LOCUS       NM_032259               3243 bp    mRNA    linear   PRI 12-NOV-2023
DEFINITION  Homo sapiens WD repeat domain 24 (WDR24), mRNA.
ACCESSION   NM_032259 NM_001303027
VERSION     NM_032259.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3243)
  AUTHORS   Yin S, Liu L, Ball LE, Wang Y, Bedford MT, Duncan SA, Wang H and
            Gan W.
  TITLE     CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and
            tumor growth
  JOURNAL   Cell Rep 42 (4), 112316 (2023)
   PUBMED   36995937
  REMARK    GeneRIF: CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1
            signaling and tumor growth.
REFERENCE   2  (bases 1 to 3243)
  AUTHORS   Dai X, Jiang C, Jiang Q, Fang L, Yu H, Guo J, Yan P, Chi F, Zhang
            T, Inuzuka H, Asara JM, Wang P, Guo J and Wei W.
  TITLE     AMPK-dependent phosphorylation of the GATOR2 component WDR24
            suppresses glucose-mediated mTORC1 activation
  JOURNAL   Nat Metab 5 (2), 265-276 (2023)
   PUBMED   36732624
REFERENCE   3  (bases 1 to 3243)
  AUTHORS   Jiang C, Dai X, He S, Zhou H, Fang L, Guo J, Liu S, Zhang T, Pan W,
            Yu H, Fu T, Li D, Inuzuka H, Wang P, Xiao J and Wei W.
  TITLE     Ring domains are essential for GATOR2-dependent mTORC1 activation
  JOURNAL   Mol Cell 83 (1), 74-89 (2023)
   PUBMED   36528027
REFERENCE   4  (bases 1 to 3243)
  AUTHORS   Zhang Y, Ting CY, Yang S, Reich J, Fru K and Lilly MA.
  TITLE     Wdr59 promotes or inhibits TORC1 activity depending on cellular
            context
  JOURNAL   Proc Natl Acad Sci U S A 120 (1), e2212330120 (2023)
   PUBMED   36577058
REFERENCE   5  (bases 1 to 3243)
  AUTHORS   Valenstein ML, Rogala KB, Lalgudi PV, Brignole EJ, Gu X, Saxton RA,
            Chantranupong L, Kolibius J, Quast JP and Sabatini DM.
  TITLE     Structure of the nutrient-sensing hub GATOR2
  JOURNAL   Nature 607 (7919), 610-616 (2022)
   PUBMED   35831510
REFERENCE   6  (bases 1 to 3243)
  AUTHORS   Saxton RA, Knockenhauer KE, Wolfson RL, Chantranupong L, Pacold ME,
            Wang T, Schwartz TU and Sabatini DM.
  TITLE     Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
  JOURNAL   Science 351 (6268), 53-58 (2016)
   PUBMED   26586190
REFERENCE   7  (bases 1 to 3243)
  AUTHORS   Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor
            JR and Sabatini DM.
  TITLE     Sestrin2 is a leucine sensor for the mTORC1 pathway
  JOURNAL   Science 351 (6268), 43-48 (2016)
   PUBMED   26449471
REFERENCE   8  (bases 1 to 3243)
  AUTHORS   Chantranupong L, Wolfson RL, Orozco JM, Saxton RA, Scaria SM,
            Bar-Peled L, Spooner E, Isasa M, Gygi SP and Sabatini DM.
  TITLE     The Sestrins interact with GATOR2 to negatively regulate the
            amino-acid-sensing pathway upstream of mTORC1
  JOURNAL   Cell Rep 9 (1), 1-8 (2014)
   PUBMED   25263562
REFERENCE   9  (bases 1 to 3243)
  AUTHORS   Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA,
            Grabiner BC, Spear ED, Carter SL, Meyerson M and Sabatini DM.
  TITLE     A Tumor suppressor complex with GAP activity for the Rag GTPases
            that signal amino acid sufficiency to mTORC1
  JOURNAL   Science 340 (6136), 1100-1106 (2013)
   PUBMED   23723238
REFERENCE   10 (bases 1 to 3243)
  AUTHORS   Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C,
            Kearney L, Buckle VJ, Doggett NA, Flint J and Higgs DR.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136863.1 and BC009761.2.
