LOCUS       NM_018117               4545 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens WD repeat domain 11 (WDR11), mRNA.
ACCESSION   NM_018117
VERSION     NM_018117.12
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4545)
  AUTHORS   Srinivasan,S., Liju,S., Sathish,N., Siddiqui,M.K., Anjana,R.M.,
            Pearson,E.R., Doney,A.S.F., Mohan,V., Radha,V. and Palmer,C.N.A.
  TITLE     Common and Distinct Genetic Architecture of Age at Diagnosis of
            Diabetes in South Indian and European Populations
  JOURNAL   Diabetes Care 46 (8), 1515-1523 (2023)
   PUBMED   37308106
  REMARK    GeneRIF: Common and Distinct Genetic Architecture of Age at
            Diagnosis of Diabetes in South Indian and European Populations.
REFERENCE   2  (bases 1 to 4545)
  AUTHORS   Haag,N., Tan,E.C., Begemann,M., Buschmann,L., Kraft,F.,
            Holschbach,P., Lai,A.H.M., Brett,M., Mochida,G.H., DiTroia,S.,
            Pais,L., Neil,J.E., Al-Saffar,M., Bastaki,L., Walsh,C.A., Kurth,I.
            and Knopp,C.
  TITLE     Biallelic loss-of-function variants in WDR11 are associated with
            microcephaly and intellectual disability
  JOURNAL   Eur J Hum Genet 29 (11), 1663-1668 (2021)
   PUBMED   34413497
  REMARK    GeneRIF: Biallelic loss-of-function variants in WDR11 are
            associated with microcephaly and intellectual disability.
REFERENCE   3  (bases 1 to 4545)
  AUTHORS   Navarro Negredo,P., Edgar,J.R., Manna,P.T., Antrobus,R. and
            Robinson,M.S.
  TITLE     The WDR11 complex facilitates the tethering of AP-1-derived
            vesicles
  JOURNAL   Nat Commun 9 (1), 596 (2018)
   PUBMED   29426865
  REMARK    GeneRIF: Data indicate a functional link between adaptor protein
            complex 1 (AP-1) and the WD repeat protein 11 (WDR11) complex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4545)
  AUTHORS   Kim,Y.J., Osborn,D.P., Lee,J.Y., Araki,M., Araki,K., Mohun,T.,
            Kansakoski,J., Brandstack,N., Kim,H.T., Miralles,F., Kim,C.H.,
            Brown,N.A., Kim,H.G., Martinez-Barbera,J.P., Ataliotis,P.,
            Raivio,T., Layman,L.C. and Kim,S.H.
  TITLE     WDR11-mediated Hedgehog signalling defects underlie a new
            ciliopathy related to Kallmann syndrome
  JOURNAL   EMBO Rep 19 (2), 269-289 (2018)
   PUBMED   29263200
  REMARK    GeneRIF: Our study reveals a novel class of ciliopathy caused by
            WDR11 mutations and suggests that CHH/KS may be a part of the human
            ciliopathy spectrum.
REFERENCE   5  (bases 1 to 4545)
  AUTHORS   Shin,J.J.H., Gillingham,A.K., Begum,F., Chadwick,J. and Munro,S.
  TITLE     TBC1D23 is a bridging factor for endosomal vesicle capture by
            golgins at the trans-Golgi
  JOURNAL   Nat Cell Biol 19 (12), 1424-1432 (2017)
   PUBMED   29084197
  REMARK    Erratum:[Nat Cell Biol. 2018 Feb;20(2):222. doi:
            10.1038/s41556-017-0026-7.. PMID: 29311657]
REFERENCE   6  (bases 1 to 4545)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   7  (bases 1 to 4545)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Recombination cluster around FGFR2-WDR11-HTPAPL locus on human
            chromosome 10q26
  JOURNAL   Int J Mol Med 11 (5), 579-583 (2003)
   PUBMED   12684693
  REMARK    GeneRIF: Data show that the HTPAPL-WDR11-FGFR2 locus was more
            susceptible to recombination than to nucleotide substitution.
REFERENCE   8  (bases 1 to 4545)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     FGFR2 and WDR11 are neighboring oncogene and tumor suppressor gene
            on human chromosome 10q26
  JOURNAL   Int J Oncol 22 (5), 1155-1159 (2003)
   PUBMED   12684685
  REMARK    GeneRIF: This gene is expressed on chromosome 10p26.
REFERENCE   9  (bases 1 to 4545)
  AUTHORS   Chernova,O.B., Hunyadi,A., Malaj,E., Pan,H., Crooks,C., Roe,B. and
            Cowell,J.K.
