LOCUS       NM_001354044            5146 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens WD repeat containing planar cell polarity effector
            (WDPCP), transcript variant 4, mRNA.
ACCESSION   NM_001354044 XM_017004252
VERSION     NM_001354044.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5146)
  AUTHORS   O'Farrell,F., Aleyakpo,B., Mustafa,R., Jiang,X., Pinto,R.C.,
            Elliott,P., Tzoulaki,I., Dehghan,A., Loh,S.H.Y., Barclay,J.W.,
            Martins,L.M. and Pazoki,R.
  TITLE     Evidence for involvement of the alcohol consumption WDPCP gene in
            lipid metabolism, and liver cirrhosis
  JOURNAL   Sci Rep 13 (1), 20616 (2023)
   PUBMED   37996473
  REMARK    GeneRIF: Evidence for involvement of the alcohol consumption WDPCP
            gene in lipid metabolism, and liver cirrhosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5146)
  AUTHORS   Bruel,A.L., Franco,B., Duffourd,Y., Thevenon,J., Jego,L., Lopez,E.,
            Deleuze,J.F., Doummar,D., Giles,R.H., Johnson,C.A., Huynen,M.A.,
            Chevrier,V., Burglen,L., Morleo,M., Desguerres,I., Pierquin,G.,
            Doray,B., Gilbert-Dussardier,B., Reversade,B.,
            Steichen-Gersdorf,E., Baumann,C., Panigrahi,I.,
            Fargeot-Espaliat,A., Dieux,A., David,A., Goldenberg,A., Bongers,E.,
            Gaillard,D., Argente,J., Aral,B., Gigot,N., St-Onge,J.,
            Birnbaum,D., Phadke,S.R., Cormier-Daire,V., Eguether,T.,
            Pazour,G.J., Herranz-Perez,V., Goldstein,J.S., Pasquier,L.,
            Loget,P., Saunier,S., Megarbane,A., Rosnet,O., Leroux,M.R.,
            Wallingford,J.B., Blacque,O.E., Nachury,M.V., Attie-Bitach,T.,
            Riviere,J.B., Faivre,L. and Thauvin-Robinet,C.
  TITLE     Fifteen years of research on oral-facial-digital syndromes: from 1
            to 16 causal genes
  JOURNAL   J Med Genet 54 (6), 371-380 (2017)
   PUBMED   28289185
  REMARK    Review article
REFERENCE   3  (bases 1 to 5146)
  AUTHORS   Ma,Y., Sun,Y., Jiang,L., Zuo,K., Chen,H., Guo,J., Chen,F., Lai,Y.
            and Shi,J.
  TITLE     WDPCP regulates the ciliogenesis of human sinonasal epithelial
            cells in chronic rhinosinusitis
  JOURNAL   Cytoskeleton (Hoboken) 74 (2), 82-90 (2017)
   PUBMED   28001338
  REMARK    GeneRIF: Inflammatory cytokines cause reduced WDPCP expression,
            which contributes to impaired ciliogenesis in human rhinosinusitis.
REFERENCE   4  (bases 1 to 5146)
  AUTHORS   Toriyama,M., Lee,C., Taylor,S.P., Duran,I., Cohn,D.H., Bruel,A.L.,
            Tabler,J.M., Drew,K., Kelly,M.R., Kim,S., Park,T.J., Braun,D.A.,
            Pierquin,G., Biver,A., Wagner,K., Malfroot,A., Panigrahi,I.,
            Franco,B., Al-Lami,H.A., Yeung,Y., Choi,Y.J., Duffourd,Y.,
            Faivre,L., Riviere,J.B., Chen,J., Liu,K.J., Marcotte,E.M.,
            Hildebrandt,F., Thauvin-Robinet,C., Krakow,D., Jackson,P.K. and
            Wallingford,J.B.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     The ciliopathy-associated CPLANE proteins direct basal body
            recruitment of intraflagellar transport machinery
  JOURNAL   Nat Genet 48 (6), 648-656 (2016)
   PUBMED   27158779
  REMARK    Erratum:[Nat Genet. 2016 Jul 27;48(8):970. doi:
            10.1038/ng0816-970b.. PMID: 27463398]
REFERENCE   5  (bases 1 to 5146)
  AUTHORS   Aliferis,K., Helle,S., Gyapay,G., Duchatelet,S., Stoetzel,C.,
            Mandel,J.L. and Dollfus,H.
