LOCUS       NM_018256               8068 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens WD repeat domain 12 (WDR12), transcript variant 1,
            mRNA.
ACCESSION   NM_018256
VERSION     NM_018256.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8068)
  AUTHORS   Yin,L., Li,L., Gao,M., Qi,Y., Xu,L. and Peng,J.
  TITLE     circMIRIAF aggravates myocardial ischemia-reperfusion injury via
            targeting miR-544/WDR12 axis
  JOURNAL   Redox Biol 73, 103175 (2024)
   PUBMED   38795544
  REMARK    GeneRIF: circMIRIAF aggravates myocardial ischemia-reperfusion
            injury via targeting miR-544/WDR12 axis.
REFERENCE   2  (bases 1 to 8068)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 8068)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 8068)
  AUTHORS   Li,J.L., Chen,C., Chen,W., Zhao,L.F., Xu,X.K., Li,Y., Yuan,H.Y.,
            Lin,J.R., Pan,J.P., Jin,B.L. and Li,F.C.
  TITLE     Integrative genomic analyses identify WDR12 as a novel oncogene
            involved in glioblastoma
  JOURNAL   J Cell Physiol 235 (10), 7344-7355 (2020)
   PUBMED   32180229
  REMARK    GeneRIF: Integrative genomic analyses identify WDR12 as a novel
            oncogene involved in glioblastoma.
REFERENCE   5  (bases 1 to 8068)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 8068)
  AUTHORS   Holzel,M., Rohrmoser,M., Schlee,M., Grimm,T., Harasim,T.,
            Malamoussi,A., Gruber-Eber,A., Kremmer,E., Hiddemann,W.,
            Bornkamm,G.W. and Eick,D.
  TITLE     Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is
            required for ribosome biogenesis and cell proliferation
  JOURNAL   J Cell Biol 170 (3), 367-378 (2005)
   PUBMED   16043514
  REMARK    GeneRIF: WDR12 triggers accumulation of p53 in a p19ARF-independent
            manner in proliferating cells but not in quiescent cells.
REFERENCE   7  (bases 1 to 8068)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   8  (bases 1 to 8068)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   9  (bases 1 to 8068)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   10 (bases 1 to 8068)
  AUTHORS   Nal,B., Mohr,E., Silva,M.I., Tagett,R., Navarro,C., Carroll,P.,
            Depetris,D., Verthuy,C., Jordan,B.R. and Ferrier,P.
  TITLE     Wdr12, a mouse gene encoding a novel WD-Repeat Protein with a
            notchless-like amino-terminal domain
  JOURNAL   Genomics 79 (1), 77-86 (2002)
   PUBMED   11827460
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010900.12.
            
            On Jul 22, 2019 this sequence version replaced NM_018256.3.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. This protein is
            highly similar to the mouse WD repeat domain 12 protein at the
            amino acid level. The protein encoded by this gene is a component
            of a nucleolar protein complex that affects maturation of the large
            ribosomal subunit.[provided by RefSeq, Dec 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056092.1, AK001743.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261015.5/ ENSP00000261015.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC010900.12        104051-104288       c
            239-333             AC010900.12        100480-100574       c
            334-428             AC010900.12        93640-93734         c
            429-535             AC010900.12        92146-92252         c
            536-651             AC010900.12        89915-90030         c
            652-806             AC010900.12        88680-88834         c