            
            On Nov 23, 2018 this sequence version replaced NM_032259.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008025.1, AL136863.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293883.9/ ENSP00000293883.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-974               AL136863.1         4-977
            975-3243            BC009761.2         1-2269
FEATURES             Location/Qualifiers
     source          1..3243
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3243
                     /gene="WDR24"
                     /gene_synonym="C16orf21; JFP7"
                     /note="WD repeat domain 24"
                     /db_xref="GeneID:84219"
                     /db_xref="HGNC:HGNC:20852"
                     /db_xref="MIM:620307"
     exon            1..1239
                     /gene="WDR24"
                     /gene_synonym="C16orf21; JFP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             759..3131
                     /gene="WDR24"
                     /gene_synonym="C16orf21; JFP7"
                     /EC_number="2.3.2.27"
                     /note="WD repeat-containing protein 24; GATOR complex
                     protein WDR24"
                     /codon_start=1
                     /product="GATOR2 complex protein WDR24"
                     /protein_id="NP_115635.1"
                     /db_xref="CCDS:CCDS10420.1"
                     /db_xref="GeneID:84219"
                     /db_xref="HGNC:HGNC:20852"
                     /db_xref="MIM:620307"
                     /translation="MEKMSRVTTALGGSVLTGRTMHCHLDAPANAISVCRDAAQVVVA
                     GRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTW
                     NLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFS
                     GQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPE
                     DRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPECRHHLATCSMMVDH
                     NIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSLCQHLFRDASQP
                     VERANPEGLCYGLFGDLAFAAKESLVAAESGRKPYTGDRRHPIFFKRKLDPAEPFAGL
                     ASSALSVFETEPGGGGMRWFVDTAERYALAGRPLAELCDHNAKVARELGRNQVAQTWT
                     MLRIIYCSPGLVPTANLNHSVGKGGSCGLPLMNSFNLKDMAPGLGSETRLDRSKGDAR
                     SDTVLLDSSATLITNEDNEETEGSDVPADYLLGDVEGEEDELYLLDPEHAHPEDPECV
                     LPQEAFPLRHEIVDTPPGPEHLQDKADSPHVSGSEADVASLAPVDSSFSLLSVSHALY
                     DSRLPPDFFGVLVRDMLHFYAEQGDVQMAVSVLIVLGERVRKDIDEQTQEHWYTSYID
                     LLQRFRLWNVSNEVVKLSTSRAVSCLNQASTTLHVNCSHCKRPMSSRGWVCDRCHRCA
                     SMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCPAGCGHLCEYS"
     exon            1240..1417
                     /gene="WDR24"
                     /gene_synonym="C16orf21; JFP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..2090
                     /gene="WDR24"
                     /gene_synonym="C16orf21; JFP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2209
                     /gene="WDR24"
                     /gene_synonym="C16orf21; JFP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2331
                     /gene="WDR24"
                     /gene_synonym="C16orf21; JFP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2436
                     /gene="WDR24"
                     /gene_synonym="C16orf21; JFP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2777
                     /gene="WDR24"
                     /gene_synonym="C16orf21; JFP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2962
                     /gene="WDR24"
                     /gene_synonym="C16orf21; JFP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3243
                     /gene="WDR24"
                     /gene_synonym="C16orf21; JFP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3224..3229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR24"
                     /gene_synonym="C16orf21; JFP7"
                     /note="hexamer: AATAAA"
     polyA_site      3243
                     /gene="WDR24"
                     /gene_synonym="C16orf21; JFP7"
