LOCUS       NM_001012361            4871 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens WD repeat domain 31 (WDR31), transcript variant 1,
            mRNA.
ACCESSION   NM_001012361
VERSION     NM_001012361.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4871)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4871)
  AUTHORS   Luke,M.M., O'Meara,E.S., Rowland,C.M., Shiffman,D., Bare,L.A.,
            Arellano,A.R., Longstreth,W.T. Jr., Lumley,T., Rice,K., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Gene variants associated with ischemic stroke: the cardiovascular
            health study
  JOURNAL   Stroke 40 (2), 363-368 (2009)
   PUBMED   19023099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 4871)
  AUTHORS   Shiffman,D., O'Meara,E.S., Bare,L.A., Rowland,C.M., Louie,J.Z.,
            Arellano,A.R., Lumley,T., Rice,K., Iakoubova,O., Luke,M.M.,
            Young,B.A., Malloy,M.J., Kane,J.P., Ellis,S.G., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Association of gene variants with incident myocardial infarction in
            the Cardiovascular Health Study
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (1), 173-179 (2008)
   PUBMED   17975119
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 4871)
  AUTHORS   Altwegg,M. and Kubli,E.
  TITLE     The nucleotide sequence of phenylalanine tRNA2 of Drosophila
            melanogaster: four isoacceptors with one basic sequence
  JOURNAL   Nucleic Acids Res 7 (1), 93-105 (1979)
   PUBMED   114987
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA209351.1, AK093240.1,
            AL449305.4 and AI091187.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001012361.3.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. Multiple
            alternatively spliced transcript variants encoding distinct
            isoforms have been found for this gene but the biological validity
            of some variants has not been determined. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.311274.1, BC022982.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374193.9/ ENSP00000363308.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 DA209351.1         66-71
            7-2233              AK093240.1         1-2227
            2234-4464           AL449305.4         144955-147185       c
            4465-4871           AI091187.1         21-427              c
FEATURES             Location/Qualifiers
     source          1..4871
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..4871
                     /gene="WDR31"
                     /note="WD repeat domain 31"
                     /db_xref="GeneID:114987"
                     /db_xref="HGNC:HGNC:21421"
                     /db_xref="MIM:620951"
     exon            1..59
                     /gene="WDR31"
                     /inference="alignment:Splign:2.1.0"
     exon            60..212
                     /gene="WDR31"
                     /inference="alignment:Splign:2.1.0"
     exon            213..356
                     /gene="WDR31"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1344
                     /gene="WDR31"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 31"
                     /codon_start=1
                     /product="WD repeat-containing protein 31 isoform 1"
                     /protein_id="NP_001012361.1"
                     /db_xref="CCDS:CCDS35110.1"
                     /db_xref="GeneID:114987"
                     /db_xref="HGNC:HGNC:21421"
                     /db_xref="MIM:620951"
                     /translation="MLLLRCQLKQAPPQKVSFRFCVVMGKQQSKLKHSTYKYGRPDEI
                     IEERIQTKAFQEYSPAHMDTVSVVAALNSDLCVSGGKDKTVVAYNWKTGNVVKRFKGH
                     EHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQLCGHAMVVTGLAVSPDSSQ
