LOCUS       NM_001379403            7367 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens WD repeat domain 26 (WDR26), transcript variant 3,
            mRNA.
ACCESSION   NM_001379403
VERSION     NM_001379403.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7367)
  AUTHORS   Gottemukkala,K.V., Chrustowicz,J., Sherpa,D., Sepic,S., Vu,D.T.,
            Karayel,O., Papadopoulou,E.C., Gross,A., Schorpp,K., von Gronau,S.,
            Hadian,K., Murray,P.J., Mann,M., Schulman,B.A. and Alpi,A.F.
  TITLE     Non-canonical substrate recognition by the human WDR26-CTLH E3
            ligase regulates prodrug metabolism
  JOURNAL   Mol Cell 84 (10), 1948-1963 (2024)
   PUBMED   38759627
  REMARK    GeneRIF: Non-canonical substrate recognition by the human
            WDR26-CTLH E3 ligase regulates prodrug metabolism.
REFERENCE   2  (bases 1 to 7367)
  AUTHORS   Gross,A., Muller,J., Chrustowicz,J., Strasser,A.,
            Gottemukkala,K.V., Sherpa,D., Schulman,B.A., Murray,P.J. and
            Alpi,A.F.
  TITLE     Skraban-Deardorff intellectual disability syndrome-associated
            mutations in WDR26 impair CTLH E3 complex assembly
  JOURNAL   FEBS Lett 598 (9), 978-994 (2024)
   PUBMED   38575527
  REMARK    GeneRIF: Skraban-Deardorff intellectual disability
            syndrome-associated mutations in WDR26 impair CTLH E3 complex
            assembly.
REFERENCE   3  (bases 1 to 7367)
  AUTHORS   Hu,J., Xu,M., Zhu,X. and Zhang,Y.
  TITLE     Two Novel Variants of WDR26 in Chinese Patients with Intellectual
            Disability
  JOURNAL   Genes (Basel) 13 (5), 813 (2022)
   PUBMED   35627197
  REMARK    GeneRIF: Two Novel Variants of WDR26 in Chinese Patients with
            Intellectual Disability.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7367)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   5  (bases 1 to 7367)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 7367)
  AUTHORS   Higa,L.A., Wu,M., Ye,T., Kobayashi,R., Sun,H. and Zhang,H.
  TITLE     CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat
            proteins and regulates histone methylation
  JOURNAL   Nat Cell Biol 8 (11), 1277-1283 (2006)
   PUBMED   17041588
REFERENCE   7  (bases 1 to 7367)
  AUTHORS   Sawada,S. and Takei,M.
  TITLE     Epstein-Barr virus etiology in rheumatoid synovitis
  JOURNAL   Autoimmun Rev 4 (2), 106-110 (2005)
   PUBMED   15722257
  REMARK    Review article
REFERENCE   8  (bases 1 to 7367)
  AUTHORS   Zhu,Y., Wang,Y., Xia,C., Li,D., Li,Y., Zeng,W., Yuan,W., Liu,H.,
            Zhu,C., Wu,X. and Liu,M.
  TITLE     WDR26: a novel Gbeta-like protein, suppresses MAPK signaling
            pathway
  JOURNAL   J Cell Biochem 93 (3), 579-587 (2004)
   PUBMED   15378603
  REMARK    GeneRIF: WDR26 may act as a negative regulator in MAPK signaling
            pathway and play an important role in cell signal transduction.
REFERENCE   9  (bases 1 to 7367)
  AUTHORS   Takei,M., Ishiwata,T., Mitamura,K., Fujiwara,S., Sasaki,K.,
            Nishi,T., Kuga,T., Ookubo,T., Horie,T., Ryu,J., Ohi,H. and
            Sawada,S.
  TITLE     Decreased expression of signaling lymphocytic-activation
            molecule-associated protein (SAP) transcripts in T cells from
            patients with rheumatoid arthritis
  JOURNAL   Int Immunol 13 (4), 559-565 (2001)
   PUBMED   11282995
REFERENCE   10 (bases 1 to 7367)
  AUTHORS   Skraban,C.M., Grand,K.L. and Deardorff,M.A.
