LOCUS       NM_006784              10004 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens WD repeat domain 3 (WDR3), mRNA.
ACCESSION   NM_006784
VERSION     NM_006784.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10004)
  AUTHORS   Liu,W., Xie,A., Xiong,J., Li,S., Yang,L. and Liu,W.
  TITLE     WDR3 promotes stem cell-like properties in prostate cancer by
            inhibiting USF2-mediated transcription of RASSF1A
  JOURNAL   J Gene Med 25 (7), e3498 (2023)
   PUBMED   36905106
  REMARK    GeneRIF: WDR3 promotes stem cell-like properties in prostate cancer
            by inhibiting USF2-mediated transcription of RASSF1A.
REFERENCE   2  (bases 1 to 10004)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 10004)
  AUTHORS   Su,W., Zhu,S., Chen,K., Yang,H., Tian,M., Fu,Q., Shi,G., Feng,S.,
            Ren,D., Jin,X. and Yang,C.
  TITLE     Overexpressed WDR3 induces the activation of Hippo pathway by
            interacting with GATA4 in pancreatic cancer
  JOURNAL   J Exp Clin Cancer Res 40 (1), 88 (2021)
   PUBMED   33648545
  REMARK    GeneRIF: Overexpressed WDR3 induces the activation of Hippo pathway
            by interacting with GATA4 in pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10004)
  AUTHORS   Kobayashi,M., Jitoku,D., Iwayama,Y., Yamamoto,N., Toyota,T.,
            Suzuki,K., Kikuchi,M., Hashimoto,T., Kanahara,N., Kurumaji,A.,
            Yoshikawa,T. and Nishikawa,T.
  TITLE     Association studies of WD repeat domain 3 and
            chitobiosyldiphosphodolichol beta-mannosyltransferase genes with
            schizophrenia in a Japanese population
  JOURNAL   PLoS One 13 (1), e0190991 (2018)
   PUBMED   29309433
  REMARK    GeneRIF: evaluated the genetic association of WDR3 and ALG1 in
            schizophrenia. We examined 21 single nucleotide polymorphisms
            [SNPs; W1 (rs1812607)-W16 (rs6656360), A1 (rs8053916)-A10
            (rs9673733)] from these genes using the Japanese case-control
            sample (1,808 schizophrenics and 2,170 matched controls). No
            significant genetic associations of these SNPs were identified.
            However, we detected a significant association of W4 (rs319471)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10004)
  AUTHORS   Garcia-Quispes,W.A., Pastor,S., Galofre,P., Biarnes,J., Castell,J.,
            Velazquez,A. and Marcos,R.
  TITLE     Possible role of the WDR3 gene on genome stability in thyroid
            cancer patients
  JOURNAL   PLoS One 7 (9), e44288 (2012)
   PUBMED   23049746
  REMARK    GeneRIF: WDR3 can modulate genome stability in thyroid cancer
            patients.
REFERENCE   6  (bases 1 to 10004)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   7  (bases 1 to 10004)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   8  (bases 1 to 10004)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   9  (bases 1 to 10004)
  AUTHORS   Claudio,J.O., Liew,C.C., Ma,J., Heng,H.H., Stewart,A.K. and
            Hawley,R.G.
  TITLE     Cloning and expression analysis of a novel WD repeat gene, WDR3,
            mapping to 1p12-p13
  JOURNAL   Genomics 59 (1), 85-89 (1999)
   PUBMED   10395803
REFERENCE   10 (bases 1 to 10004)
  AUTHORS   Claudio,J.O., Liew,C.C., Dempsey,A.A., Cukerman,E., Stewart,A.K.,
            Na,E., Atkins,H.L., Iscove,N.N. and Hawley,R.G.
  TITLE     Identification of sequence-tagged transcripts differentially
            expressed within the human hematopoietic hierarchy
  JOURNAL   Genomics 50 (1), 44-52 (1998)
   PUBMED   9628821
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121993.7, BP281064.1,
            AK292438.1, AF083217.1, BU685597.1 and AA258068.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006784.2.
