa tttgttcgga catcaacaaa taaagtaaag
      541 tgtcctgtat ttgttgttag gtggactcca gaaggaagac gcttggtcac tggagcttct
      601 agtggggagt ttaccctgtg gaatggactc actttcaatt ttgaaacaat attacaggct
      661 cacgacagcc cagtgagggc catgacgtgg tcacataatg acatgtggat gttgacagca
      721 gaccacggag gatatgtgaa atattggcag tcgaacatga acaacgtcaa gatgttccag
      781 gcacataagg aggcgattag agaggccagt ttctcaccca cggataataa atttgctaca
      841 tgctctgatg acggcactgt tagaatctgg gactttcttc gttgccatga ggaaagaatt
      901 ctccgagggc atggtgctga tgtgaaatgt gtagactggc atccaaccaa agggttagtt
      961 gtttcaggaa gtaaagatag tcaacagcca atcaagttct gggatcccaa gactgggcag
     1021 agtcttgcaa cacttcatgc ccataaaaac acagtaatgg aagtgaaatt aaacctcaat
     1081 ggcaattggc tactcacagc atcacgtgat catctctgta aactttttga tatcagaaac
     1141 ctaaaagaag agcttcaagt cttccgaggt cataagaaag aagccacagc tgtggcctgg
     1201 catcctgttc atgaaggact ttttgccagt ggagggtctg atggttcttt gttattctgg
     1261 catgttgggg tagagaagga agtgggtggg atggagatgg ctcacgaagg gatgatctgg
     1321 agtctggctt ggcatcctct tgggcatatt ctctgctcag gctcaaatga ccatactagc
     1381 aaattctgga ctcgaaaccg accaggtgat aaaatgcgag atcgatataa tctaaacctt
     1441 ttacctggaa tgtctgaaga tggagtagaa tatgatgacc tcgaacctaa tagcctggca
     1501 gtaattccag gaatgggaat accagaacaa ctaaaattag ctatggaaca agaacagatg
     1561 gggaaagatg aatcaaatga aattgaaatg acaattccag gtttagattg gggaatggag
     1621 gaagtgatgc aaaaggatca gaaaaaagta cctcagaaga aagttcctta tgcaaaaccc
     1681 attcctgctc agttccagca ggcttggatg caaaataaag ttccaattcc tgctccaaat
     1741 gaggtgctga atgacagaaa agaagacatt aaattggaag agaagaaaaa aacacaagca
     1801 gaaattgagc aagaaatggc tacattacaa tatactaacc cacaacttct ggagcaactt
     1861 aaaattgaaa gacttgcaca gaaacaagtt gagcaaattc agcctcctcc ctcatctggc
     1921 acccctctcc tcggacccca gccttttcca ggacaaggtc caatgtctca gattcctcaa
     1981 ggttttcaac agccccatcc atctcagcag atgccaatga acatggctca aatggggcct
     2041 ccaggtccac agggacagtt taggcctcct ggaccccagg gacaaatggg accacaaggt
     2101 cctccactgc atcagggagg tggggggcca caaggattca tgggaccaca ggggccccag
     2161 ggcccgcccc aggggttgcc acggcctcag gacatgcatg ggccccaagg aatgcagagg
     2221 catcctggac ctcatggccc tttgggacct caagggccac ctggaccaca aggtagttct
     2281 ggtcctcaag gtcatatggg tcctcagggt ccacctggcc cacagggtca cataggcccc
     2341 caaggcccgc ctggccctca gggtcacttg ggcccacagg ggcctccggg tactcaaggt
     2401 atgcagggac cacctggtcc cagaggaatg caagggcctc ctcatcctca tgggatccaa
     2461 ggcggaccag ggtctcaagg gatccaaggt cctgtgtctc agggacctct gatgggattg
     2521 aatccaagag gaatgcaggg gcctccaggc ccccgggaga accagggtcc tgctccccaa
     2581 gggatgatta tgggccaccc gcctcaagag atgagaggac ctcaccctcc aggtggacta
     2641 ctgggacacg gccctcagga aatgagaggt cctcaggaga tccgaggcat gcaggggcct
     2701 ccaccccaag gatcaatgct gggacctccc caggaattgc gagggcctcc aggctcacaa
