LOCUS       NM_025132               4395 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens WD repeat domain 19 (WDR19), transcript variant 1,
            mRNA.
ACCESSION   NM_025132
VERSION     NM_025132.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4395)
  AUTHORS   Yu,J.H., Kim,J.H., Soung,N.K., Moon,E.Y. and Koo,J.H.
  TITLE     Identification of the primary ciliary proteins IFT38 and IFT144 to
            enhance serum-mediated YAP activation and cell proliferation
  JOURNAL   Biochem Biophys Res Commun 681, 186-193 (2023)
   PUBMED   37783116
  REMARK    GeneRIF: Identification of the primary ciliary proteins IFT38 and
            IFT144 to enhance serum-mediated YAP activation and cell
            proliferation.
REFERENCE   2  (bases 1 to 4395)
  AUTHORS   Sajovic,J., Meglic,A., Volk,M., Maver,A., Jarc-Vidmar,M.,
            Hawlina,M. and Fakin,A.
  TITLE     Stargardt-like Clinical Characteristics and Disease Course
            Associated with Variants in the WDR19 Gene
  JOURNAL   Genes (Basel) 14 (2), 291 (2023)
   PUBMED   36833218
  REMARK    GeneRIF: Stargardt-like Clinical Characteristics and Disease Course
            Associated with Variants in the WDR19 Gene.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4395)
  AUTHORS   Coussa,R.G., Otto,E.A., Gee,H.Y., Arthurs,P., Ren,H., Lopez,I.,
            Keser,V., Fu,Q., Faingold,R., Khan,A., Schwartzentruber,J.,
            Majewski,J., Hildebrandt,F. and Koenekoop,R.K.
  TITLE     WDR19: an ancient, retrograde, intraflagellar ciliary protein is
            mutated in autosomal recessive retinitis pigmentosa and in
            Senior-Loken syndrome
  JOURNAL   Clin Genet 84 (2), 150-159 (2013)
   PUBMED   23683095
  REMARK    GeneRIF: WDR19: an ancient, retrograde, intraflagellar ciliary
            protein is mutated in autosomal recessive retinitis pigmentosa and
            in Senior-Loken syndrome.
REFERENCE   4  (bases 1 to 4395)
  AUTHORS   Halbritter,J., Porath,J.D., Diaz,K.A., Braun,D.A., Kohl,S.,
            Chaki,M., Allen,S.J., Soliman,N.A., Hildebrandt,F. and Otto,E.A.
  CONSRTM   GPN Study Group
  TITLE     Identification of 99 novel mutations in a worldwide cohort of 1,056
            patients with a nephronophthisis-related ciliopathy
  JOURNAL   Hum Genet 132 (8), 865-884 (2013)
   PUBMED   23559409
  REMARK    GeneRIF: Mutations in WDR19 gene is associated with Caroli disease.
REFERENCE   5  (bases 1 to 4395)
  AUTHORS   Bredrup,C., Saunier,S., Oud,M.M., Fiskerstrand,T., Hoischen,A.,
            Brackman,D., Leh,S.M., Midtbo,M., Filhol,E., Bole-Feysot,C.,
            Nitschke,P., Gilissen,C., Haugen,O.H., Sanders,J.S.,
            Stolte-Dijkstra,I., Mans,D.A., Steenbergen,E.J., Hamel,B.C.,
            Matignon,M., Pfundt,R., Jeanpierre,C., Boman,H., Rodahl,E.,
            Veltman,J.A., Knappskog,P.M., Knoers,N.V., Roepman,R. and Arts,H.H.
  TITLE     Ciliopathies with skeletal anomalies and renal insufficiency due to
            mutations in the IFT-A gene WDR19
  JOURNAL   Am J Hum Genet 89 (5), 634-643 (2011)
   PUBMED   22019273
  REMARK    GeneRIF: Ciliopathies with skeletal anomalies and renal
            insufficiency due to mutations in the IFT-A gene WDR19
REFERENCE   6  (bases 1 to 4395)
  AUTHORS   Lin,B., Utleg,A.G., Gravdal,K., White,J.T., Halvorsen,O.J., Lu,W.,
            True,L.D., Vessella,R., Lange,P.H., Nelson,P.S., Hood,L.,
            Kalland,K.H. and Akslen,L.A.