            
            Summary: This gene encodes a nuclear protein containing 10 WD
            repeats. WD repeats are approximately 30- to 40-amino acid domains
            containing several conserved residues, which usually include a
            trp-asp at the C-terminal end. Proteins belonging to the WD repeat
            family are involved in a variety of cellular processes, including
            cell cycle progression, signal transduction, apoptosis, and gene
            regulation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.27264.1,
                                           SRR1660807.233060.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349139.6/ ENSP00000308179.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL121993.7         53164-53173
            11-15               BP281064.1         1-5
            16-2652             AK292438.1         1-2637
            2653-2935           AF083217.1         2624-2906
            2936-3560           BU685597.1         18-642
            3561-3608           AA258068.1         281-328             c
            3609-3633           AA258068.1         252-276             c
            3634-3887           AF083217.1         3597-3850
            3888-10004          AL121993.7         83852-89968
FEATURES             Location/Qualifiers
     source          1..10004
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p12"
     gene            1..10004
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /note="WD repeat domain 3"
                     /db_xref="GeneID:10885"
                     /db_xref="HGNC:HGNC:12755"
                     /db_xref="MIM:604737"
     exon            1..44
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            45..247
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..2908
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /note="dJ776P7.2 (WD repeat domain 3)"
                     /codon_start=1
                     /product="WD repeat-containing protein 3"
                     /protein_id="NP_006775.1"
                     /db_xref="CCDS:CCDS898.1"
                     /db_xref="GeneID:10885"
                     /db_xref="HGNC:HGNC:12755"
                     /db_xref="MIM:604737"
                     /translation="MGLTKQYLRYVASAVFGVIGSQKGNIVFVTLRGEKGRYVAVPAC
                     EHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVT
                     FNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLRE
                     KNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW
                     DIAYLQEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMR
                     EGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSS
                     KGEEEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVELY
                     SLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWNRSTLQCIR
                     TMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQ
                     RGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAV
                     SLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGD
                     CHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLA
                     VSPSGDYVVSSSHDKSLRLWERTREPLILEEEREMEREAEYEESVAKEDQPAVPGETQ
                     GDSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHKAICKAAGKEVPLPSNPILMA
                     YGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILKLFNEFIQLGSDVELICRCL
                     FFLLRIHFGQITSNQMLVPVIEKLRETTISKVSQVRDVIGFNMAGLDYLKRECEAKSE
                     VMFFADATSHLEEKKRKRKKREKLILTLT"
     exon            248..457
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            458..576
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            577..655
