LOCUS       NM_007086               6019 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens WD repeat and HMG-box DNA binding protein 1 (WDHD1),
            transcript variant 1, mRNA.
ACCESSION   NM_007086
VERSION     NM_007086.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6019)
  AUTHORS   Wang,K., Guo,D., Yan,T., Sun,S., Wang,Y., Zheng,H., Wang,G. and
            Du,J.
  TITLE     ZBTB16 inhibits DNA replication and induces cell cycle arrest by
            targeting WDHD1 transcription in lung adenocarcinoma
  JOURNAL   Oncogene 43 (23), 1796-1810 (2024)
   PUBMED   38654107
  REMARK    GeneRIF: ZBTB16 inhibits DNA replication and induces cell cycle
            arrest by targeting WDHD1 transcription in lung adenocarcinoma.
REFERENCE   2  (bases 1 to 6019)
  AUTHORS   Gou,W., Yu,X., Wu,S., Wu,H., Chang,H., Chen,L., Wei,H., Bi,C.,
            Ning,H., Wu,Y., Hou,W., Zuo,D. and Li,Y.
  TITLE     Targeted inhibition of acidic nucleoplasmic DNA-binding protein 1
            enhances radiosensitivity of non-small cell lung cancer
  JOURNAL   Cancer Lett 530, 100-109 (2022)
   PUBMED   35065237
  REMARK    GeneRIF: Targeted inhibition of acidic nucleoplasmic DNA-binding
            protein 1 enhances radiosensitivity of non-small cell lung cancer.
REFERENCE   3  (bases 1 to 6019)
  AUTHORS   Wu,J.Y., Lan,X.L., Yan,D.M., Fang,Y.Y., Peng,Y.X., Liang,F.F.,
            Jiang,L., Huang,S.N., Mo,M., Lin,C.X., Niu,Y.T., Wu,X.W. and
            Wei,Z.X.
  TITLE     The clinical significance of transcription factor WD repeat and
            HMG-box DNA binding protein 1 in laryngeal squamous cell carcinoma
            and its potential molecular mechanism
  JOURNAL   Pathol Res Pract 230, 153751 (2022)
   PUBMED   34999279
  REMARK    GeneRIF: The clinical significance of transcription factor WD
            repeat and HMG-box DNA binding protein 1 in laryngeal squamous cell
            carcinoma and its potential molecular mechanism.
REFERENCE   4  (bases 1 to 6019)
  AUTHORS   Ertay,A., Liu,H., Liu,D., Peng,P., Hill,C., Xiong,H., Hancock,D.,
            Yuan,X., Przewloka,M.R., Coldwell,M., Howell,M., Skipp,P.,
            Ewing,R.M., Downward,J. and Wang,Y.
  TITLE     WDHD1 is essential for the survival of PTEN-inactive
            triple-negative breast cancer
  JOURNAL   Cell Death Dis 11 (11), 1001 (2020)
   PUBMED   33221821
  REMARK    GeneRIF: WDHD1 is essential for the survival of PTEN-inactive
            triple-negative breast cancer.
            Erratum:[Cell Death Dis. 2021 Mar 15;12(3):269. doi:
            10.1038/s41419-021-03530-0.. PMID: 33723224]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6019)
  AUTHORS   Zhou,Y., Pei,F., Ji,M., Zhang,F., Sun,Y., Zhao,Q., Wang,X.,
            Hong,Y., Tian,J., Wang,Y. and Chen,J.J.
  TITLE     WDHD1 facilitates G1 checkpoint abrogation in HPV E7 expressing
            cells by modulating GCN5
  JOURNAL   BMC Cancer 20 (1), 840 (2020)
   PUBMED   32883234
  REMARK    GeneRIF: WDHD1 facilitates G1 checkpoint abrogation in HPV E7
            expressing cells by modulating GCN5.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6019)
  AUTHORS   Rajaraman,P., Brenner,A.V., Butler,M.A., Wang,S.S., Pfeiffer,R.M.,
            Ruder,A.M., Linet,M.S., Yeager,M., Wang,Z., Orr,N., Fine,H.A.,
            Kwon,D., Thomas,G., Rothman,N., Inskip,P.D. and Chanock,S.J.
