LOCUS       NM_017491               2993 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens WD repeat domain 1 (WDR1), transcript variant 1, mRNA.
ACCESSION   NM_017491
VERSION     NM_017491.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2993)
  AUTHORS   Cheng,J., Huo,D., Zhang,Z., Zhang,J., Dong,B., Liu,Z., Zhou,Z. and
            Lu,Y.
  TITLE     WDR1 promotes prostate cancer progression through Wnt/beta-catenin
            signaling
  JOURNAL   Med Oncol 41 (6), 151 (2024)
   PUBMED   38743149
  REMARK    GeneRIF: WDR1 promotes prostate cancer progression through
            Wnt/beta-catenin signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2993)
  AUTHORS   An,R., Wang,J., Chen,X., Xu,R., Hu,J., Liu,Z., Wei,C., Zhang,C. and
            Yuan,B.
  TITLE     YAP signaling is involved in WDR1-regulated proliferation and
            migration of non-small-cell lung cancer cells
  JOURNAL   Exp Biol Med (Maywood) 247 (18), 1619-1629 (2022)
   PUBMED   35861209
  REMARK    GeneRIF: YAP signaling is involved in WDR1-regulated proliferation
            and migration of non-small-cell lung cancer cells.
REFERENCE   3  (bases 1 to 2993)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2993)
  AUTHORS   Tang,V.W., Nadkarni,A.V. and Brieher,W.M.
  TITLE     Catastrophic actin filament bursting by cofilin, Aip1, and coronin
  JOURNAL   J Biol Chem 295 (38), 13299-13313 (2020)
   PUBMED   32723865
  REMARK    GeneRIF: Catastrophic actin filament bursting by cofilin, Aip1, and
            coronin.
REFERENCE   5  (bases 1 to 2993)
  AUTHORS   Li,H., Liu,X., Jiang,S., Zhou,X., Yao,L., Di,Y., Jiang,Y., Gu,J.,
            Mao,Y., Li,J., Jin,C., Yang,P. and Fu,D.
  TITLE     WD repeat-containing protein 1 maintains beta-Catenin activity to
            promote pancreatic cancer aggressiveness
  JOURNAL   Br J Cancer 123 (6), 1012-1023 (2020)
   PUBMED   32601462
  REMARK    GeneRIF: WD repeat-containing protein 1 maintains beta-Catenin
            activity to promote pancreatic cancer aggressiveness.
REFERENCE   6  (bases 1 to 2993)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   7  (bases 1 to 2993)
  AUTHORS   Rodal,A.A., Tetreault,J.W., Lappalainen,P., Drubin,D.G. and
            Amberg,D.C.
  TITLE     Aip1p interacts with cofilin to disassemble actin filaments
  JOURNAL   J Cell Biol 145 (6), 1251-1264 (1999)
   PUBMED   10366597
REFERENCE   8  (bases 1 to 2993)
  AUTHORS   Adler,H.J., Winnicki,R.S., Gong,T.W. and Lomax,M.I.
  TITLE     A gene upregulated in the acoustically damaged chick basilar
            papilla encodes a novel WD40 repeat protein
  JOURNAL   Genomics 56 (1), 59-69 (1999)
   PUBMED   10036186
REFERENCE   9  (bases 1 to 2993)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   10 (bases 1 to 2993)
  AUTHORS   Gogstad,G.O., Hagen,I., Korsmo,R. and Solum,N.O.
  TITLE     Characterization of the proteins of isolated human platelet
            alpha-granules. Evidence for a separate alpha-granule-pool of the
            glycoproteins IIb and IIIa
  JOURNAL   Biochim Biophys Acta 670 (2), 150-162 (1981)
   PUBMED   6457647
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093664.4, AB209746.1,
            AB010427.2 and AL110208.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_017491.4.
