LOCUS       NM_014991              14559 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens WD repeat and FYVE domain containing 3 (WDFY3), mRNA.
ACCESSION   NM_014991 XM_005262859
VERSION     NM_014991.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14559)
  AUTHORS   Shi,J., Wu,X., Wang,Z., Li,F., Meng,Y., Moore,R.M., Cui,J., Xue,C.,
            Croce,K.R., Yurdagul,A. Jr., Doench,J.G., Li,W., Zarbalis,K.S.,
            Tabas,I., Yamamoto,A. and Zhang,H.
  TITLE     A genome-wide CRISPR screen identifies WDFY3 as a regulator of
            macrophage efferocytosis
  JOURNAL   Nat Commun 13 (1), 7929 (2022)
   PUBMED   36566259
  REMARK    GeneRIF: A genome-wide CRISPR screen identifies WDFY3 as a
            regulator of macrophage efferocytosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14559)
  AUTHORS   Soreng,K., Pankiv,S., Bergsmark,C., Haugsten,E.M., Dahl,A.K., de la
            Ballina,L.R., Yamamoto,A., Lystad,A.H. and Simonsen,A.
  TITLE     ALFY localizes to early endosomes and cellular protrusions to
            facilitate directional cell migration
  JOURNAL   J Cell Sci 135 (4) (2022)
   PUBMED   35099014
  REMARK    GeneRIF: ALFY localizes to early endosomes and cellular protrusions
            to facilitate directional cell migration.
REFERENCE   3  (bases 1 to 14559)
  AUTHORS   Reinhart,E.F., Litt,N.A., Katzenell,S., Pellegrini,M., Yamamoto,A.
            and Ragusa,M.J.
  TITLE     A highly conserved glutamic acid in ALFY inhibits membrane binding
            to aid in aggregate clearance
  JOURNAL   Traffic 22 (1-2), 23-37 (2021)
   PUBMED   33225481
  REMARK    GeneRIF: A highly conserved glutamic acid in ALFY inhibits membrane
            binding to aid in aggregate clearance.
REFERENCE   4  (bases 1 to 14559)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 14559)
  AUTHORS   Fox,L.M., Kim,K., Johnson,C.W., Chen,S., Croce,K.R., Victor,M.B.,
            Eenjes,E., Bosco,J.R., Randolph,L.K., Dragatsis,I., Dragich,J.M.,
            Yoo,A.S. and Yamamoto,A.
  TITLE     Huntington's Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3
            and Selective Macroautophagy
  JOURNAL   Neuron 105 (5), 813-821 (2020)
   PUBMED   31899071
  REMARK    GeneRIF: Alfy is required in the adult brain for the
            autophagy-dependent clearance of proteinaceous deposits, and its
            depletion in neurons derived from Huntington's disease patient
            fibroblasts accelerates the aberrant accumulation of this
            pathological hallmark shared across adult-onset neurodegenerative
            diseases.
REFERENCE   6  (bases 1 to 14559)
  AUTHORS   Deretic,V.
  TITLE     A master conductor for aggregate clearance by autophagy
  JOURNAL   Dev Cell 18 (5), 694-696 (2010)
   PUBMED   20493804
REFERENCE   7  (bases 1 to 14559)
  AUTHORS   Filimonenko,M., Isakson,P., Finley,K.D., Anderson,M., Jeong,H.,
            Melia,T.J., Bartlett,B.J., Myers,K.M., Birkeland,H.C., Lamark,T.,
            Krainc,D., Brech,A., Stenmark,H., Simonsen,A. and Yamamoto,A.
  TITLE     The selective macroautophagic degradation of aggregated proteins
            requires the PI3P-binding protein Alfy
  JOURNAL   Mol Cell 38 (2), 265-279 (2010)
   PUBMED   20417604
  REMARK    GeneRIF: The selective macroautophagic degradation of aggregated
            proteins requires the PI3P-binding protein Alfy.
REFERENCE   8  (bases 1 to 14559)
  AUTHORS   Clausen,T.H., Lamark,T., Isakson,P., Finley,K., Larsen,K.B.,
            Brech,A., Overvatn,A., Stenmark,H., Bjorkoy,G., Simonsen,A. and
            Johansen,T.
