LOCUS       NM_182552               3554 bp    mRNA    linear   PRI 29-AUG-2024
DEFINITION  Homo sapiens WD repeat domain 27 (WDR27), transcript variant 1,
            mRNA.
ACCESSION   NM_182552
VERSION     NM_182552.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3554)
  AUTHORS   Bradfield,J.P., Qu,H.Q., Wang,K., Zhang,H., Sleiman,P.M., Kim,C.E.,
            Mentch,F.D., Qiu,H., Glessner,J.T., Thomas,K.A., Frackelton,E.C.,
            Chiavacci,R.M., Imielinski,M., Monos,D.S., Pandey,R., Bakay,M.,
            Grant,S.F., Polychronakos,C. and Hakonarson,H.
  TITLE     A genome-wide meta-analysis of six type 1 diabetes cohorts
            identifies multiple associated loci
  JOURNAL   PLoS Genet 7 (9), e1002293 (2011)
   PUBMED   21980299
REFERENCE   2  (bases 1 to 3554)
  AUTHORS   Stirnimann,C.U., Petsalaki,E., Russell,R.B. and Muller,C.W.
  TITLE     WD40 proteins propel cellular networks
  JOURNAL   Trends Biochem Sci 35 (10), 565-574 (2010)
   PUBMED   20451393
  REMARK    Review article
REFERENCE   3  (bases 1 to 3554)
  AUTHORS   Smith,T.F.
  TITLE     Diversity of WD-repeat proteins
  JOURNAL   Subcell Biochem 48, 20-30 (2008)
   PUBMED   18925368
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB292377.1, AL513547.16,
            BC040606.1 and AL031315.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_182552.4.
            
            Summary: This gene encodes a protein with multiple WD repeats.
            Proteins with these repeats may form scaffolds for protein-protein
            interaction and play key roles in cell signalling. Alternative
            splicing results in multiple transcript variants, but the
            full-length structure of some of these variants cannot be
            determined. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040606.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448612.6/ ENSP00000416289.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               DB292377.1         35-318
            285-376             AL513547.16        68670-68761         c
            377-883             BC040606.1         1-507
            884-884             AL513547.16        37643-37643         c
            885-1032            BC040606.1         509-656
            1033-1033           AL513547.16        35111-35111         c
            1034-1254           BC040606.1         658-878
            1255-1255           AL513547.16        32516-32516         c
            1256-1820           BC040606.1         879-1443
            1821-1821           AL513547.16        25359-25359         c
            1822-1943           BC040606.1         1445-1566
            1944-1944           AL513547.16        18969-18969         c
            1945-2245           BC040606.1         1568-1868
            2246-2246           AL513547.16        5664-5664           c
            2247-2423           BC040606.1         1869-2045
            2424-2424           AL513547.16        3452-3452           c
            2425-3018           BC040606.1         2047-2640
            3019-3109           AL031315.1         62454-62544
            3110-3554           BC040606.1         2732-3176
FEATURES             Location/Qualifiers
     source          1..3554
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..3554
                     /gene="WDR27"
                     /note="WD repeat domain 27"
                     /db_xref="GeneID:253769"
                     /db_xref="HGNC:HGNC:21248"
                     /db_xref="MIM:620936"
     exon            1..479
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            480..675
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     CDS             487..3174
                     /gene="WDR27"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 27"
                     /codon_start=1