            
            Summary: This gene encodes a protein containing 9 WD repeats. WD
            repeats are approximately 30- to 40-amino acid domains containing
            several conserved residues, mostly including a trp-asp at the
            C-terminal end. WD domains are involved in protein-protein
            interactions. The encoded protein may help induce the disassembly
            of actin filaments. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.670624.1,
                                           SRR1803614.101125.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000499869.7/ ENSP00000427687.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC093664.4         33443-33519         c
            78-685              AB209746.1         1-608
            686-691             AB010427.2         755-760
            692-2820            AB209746.1         615-2743
            2821-2993           AL110208.1         1573-1745
FEATURES             Location/Qualifiers
     source          1..2993
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..2993
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /note="WD repeat domain 1"
                     /db_xref="GeneID:9948"
                     /db_xref="HGNC:HGNC:12754"
                     /db_xref="MIM:604734"
     exon            1..149
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1954
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 1; actin-interacting protein 1;
                     epididymis secretory protein Li 52"
                     /codon_start=1
                     /product="WD repeat-containing protein 1 isoform 1"
                     /protein_id="NP_059830.1"
                     /db_xref="CCDS:CCDS54740.1"
                     /db_xref="GeneID:9948"
                     /db_xref="HGNC:HGNC:12754"
                     /db_xref="MIM:604734"
                     /translation="MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRN
                     IDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFA
                     GKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPY
                     RLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDG
                     KTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGS
                     TVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGK
                     SYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTS
                     LMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEV
                     VAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCD
                     ASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPET
                     RVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY"
     exon            150..271
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /inference="alignment:Splign:2.1.0"
     exon            272..362
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /inference="alignment:Splign:2.1.0"
     exon            363..510
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /inference="alignment:Splign:2.1.0"
     exon            511..691
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /inference="alignment:Splign:2.1.0"
     exon            692..769
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /inference="alignment:Splign:2.1.0"
     exon            770..850
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1084
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1172
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1329
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1417
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1528
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1702
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1847
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2993
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2162..2167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /note="hexamer: AATAAA"
     polyA_site      2180
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /note="major polyA site"
     regulatory      2832..2837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /note="hexamer: ATTAAA"