  TITLE     p62/SQSTM1 and ALFY interact to facilitate the formation of p62
            bodies/ALIS and their degradation by autophagy
  JOURNAL   Autophagy 6 (3), 330-344 (2010)
   PUBMED   20168092
  REMARK    GeneRIF: Data suggest that p62 and ALFY interact to organize
            misfolded, ubiquitinated proteins into protein bodies that become
            degraded by autophagy.
REFERENCE   9  (bases 1 to 14559)
  AUTHORS   Komatsu,M., Waguri,S., Koike,M., Sou,Y.S., Ueno,T., Hara,T.,
            Mizushima,N., Iwata,J., Ezaki,J., Murata,S., Hamazaki,J.,
            Nishito,Y., Iemura,S., Natsume,T., Yanagawa,T., Uwayama,J.,
            Warabi,E., Yoshida,H., Ishii,T., Kobayashi,A., Yamamoto,M., Yue,Z.,
            Uchiyama,Y., Kominami,E. and Tanaka,K.
  TITLE     Homeostatic levels of p62 control cytoplasmic inclusion body
            formation in autophagy-deficient mice
  JOURNAL   Cell 131 (6), 1149-1163 (2007)
   PUBMED   18083104
REFERENCE   10 (bases 1 to 14559)
  AUTHORS   Simonsen,A., Birkeland,H.C., Gillooly,D.J., Mizushima,N., Kuma,A.,
            Yoshimori,T., Slagsvold,T., Brech,A. and Stenmark,H.
  TITLE     Alfy, a novel FYVE-domain-containing protein associated with
            protein granules and autophagic membranes
  JOURNAL   J Cell Sci 117 (Pt 18), 4239-4251 (2004)
   PUBMED   15292400
  REMARK    GeneRIF: Alfy might target cytosolic protein aggregates for
            autophagic degradation.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108021.3, AC095046.3 and
            AC104082.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 3, 2020 this sequence version replaced NM_014991.5.
            
            Summary: This gene encodes a phosphatidylinositol
            3-phosphate-binding protein that functions as a master conductor
            for aggregate clearance by autophagy. This protein shuttles from
            the nuclear membrane to colocalize with aggregated proteins, where
            it complexes with other autophagic components to achieve
            macroautophagy-mediated clearance of these aggregated proteins.
            However, it is not necessary for starvation-induced macroautophagy.
            [provided by RefSeq, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295888.9/ ENSP00000295888.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               AC108021.3         70365-70846         c
            483-576             AC108021.3         36426-36519         c
            577-676             AC108021.3         1067-1166           c
            677-887             AC095046.3         129158-129368       c
            888-1011            AC095046.3         118648-118771       c
            1012-1121           AC095046.3         109900-110009       c
            1122-1283           AC095046.3         105675-105836       c
            1284-1476           AC095046.3         100159-100351       c
            1477-1663           AC095046.3         97750-97936         c
            1664-1830           AC095046.3         95561-95727         c
            1831-2298           AC095046.3         89830-90297         c
            2299-2400           AC095046.3         88831-88932         c
            2401-2594           AC095046.3         86138-86331         c
            2595-3052           AC095046.3         78633-79090         c
            3053-3136           AC095046.3         77080-77163         c
            3137-3314           AC095046.3         72036-72213         c
            3315-3529           AC095046.3         70396-70610         c
            3530-3642           AC095046.3         66742-66854         c
            3643-3874           AC095046.3         65267-65498         c
            3875-3975           AC095046.3         63625-63725         c
            3976-4194           AC095046.3         63265-63483         c
            4195-4376           AC095046.3         58472-58653         c
            4377-4608           AC095046.3         56228-56459         c
            4609-4769           AC095046.3         54725-54885         c
            4770-4881           AC095046.3         51709-51820         c
            4882-5072           AC095046.3         48854-49044         c
            5073-5225           AC095046.3         47249-47401         c
            5226-5299           AC095046.3         43811-43884         c
            5300-5461           AC095046.3         43566-43727         c
            5462-5556           AC095046.3         41581-41675         c
            5557-5677           AC095046.3         34998-35118         c
            5678-5895           AC095046.3         34556-34773         c