     2761 agtcagcagg ggccgcccca gggctcttta ggacctccac cccagggtgg catgcaagga
     2821 ccccccggac ctcagggaca gcagaaccca gcaagagggc cacatccatc tcaagggcca
     2881 ataccattcc agcaacagaa aacgcctctg ctaggtgatg ggccccgggc ccccttcaac
     2941 caggaaggac agagcacagg ccccccaccc ctgataccag gcctagggca gcagggagca
     3001 caaggtcgca ttccccctct gaaccccgga caaggacctg gccccaacaa aggtgactcc
     3061 cgcggccctc caaaccatca catgggcccg atgtcagaga ggcggcatga gcagagcggc
     3121 gggcctgagc atgggcccga gagggggcct ttccggggtg gccaggactg caggggtccc
     3181 cctgataggc gtggccctca cccagacttc cccgatgact tcagcagacc agatgacttc
     3241 caccctgaca agcgctttgg ccaccggtta cgtgaatttg aggggcgagg aggaccttta
     3301 ccgcaagaag agaagtggag gcgagggggc cctgggcctc cgtttccccc tgatcacagg
     3361 gaattcagcg agggggatgg ccggggtgca gcccgaggcc ctccgggggc atgggaaggc
     3421 cgcaggcccg gagatgaacg tttcccccgg gatcccgagg acccacgttt tcgagggcgc
     3481 agagaagaaa gtttcagaag aggagccccg ccgaggcatg agggccgtgc tccccccaga
     3541 ggaagggatg gttttcctgg tcctgaagac tttggtccag aggagaattt tgatgcttct
     3601 gaggaagcgg cccgaggacg agatctcaga ggtcgaggtc ggggtacccc acgaggagga
     3661 aggaagggtt tacttcccac tcctgacgag ttccctcgct ttgaaggagg gcggaagcca
     3721 gattcctggg atggaaacag agagcctggg ccaggtcatg aacattttcg tgatactccc
     3781 cgccctgatc atccccctca cgacggtcat tccccagcca gcagagaacg ctcctcttct
     3841 ctccaaggca tggacatggc atccctacct ccccgaaagc gcccctggca tgatggccca
     3901 ggcacttctg agcacagaga gatggaggcc ccaggaggcc cttctgaaga ccgaggaggc
     3961 aaaggccgag ggggcccagg acctgctcag agagtgccca aatctgggcg ttccagctcc
     4021 ttagacggag agcaccacga tggataccac agagatgaac cttttggggg ccctccaggc
     4081 agtggcaccc cttctcgagg gggccggagt ggcagtaact ggggtagagg gagtaacatg
     4141 aactctggcc cgccgaggcg aggagcttca cggggtggtg gaaggggtcg gtagaagctg
     4201 gaactgagta ccctgaggcc tctctggaca gtatgtaaga acttcttgtg gactcaccaa
     4261 gagaaacaaa aggaagcctg caccattgta gccctgaact cttttctggg cacctgaatc
     4321 ccaggaaccc tcaatgaggt cttcaagatg aagagactgc tgccagctac cagcctggct
     4381 ggccctgtcc tgtccaccct cattgcccca actcccatgt tgttttgtga agataaaagc
     4441 tgggatcttt ttcttttttt taagtctcac aagacatggg gcatctccac aaatttaagt
     4501 tcctgtccat ttggaaattt gtttctatgt gtacagtttg tcagagaaaa acaaagtttt
     4561 tgtatgaata cagaatgtga tttacgcaag aattgacaga aaactagttg tgaagtgctt
     4621 gccttaagga aacctttggt ttccatcgca tcccatctgc caaggaatgc acggttgttg
     4681 ctgatgttca tgagcatatt aaccactagg ttatctaaat taatctcagc tgtgaacttt
     4741 gtgtttttca acacattctg tcacaccatt tttgtgacag aaaaatactt gaaaattatt
     4801 ctaatgtagt ttgtagtagg ttcaaatttt tattcagaca tgctctgaca gatggaaaat
     4861 tgtactctga agagaaaatg caatcttctg gatgtccaac gagggagctt ccccttggaa
     4921 gcatctccta agaatcacag tttaggtttg aatcgccttg ttatgatgag gagaggaact
