LOCUS       NM_024100               1521 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens WD repeat domain 18 (WDR18), transcript variant 1,
            mRNA.
ACCESSION   NM_024100
VERSION     NM_024100.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1521)
  AUTHORS   Gordon,J., Chapus,F.L., Viverette,E.G., Williams,J.G.,
            Deterding,L.J., Krahn,J.M., Borgnia,M.J., Rodriguez,J., Warren,A.J.
            and Stanley,R.E.
  TITLE     Cryo-EM reveals the architecture of the PELP1-WDR18 molecular
            scaffold
  JOURNAL   Nat Commun 13 (1), 6783 (2022)
   PUBMED   36351913
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1521)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   3  (bases 1 to 1521)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1521)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   5  (bases 1 to 1521)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 1521)
  AUTHORS   Castle,C.D., Cassimere,E.K. and Denicourt,C.
  TITLE     LAS1L interacts with the mammalian Rix1 complex to regulate
            ribosome biogenesis
  JOURNAL   Mol Biol Cell 23 (4), 716-728 (2012)
   PUBMED   22190735
REFERENCE   7  (bases 1 to 1521)
  AUTHORS   Finkbeiner,E., Haindl,M. and Muller,S.
  TITLE     The SUMO system controls nucleolar partitioning of a novel
            mammalian ribosome biogenesis complex
  JOURNAL   EMBO J 30 (6), 1067-1078 (2011)
   PUBMED   21326211
  REMARK    GeneRIF: These data define the PELP1-TEX10-WDR18 complex as a
            regulator of ribosome biogenesis and suggests that its
            SUMO-controlled distribution coordinates the rate of ribosome
            formation.
REFERENCE   8  (bases 1 to 1521)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   9  (bases 1 to 1521)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   10 (bases 1 to 1521)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC000040.2, BC001648.2 and BU154887.1.
            
            On Aug 8, 2019 this sequence version replaced NM_024100.3.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001648.2, SRR11853565.14495.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000585809.6/ ENSP00000476117.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               BC000040.2         3-190
            189-522             BC001648.2         186-519
            523-892             BU154887.1         330-699
            893-1521            BC000040.2         895-1523
FEATURES             Location/Qualifiers
     source          1..1521
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1521
                     /gene="WDR18"
                     /gene_synonym="Ipi3; R32184_1"
                     /note="WD repeat domain 18"
                     /db_xref="GeneID:57418"
                     /db_xref="HGNC:HGNC:17956"
                     /db_xref="MIM:620291"
     exon            1..219
                     /gene="WDR18"
                     /gene_synonym="Ipi3; R32184_1"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1308
                     /gene="WDR18"
                     /gene_synonym="Ipi3; R32184_1"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 18; Involved in Processing ITS2
                     3 homolog"
                     /codon_start=1
                     /product="WD repeat-containing protein 18 isoform 1"
                     /protein_id="NP_077005.2"
                     /db_xref="CCDS:CCDS12051.1"
                     /db_xref="GeneID:57418"
                     /db_xref="HGNC:HGNC:17956"
                     /db_xref="MIM:620291"
                     /translation="MAAPMEVAVCTDSAAPMWSCIVWELHSGANLLTYRGGQAGPRGL
                     ALLNGEYLLAAQLGKNYISAWELQRKDQLQQKIMCPGPVTCLTASPNGLYVLAGVAES
                     IHLWEVSTGNLLVILSRHYQDVSCLQFTGDSSHFISGGKDCLVLVWSLCSVLQADPSR
                     IPAPRHVWSHHALPITDLHCGFGGPLARVATSSLDQTVKLWEVSSGELLLSVLFDVSI