                     /note="major polyA site"
ORIGIN      
        1 ggcttccggc gcggcggttc cggacaaccg tgcgctttta gtaaaagatt ggggttcgcg
       61 cgggggagaa gggctgcccc gggccctctg gttctcgtcc cgcagcgtcc gctcccccgc
      121 gccactgcgc cgctcccagg aaccctgtac tccggggtcg ccggcttctc tcctgcctcc
      181 ggtcccgcca gacacctcga gctccttaag tagctcggtc cttgacgtcc ctctgggccc
      241 ttcccgcgtc tatcgcctga gtccccgggc ccctctagcc ctctgttccc tcccctcttt
      301 tgttcctccc tagagccccg ccgccctcag ggctgacagt gtggacggcg ggagtctcct
      361 cgctcccctg ctgggattga ctgaccgagc gtttagtgac tgcccagatc tggctgatgg
      421 gggtaccgag aggtggcctg ggccgggaat gtccagctag agtcttccgt ggaagtcaga
      481 catgaaactg acaggcctaa gggaagctag gaagtcccct caccgctcag ccagggtgat
      541 gggctggact gacagactcc agtgaatttg agcttgcctg tcaggctgat tggctgatag
      601 acagccctgg attggctcac taagactgac cagcccggga ccaagcagtt ctggggtccc
      661 aacctgggtg gaaggtctga actgatgacc cacccaggct gaccaggcca gcccacctca
      721 ctgacctcct gacccctgac ctcatcacct gtgcagccat ggagaagatg tcccgtgtga
      781 ccacagccct gggtggcagc gtgctgacag gccgcaccat gcactgccac ctggatgctc
      841 ccgccaatgc catcagtgtg tgccgcgacg cagcccaggt ggtcgtggca ggccgtagca
      901 tcttcaagat ctatgccatc gaggaggaac agttcgtgga aaagctgaac ctgcgtgtgg
      961 ggcgcaagcc ttcgcttaac ctgagctgtg ctgacgtggt ctggcaccag atggatgaga
     1021 acctgctggc cacagcagcc accaatggcg tggtggtcac gtggaacctg ggccggccat
     1081 cccgcaacaa gcaggaccag ctgttcacag aacacaagcg cacggtaaac aaagtctgct
     1141 tccaccccac cgaagcccac gtgctgctca gtggctccca ggatggcttc atgaagtgct
     1201 ttgacctccg cagaaaggac tctgtcagca ccttctcggg ccagtcggag agcgtgcggg
     1261 acgtgcagtt cagtatccgg gactacttca ccttcgcctc cacctttgag aacggcaatg
     1321 tgcagctctg ggacatccgg cgtcccgacc ggtgcgagag gatgttcaca gcccacaacg
     1381 gacccgtctt ctgctgcgac tggcaccccg aggacagggg ctggttggcc actggagggc
     1441 gcgacaagat ggtgaaggtc tgggacatga ccacgcaccg tgccaaggag atgcactgtg
     1501 tgcagaccat cgcctcggtg gcccgtgtga agtggcggcc agagtgccgc caccacctgg
     1561 ccacgtgctc catgatggtg gaccacaaca tctatgtttg ggacgtgcgc cggcccttcg
     1621 tgccagctgc catgtttgag gaacaccgag acgtcaccac gggaattgcc tggcgccacc
     1681 cccacgaccc ctccttcctg ctgtctggct ccaaggacag ctcgctgtgc cagcacctgt
     1741 tccgcgacgc cagccagccc gtcgagcgcg ccaaccctga gggcctctgc tacggcctct
     1801 tcggggacct ggccttcgcc gccaaggaga gcctcgtggc tgccgagtcg gggcgcaagc
     1861 cctacactgg cgaccggcgc caccccatct tctttaagcg caagctggac cctgccgagc
     1921 ccttcgcagg cctcgcctcc agtgccctca gtgtctttga gacggagcca ggtggcggcg
     1981 gcatgcgctg gtttgtggac acagctgagc gttatgcgct ggctggccgg ccactggccg
     2041 agctctgtga ccacaacgca aaggtggctc gagagcttgg ccgcaaccag gtggcgcaaa
     2101 cgtggaccat gctgcggatc atctactgca gccctggcct agtgcccact gcaaacctca
     2161 accacagtgt gggcaagggt ggctcctgtg gcctcccgct catgaacagt ttcaacctga
     2221 aggatatggc cccagggttg ggcagtgaga cgcggctgga ccgcagcaaa ggagatgcac
     2281 ggagcgacac agttctgctc gactcctcgg ccacactcat caccaatgag gataacgagg
     2341 aaaccgaggg cagcgacgta cctgccgact acctgctggg tgacgtggaa ggtgaggagg
     2401 acgagctgta cctgctggat ccggaacacg cgcaccccga ggaccctgag tgcgtgctgc
     2461 cgcaggaggc ctttccgctg cgccacgaga tcgtggacac gcctcccggg cccgagcacc
     2521 tgcaggacaa ggccgactcc ccgcacgtga gcggcagcga ggcggatgtg gcctccctgg
     2581 cccccgtgga ctcctccttc tcgctcctgt ctgtctcaca cgcgctctac gacagccgcc
     2641 tgccgcccga cttcttcggc gtgctggtgc gcgacatgct gcacttctac gctgagcagg
     2701 gcgacgtgca gatggctgtg tctgtgctca tcgtcctggg tgaacgggtg cgcaaggaca
     2761 tcgacgagca gacccaggag cactggtaca cttcctacat cgacctgctg cagcgcttcc
     2821 gcctctggaa cgtgtccaac gaggtggtca agctgagcac cagccgcgcc gtcagctgcc
     2881 tcaaccaggc ctccaccacc ctgcacgtca actgcagcca ctgcaagcgg cccatgagca
     2941 gccggggctg ggtctgcgac aggtgccacc gctgcgccag catgtgtgcc gtctgccacc
     3001 acgtagtcaa gggtctcttc gtgtggtgcc agggctgcag ccacggcggc cacctgcagc
     3061 acatcatgaa gtggctggaa ggcagctccc actgtcccgc aggctgcggc cacctctgcg
     3121 agtactcctg acggggcatc tgctgggctt gcccgggcgg ccgcgtgcag aaccccgcct
     3181 ggtcttgtgc ccgagacggg cggaggctgg aacttgagac ctcaataaag gaagtagagc
     3241 cgc
//
