LOCUS       NM_001161476            1923 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens WD repeat domain 25 (WDR25), transcript variant 2,
            mRNA.
ACCESSION   NM_001161476
VERSION     NM_001161476.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1923)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1923)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1923)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1923)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   5  (bases 1 to 1923)
  AUTHORS   Jin,F., Dai,J., Ji,C., Gu,S., Wu,M., Qian,J., Xie,Y. and Mao,Y.
  TITLE     A novel human gene (WDR25) encoding a 7-WD40-containing protein
            maps on 14q32
  JOURNAL   Biochem Genet 42 (11-12), 419-427 (2004)
   PUBMED   15587985
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL135838.6 and AL845552.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 2, 2020 this sequence version replaced NM_001161476.2.
            
            Summary: This gene encodes a protein containing 7 WD repeats. WD
            repeats are approximately 30 to 40-amino acid domains containing
            several conserved residues, typically having a Tryptophan-Aspartic
            acid dipeptide (WD) at the C-terminal end. WD domains are involved
            in protein-protein interactions in a variety of cellular processes,
            including cell cycle progression, signal transduction, apoptosis,
            and gene regulation. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Apr 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291960.1, SRR14038194.1630503.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402312.8/ ENSP00000385540.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL135838.6         77432-77442         c
            12-848              AL135838.6         72181-73017         c
            849-996             AL845552.2         15606-15753
            997-1127            AL845552.2         31579-31709
            1128-1298           AL845552.2         73455-73625
            1299-1439           AL845552.2         76653-76793
            1440-1923           AL845552.2         77405-77888
FEATURES             Location/Qualifiers
     source          1..1923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.2"
     gene            1..1923
                     /gene="WDR25"
                     /gene_synonym="C14orf67"
                     /note="WD repeat domain 25"
                     /db_xref="GeneID:79446"
                     /db_xref="HGNC:HGNC:21064"
                     /db_xref="MIM:618059"
     exon            1..11
                     /gene="WDR25"
                     /gene_synonym="C14orf67"
                     /inference="alignment:Splign:2.1.0"
     exon            12..848
                     /gene="WDR25"
                     /gene_synonym="C14orf67"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1661
                     /gene="WDR25"
                     /gene_synonym="C14orf67"
                     /note="isoform a is encoded by transcript variant 2; WD
                     repeat-containing protein 25; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="WD repeat-containing protein 25 isoform a"
                     /protein_id="NP_001154948.1"
                     /db_xref="CCDS:CCDS32157.1"
                     /db_xref="GeneID:79446"
                     /db_xref="HGNC:HGNC:21064"
                     /db_xref="MIM:618059"
                     /translation="MTARTLSLMASLVAYDDSDSEAETEHAGSFNATGQQKDTSGVAR
                     PPGQDFASGTLDVPKAGAQPTKHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKE
                     PQVTFPIKEPSCSSLWTSHVPASHMPLAAARFKQVKLSRNFPKSSFHAQSESETVGKN
                     GSSFQKKKCEDCVVPYTPRRLRQRQALSTETGKGKDVEPQGPPAGRAPAPLYVGPGVS
                     EFIQPYLNSHYKETTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVW
                     NAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDF
                     RITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFL
                     SSTDASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYL
                     ALFSTVWPYRMSRRRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRA
                     CTLQGHTQACVGTTYHPVLPSVLATCSWGGDMKIWH"
     exon            849..996
                     /gene="WDR25"
                     /gene_synonym="C14orf67"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1127
                     /gene="WDR25"
                     /gene_synonym="C14orf67"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1298
                     /gene="WDR25"
                     /gene_synonym="C14orf67"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1439
                     /gene="WDR25"
                     /gene_synonym="C14orf67"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1923
                     /gene="WDR25"
                     /gene_synonym="C14orf67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1883..1888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR25"
                     /gene_synonym="C14orf67"
                     /note="hexamer: AATAAA"
     polyA_site      1923
                     /gene="WDR25"
                     /gene_synonym="C14orf67"
                     /note="major polyA site"
ORIGIN      
        1 gagcgcttcc ggtggtttgg ctttgaatga cagcaagaac tctgtcttta atggcttcat
       61 tggtagcgta tgatgattcg gactcggagg ctgagacaga gcatgcagga agttttaatg
      121 ctaccggcca gcagaaagac acttctggtg tggccagacc acctgggcag gattttgcat
      181 ctggtacact ggatgtgccc aaagcagggg cacagcccac aaagcatggc tcctgtgaag
      241 acccaggggg ctatcgcctt ccattggctc agcttgggag aagcgattgg ggatcttgcc
      301 ccagccagag gctacagtgg cccgggaagg agcctcaagt caccttcccc atcaaagagc
      361 cttcttgttc ttctctgtgg acgagccatg ttccagccag ccacatgccc ctggcagctg
      421 cccgctttaa gcaagtaaaa ctctccagga actttcccaa gtcatctttc catgctcaaa
      481 gtgagtctga aaccgtaggt aaaaatggca gctcttttca gaagaaaaaa tgtgaggact
      541 gtgtggtacc ctatactccc agaagactaa gacagcggca ggcattaagc acggagacag
      601 gcaagggtaa agacgtggag ccacaggggc cccctgcagg gcgtgcccca gcccctctct
      661 acgtgggccc gggagtgtct gagtttattc agccatattt gaatagccat tataaagaaa
      721 ccacagttcc ccggaaagtg cttttccacc tgagaggcca caggggccct gtcaacacca
      781 ttcagtggtg tccagtcctt tctaagagcc acatgcttct ctccacttct atggataaaa
      841 ctttcaaggt atggaacgcc gtggactccg ggcactgcct gcagacctac tccctgcaca
      901 cagaggcagt gcgggccgcc cggtgggctc cctgtggccg gcgcatcctc agtggtggct
      961 ttgacttcgc gctgcaccta acagaccttg aaacaggaac ccagctattt agtggtcgaa
     1021 gtgactttag aatcactacc ttgaaattcc atccaaaaga ccacaacatc tttttatgtg
     1081 gaggcttcag ctctgaaatg aaagcttggg atataaggac tggcaaggtg atgagaagct
     1141 acaaggcgac catccagcag accttggaca tcctgttcct ccgggaaggc tccgagttcc
     1201 tgagcagcac agacgcttcc acccgggact cagctgaccg caccattatt gcctgggatt
     1261 tccggacctc tgccaaaatc tccaaccaga ttttccacga gaggttcacc tgccccagcc
     1321 tcgccttgca cccgagagag cccgtgttcc tggcacagac caatggcaac tacctggccc
     1381 ttttctccac tgtgtggccc taccggatga gcagacggcg gcgctatgaa gggcacaagg
     1441 tggagggcta ctcagtgggc tgcgagtgct ccccaggcgg tgacttgctg gtgacgggca
     1501 gcgccgatgg ccgggtcctg atgtacagct tccgcacagc cagccgagca tgcacactgc
     1561 aggggcacac acaggcctgt gtcggcacca cctatcaccc cgtgctgccc tccgtcctcg
     1621 ccacctgctc ctggggaggg gacatgaaga tctggcactg agctttttgt cactgaacct
     1681 tcccgatgcc agctgggctc ttggactccc ctcttcctca agggtagatg agaggaacga
     1741 gcacagaggt tggctgtggg tcctgggtac caccttctga gcctcagttt cctcatctgt
     1801 aaagtgggga gaaaagtctg tttgcctcag gagtgtgagg actacactag tgaaagcgcc
     1861 tggcgggcag ccggcgatgc ccaataaatg tgtgttttgc tgtttgttaa gtgatttcag
     1921 caa
//