            807-852             AC010900.12        87196-87241         c
            853-938             AC010900.12        85232-85317         c
            939-1079            AC010900.12        77010-77150         c
            1080-1185           AC010900.12        76813-76918         c
            1186-1318           AC010900.12        76224-76356         c
            1319-1391           AC010900.12        75326-75398         c
            1392-8068           AC010900.12        66876-73552         c
FEATURES             Location/Qualifiers
     source          1..8068
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.2"
     gene            1..8068
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /note="WD repeat domain 12"
                     /db_xref="GeneID:55759"
                     /db_xref="HGNC:HGNC:14098"
                     /db_xref="MIM:616620"
     exon            1..238
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1469
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ribosome biogenesis protein WDR12; WD repeat-containing
                     protein 12"
                     /codon_start=1
                     /product="ribosome biogenesis protein WDR12 isoform 1"
                     /protein_id="NP_060726.3"
                     /db_xref="CCDS:CCDS2356.1"
                     /db_xref="GeneID:55759"
                     /db_xref="HGNC:HGNC:14098"
                     /db_xref="MIM:616620"
                     /translation="MAQLQTRFYTDNKKYAVDDVPFSIPAASEIADLSNIINKLLKDK
                     NEFHKHVEFDFLIKGQFLRMPLDKHMEMENISSEEVVEIEYVEKYTAPQPEQCMFHDD
                     WISSIKGAEEWILTGSYDKTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLS
                     ASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWST
                     VPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASW
                     DHTIRVWDVESGSLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLV
                     SLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSV
                     DWTDTGLLLSGGADNKLYSYRYSPTTSHVGA"
     exon            239..333
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /inference="alignment:Splign:2.1.0"
     exon            334..428
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..535
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..651
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..806
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..852
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..938
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1079
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1185
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1318
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1391
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..8068
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1696..1701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /note="hexamer: ATTAAA"
     polyA_site      1725
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /note="major polyA site"
     regulatory      3846..3851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /note="hexamer: AATAAA"
     polyA_site      3868
                     /gene="WDR12"
                     /gene_synonym="YTM1"
     regulatory      7266..7271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /note="hexamer: AATAAA"
     polyA_site      7287
                     /gene="WDR12"
                     /gene_synonym="YTM1"
     regulatory      7520..7525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /note="hexamer: AATAAA"