  TITLE     A novel member of the WD-repeat gene family, WDR11, maps to the
            10q26 region and is disrupted by a chromosome translocation in
            human glioblastoma cells
  JOURNAL   Oncogene 20 (38), 5378-5392 (2001)
   PUBMED   11536051
  REMARK    GeneRIF: Represents a candidate gene for the frequently proposed
            tumor suppressor gene in 10q25-26, which is involved in
            tumorigenesis of glial and other tumors showing frequent
            alterations in the distal 10q region.
REFERENCE   10 (bases 1 to 4545)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC342128.1 and BC071564.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018117.11.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. This gene is located
            in the chromosome 10q25-26 region, which is frequently deleted in
            gliomas and tumors of other tissues, and is disrupted by the
            t(10;19) translocation rearrangement in glioblastoma cells. The
            gene location suggests that it is a candidate gene for the tumor
            suppressor locus. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040469.1, SRR1660809.181542.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263461.11/ ENSP00000263461.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                DC342128.1         188-217
            31-4545             BC071564.1         1-4515
FEATURES             Location/Qualifiers
     source          1..4545
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.12"
     gene            1..4545
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /note="WD repeat domain 11"
                     /db_xref="GeneID:55717"
                     /db_xref="HGNC:HGNC:13831"
                     /db_xref="MIM:606417"
     exon            1..145
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..3734
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /note="WD repeat domain 15; bromodomain and WD
                     repeat-containing protein 2; WD repeat-containing protein
                     15; sensitization to ricin complex subunit 1"
                     /codon_start=1
                     /product="WD repeat-containing protein 11"
                     /protein_id="NP_060587.8"
                     /db_xref="CCDS:CCDS7619.1"
                     /db_xref="GeneID:55717"
                     /db_xref="HGNC:HGNC:13831"
                     /db_xref="MIM:606417"
                     /translation="MLPYTVNFKVSARTLTGALNAHNKAAVDWGWQGLIAYGCHSLVV
                     VIDSITAQTLQVLEKHKADVVKVKWARENYHHNIGSPYCLRLASADVNGKIIVWDVAA
                     GVAQCEIQEHAKPIQDVQWLWNQDASRDLLLAIHPPNYIVLWNADTGTKLWKKSYADN
                     ILSFSFDPFDPSHLTLLTSEGIVFISDFSPSKPPSGPGKKVYISSPHSSPAHNKLATA
                     TGAKKALNKVKILITQEKPSAEFITLNDCLQLAYLPSKRNHMLLLYPREILILDLEVN
                     QTVGVIAIERTGVPFLQVIPCFQRDGLFCLHENGCITLRVRRSYNNIFTTSNEEPDPD
                     PVQELTYDLRSQCDAIRVTKTVRPFSMVCCPVNENAAALVVSDGRVMIWELKSAVCNR
                     NSRNSSSGVSPLYSPVSFCGIPVGVLQNKLPDLSLDNMIGQSAIAGEEHPRGSILREV
                     HLKFLLTGLLSGLPAPQFAIRMCPPLTTKNIKMYQPLLAVGTSNGSVLVYHLTSGLLH
                     KELSIHSCEVKGIEWTSLTSFLSFATSTPNNMGLVRNELQLVDLPTGRSIAFRGERGN
                     DESAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPSHNL
                     KSLRKKQLATREAMARQTVVSDTELSIVESSVISLLQEAESKSELSQNISAREHFVFT
                     DIDGQVYHLTVEGNSVKDSARIPPDGSMGSITCIAWKGDTLVLGDMDGNLNFWDLKGR
                     VSRGIPTHRSWVRKIRFAPGKGNQKLIAMYNDGAEVWDTKEVQMVSSLRSGRNVTFRI
                     LDVDWCTSDKVILASDDGCIRVLEMSMKSACFRMDEQELTEPVWCPYLLVPRASLALK
                     AFLLHQPWNGQYSLDISHVDYPENEEIKNLLQEQLNSLSNDIKKLLLDPEFTLLQRCL
                     LVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLDICYDVLCE
                     NAYFQKFQLERVNLQEVKRSTYDHTRKCTDQLLLLGQTDRAVQLLLETSADNQHYYCD
                     SLKACLVTTVTSSGPSQSTIKLVATNMIANGKLAEGVQLLCLIDKAADACRYLQTYGE