  TITLE     WDR26-Related Intellectual Disability
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31021590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099790.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. Two transcript
            variants encoding two different isoforms have been found for this
            gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB209887.1, AY304473.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000414423.9/ ENSP00000408108.4
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on manual assertion,
                                        conservation, expression, longest
                                        protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1114              AC099790.3         89840-90953         c
            1115-1214           AC099790.3         87838-87937         c
            1215-1319           AC099790.3         87633-87737         c
            1320-1456           AC099790.3         80674-80810         c
            1457-1554           AC099790.3         75674-75771         c
            1555-1711           AC099790.3         74416-74572         c
            1712-1850           AC099790.3         67583-67721         c
            1851-1991           AC099790.3         60586-60726         c
            1992-2111           AC099790.3         57106-57225         c
            2112-2257           AC099790.3         55045-55190         c
            2258-2336           AC099790.3         54671-54749         c
            2337-2466           AC099790.3         54253-54382         c
            2467-2652           AC099790.3         49984-50169         c
            2653-7367           AC099790.3         41302-46016         c
FEATURES             Location/Qualifiers
     source          1..7367
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.11-q42.12"
     gene            1..7367
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /note="WD repeat domain 26"
                     /db_xref="GeneID:80232"
                     /db_xref="HGNC:HGNC:21208"
                     /db_xref="MIM:617424"
     exon            1..1114
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             393..2678
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /note="isoform c is encoded by transcript variant 3;
                     non-AUG (ACG) translation initiation codon; CUL4- and
                     DDB1-associated WDR protein 2; myocardial ischemic
                     preconditioning upregulated protein 2; GID complex subunit
                     7 homolog"
                     /codon_start=1
                     /transl_except=(pos:393..395,aa:Met)
                     /product="WD repeat-containing protein 26 isoform c"
                     /protein_id="NP_001366332.1"
                     /db_xref="CCDS:CCDS91162.1"
                     /db_xref="GeneID:80232"
                     /db_xref="HGNC:HGNC:21208"
                     /db_xref="MIM:617424"
                     /translation="MASLGEETLASASSSSDSDTGGASPPPRKKPRASAAEGVGEPGA
                     SAGRAGLSPPSSSSSSSSSSSSSVVVVVGLPPAAAPPAAAAVPHRSSGHSLVSGSIMQ
                     ANGAGGGGGGGGGGGGGGGGGGGQGQTPELACLSAQNGESSPSSSSSAGDLAHANGLL
                     PSAPSAASNNSNSLNVNNGVPGGAAAASSATVAAASATTAASSSLATPELGSSLKKKK
                     RLSQSDEDVIRLIGQHLNGLGLNQTVDLLMQESGCRLEHPSATKFRNHVMEGDWDKAE
                     NDLNELKPLVHSPHAIVVRGALEISQTLLGIIVRMKFLLLQQKYLEYLEDGKVLEALQ
                     VLRCELTPLKYNTERIHVLSGYLMCSHAEDLRAKAEWEGKGTASRSKLLDKLQTYLPP
                     SVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDNNLDSVSLLIDHVCSRRQFPCYTQQI
                     LTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIA
                     WSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQ
                     RGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQ
                     EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHN
                     EDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRI
                     WGPAPFIDHQNIEEECSSMDS"
     exon            1115..1214
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1319
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1456
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1554
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1711
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1850
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1991
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2111
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2257
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2336
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2466
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2652
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..7367
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3353..3358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /note="hexamer: AATAAA"
     polyA_site      3377
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /note="major polyA site"
     regulatory      4645..4650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /note="hexamer: AATAAA"
     polyA_site      4670
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
     regulatory      7345..7350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /note="hexamer: AATAAA"
     polyA_site      7367
                     /gene="WDR26"
                     /gene_synonym="CDW2; GID7; MIP2; SKDEAS"
                     /note="major polyA site"
ORIGIN      
        1 attaggcagc agctggggga agaatcaaca caccagggag cagagcggag cggatccgag
       61 gacagaggcg gcagctgcct ccgctgccgc ccgccgccgc cgccgccgca gccactgccg
      121 gggctcagcc cagcggcggg ccccgcgccc ccgcagccgc cccgcggcgc cccccggcgc
      181 gacccccggg ccgcgcaccc cgagctgcct ccgggagggg ggggggaaag ggcccggatc
      241 ctccttctcc ccctcctcct cctccccctc ctctcaccct caccctcacc ctcctaccct
      301 gaccccctcc ccgcctcccc ggcccccctc accccgaccc tctccccggc ccccgcctcc
      361 cctcccccgc ctcgccccac cggcttccca ccacggcctc tctcggcgag gaaactctgg
      421 cctccgcttc ctcctcctcc gactcggaca ccggcggagc ctccccgccc ccgcggaaga
      481 aaccccgagc ctcggcggcg gagggagtag gagagcccgg ggcttcggca ggcagagcag
      541 gcctctcccc tccgtcctcg tcgtcctcgt cctcctcctc ctcctcctcc tccgtggtgg
      601 tagtggtggg acttcccccg gctgctgccc ctcccgccgc cgctgctgtc ccccaccgaa
      661 gtagcggcca cagcctggtc agcggcagca tcatgcaggc caatggggca ggaggaggag
      721 gaggaggtgg cggcggcggc ggtggaggag gagggggcgg cgggggccag ggacagaccc
      781 cggaactcgc ctgcttgtcg gcccagaacg gggagtcgtc cccctcgtcg tcgtcgtccg
      841 cgggggacct ggcccacgcc aatgggctcc tgccttccgc cccctccgcc gccagcaaca
      901 atagcaacag cctgaatgtc aataacgggg ttcccggcgg ggcggccgcc gcatcctcag
      961 ccaccgtcgc agctgcctcc gccaccaccg ccgcctcctc ttccttggcc accccagaac
     1021 tgggcagcag cctcaagaag aagaagcggc tctcccagtc agatgaggat gtcattaggc
     1081 taataggaca gcacttgaat ggcttagggc tcaaccagac tgttgatctc ctcatgcaag
     1141 agtcaggatg tcgtttagaa catccttctg ctaccaaatt ccgaaatcat gtcatggaag
     1201 gagactggga taaggcagaa aatgacctga atgaactaaa gcctttagtg cattctcctc
     1261 atgctattgt ggtaagaggc gcacttgaaa tctctcaaac gttgttggga ataattgtga
     1321 ggatgaagtt tttgctgctg cagcagaagt acctagaata cctggaggat ggcaaggtcc
     1381 tggaggcact tcaagttcta cgctgtgaat tgacgccgct gaaatacaat acagagcgca
     1441 ttcatgttct tagtgggtat ctgatgtgta gccatgcaga agacctacgt gcaaaagcag