     polyA_site      7552
                     /gene="WDR12"
                     /gene_synonym="YTM1"
     regulatory      8039..8044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR12"
                     /gene_synonym="YTM1"
                     /note="hexamer: AGTAAA"
     polyA_site      8068
                     /gene="WDR12"
                     /gene_synonym="YTM1"
ORIGIN      
        1 gtagaagggc aacctcgtgc tttctgcaga ggagaccgga gggcagaagg cagagtccag
       61 gcttagactg cagttcctcg cttacctgtg cagtctaatt ttgagctgcc tctttgtagt
      121 cttaaaaggc aggagcttcg tgttgtgggt ctgctaaccc gtacgtttcc gtgggcaagt
      181 cgtgtgtact cctcgccatg gctcagctcc aaacacgctt ctacactgat aacaagaaat
      241 atgccgtaga tgatgttccc ttctcaatcc ctgctgcctc tgaaattgcc gaccttagta
      301 acatcatcaa taaactacta aaggacaaaa atgagttcca caaacatgtg gagtttgatt
      361 tccttattaa gggccagttt ctgcgaatgc ccttggacaa acacatggaa atggagaaca
      421 tctcatcaga agaagttgtg gaaatagaat acgtggagaa gtatactgca ccccagccag
      481 agcaatgcat gttccatgat gactggatca gttcaattaa aggggcagag gaatggatct
      541 tgactggttc ttatgataag acttctcgga tctggtcctt ggaaggaaag tcaataatga
      601 caattgtggg acatacggat gttgtaaaag atgtggcctg ggtgaaaaaa gatagtttgt
      661 cctgcttatt attgagtgct tctatggatc agactattct cttatgggag tggaatgtag
      721 agagaaacaa agtgaaagcc ctacactgct gtagaggtca tgctggaagt gtagattcta
      781 tagctgttga tggctcagga actaaatttt gcagtggctc ctgggataag atgctaaaga
      841 tctggtctac agtccctaca gatgaagaag atgaaatgga ggagtccaca aatcgaccaa
      901 gaaagaaaca gaagacagaa cagttgggac taacaaggac tcccatagtg accctctctg
      961 gccacatgga ggcagtttcc tcagttctgt ggtcagatgc tgaagaaatc tgcagtgcat
     1021 cttgggacca tacaattaga gtgtgggatg ttgagtctgg cagtcttaag tcaactttga
     1081 caggaaataa agtgtttaat tgtatttcct attctccact ttgtaaacgt ttagcatctg
     1141 gaagcacaga taggcatatc agactgtggg atccccgaac taaagatggt tctttggtgt
     1201 cgctgtccct aacgtcacat actggttggg tgacatcagt aaaatggtct cctacccatg
     1261 aacagcagct gatttcagga tctttagata acattgttaa gctgtgggat acaagaagtt
     1321 gtaaggctcc tctctatgat ctggctgctc atgaagacaa agttctgagt gtagactgga
     1381 cagacacagg gctacttctg agtggaggag cagacaataa attgtattcc tacagatatt
     1441 cacctaccac ttcccatgtt ggggcatgaa agtgaacaat aatttgacta tagagattat
     1501 ttctgtaaat gaaattggta gagaaccatg aaattacata gatgcagatg cagaaagcag
     1561 ccttttgaag tttatataat gttttcaccc ttcataacag ctaacgtatc actttttctt
     1621 attttgtatt tataataaga taggttgtgt ttataaaata caaactgtgg catacattct
     1681 ctatacaaac ttgaaattaa actgagtttt acatttctct ttaaaggtat tggtttgaat
     1741 tcagatttgc ttttttattt ttatttgttt tttttttttt tgagatggag tcttgctctg
     1801 ttgcctaggc tggagtgcag tggcgcaatc tcaactcact gcaacctccg cttcctaggt
     1861 tcaatcgatt ctcctgtctc aacctcccaa gtagctggga ttacaggcac acatcacgat
     1921 gtcctgctaa tttttgtatt tttagtagag acggggtttt gccatgttgg ccaggctggt
     1981 cttgaactcc tgacctcagg tgatctgccc acctcagcct cccaaagtga gccactgtgc
     2041 ctggccgaat taagatttgt ttttgaaatg ctgtaaaagg ttatattgga aatccagtaa
     2101 ttgattgttg agatttttat ttctgttaga gacttagatt tttttaagtt agctatttta
     2161 aaaaagcatt caaaaagatt aatgaaaatt gtaatagaga aaaagttaga aattcagttc
     2221 cttttggcag aataaatgtt caagaaaatt aggctgtgag ggtactcaga acattaaaaa
     2281 aaatgtaggc tgggcatggt ggctcacacc tgtaatccca gcacattggg aggccgaggc
     2341 aggtggatca cctgaggtca ggagtttgag accaccctgg ccaacatgtc aaaaccctgt
     2401 ctctgctaaa actacaaaaa ttagctgggc atggtggcga ccgcctgtaa tcccaactac