                     WNRAAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSVAETLHS
                     MRYFDRAALFVEACLKYGAFEVTEDTEKLITAIYADYARSLKNLGFKQGAVLFASKAG
                     AAGKDLLNELESPKEEPIEE"
     exon            146..257
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            258..411
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            412..585
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            586..772
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            773..938
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1053
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1249
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1353
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1530
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1615
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1722
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1798
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1907
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2032
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2180
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2287
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2402
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2574
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2683
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2746
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2812
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2990
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3086
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3252
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3350
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3496
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3576
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..4545
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4524..4529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /note="hexamer: AATAAA"
     polyA_site      4545
                     /gene="WDR11"
                     /gene_synonym="BRWD2; DR11; HH14; SRI1; WDR15"
                     /note="major polyA site"
ORIGIN      
        1 acagtgtccg ccgcttcctg gttgcgggtc agcgcccagg tcctgggctg gccgccggga
       61 tgttgcccta cacagtgaac ttcaaggtgt cggcgcgcac cctcacgggg gccctcaacg
      121 cccacaacaa ggcggcggtg gactggggct ggcaaggttt aattgcttat ggatgtcatt
      181 cacttgtggt agtgattgat tccattactg cccaaactct tcaagtttta gaaaagcata
      241 aagctgatgt tgtaaaggtt aaatgggcca gggaaaacta tcaccataac attggctcac
      301 catattgctt acggttagct tctgctgatg tcaatgggaa gatcatcgtc tgggatgtag
      361 cagcaggagt agctcagtgt gagatccaag agcatgccaa gcctatccag gatgttcagt
      421 ggttgtggaa tcaagatgct tcccgcgatt tactgcttgc tatccacccg ccaaattaca
      481 ttgtgctctg gaatgccgac actggcacca aactatggaa gaagagctat gcagataaca
      541 ttctttcttt ttcttttgac ccttttgatc cctcacattt aactttgctt accagcgagg
      601 gtattgtttt catctcagac ttctccccat ccaagcctcc ctcaggccct gggaaaaaag
      661 tttacatatc cagcccacac tctagcccag ctcataacaa gctggccaca gccacaggtg
      721 ccaagaaagc tctaaataaa gtaaaaattt taatcactca agagaaacct agtgctgaat
      781 tcataactct caatgattgc cttcagttgg catacctgcc ttcaaaaagg aatcacatgt
      841 tgttgctcta tcctcgagag attttaatcc ttgaccttga ggtgaatcag acggtgggtg
      901 tgattgcaat agaacgcaca ggagttccat ttttacaggt aataccctgc tttcagcgtg
      961 atggtttatt ttgtctacat gaaaatggtt gtataacttt acgtgttcga agatcttata
     1021 ataacatttt taccacttca aatgaggaac cagatccaga tccagttcag gagcttacct
     1081 atgatttacg aagccagtgt gatgcaatca gggtgacaaa aaccgtccgt cccttcagta
     1141 tggtgtgctg tcctgtcaat gagaatgcag ccgccctcgt agtgagtgat ggcagggtca
     1201 tgatatggga actcaagtct gcagtttgta atcgaaattc acggaacagt agttctggtg
     1261 tgtcaccttt atattcacca gtgtctttct gtggaattcc tgtaggagtg ctacagaata
     1321 aactcccaga cctttcctta gataacatga ttgggcaaag tgcaattgct ggggaagaac