                     /product="WD repeat-containing protein 27 isoform 1"
                     /protein_id="NP_872358.4"
                     /db_xref="CCDS:CCDS47520.2"
                     /db_xref="GeneID:253769"
                     /db_xref="HGNC:HGNC:21248"
                     /db_xref="MIM:620936"
                     /translation="MENPQDIFSSNGGCLSDIVIEKYLVESKESVSHVQLACSMQDCA
                     FPLDGTELCIWNTKDPSHQLLILRGHHQPITAMAFGNKVNPLLICSASLDYVIMWNLD
                     ECREKVLQGLVPRGTVMGSLLGKVLCLQLSLDDHVVAVCAGNKIFMLDIEQRFSVTYI
                     ERPDVNNRHKVPPPTFLHTFSQTQAVRAELQGHLGPVTAVEFCPWRAGTLISASEDRG
                     FKVWDHCTGSLIYSSSVLSAYPLLSLFIDAESRQLVTGCADGQLWIFSLMDGHHYRRV
                     ARVDLRKKTETFSTRRVKSGLCSQPEESQLPSTSALGKGEQVEVTFPVLRLAPCDLSL
                     IPNSACGCLSSENTRCVWIGSSVGLFVFNLANLEVEAALYYKDFQSLSILLAGSCALR
                     NRTADQKVLCLLASLFGGKIAVLEINPAALVRAQQCPSMGQSLSVPASSCVLPTSPLY
                     LGIAKEKSTKAASEQRRAARNVMKDQRLVFHSKVRSSGYASAPHVTMFSPKTNIKSEG
                     KGSSRSRSSCAREAYPVECAVPTKPGPQVAAAPTCTRVCCIQYSGDGQWLACGLANHL
                     LLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSARGAELALLLG
                     KDMFSKPIQSAQFYYIDAFILLSSGPEFQLLRYHIDTCKDEIKRYKQKSKSKLICRLS
                     TTGAVDMTSLSAVNDFYSHIVLAAGRNRTVEVFDLNAGCSAAVIAEAHSRPVHQICQN
                     KGSSFTTQQPQAYNLFLTTAIGDGMRLWDLRTLRCERHFEGHPTRGYPCGIAFSPCGR
                     FAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQMESRSVAHAGVQWHD
                     LGSLQPPPSRFKQFFCLSLPSSWDYSLPQLPWMVNSSSF"
     exon            676..817
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            818..942
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1146
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1198
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1269
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1390
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1511
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1615
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1683
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1805
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1888
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1967
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2045
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2143
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2233
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2355
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2489
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2587
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2709
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2807
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2910
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..3009
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3131
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3554
                     /gene="WDR27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3536..3541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR27"
                     /note="hexamer: AATAAA"
     polyA_site      3554
                     /gene="WDR27"
                     /note="major polyA site"
ORIGIN      
        1 aaccatagcg gctcgcgtgg gtcggctggc aagtaaccat agcggcgagc gtggggcgga
       61 gtgtggctcg gtagtcctct gcgtgccctc ctgggagctg ggtgctgtga gtcctcccct
      121 agcgggctgg tctcggcgcg gagtcggcgc cgaacccgag ctgctgctct ggggcgtgtg
      181 cctagggcgc agggctggag cgcgggggct gcgcggttgc tcgcggctcc gctgaggtct
      241 ctaggaaagg gggcgatttg agggttccgc cgtgaccgct tccaacggcg gacacgcgcg
      301 ctctggacca gagccgttgc ccgctgtctc gtcacccgaa gcctcctcct gacgccgtgc
      361 tagtgcgagg gtctccaggg gaattcgggg cacaagtcgg gccggagcat ccgggcggcc
      421 gcttgagatc ggcgctttga gaactgagcg catgtggagt tcggaggaaa agggctcaga