  TITLE     Differentiating Alstrom from Bardet-Biedl syndrome (BBS) using
            systematic ciliopathy genes sequencing
  JOURNAL   Ophthalmic Genet 33 (1), 18-22 (2012)
   PUBMED   22004009
REFERENCE   6  (bases 1 to 5146)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   7  (bases 1 to 5146)
  AUTHORS   Chen,J., Smaoui,N., Hammer,M.B., Jiao,X., Riazuddin,S.A.,
            Harper,S., Katsanis,N., Riazuddin,S., Chaabouni,H., Berson,E.L. and
            Hejtmancik,J.F.
  TITLE     Molecular analysis of Bardet-Biedl syndrome families: report of 21
            novel mutations in 10 genes
  JOURNAL   Invest Ophthalmol Vis Sci 52 (8), 5317-5324 (2011)
   PUBMED   21642631
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5146)
  AUTHORS   Kim,S.K., Shindo,A., Park,T.J., Oh,E.C., Ghosh,S., Gray,R.S.,
            Lewis,R.A., Johnson,C.A., Attie-Bittach,T., Katsanis,N. and
            Wallingford,J.B.
  TITLE     Planar cell polarity acts through septins to control collective
            cell movement and ciliogenesis
  JOURNAL   Science 329 (5997), 1337-1340 (2010)
   PUBMED   20671153
  REMARK    GeneRIF: study linked mutations in Fritz to Bardet-Biedl and
            Meckel-Gruber syndromes, a notable link given that other genes
            mutated in these syndromes also influence collective cell movement
            and ciliogenesis
REFERENCE   9  (bases 1 to 5146)
  AUTHORS   Collier,S., Lee,H., Burgess,R. and Adler,P.
  TITLE     The WD40 repeat protein fritz links cytoskeletal planar polarity to
            frizzled subcellular localization in the Drosophila epidermis
  JOURNAL   Genetics 169 (4), 2035-2045 (2005)
   PUBMED   15654087
REFERENCE   10 (bases 1 to 5146)
  AUTHORS   Forsyth,R. and Gunay-Aygun,M.
  TITLE     Bardet-Biedl Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301537
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016734.7, AC079353.5,
            AC067953.4, AC074367.6, AC009501.4 and BM991121.1.
            
            On Jun 1, 2019 this sequence version replaced NM_001354044.1.
            
            Summary: This gene encodes a cytoplasmic WD40 repeat protein. A
            similar gene in frogs encodes a planar cell polarity protein that
            plays a critical role in collective cell movement and ciliogenesis
            by mediating septin localization. Mutations in this gene are
            associated with Bardet-Biedl syndrome 15 and may also play a role
            in Meckel-Gruber syndrome. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jun 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.1705428.1,
                                           SRR1660807.19205.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-281               AC016734.7         125121-125401       c
            282-533             AC016734.7         108299-108550       c
            534-618             AC016734.7         29780-29864         c
            619-666             AC016734.7         24371-24418         c
            667-711             AC016734.7         23466-23510         c
            712-782             AC016734.7         21841-21911         c
            783-842             AC016734.7         21528-21587         c
            843-957             AC079353.5         89814-89928         c
            958-1091            AC079353.5         87478-87611         c
            1092-1283           AC079353.5         83802-83993         c
            1284-1893           AC079353.5         54106-54715         c
            1894-2082           AC079353.5         31964-32152         c
