LOCUS       NM_001347217            5457 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens WD repeat domain 13 (WDR13), transcript variant 4,
            mRNA.
ACCESSION   NM_001347217 XM_006724539
VERSION     NM_001347217.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5457)
  AUTHORS   Rzonca-Niewczas,S., Wierzba,J., Kaczorowska,E., Poryszewska,M.,
            Kosinska,J., Stawinski,P., Ploski,R. and Bal,J.
  TITLE     WDR13: A Novel Gene Implicated in Non-Syndromic Intellectual
            Disability
  JOURNAL   Genes (Basel) 12 (12), 1911 (2021)
   PUBMED   34946860
  REMARK    GeneRIF: WDR13: A Novel Gene Implicated in Non-Syndromic
            Intellectual Disability.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5457)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   3  (bases 1 to 5457)
  AUTHORS   Singh,B.N., Suresh,A., UmaPrasad,G., Subramanian,S., Sultana,M.,
            Goel,S., Kumar,S. and Singh,L.
  TITLE     A highly conserved human gene encoding a novel member of WD-repeat
            family of proteins (WDR13)
  JOURNAL   Genomics 81 (3), 315-328 (2003)
   PUBMED   12659815
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC115618.3, KF459106.1 and
            DQ907253.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001347217.1.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. A similar protein in
            mouse is thought to be a negative regulator of the pancreatic beta
            cell proliferation. Mice lacking this gene exhibit increased
            pancreatic islet mass and higher serum insulin levels, and are
            mildly obese. [provided by RefSeq, Nov 2016].
            
            Transcript Variant: Variants 1 and 4 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.242548.1,
                                           SRR1803612.80020.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376729.10/ ENSP00000365919.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC115618.3         35494-35616
            124-203             AC115618.3         35960-36039
            204-444             AC115618.3         36719-36959
            445-554             AC115618.3         37355-37464
            555-685             AC115618.3         37589-37719
            686-993             AC115618.3         38321-38628
            994-1174            KF459106.1         52-232
            1175-1202           KF459106.1         333-360
            1203-1316           AC115618.3         40095-40208
            1317-1435           AC115618.3         42274-42392
            1436-1760           AC115618.3         42850-43174
            1761-1782           DQ907253.2         2085-2106
            1783-5457           AC115618.3         43197-46871
FEATURES             Location/Qualifiers
     source          1..5457
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..5457
                     /gene="WDR13"
                     /gene_synonym="MG21"
                     /note="WD repeat domain 13"
                     /db_xref="GeneID:64743"
                     /db_xref="HGNC:HGNC:14352"
                     /db_xref="MIM:300512"
     exon            1..123
                     /gene="WDR13"
                     /gene_synonym="MG21"
                     /inference="alignment:Splign:2.1.0"
     exon            124..203
                     /gene="WDR13"