     1501 aatgggaagg caaagggaca gcttcccgat ctaaactatt ggataaactt cagacctatt
     1561 taccaccatc agtgatgctt cccccacggc gtttacagac tctcctgcgg caggcggtgg
     1621 aactacaaag ggatcggtgc ctatatcaca ataccaaact tgataataat ctagattctg
     1681 tgtctctgct tatagaccat gtttgtagta ggaggcagtt cccatgttat acgcagcaga
     1741 tacttacgga gcattgtaat gaagtgtggt tctgtaaatt ctctaatgat ggcactaaac
     1801 tagcaacagg atcaaaagat acaacagtta tcatatggca agttgatccg gatacacacc
     1861 tgctaaaact gcttaaaaca ttagaaggac atgcttatgg cgtttcttat attgcatgga
     1921 gtccagatga caactatctt gttgcttgtg gcccagatga ctgctctgag ctttggcttt
     1981 ggaatgtaca aacaggagaa ctaaggacaa aaatgagcca gtctcatgaa gacagtttga
     2041 caagtgtggc ttggaatcca gatgggaagc gctttgtgac tggaggtcag cgtgggcagt
     2101 tctatcagtg tgacttagat ggtaatctcc ttgactcctg ggaaggggta agagtgcaat
     2161 gcctttggtg cttgagtgat ggaaagactg ttctggcatc agatacacac cagcgaattc
     2221 ggggctataa cttcgaggac cttacagata ggaacatagt acaagaagat catcctatta
     2281 tgtcttttac tatttcaaaa aatggccgat tagctttgtt aaatgtagca actcagggag
     2341 ttcatttatg ggacttgcaa gacagagttt tagtaagaaa gtatcaaggt gttacacaag
     2401 ggttttatac aattcattca tgttttggag gccataatga agacttcatc gctagtggca
     2461 gtgaagatca caaggtttac atctggcaca aacgtagtga actgccaatt gcggagctga
     2521 cagggcacac acgtacagta aactgtgtga gctggaaccc acagattcca tccatgatgg
     2581 ccagcgcctc agatgatggc actgttagaa tatggggacc agcacctttt atagaccacc
     2641 agaatattga agaggaatgc agtagcatgg atagttgatg gtgaatttgg agcagacgac
     2701 ttctgtttaa cttaaaatta gtcgtatttt aatggcttgg gatttggtgc aaacaaacat
     2761 gattgatagc tggacagaca tgctcgtcat gaaaaaagaa ccatttctga agcccgattg
     2821 gggccaaaca tttacacctt gcttcatagt aaccagttga gatgaagcac gtcgttagaa
     2881 cgttgttgga caccatgttg aattattccc ccatcggttg tgaagaactg tgctacattc
     2941 aggcttaccc attgaactca gtatatatat ttttttcctt cctgtctttt gtctggcagg
     3001 ataccattct tgttgctctt ctgtgtaatg aagtttaaat gcttgtttgg aaaactttat
     3061 ttaacagttt agaaggcttg atagaaagag tgcattagtc tgaagagtat acattggata
     3121 ggaaagaatt tccttctttt gtttctccaa atctttccgc cttatttagc ttgagatctt
     3181 tgcagcttgg ttcatggatt ctagccttgc ccgttgcgca gtatatactg atccagatga
     3241 taaaccagtg aactatgtca aaagcactct caatattaca tttgacaaaa agttttgtac
     3301 ttttcacata gcttgttgcc ccgtaaaagg gttaacagca caatttttta aaaataaatt
     3361 aagaagtatt tataggatta aagtgacttc atttgtatac atttggaatc taaaccagct
     3421 taaaaacagt ttcctcaatg acttagatac acagtataac tgatgctctt ctggaatacc
     3481 acatgagaca tggtcagaaa cagtgcttgg aaggacatta cacaagaaat tcagagtaat
     3541 gctttgaaga tttcccccct tttgttttat tcctgaagga acatcagtac ccgatcttga
     3601 agaaattcaa gattcaaaaa gaattttaaa tacaccaaca tgagacatca gtagtcagtt
     3661 ggttttcagt aaagcttgtt ccaagttgtt ctcaacttag gaagtaattt tggtgtgatc
     3721 tagcaaaaga gtaggaatca gcgatacaac cactttggaa gtttatagta taattgaaat
     3781 tattagaaga attcagcagg ttacagacat acttaaactg ggattaaaac ctcatagtca
     3841 tttttcttaa ttgcccttaa tattttgaca tatagggata cataaattta aagaatattt
     3901 tttctcagtt ttttcagata ttgccatact gaacctcatt ctaaactggt gctgtggata
     3961 gtctttccct ctcccctcct gttttagttt aaggaaaggt ttccttcatg gaaaagcact
     4021 tttaattttg agaatttcac atttaaaata agccaaaagc ctgatgttca cattgtgctt
     4081 ttaaactccg taacagctga atacaacata acatagtctc ccttgaaatt ccctcccttt
     4141 ttcagtagag gataaatagg gtgactccag ctgttggaat gagaatgggg atacccccaa
     4201 aataagattc tggtgaagaa aaagtcttgt actaagttcc cctttaggtg tagccaagtc
     4261 tataatataa ttatgatcat gaatagactc cagaatccac aaagagaaga gggcttggat
     4321 gtcaaaaatt cttccattgt ggggtaggtg gtcggggatg ggagaaaggg aaaagtcagg
     4381 gaaggggaga agaaagaaaa acacatttgg ccttaaaata gcatgcattc tcccagaagc