            5896-6131           AC095046.3         25672-25907         c
            6132-6266           AC095046.3         24012-24146         c
            6267-6446           AC095046.3         22443-22622         c
            6447-6680           AC095046.3         20229-20462         c
            6681-6780           AC095046.3         12446-12545         c
            6781-6941           AC095046.3         10507-10667         c
            6942-7171           AC095046.3         8933-9162           c
            7172-7281           AC095046.3         7756-7865           c
            7282-7464           AC095046.3         5930-6112           c
            7465-7622           AC095046.3         4916-5073           c
            7623-7700           AC095046.3         3789-3866           c
            7701-7928           AC095046.3         2128-2355           c
            7929-7979           AC104082.3         176377-176427       c
            7980-8148           AC104082.3         173942-174110       c
            8149-8312           AC104082.3         170925-171088       c
            8313-8461           AC104082.3         167938-168086       c
            8462-8582           AC104082.3         166412-166532       c
            8583-8668           AC104082.3         164814-164899       c
            8669-8749           AC104082.3         162675-162755       c
            8750-8804           AC104082.3         158809-158863       c
            8805-8924           AC104082.3         158425-158544       c
            8925-9042           AC104082.3         154910-155027       c
            9043-9149           AC104082.3         153854-153960       c
            9150-9303           AC104082.3         151869-152022       c
            9304-9395           AC104082.3         146248-146339       c
            9396-9608           AC104082.3         145486-145698       c
            9609-9756           AC104082.3         142401-142548       c
            9757-9911           AC104082.3         141147-141301       c
            9912-10070          AC104082.3         140022-140180       c
            10071-10250         AC104082.3         137602-137781       c
            10251-10433         AC104082.3         133459-133641       c
            10434-10530         AC104082.3         131890-131986       c
            10531-10854         AC104082.3         128435-128758       c
            10855-10966         AC104082.3         127684-127795       c
            10967-11164         AC104082.3         126715-126912       c
            11165-14559         AC104082.3         119113-122507       c
FEATURES             Location/Qualifiers
     source          1..14559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.23"
     gene            1..14559
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /note="WD repeat and FYVE domain containing 3"
                     /db_xref="GeneID:23001"
                     /db_xref="HGNC:HGNC:20751"
                     /db_xref="MIM:617485"
     exon            1..482
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            483..576
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            577..676
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            677..887
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     CDS             708..11288
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /note="autophagy-linked FYVE protein"
                     /codon_start=1
                     /product="WD repeat and FYVE domain-containing protein 3"
                     /protein_id="NP_055806.2"
                     /db_xref="CCDS:CCDS3609.1"
                     /db_xref="GeneID:23001"
                     /db_xref="HGNC:HGNC:20751"
                     /db_xref="MIM:617485"
                     /translation="MNMVKRIMGRPRQEECSPQDNALGLMHLRRLFTELCHPPRHMTQ
                     KEQEEKLYMMLPVFNRVFGNAPPNTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKSTE
                     AASRAIVQFLEINQSEEASRGWMLLTTINLLASSGQKTVDCMTTMSVPSTLVKCLYLF
                     FDLPHVPEAVGGAQNELPLAERRGLLQKVFVQILVKLCSFVSPAEELAQKDDLQLLFS
                     AITSWCPPYNLPWRKSAGEVLMTISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSP
                     LEIVEMFAGLSCFLKDSSDVSQTLLDDFRIWQGYNFLCDLLLRLEQAKEAESKDALKD
                     LVNLITSLTTYGVSELKPAGITTGAPFLLPGFAVPQPAGKGHSVRNVQAFAVLQNAFL
                     KAKTSFLAQIILDAITNIYMADNANYFILESQHTLSQFAEKISKLPEVQNKYFEMLEF
                     VVFSLNYIPCKELISVSILLKSSSSYHCSIIAMKTLLKFTRHDYIFKDVFREVGLLEV
                     MVNLLHKYAALLKDPTQALNEQGDSRNNSSVEDQKHLALLVMETLTVLLQGSNTNAGI
                     FREFGGARCAHNIVKYPQCRQHALMTIQQLVLSPNGDDDMGTLLGLMHSAPPTELQLK