                     /gene_synonym="MG21"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1620
                     /gene="WDR13"
                     /gene_synonym="MG21"
                     /note="isoform 1 is encoded by transcript variant 4; WD
                     repeat-containing protein 13"
                     /codon_start=1
                     /product="WD repeat-containing protein 13 isoform 1"
                     /protein_id="NP_001334146.1"
                     /db_xref="CCDS:CCDS14302.1"
                     /db_xref="GeneID:64743"
                     /db_xref="HGNC:HGNC:14352"
                     /db_xref="MIM:300512"
                     /translation="MAAVWQQVLAVDARYNAYRTPTFPQFRTQYIRRRSQLLRENAKA
                     GHPPALRRQYLRLRGQLLGQRYGPLSEPGSARAYSNSIVRSSRTTLDRMEDFEDDPRA
                     LGARGHRRSVSRGSYQLQAQMNRAVYEDRPPGSVVPTSAAEASRAMAGDTSLSENYAF
                     AGMYHVFDQHVDEAVPRVRFANDDRHRLACCSLDGSISLCQLVPAPPTVLRVLRGHTR
                     GVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIREIPDPDSAELLCCTFQPVNNNLT
                     VVGNAKHNVHVMNISTGKKVKGGSSKLTGRVLALSFDAPGRLLWAGDDRGSVFSFLFD
                     MATGKLTKAKRLVVHEGSPVTSISARSWVSREARDPSLLINACLNKLLLYRVVDNEGT
                     LQLKRSFPIEQSSHPVRSIFCPLMSFRQGACVVTGSEDMCVHFFDVERAAKAAVNKLQ
                     GHSAPVLDVSFNCDESLLASSDASGMVIVWRREQK"
     exon            204..444
                     /gene="WDR13"
                     /gene_synonym="MG21"
                     /inference="alignment:Splign:2.1.0"
     exon            445..554
                     /gene="WDR13"
                     /gene_synonym="MG21"
                     /inference="alignment:Splign:2.1.0"
     exon            555..685
                     /gene="WDR13"
                     /gene_synonym="MG21"
                     /inference="alignment:Splign:2.1.0"
     exon            686..993
                     /gene="WDR13"
                     /gene_synonym="MG21"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1174
                     /gene="WDR13"
                     /gene_synonym="MG21"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1316
                     /gene="WDR13"
                     /gene_synonym="MG21"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1435
                     /gene="WDR13"
                     /gene_synonym="MG21"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..5457
                     /gene="WDR13"
                     /gene_synonym="MG21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1682..1687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR13"
                     /gene_synonym="MG21"
                     /note="hexamer: AATAAA"
     polyA_site      1706
                     /gene="WDR13"
                     /gene_synonym="MG21"
                     /note="major polyA site"
     polyA_site      1774
                     /gene="WDR13"
                     /gene_synonym="MG21"
                     /note="major polyA site"
     regulatory      5433..5438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR13"
                     /gene_synonym="MG21"
                     /note="hexamer: AATAAA"
     polyA_site      5457
                     /gene="WDR13"
                     /gene_synonym="MG21"
ORIGIN      
        1 ctttctgata gcaggcagcc atcttgcctg gagcctgaga aagggaggag agacagaagg
       61 aaccggcgac agtggtctca gggccgctcc ggggggcctc aagaaccgga ggcagccccg