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            656..751
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            752..865
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            866..967
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1065
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1173
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1404
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1498
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1600
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1686
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1822
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1879
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1980
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2092
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2227
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2278
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2344
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2437
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2485
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2529
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2658
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2752
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..10004
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3495..3500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /note="hexamer: AATAAA"
     regulatory      3514..3519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /note="hexamer: ATTAAA"
     polyA_site      3521
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /note="major polyA site"
     polyA_site      3534
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
     polyA_site      3563
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
     regulatory      3861..3866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /note="hexamer: AATATA"
     polyA_site      3885
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
     regulatory      4318..4323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /note="hexamer: AGTAAA"
     polyA_site      4349
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
     regulatory      7307..7312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /note="hexamer: AATAAA"
     polyA_site      7330
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
     regulatory      9976..9981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
                     /note="hexamer: AATAAA"
     polyA_site      10004
                     /gene="WDR3"
                     /gene_synonym="DIP2; UTP12"
ORIGIN      
        1 cttgtgggcg ggtccaatcg gctgggagcc tcgtggaggc tgagattgct tcacctgtgg
       61 tatcagacat cacaacatgg ggctcaccaa gcagtaccta cgctatgttg ctagtgcggt
      121 ctttggcgtt atcggcagcc aaaaaggtaa tattgtcttt gtgacacttc gtggtgagaa
      181 aggacgttat gtggcagtac cagcttgtga acacgttttc atctgggact taaggaaagg
      241 agagaagatt cttatccttc aggggcttaa acaagaagtt acttgcttat gcccctcccc
      301 agatgggcta cacttagctg ttgggtatga ggatgggtcg atccgaatct tcagtctcct
      361 gagtggggaa ggaaatgtga ccttcaatgg tcacaaagca gctatcacta ccttgaagta
      421 tgatcagcta ggaggcagac tggcatctgg gtccaaggac acagatatta ttgtatggga
      481 tgtgatcaat gaaagtggtc tgtaccgtct aaaggggcac aaggatgcca tcacacaagc
      541 attgtttcta cgagaaaaga acctgctagt tactagtggg aaagatacca tggtgaaatg
      601 gtgggacctt gatactcagc actgctttaa aacaatggtt ggccaccgga ctgaggtatg
      661 ggggttggtt ctgttgtcag aagaaaagcg actcatcact ggggcctcag acagtgaact
      721 gagggtatgg gacatagctt atctgcaaga gattgaagac ccggaagaac cagaccccaa
      781 gaaaatcaaa ggatcttctc ctggaataca agatactctt gaggcagagg atggtgcctt
      841 tgagacggat gaagcccctg aggatcgaat cctttcatgc agaaaagctg gttccataat
      901 gcgggaagga agagacagag ttgtaaacct tgcagtcgac aagacaggca ggattcttgc