                     LCTGSRDNTLLLWDVVTGQSVERASVSRNVVTHLCWVPREPYILQTSEDKTLRLWDSR
                     GLQVAHMFPAKQHIQTYCEVSVDGHKCISCSNGFGGEGCEATLWDLRQTRNRICEYKG
                     HFQTVASCVFLPRALALMPLIATSSHDCKVKIWNQDTGACLFTLSLDGSGPLTSLAVG
                     DAISLLCASFNRGIHLLRMDHSQGLELQEVAAF"
     exon            357..489
                     /gene="WDR31"
                     /inference="alignment:Splign:2.1.0"
     exon            490..564
                     /gene="WDR31"
                     /inference="alignment:Splign:2.1.0"
     exon            565..709
                     /gene="WDR31"
                     /inference="alignment:Splign:2.1.0"
     exon            710..810
                     /gene="WDR31"
                     /inference="alignment:Splign:2.1.0"
     exon            811..878
                     /gene="WDR31"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1020
                     /gene="WDR31"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1183
                     /gene="WDR31"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..4871
                     /gene="WDR31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4847..4852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR31"
                     /note="hexamer: AATAAA"
     polyA_site      4871
                     /gene="WDR31"
                     /note="major polyA site"
ORIGIN      
        1 gttcccaccc ccaggctccg cgttcccgcc ggccccagct ccagccccgc agcccaccgt
       61 gcaaacatgc ttagacagag aagagattaa cttcagtggc ttcccactaa ttacagagat
      121 taagaagtgg ctgcctgaac tattttccaa aggatacaca ttacaaatta ttgaataggg
      181 cagctaacca agaagatcct attggtttgg ggggaacaca acttccagca gccacaaggg
      241 atgctgctac tcaggtgcca actgaaacaa gctcctccac agaaggtttc gtttaggttt
      301 tgtgtcgtga tggggaaaca gcaaagcaaa ctcaaacaca gcacttataa atacggcagg
      361 cctgatgaaa ttatagaaga gagaattcaa actaaagctt ttcaagagta tagcccagct
      421 cacatggata ccgtctctgt cgtggctgct ttgaactcag acctttgtgt ctctggaggg
      481 aaagataaga cagttgtggc ctataattgg aaaactggaa atgtggtgaa aaggttcaaa
      541 ggacatgaac atgagatcac caaggtagcc tgtattccca aatccagcca gttcttcagt
      601 gcctctcgtg acaggatggt catgatgtgg gacttgcacg gttcctcaca accaaggcag
      661 caattgtgtg gccatgccat ggtggtcacc ggattggctg tgagtccaga ctcatcacag
      721 ctgtgcactg gctctcggga caacaccctg cttctgtggg atgtggtgac aggacagagt
      781 gtggaaagag catctgtctc caggaacgtg gtcactcacc tgtgctgggt ccccagagaa
      841 ccatacatac tacagacctc tgaagataaa accctcagat tatgggacag tcgggggctg
      901 caggtagctc atatgtttcc tgcaaagcag cacattcaga cctactgtga agtcagtgtg
      961 gatggacaca agtgtatctc ctgcagcaat ggctttggag gagaaggctg tgaagccacg
     1021 ttgtgggacc taagacagac tcgaaacaga atatgtgagt ataaggggca tttccagact
     1081 gtcgcatcct gcgtctttct accaagagca ttggccttga tgcctttaat tgctacctca
     1141 tcacatgatt gcaaggtgaa gatttggaac caagatactg gagcctgcct tttcaccttg
     1201 tctctggatg gatcaggacc cttgacttct ctggctgttg gtgacgccat ctccttattg
     1261 tgtgcaagtt ttaacagagg aattcactta ctcagaatgg accacagcca agggctggaa
     1321 ctgcaggaag tggcagcatt ctgaggccaa gagacactca ctggacaata tcaaaccatg
     1381 gctcctcctc agcatggctt tgtgtctttc ccagttatct tgaggggagt gggatgtagg
     1441 gctggtattc tttgcttagg ttcatttaca agatgtatca gtgttgtaag tccaataatt
     1501 taagtccagt gattcaaaat caggtataga gtccagaaac atggactaca cataaggttc
     1561 tctatttaag ttaaatacaa atgcaacttt ttagtgagct tttaggacta ctcttcaaaa
     1621 aaagtgtatt gctcagaatg atgacctgta aatgtaagag tggcaggcct ctgtctgtga
     1681 aagtcagaac acagggctcg agcctctgga actgaccctt tgcaagtctt tacaaaagaa
     1741 aaaaggcagt ggggagagag agtgttttgg ttacatcaga aataattgag atgggaaaga
     1801 atagtgcagc tccatagagg agacggactg tagacaatga gattaagctt caatcactgc