     2461 ttgggaggct aaggcaggag aattgcttga acccgggagg caggggttgt agtgagctga
     2521 gattgtgcca ctgcactcca gcctgggtga cagtgcaaga ctctgtctca acaacaacga
     2581 taacaaaata ttgattcggc agggcacggt ggctcatgct tgtaatccca gcattttggg
     2641 tggccaaggc aggcggctca cctgaggtca ggggttcgag accagcctga ccaacatggt
     2701 gaaactttgt ctctactaaa aaaaaaaaaa tccaaaacaa attagccggg tgtggtggca
     2761 cactcctgtg gtcccaagta cttgggaggc tgaggcagga gaattggttg aacccaggag
     2821 gtggaggttg cagtgagctg agatcatacc actgtgctcc agcctgggca gcagagccag
     2881 actctatctc aaaataaaga caagtagatt gccaattttt gaagaattca tcaagatatt
     2941 ttaaggaagg cactttatat taaatatatg tcagatcctt tagaaattgc atacagttgg
     3001 ttgggcacgg tggctcacgc ctgtaatccc agcactttgg gaggctgagg cgggcggatt
     3061 gcctgagctc aggagttcga aaccagcctg ggcaacacag tgaaacctcg tctctaataa
     3121 aatacaaaaa attagctggg cgtggcagca tgtgcctgta gtcccagcta ctccggaggc
     3181 tgaggcaggc aaattgcttg aacccgagag gcagaggttg cagtgagctg agattgtgcc
     3241 actgcatttc agcctgggca acagagcaag actctgtctc aaaaaaaaat aaaaaattgc
     3301 attgcataca gttttcactg taaccctaat ctttcctcat gtgtagatta gaataaattt
     3361 tttagacaaa acctttcatc agtattaaac attctacaga ttttatgata tcattagcat
     3421 ttatctttat gcatgtgtta tataaaaata tttaaagtaa atgtattttt taaatgttat
     3481 ttccattatt aatggattga tactccttaa gtagagcatt cacaaccttt tagtaatatt
     3541 tgggaaatat gtttggtctc attattagat ggtattacat ctcaaatgat gttcctgttg
     3601 cagaagtctg cgaaacaata tctaaacttg gctgcagttg agagctaaac agtgtattga
     3661 accagttagg agtttagttc tctgtagaaa accagaggca gtccagggct gatgtaggtt
     3721 ttgttccaca ttctttagga tcctaggctc cctccatccc tggtatgtgg tcctcatttt
     3781 catatagacc aagagctaga gctccagtta ccatttctta aagtatattt taatgccaaa
     3841 tagtgaataa aggtggccag aaaattcatg cacagaatcc ttctttttct cattttgtgc
     3901 tgattggtat aaattttatt gtatttgtag tctctggaaa tcttctaact ttgagaggac
     3961 aaagatgaat tcctagtcct gttttggatg gtcttcaaat gatccttaag ggcagttatt
     4021 taaaatgtct ttcttaactc acccaaccta ggctgaccga atgtagtctg tataaactag
     4081 atggttaaag ataaagaagc ctatatatca gatgcataga caaagaataa aatggcatcc
     4141 agaactggtc cccacctatt cccaatcctg gttccacagc agaatacatt catagttcag
     4201 gcattcttcc ttgagataga tataatgtaa gtgaccaagt ctcttggaca agtattgtct
     4261 ctgatcaatc cctgccaaac tcctttcctt ggttaactca agtggttaga tcttactccc
     4321 tgaacagaag gaatatgaga ggtcaataca tgcctagact attcagtcct ctgatattgc
     4381 tccacaccct ttccctcaaa agccatgaga cctttcaatg gtcccagttc ctctaccaga
     4441 acaccagaga tgcctgcttt acatggactt atatattccc aagaatcact tggataaatg
     4501 agtggtgctg ctttcccgtg gttggggaaa agctaggaac ctgacaatgc agtgctcaga
     4561 acctgctgac cggtactagt tatgctgtct tgccatagta gtgcagttct ttaaaatgtt
     4621 gatacttgct ctcttatcaa aggttggttt ttttgttttt ttgtcaagac agggtctcac
     4681 tatgtcaccc atactggagt acaatggtgt aatcttggct tactgcaacc tccaccttct
     4741 gggctcaagc tggcctctca cctcagcctt ccaagtagct gggaccacac ccagtcaatt
     4801 ttttattttt tattttttaa tttattttta ttattacttt ttttgtagag agagggtttc
     4861 gccatgtagc ccatgctggt cttgaactcc tgggctcaag ctgtctgccc acctggacct
     4921 cccaaagtgc tgagattaca ggcatgagcc accgcaccca gcccaaataa agttttaaga
     4981 aattacttgg ccaggcatag tggggccttt gtagaaaaac atagcttttc tatgagaaga
     5041 tgatcaatat tttcttttcc tttgaatttg gaattaccat tttggaactg ttgtcaacaa
     5101 tgcataataa tatatcagaa tgcttcctag tatattattg gagaaagaac aaacaaaagt
     5161 ttaaattgat ataaaatgca tataatggaa caagcaaccc tgcaaaaaaa aaaatatata
     5221 tatatatata ccatctggga atttctgata ataacattga aatctgttca cacagtctaa