      961 ttgccatgga actgactctg tgctagaatt gttttgtatc ctttccaaaa aggaaattca
     1021 gaagaaaatg gataagaaga tgaagaaagc tagaaagaaa gcaaaattac attctagcaa
     1081 aggagaggag gaagatcctg aggttaatgt tgaaatgagt ctgcaagatg aaatccagcg
     1141 ggtgactaat ataaaaactt ctgccaaaat caagtccttt gacttgattc attcacctca
     1201 cggagagtta aaggctgtct tcctgctgca gaacaacctg gtggaattgt attcactgaa
     1261 tccatccttg cctactcctc agcctgtcag gacaagcaga atcactattg ggggtcatcg
     1321 cagtgatgtg cggactttgt cattcagctc agacaatatt gctgttcttt cagctgcagc
     1381 tgattccatt aaaatatgga acaggtctac actgcagtgt attcgcacaa tgacctgtga
     1441 atatgcactt tgctcattct ttgtacctgg tgatagacag gtagtcatag gaacaaagac
     1501 agggaagctg cagctttatg acttggcttc agggaatctg ctggagacaa tagatgcaca
     1561 tgatggagct ttgtggtcca tgtccctctc tccagatcag cgtggctttg tgacaggtgg
     1621 tgcagataaa tctgtcaaat tctgggattt tgagttagtg aaagatgaaa atagtaccca
     1681 aaagagactt tctgtgaagc aaacccgaac tttgcaacta gatgaagatg ttctgtgtgt
     1741 cagttactct cccaatcaaa agctattggc tgtgtctttg ctggactgta ctgtgaaaat
     1801 tttctacgtt gatactttaa agttttttct gtcactgtat ggacacaaac tgcctgttat
     1861 atgcatggac atctctcatg atggagcact catagcaact ggctccgctg ataggaatgt
     1921 gaaaatctgg ggtttggact ttggggactg ccacaagtct ctctttgcac atgatgacag
     1981 tgtgatgtac ctacagtttg tacccaagtc tcacctcttc ttcactgccg gaaaagatca
     2041 taagattaaa cagtgggatg cagacaaatt tgaacacata cagactctgg agggtcatca
     2101 ccaggaaata tggtgtttgg ctgtaagccc cagtggagac tatgttgtat catcgtccca
     2161 tgacaaatct ctgagacttt gggagagaac aagggagcct cttattcttg aggaagaaag
     2221 ggagatggaa agagaagcag aatatgagga gagtgtggcc aaagaagacc aaccagcagt
     2281 tccaggagag actcaaggtg acagttactt tactggaaag aaaactattg aaacagtgaa
     2341 agcagctgag aggattatgg aggctattga gttgtaccga gaagaaactg caaaaatgaa
     2401 ggaacacaaa gccatttgta aagctgcagg gaaagaggtt ccacttccca gcaaccccat
     2461 cctaatggct tatggcagta tctcaccttc agcttatgta ttagagattt ttaaagggat
     2521 caagtcgagt gagctggaag aatctctact tgtgctgcct ttctcttatg tcccagacat
     2581 tcttaaactc tttaacgaat tcattcagct gggctctgat gttgaactta tatgccggtg
     2641 cctcttcttc ctccttagga ttcactttgg acagatcact agcaatcaaa tgcttgtgcc
     2701 agtgatagaa aaattaaggg aaacaactat ttcaaaagtc agccaagtcc gggatgttat
     2761 cggcttcaat atggctggtc ttgattatct caagagggaa tgcgaggcaa aaagtgaagt
     2821 tatgtttttt gctgatgcta ctagccactt ggaagagaag aagaggaaga ggaaaaagag
     2881 ggagaagttg attctaacgt tgacttagaa ctgaaatgtg gtatcttttt ttttttcaac
     2941 tttttccttt aaaggactcc taaactaagc acagaagagt tggcgtcatc ttaaaaatac
     3001 caaataacag aagatcgcat tgcagatgat atcaggatgt ggtttccagc tttgcctgag
     3061 ggaattccaa catgagatta tgggctggct ccatttcttg gacttaaaat gcattattag
     3121 tttaaaaatc tttctgtgct ctcaaagctt gagccttgca gctcaagctt gttgttccct
     3181 ttatattcta gcagggaata aataattgtt ttaattaggt atttgtttca ttggagttga
     3241 aattaacatt tcaaaagttt ttcgtatttt tttatggcag atgatttgtc atttatttat
     3301 attaggtttt actgcctatt gagacaacca ggtgcataat tgattgccct ttggccataa
     3361 aaatgcagtg tcatggatct tagagctaaa aaggactgta aaaattaccc agaacagcgt
     3421 cctcagactt aaccttctgc aagttatgtc tgtatataag aagattctaa ttgctaactg
     3481 tttatacttt tctgaataaa atagttgttt ctaattaaaa agtagccaag ctaagatgcc
     3541 tggctgggct tctgaggaat taatacactc gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3601 gtgtgtgtat gtgtatgtgt atgtacacat acatatatat agttgacact tgaaaaatgc
     3661 aggtggtagg ggcactgacc cacccctacg ccccgcacag tcaaaaatct gcatataact
     3721 tttgattccc caaagtctta agtactagta gcctgttatt gactgggagc ctgactgatg
     3781 tattatatat attgtatact gtattcttaa agtaagctag agaaaagaaa atgttactta
     3841 gaaaatcata aggaagagaa aatatattta ctgtgtttat caatactata agtgtatgtc
     3901 atctgtttat aaaatgaatt gtctgtctgg attggcaggc aaccacagcc gcagacctca