            2083-2206           AC079353.5         28444-28567         c
            2207-2270           AC067953.4         54315-54378         c
            2271-2373           AC067953.4         374-476             c
            2374-2536           AC074367.6         15842-16004         c
            2537-2616           AC009501.4         149840-149919       c
            2617-2648           AC009501.4         149259-149290       c
            2649-5145           AC009501.4         115905-118401       c
            5146-5146           BM991121.1         17-17               c
FEATURES             Location/Qualifiers
     source          1..5146
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p15"
     gene            1..5146
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /note="WD repeat containing planar cell polarity effector"
                     /db_xref="GeneID:51057"
                     /db_xref="HGNC:HGNC:28027"
                     /db_xref="MIM:613580"
     exon            1..281
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            282..533
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             531..2699
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /note="isoform 3 is encoded by transcript variant 4; WD
                     repeat-containing protein C2orf86; WD repeat-containing
                     and planar cell polarity effector protein fritz homolog;
                     Bardet-Biedl syndrome 15 protein; ciliogenesis and planar
                     polarity effector 5; ciliogenesis and planar polarity
                     effector complex subunit 5"
                     /codon_start=1
                     /product="WD repeat-containing and planar cell polarity
                     effector protein fritz homolog isoform 3"
                     /protein_id="NP_001340973.1"
                     /db_xref="GeneID:51057"
                     /db_xref="HGNC:HGNC:28027"
                     /db_xref="MIM:613580"
                     /translation="MDRDSFCHQMSFCLTELHLWSLKNTLHIADRDIGIYQYYDKKDP
                     PATEHGNLEKKQKLAESRDYPWTLKNRRPEKLRDSLKELEELMQNSRCVLSKWKNKYV
                     CQLLFGSGVLVSLSLSGPQLEKVVIDRSLVGKLISDTISDALLTDSFIILSFLAQNKL
                     CFIQFTKKMESSDVNKRLEKLSALDYKIFYYEIPGPINKTTERHLAINCVHDRVVCWW
                     PLVNDDAWPWAPISSEKDRANLLLLGYAQGRLEVLSSVRTEWDPLDVRFGTKQPYQVF
                     TVEHSVSVDKEPMADSCIYECIRNKIQCVSVTRIPLKSKAISCCRNVTEDKLILGCED
                     SSLILYETHRRVTLLAQTELLPSLISCHPSGAILLVGSNQGELQIFDMALSPINIQLL
                     AEDRLPRETLQFSKLFDASSSLVQMQWIAPQVVSQKGEGSDIYDLLFLRFERGPLGVL
                     LFKLGVFTRGQLGLIDIIFQYIHCDEIYEAINILSSMNWDTLGHQCFISMSAIVNHLL
                     RQKLTPEREAQLETSLGTFYAPTRPLLDSTILEYRDQISKYARRFFHHLLRYQRFEKA
                     FLLAVDVGARDLFMDIHYLALDKGELALAEVARKRASDIDAESITSGVELLGPLDRGD
                     MLNEAFIGLSLAPQGEDSFPDNLPPSCPTHRHILQQRILNGSSNRQIIDRRNELEKDI
                     CSGFLMTNTCNAEDGELREDGREQEIRDGGSLKMIHFGLV"
     exon            534..618
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            619..666
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            667..711
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            712..782
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            783..842
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            843..957
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1091
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1283
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1893