     4441 ccatagtaaa gaaaatgaca gatcgtggtc agcagactct tatcaaattg gtatgtaaaa
     4501 gatttcttca agctccattt tgcagagacc accacttaga gaatcaaaaa attcctgttt
     4561 tgatacttct aagttaaaat atatgttaca gtttatctgg tacttcattt ttcttaacta
     4621 aaattacttt ttactttaag cttgaataaa aatcttcatt ggtaactgta tgtaattaag
     4681 tggcaacttc tctttacctc agtatagtta aaaaccattc atattttaag tgattcatgt
     4741 ataccctgaa gccgttaata caccccagtc tctatggtaa catcactaaa tgtgggcata
     4801 gaaactccac agctgtttac aaatttggtt acagtgtgct acggtgcatt tgtaacactc
     4861 agatttgtgc ccattcaggg gcaatttggc actcagattc tactctactt cacctaacca
     4921 cccctagatc tgagttttca gagtgcttct gaagtacagt ttaaaaacac tttttaaaaa
     4981 gtggagtaaa agtgaggcac attttacaag aacataactc ctattaaaac ggagtaacaa
     5041 ctatgcaaag gtttctatag cagctaggtg agtttgtttt ccgggtctgt cttaactggc
     5101 agcttcctgt acatactggt acttatttgc tgtaaacgtc tgtttcatac atttgccatg
     5161 cagtgactgt gctcgaaagg tgaaatcaat ggtaaagaag cctaggattt tatggtatga
     5221 gaaactgatc gcaggatttt ctgatccata gctattaatt gaaaacttct gatagtgctg
     5281 taggctctat agtaggctta agagtgagtc ttatactatg aagccagcca caagatacta
     5341 acaaatgtat aaattgaaaa gtaccaatac tttttgcaca tagatcaaaa tagagtggag
     5401 aatttgggct ccaaaaatca ggttagtagg ctcatttcca tgtgcttaaa aatgtttttg
     5461 ttgttatgca ttgattaagg gctagagcaa atataaaatt aaatgtcttt ttcctccaaa
     5521 taattggtta ttaatggtaa aatgttggac ttggggatta ctgagattag tatgtgggta
     5581 gtaaagaatt ggagtgggag ttagtgggga gggatgacaa agcttcagct ttggtttttg
     5641 tattttttta gtcttcataa cagctacatt tctgttgctc ttattggcca gataaatgtg
     5701 ttatattaaa ccaggtaagt attttaaaca gagaacattt tatttgcata tatccctaca
     5761 aattggccca ttttattggg tggggggata aaaaagggat tccctaactt taaataatca
     5821 gaatatcctg caattgaaag gagaaaaaaa tccaattttg tcagtatttt cttagtctga
     5881 aaaaaacagc agtagtaatc tggtgaatgt tattattagg agtgttctgc ctctacagtg
     5941 gcatattcca tgacattaat agaaaaccct tctttcccac ccctccccat cttgacattt
     6001 tcttttttag gatgttggtt cctgcaaaca agaactgacc ctatcacctc tgcctcacag
     6061 tgggtaaata tatcatacat ctcttgaaag ggaaaatatc catgtcagtt tctttcacag
     6121 tagaagaatg gctgcttttg aatggggagg aaagaagaca tttttcttaa tatccttttt
     6181 gtcccatctc taaaatgtat aaatattttg atttggtttt actttaattt ctcattcata
     6241 atttcgcaac tgtccttttg ggttgccctc caacacatta cttccatttc agaaaccata
     6301 tctgatttaa tataaactgc taacttaaga agaggtgaat ttgcatttac acttagacac
     6361 tttctaaaaa cagggtgaac ttaattgaaa tttttcagtg ttgttaagct attgttatag
     6421 tagctgccct atagttacaa aaataaaaac tataaaaacc catcccctat ctacttaatc
     6481 cagatagcct ggatttaaca aaaccaatag tataaaaatg tgtgtgtgtg ttctgtgtgt
     6541 gtgtgagaga gagagtactt gattcattaa aaagtcctgg aaacagctgt tctaggatct
     6601 tgtcattttt actgaaagtc tcgtgcacat gtgaagtgcc ctctgagttt aaggtttggt
     6661 taatactggt atatttttat aagattgaaa ttgtgtcccc atctttaact taaacatttt
     6721 cattatcagg gtcaatgtgc tagaactgaa ttgtaacatt tttaggcaca gatggaaaaa
     6781 aatgttattg gctccttgaa aatgtgtgtg tgtggcgagg ggaatagatc cacaaaagca
     6841 tgtatgtact tacaaaccaa gctgtagaga tcaagaaaag aacttaagtg ttgatctcaa
     6901 gatttctaaa ttgtcaagat ttacatggca ttgtggtgga actagttaac acttagagct
     6961 tttggtatgt aataactatt tgctatggac tgattaaatg tttcaaaaga ttgtgttctt
     7021 caattttggt gggttttgat ttttgttttt ttaactgcct ctcagattat atttacttag
     7081 tttaaatttc tttgctttat tcattaaagt ataaaaactt caggtctctg atatttattt
     7141 tcacttgttt actaattatt tacaaaacac cctttgttga cttttatttt ataaatgtgt
     7201 aatgtattaa acgtctttaa atttttgttc aactgaaact acattaactt tgatttgctt
     7261 tactgggatt tttttttaaa gacacttttt ccatgtcagt gcgcagcact taaccagtcg
     7321 tttgtattcc ctttctttca atccaataaa cagaatgaat acctaaa
//