  TITLE     WDR19 expression is increased in prostate cancer compared with
            normal cells, but low-intensity expression in cancers is associated
            with shorter time to biochemical failures and local recurrence
  JOURNAL   Clin Cancer Res 14 (5), 1397-1406 (2008)
   PUBMED   18316561
  REMARK    GeneRIF: Overexpression of WDR19 is associated with prostate cancer
REFERENCE   7  (bases 1 to 4395)
  AUTHORS   Lin,B., White,J.T., Utleg,A.G., Wang,S., Ferguson,C., True,L.D.,
            Vessella,R., Hood,L. and Nelson,P.S.
  TITLE     Isolation and characterization of human and mouse WDR19,a novel
            WD-repeat protein exhibiting androgen-regulated expression in
            prostate epithelium
  JOURNAL   Genomics 82 (3), 331-342 (2003)
   PUBMED   12906858
  REMARK    GeneRIF: Expressed in normal and neoplastic prostate epithelium and
            is regulated by androgenic hormones.
REFERENCE   8  (bases 1 to 4395)
  AUTHORS   Stokman,M., Lilien,M. and Knoers,N.
  TITLE     Nephronophthisis-Related Ciliopathies
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27336129
REFERENCE   9  (bases 1 to 4395)
  AUTHORS   Tan,W., Lin,A. and Keppler-Noreuil,K.
  TITLE     Cranioectodermal Dysplasia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24027799
REFERENCE   10 (bases 1 to 4395)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY029257.1, BC032578.2,
            AK026780.1, AB046858.1 and AK122908.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_025132.3.
            
            Summary: The protein encoded by this gene is a member of the WD
            (tryptophan-aspartic acid) repeat family, which is a large family
            of structurally-related proteins known to participate in a wide
            range of cellular processes. Each WD repeat typically contains
            about 40 amino acids that are usually bracketed by
            glycine-histidine and tryptophan-aspartic acid (WD) dipeptides.
            This protein contains six WD repeats, three transmembrane domains,
            and a clathrin heavy-chain repeat. Mutations in this gene have been
            described in individuals with a wide range of disorders affecting
            function of the cilium. These disorders are known as ciliopathies,
            and include Jeune syndrome, Sensenbrenner syndromes, Senior-Loken
            syndrome, combined or isolated nephronophthisis (NPHP), and
            retinitis pigmentosa (RP). Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY029257.1, SRR1660803.208102.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399820.8/ ENSP00000382717.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AY029257.1         126-217
            93-919              BC032578.2         74-900
            920-1385            AK026780.1         920-1385
            1386-3745           AB046858.1         355-2714
            3746-3776           AK122908.1         2028-2058
            3777-4395           AY029257.1         3902-4520
FEATURES             Location/Qualifiers
     source          1..4395
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..4395
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /note="WD repeat domain 19"
                     /db_xref="GeneID:57728"
                     /db_xref="HGNC:HGNC:18340"
                     /db_xref="MIM:608151"
     exon            1..35
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..4058
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat membrane protein PWDMP; intraflagellar transport