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2082
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2206
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2270
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2373
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2536
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2616
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2648
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..5146
                     /gene="WDPCP"
                     /gene_synonym="BBS15; C2orf86; CHDTHP; CPLANE5; FRITZ;
                     FRTZ"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gataagttgg gacgaccgga cagcttctca ggttgctaag cgacgaggcg ggagcgcacg
       61 cacaccctgg ctgctttgta gcacctgagg aaactgtggc ggcggcggcg gcgtcctgga
      121 gacccaagag accaagcgag cgtgtcgctc cctctcgggt ccgaggacct agcctaggaa
      181 ccttctgccc ggggtagtgt ctggtgatga ggcgagagtt ttgctgggac gcctactcca
      241 aagcggccgg gagtcgcgct tcttccccac tcccgagaca gaaaaccatg ataaattctg
      301 gacaaaatac agaaaaccca caactctctg aaggcactgg agagtgacca tagcaggcat
      361 aaactgaaag gaagtctata cttggaaaga gggagtatca ccgaataaac aaaaatgagg
      421 ttttgttgcc agcagacctt cactgcaaga aatgctaaag gaaattcttc aggctgaaag
      481 gaaatgatac cagatggaaa cttggatctg aggaatggag aactccagaa atggatagag
      541 attccttctg ccatcagatg tctttctgct tgactgaact gcacctgtgg tctttgaaga
      601 ataccttaca cattgcggat agagacattg ggatctacca gtattatgac aagaaagatc
      661 caccagcgac agagcatggt aacttagaaa agaagcagaa gctggcagag tcacgagatt
      721 atccttggac gctcaaaaac agacgcccag aaaaactccg agactcgctc aaagagttgg
      781 aggagctgat gcaaaacagt cggtgtgtgc tgagcaaatg gaagaacaaa tatgtctgtc
      841 agctcctttt tggttcaggt gtgctggtgt ctctaagcct ttctgggccg cagctggaga
      901 aagtggtgat tgacagaagc ctggtgggga agctcatctc agacaccatc agtgatgctc
      961 ttctcacaga cagttttatc atcttatcat ttttggcaca aaacaaacta tgttttattc
     1021 agtttaccaa gaagatggag tcttctgatg taaacaaaag actggaaaaa ctctcagcct
     1081 tggattataa gattttctat tatgaaatac ccggcccaat aaacaagaca acagagcgac
     1141 atctagctat caactgtgtt catgatagag ttgtttgctg gtggccactg gtcaacgatg
     1201 atgcttggcc ttgggccccc atttcttctg agaaggacag agccaatcta ctcctcctgg
     1261 gttatgctca aggaagacta gaggttctga gttctgtccg cacagaatgg gacccactgg
     1321 atgttcgctt tggcaccaaa cagccttatc aggtgttcac agtggagcac tccgtaagtg
     1381 tagacaaaga gcccatggct gacagctgca tctatgaatg cattcggaat aaaatccagt
     1441 gtgtgtcagt caccagaata ccactaaagt caaaggccat cagctgctgc aggaatgtta
     1501 ctgaagacaa actgattctg ggctgtgaag attcttcgct aattctttat gaaactcacc
     1561 gtagagtgac tctcttagca cagactgaac ttttgccttc attaataagc tgccacccaa
     1621 gtggtgccat tctgctagtt ggcagcaacc aaggggagtt gcaaattttt gatatggctc
     1681 tatcccctat taacatccaa ctgttggctg aagaccgctt acccagggag actctgcaat
     1741 tcagtaaatt atttgatgcc tccagcagtc ttgttcaaat gcaatggata gctcctcagg
     1801 ttgtttctca gaagggtgaa ggtagtgata tctatgatct cctcttcctc aggtttgaaa
     1861 gaggaccttt gggtgtgctg ttgtttaaac taggcgtctt cactcgagga cagctgggcc
     1921 tgatagacat catcttccag tacattcact gtgatgagat ctatgaggca ataaacatcc
     1981 tgagcagcat gaactgggac actctgggcc accagtgctt tatcagcatg agcgccattg
     2041 taaaccatct tcttagacag aagctcactc cagagagaga agcacagctt gagacaagcc
     2101 ttggaacctt ctatgctcca acaagaccac ttctggattc cactatattg gaatatagag
     2161 atcaaatcag caaatatgca aggagattct tccatcactt gctcaggtac cagaggtttg
     2221 aaaaggcatt tctcctagct gttgacgttg gtgctcgtga cctctttatg gatattcatt
     2281 accttgcact agataaaggt gaattggcac tagctgaagt ggcaagaaaa agagctagtg