      481 ttgaagatgg aaaatcccca agacattttc tcaagtaatg gtggctgtct aagtgatata
      541 gttatagaaa aatacctggt tgaatccaag gagtctgtgt ctcatgttca gcttgcttgc
      601 agcatgcagg actgtgcttt ccctttggat ggaactgaac tttgtatatg gaacactaag
      661 gatccttctc atcagcttct aatcctacga ggacaccatc agccaattac tgctatggct
      721 tttggaaata aagtgaaccc acttctaatc tgctcagcat cactggatta tgttataatg
      781 tggaacctgg atgaatgtag agagaaagta cttcaagggc tggtccctcg agggactgtc
      841 atgggctcgc ttttgggaaa ggtgctgtgt ttacagttga gcctggatga tcatgttgtt
      901 gccgtgtgtg ctggaaacaa aatattcatg ctggatattg agcagcgatt ttctgtgaca
      961 tacatagaac gtcctgatgt taataaccgc cacaaagtcc caccaccgac cttcctgcac
     1021 acattctctc agactcaggc tgttcgggcc gagctgcagg gccacctggg cccggtgact
     1081 gcggtggagt tctgtccctg gcgagcaggc accctcatct cggcgtctga ggacagaggc
     1141 tttaaggtct gggaccattg tacaggatca ttaatataca gttcatctgt gttatcagca
     1201 tatcctcttc tcagtttatt cattgatgca gaaagcaggc agctggtcac cgggtgtgct
     1261 gacggccagc tttggatctt cagtttgatg gatggacacc attatcgtcg tgtggcacgg
     1321 gttgacctaa ggaagaagac agagactttc tccacaagaa gggttaagtc tgggctgtgc
     1381 agccagccag aagaaagcca gcttccctct acaagtgctc tgggaaaagg agagcaggtt
     1441 gaagtaacat ttcctgtact gagacttgca ccctgtgatc tctcactcat cccaaattct
     1501 gcatgtggat gtctttcttc tgagaacacc cgatgtgtgt ggatcggaag ctcagtgggc
     1561 ttattcgtat ttaacctggc aaacctggaa gtggaagctg ctttgtatta caaggatttc
     1621 cagagcctca gcatcctgct ggccggatcg tgtgccctga ggaaccgcac tgcggatcaa
     1681 aaggtgctgt gcttgctggc ctccctcttt ggcgggaaga ttgccgtgtt ggagatcaac
     1741 ccggccgcgc tagtcagggc tcagcagtgc cccagcatgg ggcagagcct ctcggtgcca
     1801 gccagctcct gtgtcctacc gacctctcca ctgtatctgg gaattgccaa ggagaagagt
     1861 accaaggctg ctagtgaaca gcgacgtgct gcacggaacg tcatgaagga ccaacgcctg
     1921 gttttccata gtaaagttag gtcatctggt tatgcgtcag caccacatgt aactatgttt
     1981 tcaccaaaga ccaacatcaa gagtgagggg aaaggatctt caaggagcag gagcagctgc
     2041 gcacgggagg cataccccgt ggagtgcgct gtgcccacca agcccggccc ccaggtcgct
     2101 gccgccccca cctgcacacg tgtatgctgc atccagtact caggagatgg gcagtggctg
     2161 gcctgtgggt tggccaacca tctgttactc gtttttgatg ccagcctgac tgggacacct
     2221 gctgtgtttt caggtcacga cggggcagtg aatgccgtgt gctggagcca ggaccggagg
     2281 tggctgctct ctgcggcccg ggacgggacc ctgcgaatgt ggtcggctcg tggggcagag
     2341 ctcgcactgc ttctgggcaa agacatgttt tctaaaccta tacagtctgc acagttctat
     2401 tatatagatg cctttatatt gttatcttct ggccctgaat ttcagctact gaggtatcac
     2461 attgacactt gcaaagatga gattaagaga tataaacaga agagcaagtc caagctgatt
     2521 tgcaggctct ccacgacggg tgcagtagac atgaccagtt tatcggcagt caacgacttt
     2581 tattcccaca tcgtactcgc agctggccgg aacaggaccg tggaagtgtt tgacctcaac
     2641 gccggctgca gtgcagcggt gatagcggaa gcccactcac ggcctgtcca tcaaatctgc
     2701 caaaataaag gttcatcatt tacaacccaa cagcctcagg cttataacct tttcctgacc
     2761 acggccattg gcgatgggat gagactgtgg gacctgagaa ccctgaggtg tgagcgccac
     2821 tttgaagggc atccaacccg cggctatcca tgtggaatcg ctttcagtcc ttgtggacga
     2881 ttcgcggctt gtggggccga ggacagacac gcttacgtgt atgaaatggg ctcaagcacg
     2941 ttttctcacc ggctggctgg gcacacagac actgtcactg gagtggcctt caacccatca
     3001 gcgccccaga tggagtctcg ctctgtcgcc cacgctggag tgcagtggca cgatctcggt
     3061 tcactgcaac ctccgccttc caggttcaag caattcttct gcctcagcct cccgagtagc
     3121 tgggattaca gcttgccaca gctaccttgg atggtaaact ccagctcttt ctagctgagt
     3181 aaccactgac ctgtgagctg ggtccaggaa tgctgtgagg aacaacttaa aagtaagaag
     3241 tagtggttca tccatcaggg ggccagaagc agcaactgtt tttcatattt tgagacttgc
     3301 ctcagatttc ccccgtttgc aagctcctcc cctctgtgtg tgccatgtca gagttttatg
     3361 tctttctgct cctcaaaagg gatccccttc attgggaaaa tggaaatggc gtccagtact
     3421 tctgcacaga atttggtaaa gttaaaacaa aatatctttc aataaaacat aatatagtat
     3481 ttgtttgata attagagttg gaagaaaaaa gagagaattt cttttgggca gtgaaaataa
     3541 agcagttaac agtc
//