                     144 homolog; WD repeat-containing protein 19"
                     /codon_start=1
                     /product="WD repeat-containing protein 19 isoform 1"
                     /protein_id="NP_079408.3"
                     /db_xref="CCDS:CCDS47042.1"
                     /db_xref="GeneID:57728"
                     /db_xref="HGNC:HGNC:18340"
                     /db_xref="MIM:608151"
                     /translation="MKRIFSLLEKTWLGAPIQFAWQKTSGNYLAVTGADYIVKIFDRH
                     GQKRSEINLPGNCVAMDWDKDGDVLAVIAEKSSCIYLWDANTNKTSQLDNGMRDQMSF
                     LLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAENLLALGGEDK
                     MITVSNQEGDTIRQTQVRSEPSNMQFFLMKMDDRTSAAESMISVVLGKKTLFFLNLNE
                     PDNPADLEFQQDFGNIVCYNWYGDGRIMIGFSCGHFVVISTHTGELGQEIFQARNHKD
                     NLTSIAVSQTLNKVATCGDNCIKIQDLVDLKDMYVILNLDEENKGLGTLSWTDDGQLL
                     ALSTQRGSLHVFLTKLPILGDACSTRIAYLTSLLEVTVANPVEGELPITVSVDVEPNF
                     VAVGLYHLAVGMNNRAWFYVLGENAVKKLKDMEYLGTVASICLHSDYAAALFEGKVQL
                     HLIESEILDAQEERETRLFPAVDDKCRILCHALTSDFLIYGTDTGVVQYFYIEDWQFV
                     NDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFVYCPVNDATYEIPDFSPTIKGVLWENW
                     PMDKGVFIAYDDDKVYTYVFHKDTIQGAKVILAGSTKVPFAHKPLLLYNGELTCQTQS
                     GKVNNIYLSTHGFLSNLKDTGPDELRPMLAQNLMLKRFSDAWEMCRILNDEAAWNELA
                     RACLHHMEVEFAIRVYRRIGNVGIVMSLEQIKGIEDYNLLAGHLAMFTNDYNLAQDLY
                     LASSCPIAALEMRRDLQHWDSALQLAKHLAPDQIPFISKEYAIQLEFAGDYVNALAHY
                     EKGITGDNKEHDEACLAGVAQMSIRMGDIRRGVNQALKHPSRVLKRDCGAILENMKQF
                     SEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQYAKAKEADGRYKEA
                     VVAYENAKQWQSVIRIYLDHLNNPEKAVNIVRETQSLDGAKMVARFFLQLGDYGSAIQ
                     FLVMSKCNNEAFTLAQQHNKMEIYADIIGSEDTTNEDYQSIALYFEGEKRYLQAGKFF
                     LLCGQYSRALKHFLKCPSSEDNVAIEMAIETVGQAKDELLTNQLIDHLLGENDGMPKD
                     AKYLFRLYMALKQYREAAQTAIIIAREEQSAGNYRNAHDVLFSMYAELKSQKIKIPSE
                     MATNLMILHSYILVKIHVKNGDHMKGARMLIRVANNISKFPSHIVPILTSTVIECHRA
                     GLKNSAFSFAAMLMRPEYRSKIDAKYKKKIEGMVRRPDISEIEEATTPCPFCKFLLPE
                     CELLCPGCKNSIPYCIATGRHMLKDDWTVCPHCDFPALYSELKIMLNTESTCPMCSER
                     LNAAQLKKISDCTQYLRTEEEL"
     exon            36..127
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            128..193
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            194..319
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            320..435
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            436..551
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            552..632
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            633..745
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            746..919
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            920..990
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1163
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1278
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1385
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1508
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1658
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1806
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2011
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2171
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2282
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2392