     2341 acattgatgc agaatcaata acctctgggg ttgaactcct gggacccttg gacagagggg
     2401 atatgctaaa tgaagcattt attggcctgt ctttagcacc tcaaggagaa gactcatttc
     2461 cagataacct ccctccctct tgcccaaccc acagacatat tttacaacaa agaatactga
     2521 atggctcttc taacagacaa ataattgaca gaaggaatga acttgaaaaa gacatctgtt
     2581 ctggattttt gatgactaat acctgtaatg cagaagacgg agaactgaga gaagacggca
     2641 gagaacagga aatcagagat ggtggttctc tcaaaatgat tcactttggt ctggtgtaaa
     2701 cattaagaaa aaaagaaaac tgccttcttc atatctaaac ttttcatggc ctgatacaga
     2761 cttaaaatcc cccgtgtgga tttttaacaa gagacagtat gaatcatata aattagttaa
     2821 gagttttgag ttgagtgttt gttttcaaaa taaagtttta ttatttcaaa aacatgcagc
     2881 ataacagcaa agtgatcgta agtaaaagtc ttcaacctac ttattttcaa taatgtaaaa
     2941 ttttgaaagt gtcttaaatt gtatgttaat taggtgctac aaaaatagaa tatttaaact
     3001 ttgttctccc aggtacttta aaaaaggggc agtagggggc aggcatagtg ctcatgcctg
     3061 tagtcccagt gctttaggag gccaaggctg aaggatcact tgagcccagg agttcaagac
     3121 tagcctgtgc aacatagtga aacgctgtct ctagaaaaaa ttttaaaaat tagccaggca
     3181 tggtggtaca tgcttgtgaa gctgaggcag aagaattgct tgagcccagg agttcaaggc
     3241 tacagtgagc tgtgatcgcg ccactgcact ctaacctggg caacagagag tgaccctgtc
     3301 tccaaaaaaa aaaaaaaaaa aaaagaaaga aaagaaagaa agaaagtcct cttctgctct
     3361 tgtttacatt attaatttac attacaaata cagtatttat tatgcaaatt tttcagccca
     3421 gatccattgt tagaagacaa ttctccatgg ttctctcgaa ttactgctat gagtaatttg
     3481 ccctgactgc cccttagaac acagatactg tttccctctg gagaaagggg caggcatgct
     3541 tatcaacttt tatatgagat ttgagttctt taaactcaga atgcctctcc tttacactgc
     3601 ccattgagtg tgcaggtgtc atctagccct cttaacattg ctctatagga atagggctca
     3661 gagaatccat gaagaaaaga aaaaaatgcc gataccctgg ttactatcat ttgtctctga
     3721 ctcaggagtc tcatgtcttc taacagcatc catgaaacta tagtgtggta acttgttagc
     3781 tagtaagtag ggtaaaatct catacccttc acagttattg acacccattc tttagcagat
     3841 aactgatatt tcacaattat agacatctat aggccaggca cggtggctca cgcctgtaat
     3901 cccagcactt tgggaggcca aggcgggcga atcacgaggt caggagatgg agaccatcct
     3961 agacaacatg gtgaaacccc gtctctacta aaaatacaaa aaaaaaaaaa attagccggg
     4021 cgtggtggcg tgcacctgta gtcccaacta cttgggaggc tgaagcagga gaatggcgtg
     4081 aacccggagg gcggaggctg cagtgagctg aggtcgcacc attacgctcc agcctgggtg
     4141 acaaagtaag actccgttgc aaaaaaaaaa aaaaaaaaaa ttatagacat ctataataat
     4201 aatcaacatt gtttaatatt agacaataat tacattatat aattaaatct tagagttcaa
     4261 agttaatcag actgaaggct tttatacttc aaatttttct ttctacttcc catttatctg
     4321 tacctctacc agagggtatg acaaaaaaag gtgaaactca aattagattt ttcattttgt
     4381 tattgctctg aaaaaatttt aataatgcat aacatgtaag ccaaactgag ttaccagcaa
     4441 attttcattc tcctattccc aaccttcttt atcacacaga taatcaaaag ttaactaatt
     4501 tttagagaaa aaattgtatt taaaaaaata gggttttgtc aagattgcag aattttctcc
     4561 agattttccg ggtaaatagt cattaaccca aaataccttt cctgtgagat actaaagata
     4621 aaatatggat attgatacat ctatgttttt ctacataatg ataataataa tgaaaatgtt
     4681 tgccagttat gtaggtgaaa attaaacaaa tcatagttct taaagtaccc attttcccca
     4741 cttcacatac ctctagaaaa gttaaatgta cagaaaacca agtttagata gtaagaatat
     4801 attatgaatg atctttgata atgtccatga tttataaatg ctgttatttc ccagatgttg
     4861 taaatctgag aatattaatt aaattgatat tcctcctctg ctagaacctg aaaggattat
     4921 gaaggggcta ccatagctct aaagtaagaa gagtggtata ggcaggaaca gctaggtagt
     4981 atctgtccta gcactgacag gttcacaggt tgtcctttag gaatagaccc atgagctttt
     5041 tcaactattt tccagatttc tcagatctga ggtaatttcc acagtaattt atattagctg
     5101 tcacattgtg tcttattgct agaataaact ttgcttggaa tgctaa
//