      121 gaggctgccg cgggcggaca cgccagagga ggaggccggg gaatggccgc ggtgtggcag
      181 caagtcttag cagtggacgc gaggtacaac gcgtaccgca caccaacgtt tccacagttt
      241 cggacgcagt atatccgccg gcgcagccag ctgctgcggg agaatgccaa ggctgggcac
      301 cccccagcgc tgcgtcggca gtacctgagg cttcgggggc agctgctggg ccagcgctac
      361 gggcccctct ccgagccagg cagtgctcgt gcctatagca acagcatcgt ccgcagtagc
      421 cgcactactc ttgaccgcat ggaggacttt gaggatgatc ctcgggccct gggggcccgt
      481 gggcaccgtc gttctgtcag cagaggctcc taccagctgc aggcgcagat gaaccgtgcc
      541 gtctatgagg acaggccccc tggcagcgtg gtgcccacgt cagcagcaga ggcaagtcgg
      601 gccatggccg gggacacgtc actgagcgag aactatgcct ttgcgggcat gtatcatgtt
      661 tttgaccagc acgtggatga ggcagtccca agggtgcgct tcgccaatga tgaccgacac
      721 cgcctggcct gctgctcact cgacggcagc atctccctgt gccagctggt gcctgcccca
      781 cccacagtgc ttcgcgtgct acggggccac acccgtggtg tctccgactt cgcctggtcc
      841 ctctccaatg acatcctcgt gtccacctca ctggatgcca ccatgcgcat ctgggcctct
      901 gaggatggtc gctgcatccg agagatccct gaccccgata gcgctgaact gctctgctgc
      961 accttccagc ctgtcaacaa caacctcact gtggtgggga acgccaagca caacgtgcat
     1021 gtcatgaaca tctccacagg caagaaagtg aaggggggct ccagcaagct gacaggccgt
     1081 gtccttgctc tgtcctttga tgcccctggc cggctgctct gggcgggtga tgaccgtggc
     1141 agtgtcttct ctttcctctt tgatatggcc acagggaagc tgaccaaagc caagcgtttg
     1201 gtggtgcatg aggggagccc tgtgaccagc atctcagccc ggtcctgggt cagccgcgag
     1261 gcccgggatc cctcactgct catcaatgct tgcctcaaca agttgctgct ctacagggtg
     1321 gtagacaacg aggggaccct gcagctgaag agaagcttcc ccatcgagca gagctcacat
     1381 cctgtgcgca gcatcttctg tcccctcatg tccttccgcc agggggcctg cgtggtgacg
     1441 ggcagtgagg acatgtgcgt gcacttcttt gatgtggagc gggcggccaa ggctgctgtc
     1501 aacaagctgc agggccacag tgcacctgtg cttgatgtca gcttcaactg cgacgagagc
     1561 ctactggcct ccagtgacgc cagcggcatg gtcatcgtct ggaggcggga gcagaagtag
     1621 ggtcctgtcg gccctgctgc tgtcctccat cccacccctc ttactccagc ctcgtgttgt
     1681 aaataaagtt tcggtggtca tgctgagggc cggctcccag ctctgccggg gacggacagg
     1741 gcagagggca gcgggcagct ccaggaacac ggtggaacgg ggttcattga ctcatttgtg
     1801 cattcatgca tcgacggatt cattcattcc acaagcattg attgaatgtc tgctgggtta
     1861 caggccctgc cttaactgtt ttacacactt atgcattcga tagacattag tgagccctga
     1921 ccgtgtgcca ggaactgttc taggcactgg ggatactgct ctgacctaaa ctgatggaaa
     1981 tgcctgcctt cattgggctt gcatcatagc ggagacagta gataaaaaca tggaacaggc
     2041 cagctaatga tgagtggtat gaagaaaata aagcaaggat gggagacaga gctgcagaag
     2101 ttgggggagt gggctcttta tggtgacagc atcagggaag atgatcctga cagggtgact
     2161 tttttgtttt tgagacaggg tctcactctg tcacccaggt tggaatgcag tggcatgacc
     2221 atagctcact gcagcctcaa cctccagggc tcaagtgatc ctcacttaag cctcccaagt
     2281 agctgggact acaggtgtgt gccaccacac tcgggtaatt tttgtatttt tagtagagac
     2341 ggggtctcgc catgttgctc aggctggtct tgaactcctg ggctcaagcg atccactcgc
     2401 ctcagcctcc caaagtgctg ggattacagg catgaaccac cacgcctggc tcagggtgac
     2461 atttaaagac ctgaatgaag tgagtgggag tcatagtgta gggggagaac attccaggca
     2521 gagagaaagc cagcctaaag gcactgaggc tggagcgctc cagaaggatc attgtgtatg
     2581 ccagagtctt gctggaccag agtgtgacag tacatgaggt cagacaggcc agatgcttca
     2641 tgggccacag ttaggacttt ggcttttttt ctgagtgggg gtgaccagaa ggtgtcaagc
     2701 agaggaggaa catgatctga cttggtcata gaggctccct ctggctgctg aaggggacag