     1381 atcccagagg ttcaattctg cgggaagtgc acctcaagtt cctgctgacg ggactgcttt
     1441 caggactgcc cgcaccacag tttgctattc gtatgtgtcc accgttgacc acaaaaaaca
     1501 tcaagatgta tcagccactg ctggctgttg gtacaagtaa tggttctgtc ctggtgtacc
     1561 atctcaccag tggtctgcta cacaaagagt taagcatcca ctcatgtgaa gtcaagggta
     1621 ttgaatggac aagtttgact agttttcttt cttttgctac ctcaacacca aacaatatgg
     1681 gattagtgag aaatgaactt caactggttg atcttccaac aggtaggagc attgcttttc
     1741 gtggtgaaag aggcaatgat gaatctgcca tcgaaatgat taaagtatct catttgaagc
     1801 agtatttggc agtcgtattc agagataaac ccctggagct atgggatgtt aggacttgta
     1861 cccttcttag agagatgtcc aaaaacttcc ctacaataac tgctttggag tggtcaccat
     1921 ctcacaactt gaagagcctg agaaagaagc aacttgcaac tcgagaggcc atggcccgcc
     1981 agaccgtagt ctcagacaca gagctgagta ttgttgaatc atctgtgatc agcttgctgc
     2041 aggaggcaga aagtaaatct gaacttagtc agaacatctc tgcccgggaa cattttgtat
     2101 ttaccgatat tgatggccaa gtgtatcatc tcactgttga aggaaactca gtaaaagaca
     2161 gtgctcggat tccaccagat ggaagtatgg gtagtattac ctgcatcgct tggaaaggtg
     2221 atacattagt gcttggagat atggatggaa atttaaattt ctgggacttg aaaggcagag
     2281 tatccagagg aatacccaca caccgaagtt gggtgaggaa gattcgtttt gctcctggta
     2341 aaggaaatca aaaattaata gcaatgtaca atgatggagc tgaagtgtgg gatactaaag
     2401 aggttcagat ggtgagcagt ttaagaagtg gcagaaatgt gacctttcgt atattggatg
     2461 tggactggtg tacgtcagat aaagtgatct tggcctcaga tgatgggtgc atcagagtcc
     2521 tagagatgtc tatgaagtct gcgtgcttta gaatggatga acaagagtta accgagcctg
     2581 tgtggtgccc ctatctcctt gttccaaggg cctctcttgc cttgaaagcc ttcttattac
     2641 accagccttg gaatggacag tattctttgg acatttctca tgttgactat ccagaaaatg
     2701 aagaaataaa gaatctcctc caagaacagt tgaattcatt gtctaatgac ataaagaaac
     2761 tgttgcttga tccagaattc actctcttgc agaggtgcct gcttgtttca aggctctatg
     2821 gtgatgaatc ggagctgcac ttctggactg tcgctgccca ctacctgcac agcttatccc
     2881 aggaaaagtc agccagcaca acagctccta aagaagctgc tcctcgagac aaactgagca
     2941 acccactgga tatatgctat gacgtgctct gtgaaaatgc ctactttcag aaatttcagc
     3001 tagaaagggt taatctgcag gaagtgaaac ggtcaactta tgatcataca aggaaatgta
     3061 cagaccagct actgctcttg ggtcaaacag acagagctgt gcagttgctg ttggaaacaa
     3121 gtgcagataa ccagcattat tactgtgatt cactgaaagc ctgtttagtc actactgtca
     3181 cctcgtcagg cccctctcag agcaccatta agttggtggc aacgaatatg attgccaatg
     3241 gcaaattggc agagggcgtt cagttgctct gcctgataga taaggctgca gacgcctgcc
     3301 gctacctgca gacatacggc gagtggaatc gggctgcatg gctggcaaaa gtccgtttga
     3361 atcctgagga gtgtgccgat gttttaaggc ggtgggttga ccacctttgt tctccacaag
     3421 tcaatcagaa atcaaaggct ctcctggttc tcctctctct gggctgcttt tttagcgtgg
     3481 cagagacgct tcacagcatg agatactttg atagagcagc cttatttgtg gaagcttgcc
     3541 tcaagtatgg agcatttgaa gtcactgagg acacagagaa actcatcact gctatatatg
     3601 cagattatgc ccggagtttg aagaacctcg gttttaagca gggagcagtt ctctttgctt
     3661 caaaagccgg agcagctggc aaagacttat tgaatgagct tgagtccccc aaggaagaac
     3721 ccattgaaga gtgacagctt aataaatgcc agggaatctg acctggaagg cagatgggag
     3781 ggggctggtc tggctgtggc caccgtcaca gtccaggatg aagaggagta cagggtcctg
     3841 tgagctgttt gaccactgtt ctaagactat gtgtgcccaa aagcacataa gcatctatgt
     3901 tgagagtaag tttgtatcct gcgttggtct cagaaagaac gtgaatgctt aagattttga
     3961 aagtacataa tattttatac tttgggagag agctttaaga gtccctggaa atacttttta
     4021 atttttttaa cttaaaattc aagagactga atcacttttc tcattgatta aatgtaaaga
     4081 ttattgagaa acctatagta aatgaaattt gtgagatgtt ttctcaaata tatgctgtgc
     4141 ctgtacttat atacagtctt tcaagagaga tacaaacaag gcagaaacat ttaaactagt
     4201 attaaaggta gtttaccaaa gcattttttg ttttcttacc ttgaaaacac agaaccgtta
     4261 attccttggt ttaagcagtt gctaagtttt gtaattttag gctcagagga ccataggagg
     4321 ttttaagatt tatgtttagt ccgataggtg aggtctttga tattttgaat tttaactcct
     4381 tttatgatac atcacagtaa cctcattttt gaagtctttc tttgtacttt aatgttctct
     4441 ctgttctaat agttgaagta tgagatgtaa ctattataaa ctgttgctga aaacataaat
     4501 gtctgtaact tacaaacatg ataaataaat taaaaattcc atcca
//