     3961 atctgtggta cttatcaagc atcagctttt tcttgtaatg tcatgacttt tctctgcttt
     4021 ttgggagcac tgtgatatgc agtttactgg ggcgatgagt tgttcatgca caggtgatta
     4081 gtgtcacagc attttaagtg catacgcaca acacttgagc tcactgcata gcaacaggag
     4141 gtggctgtga aattatttca gtaacatact gtgtattaca gttcatttta tgcagctatg
     4201 atttaatact gcatctttac attattttac atttctccca aaactgtgaa ttgcaccatg
     4261 tatgatctgt atttgtgtgt gttaatgttg ataatagatt tgcgtgtatt ttatggcagt
     4321 aaatgataaa atagtctagt atctacatat attttgtgca ttcatgatat aactactttt
     4381 ttcctaattt ttttcatctg aaacttttct cattgtttca gatctccaaa aatttttcca
     4441 atatatttat tgaaaatatc tgggctgcgt gcagtggctc acgcctgtaa tcccaccact
     4501 gtgggaggcc gaggcaggcg gatcacaagg tcaggagttc cagaccagcc tggccaacat
     4561 ggtgaaacct catctctact aaaaatacaa aaaactagct gggcgtggtg gcaggcgctt
     4621 gtaatcccag ctactcagga ggctgagaca ggagaatcac ttgaacccgg caggcggaga
     4681 ttgcagttag ccaagacagt gccaccagca ttccagcctg ggcaacacag tgagactcca
     4741 tctccaaaat aataatagta aaaaaaaatc tgtataacag tggagccaag tggttaaaac
     4801 ccatgttcaa cggattgtct actgtatatc ttcatggtaa ggatttgggg aatgttctag
     4861 gaaaagatat tgacagatac ctctgggtct gggcttttct tttggggaag tttataaatg
     4921 actaaatcat acttcttgtt acaggcctgt ttagatgttc tgtatcttct tgagacagtt
     4981 ttgcttttta tcttttttgt tgttgttaat cccaaagatt taaaactatg gtttctgtct
     5041 gaatttggtc attgcaacca agttactgtg ttgtggggcc accattttct tctaggctca
     5101 gatatgcagt ccttgtggct tgccgatttg tgtcccaaac cacaagtctt aatgttcttg
     5161 agcataacac aatcactgaa gtgagtaagg gatgcagtgg tgttatttgt tgggcagaat
     5221 aaataagtga attttggcat agagtttctg aaggcataac tatgaaggca agagaatagg
     5281 caggcaggat aatgcattct aggtgctttc caaggagtca gtgttgttta ggcagctatt
     5341 cctgccacca gggagaggag ttaattcttg aaaaaaaatt taatttttta tgagaacaga
     5401 agttgattca atatccttct tagagttgct catcagaaca taaatgtcac tttctagtaa
     5461 catttttgat ggtttccaaa ccaaaacaag ttccaggagg gcattcgaga tgtatacatc
     5521 atcaataatt actcttatgt taaaagttgc tgttttcccg tagctttgcc accatttata
     5581 actcaaaagc ctgatagtgc tagggaatgt aaagatgttt ctgtctgcta agtgttatac
     5641 taatcgaaga gaaggagaac ttttatgata aagtgacatg tacagaacct agccaagtta
     5701 caatttttgg tcaaaatact tgaaactctt taactctaaa agtttaaggt caataggtgc
     5761 attataaagt aaattttaag ccaggcaaat ttctagtcat taagtcagta ttcattgcct
     5821 tagtcagcca ttggctgtat ataatcctta atataaaaac catctaatga ctaatatctc
     5881 ttgcatattg tgaagtaagt tacctataga aattctgtag taccataaag aaaagccttt
     5941 tgagattgca gtgagctgag attgtgccac tgcactccag tctgggcaac agagccagac
     6001 tccattgaaa aaaaaaaaaa aggctcttga atgatgtatt gggagtaaaa catttaggct
     6061 tatttttaaa aatgtatata tccatccact tagagaaaat atgcttaaaa attttgaaat
     6121 tcactggctg gaagctaggt gctttgtata tttggtatta aattgtttct caatggcaaa
     6181 tgtcataaat tatatctcat tctaaagata tctagcaaat ctccagcaga gatctaggac
     6241 agtgcccagg aaagcaatgg tatctgttgg taggtacagg actgtatata ggactctatt
     6301 cacttagctg taaatgatga gcctgctcaa tgcagccttt tcaggccaga ttagtcttca
     6361 gaaagagagg gaggttgtga gcagaagctt aatgaagaaa ccacattggc ttacagttac
     6421 tgtctgcaat ccacccccat tcctcacaat ttaagctcct aagtttgaga tggggctaag
     6481 gttcttaaag gtagtatcac catatattca agtcctttct ctttatttct gaggtttttg
     6541 ggatccaagc agccctggta tgtttttaga acacagtaca cattgtgtaa cagtcactga
     6601 gcccaactct tacatagggc ctggcagtgt tgcccttgtg tatcccttcc ccttgagtat
     6661 ggggtcggac ctagtgactg gcttctagtg aacagaatac agtaaatata atgggatgtg
     6721 tcttccaaga ttagggtata aagcactgaa ttctaccttg catgagcatt acattttata
     6781 atatatataa agaagcaact agtatagtta tttaaacaaa tattttcttt tttttttttt
     6841 ttgagacaga gtctcgctct gtctcccagg ctggagtgca gtggcacgat cttggctcac
     6901 tgcaagctcc gcttcctggg ttcacgccat tctcctgcct cagcctccag agtagctggg