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2450
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2591
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2674
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2758
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2905
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..3030
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3143
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3212
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            3213..3290
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            3291..3387
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            3388..3512
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            3513..3594
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            3595..3745
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            3746..3869
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            3870..3946
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            3947..4071
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            4072..4395
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4377..4382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /note="hexamer: AATAAA"
     polyA_site      4395
                     /gene="WDR19"
                     /gene_synonym="ATD5; CED4; CFAP66; DYF-2; FAP66; IFT144;
                     NPHP13; ORF26; Oseg6; PWDMP; SPGF72; SRTD5"
                     /note="major polyA site"
ORIGIN      
        1 atagttcgcg tagcggctcg agcgtggaga tgaagcgtat tttctcactg ctagaaaaga
       61 cttggcttgg cgcaccaata cagtttgcct ggcaaaaaac atcaggaaac taccttgcag
      121 taacaggagc tgattatatt gtgaaaatct ttgatcgcca tggtcaaaaa agaagtgaaa
      181 ttaacttacc tggtaactgt gttgccatgg attgggataa agatggagat gtcctagcag
      241 tgattgctga gaaatctagc tgcatttatc tttgggatgc caacacaaat aagaccagcc
      301 agttagacaa tggcatgagg gatcaaatgt ctttccttct ttggtcaaaa gttggaagtt
      361 tcctggctgt tggaactgtt aaaggaaatt tgcttattta taatcatcag acatctcgaa
      421 agattcctgt ccttggaaaa catactaaga gaatcacttg tggatgttgg aatgcagaaa
      481 atctgcttgc tttaggtggt gaagataaaa tgattacagt tagtaatcag gaaggtgaca
      541 cgataagaca gacacaagtg agatcagagc ctagcaacat gcagtttttc ttgatgaaga
      601 tggatgaccg aacctctgct gctgaaagca tgataagtgt ggtgcttggc aagaaaactt
      661 tgtttttttt aaatctgaat gaaccagata acccagctga tcttgaattt cagcaggact
      721 ttggcaacat tgtctgctat aattggtatg gtgatggccg catcatgatt ggtttttcat
      781 gtggacattt tgtggtcatt tctactcata ctggagagct tggtcaagag atatttcagg
      841 ctcgtaacca taaagataat ctaaccagca ttgcagtatc acagactctt aacaaagttg
      901 ctacatgtgg agataactgc attaaaatcc aagacttggt tgacttaaaa gacatgtatg
      961 ttatactcaa cctggatgag gaaaataaag gattgggtac cttgtcctgg actgatgatg
     1021 gccagttgct agcactctct acccaaaggg gctcacttca tgttttcctg accaagcttc
     1081 ccatacttgg ggatgcctgc agcacaagga ttgcctatct cacctccctc cttgaagtca
     1141 ccgtagccaa ccctgttgaa ggagagctac caatcacagt ttctgttgat gtggaaccca
     1201 actttgtggc agtaggtctt tatcatctgg ctgtaggaat gaataatcga gcttggtttt
     1261 atgtccttgg agaaaatgct gtgaaaaaat tgaaagatat ggagtatctg ggaacagtag
     1321 ccagtatttg ccttcattct gactatgctg ctgcactttt tgaaggcaaa gtccagttac
     1381 atttgataga aagcgaaatc ttggatgctc aagaagaacg tgagactcgg cttttcccag
     1441 cagtggatga taagtgccgt atcttatgcc atgccttaac tagtgatttc ctcatctatg
     1501 gtacagatac tggtgtcgtt cagtatttct acattgaaga ctggcaattc gttaatgatt
     1561 atcgacatcc tgtcagtgtg aaaaagattt ttcccgaccc aaatgggacc agattagttt