  TITLE     Common variation in genes related to innate immunity and risk of
            adult glioma
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (5), 1651-1658 (2009)
   PUBMED   19423540
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6019)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 6019)
  AUTHORS   Zhu,W., Ukomadu,C., Jha,S., Senga,T., Dhar,S.K., Wohlschlegel,J.A.,
            Nutt,L.K., Kornbluth,S. and Dutta,A.
  TITLE     Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for
            initiation of DNA replication
  JOURNAL   Genes Dev 21 (18), 2288-2299 (2007)
   PUBMED   17761813
  REMARK    GeneRIF: Mcm10 is required for chromatin loading of And-1.
REFERENCE   9  (bases 1 to 6019)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 6019)
  AUTHORS   Kohler,A., Schmidt-Zachmann,M.S. and Franke,W.W.
  TITLE     AND-1, a natural chimeric DNA-binding protein, combines an HMG-box
            with regulatory WD-repeats
  JOURNAL   J Cell Sci 110 (Pt 9), 1051-1062 (1997)
   PUBMED   9175701
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB082418.1, BC063041.1,
            AL160471.5 and CB053003.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007086.3.
            
            Summary: The protein encoded by this gene contains multiple
            N-terminal WD40 domains and a C-terminal high mobility group (HMG)
            box. WD40 domains are found in a variety of eukaryotic proteins and
            may function as adaptor/regulatory modules in signal transduction,
            pre-mRNA processing and cytoskeleton assembly. HMG boxes are found
            in many eukaryotic proteins involved in chromatin assembly,
            transcription and replication. Alternative splicing results in two
            transcript variants encoding different isoforms. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.3949569.1,
                                           SRR14038194.1070046.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360586.8/ ENSP00000353793.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DB082418.1         3-24
            23-3796             BC063041.1         1-3774
            3797-5420           AL160471.5         92764-94387
            5421-6019           CB053003.1         39-637              c
FEATURES             Location/Qualifiers
     source          1..6019
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.2-q22.3"
     gene            1..6019
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /note="WD repeat and HMG-box DNA binding protein 1"
                     /db_xref="GeneID:11169"
                     /db_xref="HGNC:HGNC:23170"
                     /db_xref="MIM:608126"
     exon            1..72
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            73..165
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..3478
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /note="isoform 1 is encoded by transcript variant 1; CTF4,
                     chromosome transmission fidelity factor 4 homolog; Acidic
                     nucleoplasmic DNA-binding protein 1"
                     /codon_start=1
                     /product="WD repeat and HMG-box DNA-binding protein 1
                     isoform 1"
                     /protein_id="NP_009017.1"
                     /db_xref="CCDS:CCDS9721.1"
                     /db_xref="GeneID:11169"
                     /db_xref="HGNC:HGNC:23170"
                     /db_xref="MIM:608126"
                     /translation="MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLD
                     DDDPKFINVGEKAYSCALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVF
                     NGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSV
                     RVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESW
                     SHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAI
                     CGLAWHPTCGRISYTDAEGNLGLLENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSN
                     AGDFLNDNAVEIPSFSKGIINDDEDDEDLMMASGRPRQRSHILEDDENSVDISMLKTG
                     SSLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWN
                     SIGIIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELA
                     SKLHCLHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEV
                     FSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRK
                     SYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHE
                     NPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLD
                     YLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIK
                     YASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPR
                     FRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKSGAVTFSSQGRVNPF
                     KVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQ
                     ASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENR
                     SNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEAKKRKRVVD
                     ESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE"
     exon            166..277
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            278..429
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            430..541
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            542..592
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            593..688
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            689..781
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            782..888
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1030
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1241
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1429
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1614
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1856
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1994
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2151
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2266
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2398
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2619
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2735
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2789
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2833
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..3004
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3138
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3277
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     exon            3278..6019
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3776..3781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /note="hexamer: ATTAAA"
     regulatory      3790..3795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /note="hexamer: ATTAAA"
     polyA_site      3796
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /note="major polyA site"
     polyA_site      3810
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
     regulatory      4057..4062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /note="hexamer: AATGAA"
     polyA_site      4077
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
     regulatory      4986..4991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /note="hexamer: AGTAAA"
     polyA_site      5015
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
     regulatory      5422..5427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /note="hexamer: AATAAA"
     polyA_site      5456
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
     regulatory      5997..6002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /note="hexamer: AATAAA"