                     TDILRALLSVLRESHRSRTVFRKVGGFVYITSLLVAMERSLSCPPKNGWEKVNQNQVF
                     ELLHTVFCTLTAAMRYEPANSHFFKTEIQYEKLADAVRFLGCFSDLRKISAMNVFPSN
                     TQPFQRLLEEDVISIESVSPTLRHCSKLFIYLYKVATDSFDSRAEQIPPCLTSESSLP
                     SPWGTPALSRKRHAYHSVSTPPVYPPKNVADLKLHVTTSSLQSSDAVIIHPGAMLAML
                     DLLASVGSVTQPEHALDLQLAVANILQSLVHTERNQQVMCEAGLHARLLQRCSAALAD
                     EDHSLHPPLQRMFERLASQALEPMVLREFLRLASPLNCGAWDKKLLKQYRVHKPSSLS
                     YEPEMRSSMITSLEGLGTDNVFSLHEDNHYRISKSLVKSAEGSTVPLTRVKCLVSMTT
                     PHDIRLHGSSVTPAFVEFDTSLEGFGCLFLPSLAPHNAPTNNTVTTGLIDGAVVSGIG
                     SGERFFPPPSGLSYSSWFCIEHFSSPPNNHPVRLLTVVRRANSSEQHYVCLAIVLSAK
                     DRSLIVSTKEELLQNYVDDFSEESSFYEILPCCARFRCGELIIEGQWHHLVLVMSKGM
                     LKNSTAALYIDGQLVNTVKLHYVHSTPGGSGSANPPVVSTVYAYIGTPPAQRQIASLV
                     WRLGPTHFLEEVLPSSNVTTIYELGPNYVGSFQAVCMPCKDAKSEGVVPSPVSLVPEE
                     KVSFGLYALSVSSLTVARIRKVYNKLDSKAIAKQLGISSHENATPVKLIHNSAGHLNG
                     SARTIGAALIGYLGVRTFVPKPVATTLQYVGGAAAILGLVAMASDVEGLYAAVKALVC
                     VVKSNPLASKEMERIKGYQLLAMLLKKKRSLLNSHILHLTFSLVGTVDSGHETSIIPN
                     STAFQDLLCDFEVWLHAPYELHLSLFEHFIELLTESSEASKNAKLMREFQLIPKLLLT
                     LRDMSLSQPTIAAISNVLSFLLQGFPSSNDLLRFGQFISSTLPTFAVCEKFVVMEINN
                     EEKLDTGTEEEFGGLVSANLILLRNRLLDILLKLIYTSKEKTSINLQACEELVKTLGF
                     DWIMMFMEEHLHSTTVTAAMRILVVLLSNQSILIKFKEGLSGGGWLEQTDSVLTNKIG
                     TVLGFNVGRSAGGRSTVREINRDACHFPGFPVLQSFLPKHTNVPALYFLLMALFLQQP
                     VSELPENLQVSVPVISCRSKQGCQFDLDSIWTFIFGVPASSGTVVSSIHNVCTEAVFL
                     LLGMLRSMLTSPWQSEEEGSWLREYPVTLMQFFRYLYHNVPDLASMWMSPDFLCALAA
                     TVFPFNIRPYSEMVTDLDDEVGSPAEEFKAFAADTGMNRSQSEYCNVGTKTYLTNHPA
                     KKFVFDFMRVLIIDNLCLTPASKQTPLIDLLLEASPERSTRTQQKEFQTYILDSVMDH
                     LLAADVLLGEDASLPITSGGSYQVLVNNVFYFTQRVVDKLWQGMFNKESKLLIDFIIQ
                     LIAQSKRRSQGLSLDAVYHCLNRTILYQFSRAHKTVPQQVALLDSLRVLTVNRNLILG
                     PGNHDQEFISCLAHCLINLHVGSNVDGFGLEAEARMTTWHIMIPSDIEPDGSYSQDIS
                     EGRQLLIKAVNRVWTELIHSKKQVLEELFKVTLPVNERGHVDIATARPLIEEAALKCW
                     QNHLAHEKKCISRGEALAPTTQSKLSRVSSGFGLSKLTGSRRNRKESGLNKHSLSTQE
                     ISQWMFTHIAVVRDLVDTQYKEYQERQQNALKYVTEEWCQIECELLRERGLWGPPIGS
                     HLDKWMLEMTEGPCRMRKKMVRNDMFYNHYPYVPETEQETNVASEIPSKQPETPDDIP
                     QKKPARYRRAVSYDSKEYYMRLASGNPAIVQDAIVESSEGEAAQQEPEHGEDTIAKVK
                     GLVKPPLKRSRSAPDGGDEENQEQLQDQIAEGSSIEEEEKTDNATLLRLLEEGEKIQH
                     MYRCARVQGLDTSEGLLLFGKEHFYVIDGFTMTATREIRDIETLPPNMHEPIIPRGAR
                     QGPSQLKRTCSIFAYEDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQR
                     FLAVVPSLTDSSESVSGQRPNTSVEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHL
                     NTLAGRSYNDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKR
                     YKDWEDPNGETPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSV
                     REAWYSASKHNMADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWAKGD
                     PREFIRVHREALECDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYN
                     INDPLKETATIGFINNFGQIPKQLFKKPHPPKRVRSRLNGDNAGISVLPGSTSDKIFF
                     HHLDNLRPSLTPVKELKEPVGQIVCTDKGILAVEQNKVLIPPTWNKTFAWGYADLSCR
                     LGTYESDKAMTVYECLSEWGQILCAICPNPKLVITGGTSTVVCVWEMGTSKEKAKTVT
                     LKQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAPVSALC
                     INELTGDIVSCAGTYIHVWSINGNPIVSVNTFTGRSQQIICCCMSEMNEWDTQNVIVT
                     GHSDGVVRFWRMEFLQVPETPAPEPAEVLEMQEDCPEAQIGQEAQDEDSSDSEADEQS
                     ISQDPKDTPSQPSSTSHRPRAASCRATAAWCTDSGSDDSRRWSDQLSLDEKDGFIFVN
                     YSEGQTRAHLQGPLSHPHPNPIEVRNYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNA
                     HPAEVTALGISKDHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVR
                     FSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHERGSEDGPR
                     NC"
     exon            888..1011
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1121
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1283
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1476
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1663
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1830
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..2298
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2400
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2594
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..3052