     4981 tgatgttagt cagaaataaa gtcacatgcc ctttagataa cttgaaatca cacatggagt
     5041 tgataaggaa tggaccaaaa taggtcctca aacaattttg caacacttaa ttaagttttc
     5101 ctctcttcct cttccatact atgtggaaat accagtgtta cggcagggcg tacttctaac
     5161 tcacagtaag ccagatagat cttgtccatg gcaaattcct tgtttaaaat aaacatacca
     5221 tttagcccag tttggattgg aagccaaaaa ttcagtttgt tatatacccc atgatacttt
     5281 ctatactgac ctttattttg gttttacatg gaagctttta ttaaaaggac tgtcctatgg
     5341 ccaccttaac atttcattac attggcagct tcagttttgg catcagtcaa atttatttgg
     5401 caaatttagt ggtgctggaa gtttcttttt ttcttttcct tttttgacag agtcttgctc
     5461 tgtcacccag ccaggagtgc agtggtgcaa tcacggctca cttcagcttt gaccctgcct
     5521 cagcctccct agtagctagg actacaggca tatgccacca tgcccagcta attttttgtg
     5581 tgtgtgtttt ttgtagagat ggagtttcac cactttgtct atgctggttt caaactcctg
     5641 ggctcaagcg gtccacctgc tgtggcctcc caaagtgctg ggattgcaga tctgagccac
     5701 agtacctggc cgctggtgct ggaagtttca atggttgctt agaaaaggca tactgatata
     5761 gtttaacagg atatgaaaat ttaactggtt ctctatgaat gtaaaaaaca gcaaaagcta
     5821 attgatttct gtggagtgag aaaatgtcag ccatatacac tgcttttcag tgttagaatc
     5881 tagagactat ttttttttta actttgaaat tacagcttat ttaatcagcg ctccaccata
     5941 aacatgctat taggaggctc aagattgctt taggttatgg gtatttcttc actcaccccc
     6001 aactggtata gcttaaagag agagaaactg taatcaaatt tcatgaagct aaaaccggat
     6061 ccagagacca aacccatatc aagattagac tttttttccc tgagattcta gtggaaaaat
     6121 tttcattatt ttgggcttta actttagaaa catagtatct cagtaagcag ataaccagat
     6181 cacatttaaa aattttcatt ttaccttgaa gctctactgg acttgacaga tcacattttg
     6241 agagtgaatt catttaaaca ataaacctct acattatact tattaaatat atatggcatt
     6301 taaaaacatc actgtcagca tacatactag atgttgtgat ttgaagctta taaaaagtag
     6361 attttcaatg atgtttgatt tgagaaaaaa tttttgagac aaggtctcgc tgttgcctag
     6421 gctgtggtgc agtggtgtga tcacagttca ctgcagcctc aacctcctgg gctcaagtga
     6481 tcttcccacc tcagccccac cccaagtagc tgggatcaca gttgtgtgcc accatatctg
     6541 gcaaattttt tgaagatttt ctgtggcgat ggggtttaac tgtgttgccc aggctggtct
     6601 tgaactcctg gcctcaagtg atcctcccgc cttggcctcc caaaatgctg ggattacagg
     6661 tgtgagccac cagctgagaa atgttgaatt tttaagtttt tatttaagaa ataaacattg
     6721 taaaacatca ttataaaacc cccaactatt gcaagttcta gagaaattta aaactagaac
     6781 agaaatttag gggactagaa agagcagcca atggcacaag tctttacaat taattaaaaa
     6841 aataaatcat tctgaagata ctgcatttgc tctctcacaa gcagcctcct gaggtaggta
     6901 accttgttta ctgatgggga acaaggcagt gttctttacc aaatctcagg gcgggtagcc
     6961 tgcaagccta cagtgtggat gttggccact tgtgtcactt cttgggacgg ggcttaggga
     7021 cctgacttac ttaggaacat aaattttggg gttggaggaa gcagcagtgc tctactgcgg
     7081 cacgacagac accctgttaa ggcaacactg ggatccagct caggaaaagc attactttca
     7141 aattgtgcaa gccaatgcac agaaaagtgg tcctcaaact tggggaacgt agaatcactt
     7201 ggggagcttt aaaaaggtcc tgatgtctgg gacctacttc ccaggttctg actgcattga