     polyA_site      6019
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
ORIGIN      
        1 agtgtggtga gcgagccgaa gcgcgggaag cagctcttgt ggatcctcag tggcggaggc
       61 tcggtcaccc ggataggtaa aggaaaacat gcctgccaca cggaagccaa tgagatatgg
      121 gcatacagag ggacacacgg aggtctgttt tgatgattct gggagtttta ttgtgacttg
      181 tggaagtgat ggtgatgtga ggatttggga agacttggat gatgatgatc ctaagttcat
      241 taatgttgga gaaaaggcat attcatgtgc tttgaagagt ggaaaactgg tcactgcagt
      301 ttctaataat actattcaag tccacacatt tcctgaagga gttccagatg gtatattgac
      361 tcgcttcact acaaatgcaa accatgtggt ctttaatggg gatggtacta aaattgctgc
      421 tggatctagt gattttctag tcaaaattgt ggatgtgatg gatagcagcc aacagaaaac
      481 atttcgagga catgatgccc ctgttttaag tctttccttt gatcctaagg acatctttct
      541 ggcatcagct agttgtgatg gatctgtcag agtgtggcaa atttcagatc agacatgtgc
      601 tattagttgg ccactgctac aaaaatgcaa cgatgtgata aatgcaaaat caatctgcag
      661 acttgcttgg cagccaaaaa gtgggaagtt actggcaatt cctgtggaaa aatctgttaa
      721 gctatataga agagaatctt ggagtcatca atttgatctt tcagataatt tcatctctca
      781 gaccctcaat atagtaacct ggtctccctg tgggcaatat ttagctgcag gtagtattaa
      841 tggtctaatc atagtttgga atgtggaaac caaagactgc atggaaaggg tgaaacatga
      901 gaaaggttat gcaatttgtg gtctggcatg gcatcctact tgtggtcgaa tatcgtatac
      961 tgatgcggaa ggaaatctag ggcttctaga gaatgtttgt gaccccagtg gaaagacatc
     1021 aagcagtaag gtatctagca gagtggaaaa ggattataat gatctttttg atggagatga
     1081 tatgagtaat gctggtgatt ttctaaatga caatgcagtt gagatccctt ctttttcaaa
     1141 agggattata aatgatgatg aggatgatga agacctcatg atggcttcag gtcgtcctag
     1201 acagcgaagt cacatcctag aagatgatga aaactcagtt gatatttcaa tgctaaaaac
     1261 tggttctagt cttctcaaag aggaggagga agatggtcaa gaaggcagca ttcacaatct
     1321 accacttgta acatcccaaa ggccatttta tgatggaccc atgccaactc cccggcaaaa
     1381 gccatttcag tcaggttcta caccgttgca tctcactcac agattcatgg tgtggaactc
     1441 tattggaatt attcgctgct ataatgatga gcaagacaat gccatagatg tggagttcca
     1501 tgatacctcc atacaccatg caacacactt atcaaacact ttgaattata caatagcaga
     1561 tctttcccac gaagctattt tgttggcatg tgaaagcact gatgaactag caagcaagct
     1621 tcactgcctg cactttagtt cttgggattc aagcaaagag tggataatag acttgcctca
     1681 gaatgaggat attgaagcca tatgtctcgg tcaaggatgg gctgctgccg ctactagtgc
     1741 cctgcttctt cgattgttta ctattggagg ggttcaaaaa gaggtattca gccttgctgg
     1801 acctgtggtg tcaatggcag gacatggaga acagcttttc attgtttatc acagaggtac
     1861 aggatttgat ggggatcagt gccttggagt tcaactgcta gagctgggga aaaagaaaaa
     1921 acaaattttg catggtgacc ctcttcctct tacaaggaaa tcctaccttg catggattgg
     1981 gttttcagct gaaggtaccc cttgttacgt ggattcagaa ggaattgttc gaatgcttaa
     2041 cagaggactt ggtaatacgt ggactcctat atgtaataca agagagcact gcaaaggaaa
     2101 atctgatcac tactgggtgg ttggtatcca tgaaaatccc cagcaactaa ggtgcattcc
     2161 ttgtaaaggt tctcggtttc ccccaaccct tccacgccct gctgttgcta tattatcctt
     2221 taagcttcct tactgtcaga ttgcaacaga gaaaggacaa atggaggagc aattttggcg
     2281 ttcagttata tttcacaacc accttgatta tttagctaaa aatggttatg aatatgaaga
     2341 gagcactaaa aatcaagcaa caaaagagca acaggaactt ttaatgaaaa tgcttgcgct
     2401 ttcttgtaaa ctggagcgag aattccgttg tgtggaactt gctgatctaa tgactcaaaa
     2461 tgctgtgaat ttagccatta aatatgcttc tcgctctcgg aaattaatac tggctcaaaa
     2521 actaagtgaa ctggctgtag agaaggcagc cgaattgaca gcaacccagg tggaagagga
     2581 agaagaagaa gaagatttca gaaaaaagct gaatgctggt tacagcaata ctgctacaga
     2641 gtggagccaa ccaaggttca gaaatcaagt tgaagaagat gctgaggaca gtggagaagc
     2701 tgatgatgaa gaaaaaccag aaatacataa gcctggacag aactcgtttt ccaaaagtac
     2761 aaattcctct gatgtttcag ctaagtcagg tgcagttacc tttagcagcc aaggacgagt
     2821 aaatcccttt aaggtatcag ccagttccaa agaaccagcc atgtcaatga attcagcacg
     2881 ttcaactaat attttagaca atatgggcaa atcatccaag aaatccactg cacttagtcg
     2941 aactacaaat aatgaaaagt ctcccattat aaagcctctg attccaaagc cgaagcctaa