     1621 tcattgatga aaaaagtgat ggatttgttt actgtccagt caatgacgct acctatgaga
     1681 ttccagattt ttcaccaacc attaaaggtg ttctttggga aaactggcca atggataaag
     1741 gtgtatttat tgcttatgat gatgataagg tgtacactta tgtctttcac aaggacacta
     1801 tacaaggagc caaggttatt ttggctggta gcaccaaagt tccttttgct cataaacctt
     1861 tgctgctata taatggagag ctgacctgcc aaacacagag tggaaaagta aacaacatct
     1921 accttagcac ccatggcttt ctcagcaact taaaagatac ggggcctgac gaactgagac
     1981 caatgctggc acagaattta atgctaaaga ggttttctga tgcttgggaa atgtgcagga
     2041 ttctgaatga tgaggctgcc tggaatgagt tggccagagc ttgtctacat cacatggaag
     2101 tggagtttgc aatccgtgtt tatcggagaa ttggaaatgt tggcatagtg atgtccttgg
     2161 aacaaataaa gggaatagag gactacaatc ttttggcagg acaccttgcc atgtttacca
     2221 acgattataa cctggctcag gacttgtacc ttgcatccag ctgtcctatt gctgccctgg
     2281 agatgagaag ggatttacag cattgggaca gtgctctaca actggcaaag catttggccc
     2341 cagaccagat accttttata tcaaaagaat atgctattca gcttgaattc gcgggtgatt
     2401 atgtaaatgc tttggctcat tatgagaaag gaataacagg tgataataag gaacatgatg
     2461 aagcttgtct ggctggagtg gcccagatgt ccataagaat gggagacata cgtcgagggg
     2521 ttaaccaagc cctcaagcat cccagcaggg tccttaaaag agactgtgga gccatattgg
     2581 agaatatgaa gcaattttca gaagcggccc aactgtatga aaaaggtctc tactacgata
     2641 aagcagcatc tgtttacatc cgctctaaga attgggcaaa agttggtgat cttctgcccc
     2701 acgtttcttc tcctaagatc catttgcagt atgccaaagc caaggaagca gatggaagat
     2761 acaaagaagc tgttgtagct tatgaaaatg caaaacagtg gcaaagtgta atccgcatct
     2821 atctggatca cctcaataat cctgaaaaag ctgtcaatat tgttagagag acccagtctc
     2881 tggatggagc caaaatggta gccaggtttt ttctacagct tggtgactat gggtctgcca
     2941 tccagtttct tgtcatgtcc aaatgcaaca atgaagcttt cacactggct cagcaacaca
     3001 acaaaatgga aatctatgca gatattattg gttctgaaga cactactaat gaagactatc
     3061 aaagcattgc cttatacttt gaaggagaaa agagatatct tcaggctgga aaattcttct
     3121 tgctgtgtgg ccaatattca cgagcactta aacacttcct gaaatgccca agctcggaag
     3181 ataatgtggc aatagaaatg gcaattgaaa ctgttggtca ggccaaagat gaactgctga
     3241 ccaatcagct gatagaccat ctcctggggg agaacgatgg catgcctaag gatgccaagt
     3301 acctgttccg cttgtacatg gctctgaagc aataccgaga agctgcccag actgccatca
     3361 tcattgccag agaagagcag tctgcaggca actaccggaa tgcacacgat gttctcttca
     3421 gtatgtatgc agaactgaaa tcccagaaga tcaaaattcc ctccgagatg gccaccaacc
     3481 tcatgattct gcacagctat atactagtaa agattcatgt taaaaatgga gatcacatga
     3541 aaggggctcg catgctcatt cgggtggcca acaacatcag caaatttcca tcacacattg
     3601 tacccatcct gacgtcaact gtgattgagt gtcacagggc aggcctgaag aactctgctt
     3661 tcagcttcgc agctatgttg atgaggcctg aataccgcag caaaatagat gccaaataca
     3721 aaaagaagat cgagggaatg gtcaggagac ccgatatatc tgagatagaa gaggccacga
     3781 ctccatgtcc attctgcaaa tttcttctcc cagagtgtga actcctctgt cctggatgta
     3841 aaaacagtat cccatattgc attgcaacag gtcgacacat gttgaaagat gactggacgg
     3901 tgtgtccaca ttgtgacttc cctgctctat actcagaatt gaagatcatg ctaaacactg
     3961 aaagcacatg tcctatgtgt tcagaaagat taaacgctgc tcagctgaaa aagatttcag
     4021 actgtaccca gtacctgcga acggaggagg aactgtgatt ggcacgtgca gatacaatgc
     4081 tcctgagaag acagcatttt ccacaggagg ctgtttcctc ccctggtgga tttaagagac
     4141 ggtcctttct ggatacagag aaatgaaaca acggtgacct ctccaggtcg gcactttcca
     4201 cttctgtacg gtggcaaaac gatgacatgt aaccttgctg tttattgtac tttgtatatt
     4261 atttcctctt caaagtcttt cttacacact ctatcctctg cactgttaat agtaacctat
     4321 gacataattg taaatattca gctttttgct aacttttgta ttttgaaaaa ctttaaaata
     4381 aaattgttga ctaga
//