     5281 aattcttttg atgtatcgta gttttgaaaa aaaggtaaca gtttactata tataacaaat
     5341 ataaggaaaa tattaaattt tttgaaagat actagttttt atttttgttc attttttaga
     5401 gacagggtct cactatgttg cccaagctag agtgcagcgg cccgattata gctcactgca
     5461 gcctctaact cccggactca agggatcctc ccacctcatc ctcctaacta ggaccacagg
     5521 cgcatgtcac cacatctggc tgattttaaa atttttttgt ggagacagtc ttgctgtgtt
     5581 gcccaggctg gttatgaact cttggcctca ggcagtcctc atgcctcagc ctccctaagt
     5641 gctcggatta taggcatgcc actgtgcctg gccaaaaata cagatttttt aatagatatt
     5701 actatggctc ctattcttaa aggaaaaaat atgacatttt aagactatat gcaagggata
     5761 ttccaataat atctttttta tttaaaaagc cactaattag aatcagattt cattaggcaa
     5821 gtgaaatcca gattttacta gccagaaact gccaggtgta gaaacagcaa gaacatttta
     5881 gtcacttcat tgttgacatt tttgactatc atagattaag tatcaaacac aataacagta
     5941 ttttgttata tgaaccaaat atatctcttt ttacgagaca tagtctagct ctgccatcca
     6001 ggctcaactc ctgggttcaa gggatcctcc tgccccagct tcctgagtac gtacctggga
     6061 gtacaattgc atgctgccac acccagctat tttttttatt tttgtggaga tggcgtcttg
     6121 ctatgttgcc caggctggac tccaactcct gacctcaagc aatcatctca ccttggcctc
     6181 aaaagtgcta agattacagg catgagccac tgcatccagc ctgaaccaaa tatatcttta
     6241 ttataactta ggagagaaac gtttttggct ggttagtttt acagaattaa acctaatggt
     6301 tgttctaata gcagttccaa tgatttgcag atttgaggaa gtaaattatt ttcttacagt
     6361 gtccataaaa gtaacaatga aactatatcc taccataata atcctctata ggtaataaat
     6421 tatttgcatt ttataggaga gaaaaatata tgttaaagtt tttgaacagt cacacaggca
     6481 ggaaataaat ggcagtgaat ttgaacttgg acttatcttg gacaagctct taactggtat
     6541 atattttgtc aatcttatgt cgtgcacaag aatgatgttt ttataaatgg aaagaatgag
     6601 tgtggaagtg tcttcacttg cctaacagaa aggttatatg tggctgggcg ccgtggctaa
     6661 cgcctgtaat cccaacattt tgggaggctg aggtgggcat atcatctgag gtcgggagtt
     6721 caagaatagc ctgaccaaca tggagaaacc ccgtctctac taaaaataca aaattagcca
     6781 gtcatagtgg cacatgcctg taatcccagc tacttggaag gctgaggcag aagaattgct
     6841 tgaacccagg aggtggaggt tgtggtgagc caagatcgcg ccattgcact ccatcctggg
     6901 caacaagagc gaaactccgt ctcaaaaaaa aaaaaaaaaa aagtaataca taaatttaag
     6961 tgacatttgt gggtactaaa ttacaataat atgttcagct ttgcattttt ttgcctttaa
     7021 aattaatttc aattttagcg tgccactaaa cgtattactg taatagtata taaatgtata
     7081 aagatcaatt tctgtatatt ctaataggaa ttgtatataa gcaaaaatga attttagaaa
     7141 ttatcctatt attcatgtaa ttatgtcatt catgttattt aaaggaaacc acaatgcaga
     7201 caggttaagt acctagtgtg aaggtatgta accaattaat ggagctgtgc gacatacatc
     7261 tgagtaataa agactacaga gaaagtatct tgttaggtac tatctgatac aaagtttaga
     7321 aacatgtcaa acaattctat gtatagttgg tgaaagtgta ataacatggc tgagacttaa
     7381 taccagatga agttcagtgg tttcaggggg aggaaataat ttttaaaacg atgtcgataa
     7441 cacttcacat ttaaaatcat cataataatt ctaattctag aattgtgtct aattctaata
     7501 ctgtttctag ctttgcttga ataaacagaa atgtagtagg gaagagacag aatgtttagc
     7561 ttgcagtatc taattactca tttgggtatc tgggaagata gctctccatg gccccactgt
     7621 cactgaccta taatgcttct cctgacgtct tcggtaaaat ccaacagatt acaaagaaac
     7681 tggaatgcct tgaagaaata gagctttttg tgtgatgtca gattcaatag acctctaatc
     7741 cttagtaaaa cagtacaaaa cagtagaata atttttagtg ttttctaata tcaactgagg
     7801 ttttatttgg gagattaacc agaggtttgc acaaaaacaa aagtgaagac cattagtctt
     7861 taaagaaact aagactctag gtttggatcc catttgtgga gccctacatt ccaagtcatc
     7921 taatgttctt gtctagttag cttgtaaaag tctatacaat ggaggaaaac cccttttttc
     7981 cccttagtat aagtgtatta tatgttgata gaaaggatag aaagttaaat aacagttcag
     8041 taaatgtact tctaaatgaa atttaaaa
//