     3001 gcaggcatct gcagcatcct atttccagaa aagaaattct caaactaata aaactgagga
     3061 agtgaaagaa gaaaatctta aaaatgtatt atctgaaacc ccagctatat gtcctcctca
     3121 aaacactgaa aaccaaaggc caaagaccgg gttccagatg tggttagaag aaaatagaag
     3181 taatattttg tctgacaatc ctgacttttc agatgaagca gacataataa aagaaggaat
     3241 gattcgattt agagtattgt caactgaaga aagaaaggtg tgggctaaca aagccaaagg
     3301 agaaacggca agtgaaggaa ctgaagcaaa gaagcgaaaa cgtgtggttg atgaaagtga
     3361 tgaaacagaa aaccaggaag aaaaagcaaa agagaacctg aatttgtcta aaaagcagaa
     3421 acctttagat ttttctacaa atcagaaact atcagctttt gcatttaagc aggagtaaag
     3481 gaagaaagtg accctaggga agtaatggat ttttttttac tcatctttga atatagactc
     3541 gagtctttgg gaaactcatt atatatatat tttttaaaga gtttgaagca actgtttgtc
     3601 tttataagat aatgtagtaa ttatattggt gtaggtaaca ggacatatgt aaaaactatc
     3661 atctttgcag attactctgc ctccaaatgc agggcctttc agagatgcat tgtgattgta
     3721 attactgagt tgaagctcca accaatttga atttgtttct taaccttgaa aaatcattaa
     3781 agccaaggta ttaaaacctt tgtgcattaa taccttctag gggtttggtt catttggttt
     3841 ttgtcatgtg caaggaagga caatagtcct ctttccaagt gtgttagcat agacttctct
     3901 atatgtttct actagaccta ggggatgacg tcttttaata atactggccc taaacatgta
     3961 aataatcttg taggtgagac tttttctttt gtgtttcgga aatttcctat gtggctttca
     4021 gttgtctgtt tgtatagcct ggattttttt gaggtaaatg aaactttctc atttgtatat
     4081 ttggcttgat atggtcttaa tattatcttt ccacgaaatg gatatatttc tagaaaatat
     4141 atatttacta ccataatttc taccaccacc cccattttgc tctgcattat acacagtaga
     4201 gaagaactga agacactgct gtgacagtat tgcagtccaa ggcatcatgt gctcttggtg
     4261 ggatactctg attatcagca tcaacagtac tttactgagc aagactttga aggcctgaga
     4321 agagagcaaa gttatggaaa gtatttaact cttattttat attgaacaaa caaggtttaa
     4381 tcatgtcata catttttggt tttctaagca gagactaata caaatgcagc cacataaagg
     4441 cagtgtactg ggggtgggag ggaaggaaac aatcacataa aatcagctga ctcaaaattg
     4501 aggatagtta ataggttgaa agggaaaaag tatgttgaaa atttagacat aaatgaacca
     4561 agaatattcc ttatctggtg atgattaaag ttaggaaaac atacattttt tattttttaa
     4621 ttagtagctg ctatcagaga cattatagca cagtggttat gagcacagat tccaaagcca
     4681 gattacctag gttcggagac ccgcttctct acctactact aatagttggg tcatgttggg
     4741 ccggtgaccc aaattctagc cttcattcac tcatctgtaa aatggatata atgatagtac
     4801 ctactttata ggttgttatg agaattgaat gaaatgaaag cccttagttt ctgacacata
     4861 gtaatctttt atataaatgt tagttactat tctgataatg atgatgctgt tggttatttc
     4921 atcttgcttt gtcattaggt ttgattctga atactataca aactaatttt gatttcaaga
     4981 tcttaagtaa aggtttattt atagtacatt ggaaagcatg tttgtagaca tgtattttgt
     5041 gtttggttcc tcaacttgct ttgtatatat tttataatac taggttgata taaaagtaaa
     5101 tgcagtttcg ccatttcagt ggcaaaaacc gcgatttctt ttgtgccaac ctaatgctta
     5161 aggatataat ctgtgtatat tgtatttcag attcatagca acctaataac aaggatttac
     5221 aaaagggttt ttacttccct actttttttt ggctgaagga aggtttttgt attgacttgg
     5281 tttaacttac aaatcagaac tttgaaacca agaaacatta tccttatttc tctgctatat
     5341 aatagtaaac ctgttttttt ccagtgttct tttttttttt tccagagaat tgggactgaa
     5401 tagtatgaaa gtgaaaatgg aaataaatta attattaatc atcatcatat caataatatt
     5461 gcctacttga gcttattgta tactatagaa aattgacata tacttaattt tattctccaa
     5521 aagcaaaaac tcctcacagg aggttacttt acagatttat tttggagaac aagtgaatag
     5581 gcactggggt tatgtgcagc tctggggact gtgctatgat ctaaagcctc tcatatctgt
     5641 gcagcaacct ggggtgagtc actgtcacta acatggaaca gatgccaggt agtccctttg
     5701 gacaaaagga tgaggcccat ccatgtagaa agcatcttaa tcagtgactg tcttatgggc
     5761 cctctttgtt tcccatctgt tttattatca gaatatataa ttttccccca agttttcatc
     5821 ttgaatctct caaacctaca gaaaatttga aatttgacag taagcacctg tatatccttc
     5881 ctctagtttg tcttattgtt gacattttat catgtatgct ttatagacag gatttttcct
     5941 gaaccatttg gaatatgcat atacttcatc cctcagttcc cagcatgtac cctaagaata
     6001 aagattttct tctgcataa
//