     7261 tctgaggtgt ggctcttcaa gtaactgatg tgcagtcaag cgcgaggacc actggcacac
     7321 aatgtttaaa ttctaaatat attttacttc ctagtgtatt gctactgaca aaacgtagtt
     7381 ttctggactc atcagaatgt taggctcata ccttctggca ataaattaag gtagttaaaa
     7441 gtaactgctg aacctaaaat gaaggcagca gcaattagat ataaaaaaat cttaagatca
     7501 gcctgcaaat tgtaaactag tttacaaagc aggctataca atgaggaata attcgagctt
     7561 gtagaaatcc atggtttcca ccagatacag gtattccgga tctagaatta tctttctatt
     7621 tgcaggattt ccgaagagac cgttaagcat ctacgcgccc cttcctggat cccatgcttc
     7681 ttggggcagg aaatttcttt tggtccgtcg ctttcgtcgt gaaatacaca actaattttc
     7741 ctttcatgtt ataaggcacc atatttatga ttttgttaac tgaagaaaaa acccgagata
     7801 aaccatctta agtactttta aaagtccagt ggctgaattc ggtgtttaat ctgataccct
     7861 tctggattcg ctgacactgg agagaataat ttccaagtct tagtatagcc aaaacaaaaa
     7921 actaccgtcg ctaagctaca tctaccactg gattttaaaa tgacaaaaca gcctgagaaa
     7981 aatcacaaga gcagctaact cgaagaaaaa tcctttttct ttactcagcc gaacctaaga
     8041 ccacagttac ttcgaaagca acttctaata accgtctcac atcctgtcac cagttcaatg
     8101 acaaaatctc agttttcaga gcgtgtgcca agtccagcac aaaaagctga catcgaggag
     8161 ctcccaacgc tgctgtcgcc tccgctggca gcagccgctc ccggattaga ctcgcaggct
     8221 gttagggcag ggccttcgcc acgggcttcc gcacagcggc gtgcagtcct cagctcggcc
     8281 ggcgcggtct ccgacggcgc tggctccgcg tacttcccca gcggcgaggg cgcgaggtcc
     8341 tcacacgggc agcaccttgg cgaggccggc gccgcggccc aggcgaccca gtgcgaggcg
     8401 cagcgcggtg ccgccgcccc agggcagcag cccaaccagc gcggccagca gcgcggccac
     8461 ctgcgcgccc gcgcccagca ccgtgagcag cgtgctgcga aggcccagcg cggcgaacag
     8521 cgtggcgccc agcgctgcca tgtagagcag cgcgggccgg gacggcgctt cttcgcagcg
     8581 cagcaggcgt ccgcacgccg cgccgccccg cagcagcgcg cttcccgcca acgccagcgc
     8641 cgagcccagt gaccagagca gcgcgaactt gcgcgcgcgc agcagcaaca ccggtgcgta
     8701 gagcgcggct aggccgaaac acagtgcagc cagcagcagg cacccgccgc ccgccgccag
     8761 ccgctgcccg cgcgtcacgc tcgggaggca cgtcaggccg gccgctgccg actccgcagg
     8821 gctccgcgcc cacgtccagc gcaagcccgc gcggcccagc cactcctccg ccggccggtc
     8881 cccgggctcc tccgccttct ccgcggcgag cagcggctcc gcggccgccg ggccgccagc
     8941 tttcccctgc gccaggtact cctgcagctg gcggtggagg tccgccatct tggacaaggc
     9001 ggtggcagaa aggaaaagct gcggctcact tccggccctc cgctgaagcg gttcggtctt
     9061 cgggcggcaa ttggtcggcg acggcgaaag gggcagggcc tgcggcgctc gcggaagtgc
     9121 cgcggtgcct gctctgcgga cttttgtggt gtccccaagt accgtggtcg caggtgctgc
     9181 ctgtccgctt gcagtcgccc tcccagcgcc tgaccctctt ccttgttcgg agtaggcgcc
     9241 cttgcggtct ggctaagtcc tgccagcatt aatagttgga aggcaggggt gggtgtggtt
     9301 ctaaaggggc acaagaagtg acccttttgc tgacggaaat gtcttatggc ctcactgcgt
     9361 ctaccgtggc ggtgatattg tgctagtttt gcaacatgga ggaatgggta aagggtacac
     9421 agaatctctc ttgtttctta caactgaaca caaacagtga tctcaaaata aaaatttaat
     9481 ttttaaaaaa
//