     6961 actacaggca cccgccacca cacttggctg attttttcta ttgtttagta gagacggggt
     7021 ttcaccaagt tagccaggat ggtctcgatc tcctgacctt gtgatccacc cacctcggcc
     7081 tcccaaagtg ctgggattac aggtgtgagc caccgggccc ggcctaaaca aatattttca
     7141 ttcattcagg ccaggtggct tataggtttc tgactataag aagaggggaa gaaacctggg
     7201 gtctaatacc tcaaatttga atgcttgaca atcaaattcc catttattac ttactgtacc
     7261 taatgtggag aaactttacg agacatgaag actccaagtg tggaggaata aattgtagaa
     7321 gttctctgga ccattggatt ttcttttccc tggggaaagt cttttggtcg tttatcataa
     7381 ttgctgcttg ttaaaacagg taaaatactt gttaagggct gtgcttttca tgactaaatt
     7441 atttgcatat ataaacctaa ataacatttt agaatcatag aatttcttct ctggcaacat
     7501 cagttcaatt ttaggtaact gtctatccaa tgcaaattct gcatgctcag gcttgggggt
     7561 tagaggatgg atatgccaat gtctagaatg tcttctgttc tccctagtgt acatttctct
     7621 cctaactgtg actggctttc tataaggagc catcagtatg gtcaagcccc aaaccatatc
     7681 tacatcagat ttcatgcttt tttttttttt ttttggtggg gagagggaca gatcattgtt
     7741 gacactgtaa gtaagtagat aaaagatctg ataagatttt ttgcccttta tctgtgtctg
     7801 acaggttctc tctaatctat aagcagggaa atagaaaatt tattataaat acaaatgatt
     7861 tcattgctat gatcagcagc agtgactcag gtatttgcat ctaataacct gtgtggagag
     7921 ggtaagggca cttgatttag ttaccagagg aaaaaactag ttctttggct agtttccttc
     7981 tgtcacaatg gaaaaaccct gtcattactc aaaggaagag aaaaagggag gggaggaagg
     8041 tgagaggaag ggagagagac tttcccagtg aggactttcc tttcctattt tatattttgc
     8101 tccattgtac ttactgccat cattgtttat ggtttactta ctttatgtat tgtctgtcct
     8161 cccactggaa tgtaagctac ataaaggcag gcgtttcggc atctttgaaa gcataaatga
     8221 acaaatgaac taaacttcat ttattgacat cagtgctatc tgacacaagt tcctttaact
     8281 ttctccttca cctcggaata tctgaatcat cagctatctt cagcttctcc cttgccaaga
     8341 ctaacccttc agctctgttt tttattattc ttttgccctg ttttggatat tgcagtttca
     8401 atcacttcta ctcattcata tttttaatat atatcttctg ctccactctc ttcagcctac
     8461 aaacatgtag gtctacatta aactgaaaat ccttcctata ttctgttgca tccttgagta
     8521 acatattctc ttgctctttc ctttaataaa ttttcttgaa agaatatcca taactaatgt
     8581 ttctgctttc ttaatacagt cattctttac cttttgcaat ttagttttta tcccaaccaa
     8641 atttaacact ttaaatctga attttctttg acatctcaat agcatccgtc aattgtgtcc
     8701 gtcttttcct tgaaattctt cctaaggctt ttgaagtatt tcaccatttt ctaattgctg
     8761 cttttgtctc cactggctct tcttcctcct gctccctaaa ccgactccag atttctgttc
     8821 cttgcccata cattcagcca tcacctctgt gtaaacgatg cttaaaatta ttatatctcc
     8881 aattctgact tctcagttga gatctaatat tacatataca tgattcatta cctcagccca
     8941 aaactttgaa gttgaactcg atgtcctctt tcttccatcc atcaatggct tctacctcag
     9001 attttgcagt ttccttcccc caccatgtct ttcattcatg tccctctttt atgttgactg
     9061 ttcccccact cccagttctt gtcctcacac atggcccatt caggtagact tctaatggta
     9121 cttttacaca tccagttgtt cccctttgac atgtcctgca caataaccct ggattcatct
     9181 taataaagat atgctgatca tgtcacccac agggtcagga atctgcagtg gttcactgct
     9241 gcttaaataa taaaattcaa gccaaggatt taagatcttt cataacttga ctccaaccta
     9301 ctttcccact atattcctaa tactcaagct tttggcaagt tgaactccct gccaatcatc
     9361 ccaaacacct ggagctttcc tgttgccatg gttttgttca ttatttttac ttaaagttcc
     9421 cgtcaatcaa gttttcacat tctataagat ccagctcaaa aatcaaataa atagagaact
     9481 gtaacacaag cagcacacaa ttcatgccac tggagaaagt acaaaataga aataaaatgt
     9541 gaagacttta tttctgctac aaattatata atacctttta agacagagtc caattatcca
     9601 tttttatata tgataaacta ttttatacag taccttggag gtaataggtt cttgatatct
     9661 atctaatatc tgtttggctg aagacactga taaggaggaa tgcatgcata attcagtgaa
     9721 tacccaacct ttataataat aaggtatttc ctatccttcc ataaaattat aatttttttg
     9781 tgatagatac ttgctgtttt attattctgt ctgatattcc gtagatagcc aataacattt
     9841 acatttattc aatctgaagt tactgcacat atactatgtg tcaggtattt ttttagattt
     9901 ggctaggtgc tttcaaagat gaatgaagat gctctttgtc ttaataaatt taactctgat
     9961 tttgaagata gaattaataa agtagagatg cattttgact tcca
//