     2761 attgggggtg ggggtagaag caggggaccc agcaggagac ccctctgagc gcagtgatgg
     2821 ggacttgcac cagggtagtg acagtggagg agttggcggg ggaatgttgg gtcggacccc
     2881 cagggggttc actatgttag gctgcaggac tctgctgcct cctcaggggg cgatattccc
     2941 aacccttctg tgcattgtgt tgtttattaa aagcagggag cagaggtgtt gagtcctgga
     3001 gccccaagct ggtgcaggag caacgggaag ttaaggctga cctggggcct cctgctgtgt
     3061 ggcggaatct ccatccctca gaccacccct gtctcctccc agccccatcc agggtacaaa
     3121 ttccagccct ggaacagctc agagaccaaa aagtgatgtt aagtatttga ggggagcccc
     3181 aagagaggag aaaaagcttt gagtattgat gggggtaaat aaccaaaatc acttatcagt
     3241 ggcctgcgtc accagaaaat gtcaaagtta cctgaagcag caaagaggct cttgctccgg
     3301 cccctccctt ccttctcagc tccatttgtt gccacatatg cgttgactgg aactgcgact
     3361 gacatcttgg gaccttaggg tcagtccaca gcgtggtaga gactccagct tggcccagca
     3421 ttgctgagct gctgaactcg caccaacagt cttgttggag ggaaataatc tcccgtttgt
     3481 tcagtccagt tatttgacag tgtggttact tgcaccccaa gcatttctaa ctggcacttc
     3541 catctaatag acctcagggt acatggtggt gagataggga catcagtgag ctggattgtt
     3601 cccatggtaa aggtcatgta tgtgtgtgtg tgtcatggtc ctcaatacca gccccaagcc
     3661 cagtgatttg ctaggaggac tcccaagact cagtatgtgg ttgtattcat ggctacgatt
     3721 gacttattac aacaaaaaga tatggagcaa aatcagcaaa aagaaatggt gtgcaggacc
     3781 aactcccaga gagacccagg cacaagtttc cagggcttct ctctcattgg agtcacacaa
     3841 gatgtgctcg gttcacagta atgggttgtg acaatacatg cgaaatgttg ctgaccaagg
     3901 aagctcaatt agagactcag cacccagagg ttttttttgt tgttgttgtt gttttggttt
     3961 ttttttggcg gggggggggg ggtcttgctc tgacgcccag gctggaatgc agtggcatga
     4021 tcttggctca ctgcagcctc cacctcctgg gttcaagcga tcctcgggcc tcagcttccc
     4081 gaatagctgg aactacaggc gcgcaccagc aagctcggct aatttttgta tttttagtag
     4141 ggatggggtt tcaccatgtt ggccaggctg atcttgaact cctgacctca agtgatcctc
     4201 ccacctcagc ctcccaaact gctgggatta caggcgtgag cacctggctg gtatcaagtt
     4261 tttattgggg catggtcaca taggcacccc ctgcctggca cctacccaaa tcccaggctc
     4321 ccaaaaggaa agcaggggct cagcataaac cacctttttt tttttttttt taattgagac
     4381 ggagtctcgc tttgtcgcca ggctggagtg cagtggcgtg atctcggctt actgtaacct
     4441 ccgcctcctg ggttcaagca attctcctgc ctcagcttcc tgaatagctg ggactacagg
     4501 cgcctgccac caccacgccc agctaatttt tgtattttta gtagagacgg ggtttcacca
     4561 tattggccag gctggtctcc atctcttgac cttgtgatcc gcctgcctcg acctcccaaa
     4621 gtgctgggat tacaggcatg agccaccgct cctggcccac ttttttatac aaacagctta
     4681 ggtagagtaa gccattcttt tttttctttc tttctttttt tttttttttg agacagggtc
     4741 tcactttgtt gcccaggctg gagtgcagtg gctcaaacat ggttcgctgc agcctcaacc
     4801 tcccaggctc aagcggtcct gctgcctcat cctccaaagt agctgggacc acagacatgc
     4861 accaccatga ccccagctga tttttgcaga gatgggtttt gccatgttgc ccaggctggc
     4921 cttgaactcc tgggctcaag tgatcctctc accttggcct accaaagtgc tggcgttaca
     4981 ggtgtgagcc accacacccg gcccgagtga gccattctta tctcttaggg aatggtggga
     5041 accctcctgg agtctatgtt cttagacacc acccaagggc caaccttgaa gcaggccttt
     5101 ccaaggatcg cagttgaggc ctgctctgtt actgtttttc tgcacagtgt gcaacaccac
     5161 acagatgccc agtttctacc aaggtctgtg gatggcagga taattttgag gaacctcctt
     5221 tttcgctaac actttcttct tttgtttaca ctcttcacat tgtctattga gtctggattc
     5281 aagatgattg attgtgaata ttgttgtgca tgattttggg ggtttcctcc ttgtgaaatt
     5341 ttgaggtggc agatttgaca ttctacttta aactcatctt ggtggcactt ttcttgactc
     5401 accacctaag ggggaataaa taatgaagaa agaataaaaa tagtgttatc agtcaca
//