                     MAVTMDLAEHHMFCGGSEGSIFQVDLFTWPGQRERSFHPEQDAGKVFKGHRNQVTCLS
                     VSTDGSVLLSGSHDETVRLWDVQSKQCIRTVALKGPVTNAAILLAPVSMLSSDFRPSL
                     PLPHFNKHLLGAEHGDEPRHGGLTLRLGLHQQGSEPSYLDRTEQLQAVLCSTMEKSVL
                     GGQDQLRVRVTELEDEVRNLRKINRDLFDFSTRFITRPAK"
     exon            220..330
                     /gene="WDR18"
                     /gene_synonym="Ipi3; R32184_1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..464
                     /gene="WDR18"
                     /gene_synonym="Ipi3; R32184_1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..606
                     /gene="WDR18"
                     /gene_synonym="Ipi3; R32184_1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..750
                     /gene="WDR18"
                     /gene_synonym="Ipi3; R32184_1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..815
                     /gene="WDR18"
                     /gene_synonym="Ipi3; R32184_1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..940
                     /gene="WDR18"
                     /gene_synonym="Ipi3; R32184_1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1107
                     /gene="WDR18"
                     /gene_synonym="Ipi3; R32184_1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1176
                     /gene="WDR18"
                     /gene_synonym="Ipi3; R32184_1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1521
                     /gene="WDR18"
                     /gene_synonym="Ipi3; R32184_1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1501..1506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR18"
                     /gene_synonym="Ipi3; R32184_1"
                     /note="hexamer: AACAAA"
     polyA_site      1521
                     /gene="WDR18"
                     /gene_synonym="Ipi3; R32184_1"
                     /note="major polyA site"
ORIGIN      
        1 gaaggcaaga tggcggcgcc catggaggtg gccgtgtgta cggactcggc ggccccgatg
       61 tggagctgca tcgtgtggga acttcactcg ggcgccaacc tgctcaccta ccgcggcggc
      121 caggcgggac cccgcggcct ggcgctgctc aatggcgagt atctgctggc ggcgcagctg
      181 ggcaagaatt acatcagcgc ctgggagctc cagcggaagg accagctcca gcagaagatc
      241 atgtgccccg ggcctgtcac ctgtctgact gcatcaccca atggtctcta cgtcctggca
      301 ggagttgcag aaagcatcca cctgtgggag gtctccaccg ggaaccttct ggtcatcctg
      361 agtcgacact accaggacgt ctcctgcctt cagttcacag gggacagcag ccacttcatc
      421 tcagggggca aggactgcct ggtgctggtt tggagcctct gcagcgtgct gcaggccgac
      481 ccctccagga ttccggcgcc caggcacgtc tggtctcacc acgcgctccc catcacggac
      541 ctgcactgcg gctttggggg ccccctggcc cgggtggcca cctcctcact ggaccagacg
      601 gtgaagctat gggaggtctc ctcgggggag ctgctgctct ccgtcctctt tgacgtgtcc
      661 atcatggcag tgaccatgga cctggctgag caccatatgt tctgcggggg cagtgagggc
      721 tccatcttcc aggtcgacct cttcacctgg cccggacaga gggagaggag cttccaccca
      781 gagcaggacg ccgggaaggt cttcaaaggg cacaggaacc aggtgacttg cctgtcagtg
      841 tccactgacg gcagcgtgct gctctcaggc tcccacgacg agaccgtgcg cctctgggac
      901 gtgcagagca agcagtgcat ccggacggtg gccctcaaag gcccagtcac caatgccgcc
      961 atcctgctgg cgcccgtcag catgctgagc tcagacttca ggcccagcct gccgctgccc
     1021 cacttcaaca agcacctgct gggcgccgag cacggggacg agccgcgcca cgggggcctc
     1081 actctgcgcc tgggcctcca ccagcagggc tcggagccca gctacctgga ccgcacggag
     1141 cagctgcagg ccgtcctgtg cagcaccatg gagaagagcg tgctcggcgg ccaggaccag
     1201 ctgcgcgtcc gtgtgacgga gctggaggac gaggtgcgca acctgcgcaa gatcaatcgg
     1261 gacctgttcg acttctccac gcgcttcatc acgcggccgg ccaagtgagg cccggagacc
     1321 ccggcccgag gcgcccaggc ctgagcccca tgcctcccag caaccagggc ccgcgggtgt
     1381 ggcccccacc agcccaggcc tggactctcc tcagttctgt gtcgtgttcg ggtttttcct
     1441 ctgtgactgg gccgtcttgg tgtctcgtgg cacgcgtcac agtggtgcta gtctgttttt
     1501 aacaaaagag gatgaaaagc c
//