     1861 tcctcagcaa tgtgaagaat caaagtcagg gcaagaaagc gaaagcttgg acttctattc
     1921 aaagtggcag cagagtggga gggcggtacc cttctagccc agtgctgctg agcttgtgtg
     1981 aaaatcagac ctgagatggc ttgaagcagc caagaaccac atgggcattg cccagaatta
     2041 caggagttag cacaccagct ctacagataa gaaaacattg aaattcaaag attaaggcca
     2101 aaaatatctc acttgcaatt ttaatatttt catttggatt tatataaatg aaacatatat
     2161 atgttttgga atggccagag tgaggcaaag gggatccctg aaataacatt agaacataca
     2221 ggaaaaacga ggcaggcaga tcactttagg tcaggagttc aagaccagcc tgtacgtgcg
     2281 tgcctgtagt cccagctact cgggaggctg agatgggaga atcacttgaa cctgggaggc
     2341 agagtttgca gtgagctgag attgtgccac tgcactccag tctgtgtgac agaatgagac
     2401 cttgtcttga aaaaaaaaaa aacaaaaaac cacatacagg aaaaaagaga gggatggagt
     2461 caactgtgcc ccagacatta agcccccttc agtgaggagg ggcaaggtgc tcaggcctgc
     2521 ctgtgtggcc cccaggagtc agacctcagc ctcatgctca ctggtccatt ttcctccagg
     2581 gaaaatggag ttctttctgc cttcagagat gcccacacat aaggcacatg aggctgttgg
     2641 tgacaccatc accaacactg gagattccct ttctgacaag tcccagccaa agaaagattt
     2701 tgcatttgtc ttctctgtcc tctgcttgtc tctgatacca gtgactgaca gccaccttcc
     2761 ttcttccctc tcttggtgtg atcatggcta actgcagcct caatcaccag ggctcaatca
     2821 atcctccctc cttagcctcc tgagtagctg ggactgcagg catgcaccac cacacctggc
     2881 taattttttg tgtgtttgtg tggtctaaaa ctcctgggct caagtgatcc atctgcctcg
     2941 gcctccttaa gtgttgagat tacaggtatg agccaccaca tccagctgag agtctgttct
     3001 taagctagta caaagagtca gacccgactt tgaatctcca cttctccatt tagctggatg
     3061 atcttgggca agttataaaa tctgtttcct cttcacttta taacgtgggt ttcatgatca
     3121 tacctcgcca cagggctgtt ctgaagactg gacatagcta ttttaaatgc caggaaaggc
     3181 caggcgcagt ggctcaaacc tgtaatccca gcactttggg aggccgaggc aggaggatca
     3241 cctgaggtca ggagtttgag accagcctga ccaacatgga gaaaccccgt ctctactaaa
     3301 aatacaaaaa ttagccaggc gtggtggtgc atgcctgtaa tcccagctac ctggggagcc
     3361 tgaggcggga gaatcgcttg aacccaggag gcggaggttg cggtgagccg agattgtgcc
     3421 attgcactcc agcctgggca acaagagcga aactccatct caataaataa ataaataagt
     3481 aaatgccagg aaaggtggtg acaaatggta gccataatta tttattgtcc tctctgtcca
     3541 gactaaatgt tcccttttcc atattaaaca tttaccattc tgccggacgc gttggctcat
     3601 gcctgtaatc ccagcacttt gtgaggccta ggcgggcaga tcacaaggtc aagagatcga
     3661 gaccatcctg gccaatatgg tgaaaccccg tctctactaa aaatacaaaa attagctggg
     3721 tgtggtggtg cccgcctgta gtcccagcta ctcaggaggc tgaggcagga gaatcgcttc
     3781 aaccggggag gcagaggttg cagtgagctg agattgtgcc attgcactcc agcctaggca
     3841 acagagagag actctatctc aaaataaaat aaaataaaat aaaataaaat aaacgtttac
     3901 cattccttga tccttttttt tttttttttt tttgagatgg aatcttgctc tgtcgcccag
     3961 gctggagtgc agtggtgcaa tctcggctcg ctgcaagctc cgcctcccgg gttgacgcca
     4021 ttctcctgcc tcagcctccc gaatagctgg gactacaggc gcccgccatc acgcccggct
     4081 aatttttttg tgtttttagt agagacggga tttcaccgtg ttagccagga tggtctcaat
     4141 ctcctgacct cgtgatccgc ccgcctaagt gctgggatta caggcgtgag ccactgcgcc
     4201 cggcctcctt catccattct tagatcttat cctctaaacc tttagtcatc gtttcactct
     4261 cctttgattc cttgttatgg gtctttcaac tctggaaaga caaagagata gtgggagagg
     4321 aagcccggtc actgagcatc tacagagggc taaatatatt tattctcatt tgttattccc
     4381 aatattctct gtattgtgat ttccatttca cagatgagga agctgagggc tagaaacatg
     4441 cagtactttg cccaaagtca cacacatatt aagaagagct gaggtatgaa tctgggtctg
     4501 cctgactcaa agcccaaacg ctttcctttg catcgtgtca caaagtcata gaccatgaca
     4561 ttgtttgtat cttcaagacc agttattaac tttctggctc caaggagatc ccctgcccaa
     4621 gtgcctaggg gcagtagaca gctgtctcag ggacagtcgt agcatgtgct ggattattag
     4681 tgcagcagct gacacttttt cccagaaggg agagaggcag caagtcagaa agttcacggg
     4741 aatgagttgg gagggggtcc cagggaaggg ggacaggctg ccaggagaag gaaagtacac
     4801 gggagaaaat agtggggctc tgatgagtta gtagggttct gttaccaata aaattgtttc
     4861 cataaactgt a
//