     polyA_site      2852
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
     regulatory      2973..2978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /note="hexamer: ATTAAA"
     polyA_site      2993
                     /gene="WDR1"
                     /gene_synonym="AIP1; HEL-S-52; NORI-1; PFITS"
                     /note="major polyA site"
ORIGIN      
        1 actccactcc cggcacgccc ggtgccgcct tccggctcca gtccccgggc tcggcctcgg
       61 cgaggtgtaa ttcgcagcgc gggccggccc cggaggctct cggcgagcgc ggcgcggtaa
      121 caagtgggcg aggatgccgt acgagatcaa gaaggtgttc gccagcctcc cgcaggtgga
      181 gaggggcgtc tccaagatca tcggcggcga ccctaagggc aacaattttc tgtacaccaa
      241 tggaaagtgc gtcatcctaa ggaacatcga caacccagcc cttgctgaca tctacacaga
      301 gcacgcccat caggtggtgg tggccaagta tgcgcccagc ggattctaca ttgcctccgg
      361 agatgtgtct gggaagctga ggatctggga taccacgcag aaggagcacc tgttgaagta
      421 tgagtaccag cctttcgctg ggaagatcaa agacattgct tggactgaag acagtaagag
      481 gatcgccgtg gtcggggaag gaagggagaa gtttggagca gtcttcctct gggatagtgg
      541 ctcttctgtg ggcgagatta caggacacaa caaagtcatc aacagcgtgg acatcaagca
      601 gagccggcca taccggctgg ccacgggaag cgatgataac tgcgcggcat tctttgaggg
      661 acccccattc aagttcaagt tcacaattgg cgaccacagc cgctttgtca actgtgtgcg
      721 attctctcct gatgggaaca gatttgccac agccagtgct gacggccaga tatacatcta
      781 tgacgggaag actggggaga aggtgtgcgc gctgggcgga agcaaggccc acgacggtgg
      841 gatttacgca attagttgga gtcccgacag cacccatttg ctttctgctt ctggggacaa
      901 aacttccaag atttgggacg tcagcgtgaa ctccgtggtc agcacatttc ccatgggctc
      961 cacggttctg gaccagcagc tgggctgcct atggcagaag gaccacctgc tcagtgtctc
     1021 cctgtccggg tacatcaact atctggacag aaacaacccc agcaagcccc tgcacgtcat
     1081 caagggtcac agtaaatcga tccagtgtct gacggtgcat aaaaacggcg gcaagtccta
     1141 catttactct gggagccacg acggacacat taattactgg gattcagaga cgggggagaa
     1201 cgactccttc gctgggaaag gccacacgaa ccaggtgtcc aggatgaccg tggatgagtc
     1261 ggggcagctc atcagctgca gcatggacga caccgtgcgg tacaccagcc tcatgctgcg
     1321 ggactacagc ggacaaggag ttgtgaaact ggacgttcag ccaaagtgcg tagccgtcgg
     1381 ccccggggga tacgccgtgg tcgtgtgcat tggacagatt gtcctgctga aggatcagag
     1441 gaagtgcttc agcatcgaca accccggcta cgagcccgaa gttgtggcag tgcaccccgg
     1501 cggggacacg gtggcaattg ggggtgtgga cggcaacgtc cgcctgtatt ccatcctggg
     1561 caccacgctg aaggatgagg gcaagctcct agaggccaag ggccccgtga ccgacgtggc
     1621 ctactcccac gacggcgcct tcctcgcggt gtgcgacgcc agcaaggtgg tcacagtgtt
     1681 cagcgttgct gacggctact cggagaacaa tgttttttat ggacaccatg caaaaatcgt
     1741 ctgcctggcc tggtccccag acaatgaaca ctttgcctcc ggtggcatgg acatgatggt
     1801 gtatgtttgg accctgagtg acccggaaac cagagtcaag atccaagatg cacaccggct
     1861 gcaccatgtc agcagcctgg cctggctgga cgagcacacg ctggtcacga cctcccatga
     1921 tgcctctgtc aaggagtgga caatcaccta ctgaggagcc ccacccccgc ctctggatgg
     1981 accgaatcag ggactagagt ttaactgcag cggaacatgt catttctcta tttctgtgac
     2041 gcgcccccat gcccccaccc caccacaaga ggcaggaggg cccagtcatg accctcgtct
     2101 ctgcagggtg tctgtacacg ttcttctgaa agctttagac agtaacagtt tgcacatgaa
     2161 aaataaagcg agcacctaaa caatgtgtgg agcataacta aaacccacag cccaaccaaa
     2221 ccttgagaat gcgaaacatt ccagaggcag tagcctccaa agcacacaga gcccctggcc
     2281 ccgccgcggc tctcactatc tgtcagggga ggttgtacag gtgaatgagc cggggggctc
     2341 atgttcctgc ctgcagaaca tttctgtact agtgagaaga gggaatatgc attgcagttc
     2401 agcaaagccg gaattctgtg ttgaacagat gtctgtctcc ctagtgtgtg actcacacct
     2461 tgtggctgcc ttcagagcgc cacctccaga tcagatgggg acacacaacc cctggatatg
     2521 tttcattgtc agattttgtg cttgatttta agaatggaat tgtgggtatc tttccttttt
     2581 ttttaatgta tcttaactgt tgcctgtcag tgtttacaaa ctagtgcgtt gacggcaccg
     2641 tgtccaagtt tttagaaccc ttgttagcca gaccgaggtg tcctggtcac cgtttcacca
     2701 tcatgctttg atgttcccct gtctttccct cttctgctct caagagcaaa ggttaattta
     2761 aggacaaaga tgaagtcact gtaaactaat ctgtcattgt ttttaccttc cttttctttt
     2821 tcagtgcaga aattaaaagt aagtataaag caccgtgatt gggagtgttt ttgcgtgtgt
     2881 cggaatcact ggtaaatgtt ggctgagaac aatccctccc cttgcacttg tgaaaacact
     2941 ttgagcgctt taagagatta gcctgagaaa taattaaata tcttttctct tca
//