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3136
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3314
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3529
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            3530..3642
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..3874
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            3875..3975
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            3976..4194
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            4195..4376
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            4377..4608
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            4609..4769
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            4770..4881
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            4882..5072
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            5073..5225
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            5226..5299
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            5300..5461
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            5462..5556
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            5557..5677
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            5678..5895
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            5896..6131
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            6132..6266
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            6267..6446
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            6447..6680
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            6681..6780
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            6781..6941
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            6942..7171
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            7172..7281
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            7282..7464
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            7465..7622
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            7623..7700
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            7701..7928
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            7929..7979
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            7980..8148
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            8149..8312
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            8313..8461
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            8462..8582
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            8583..8668
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            8669..8749
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            8750..8804
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            8805..8924
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            8925..9042
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            9043..9149
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            9150..9303
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            9304..9395
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            9396..9608
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            9609..9756
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            9757..9911
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            9912..10070
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            10071..10250
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            10251..10433
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            10434..10530
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            10531..10854
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            10855..10966
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            10967..11164
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     exon            11165..14559
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11838..11843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /note="hexamer: TATAAA"
     polyA_site      11865
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /note="major polyA site"
     regulatory      14341..14346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /note="hexamer: AGTAAA"
     polyA_site      14363
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /note="major polyA site"
     regulatory      14538..14543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /note="hexamer: ATTAAA"
     polyA_site      14559
                     /gene="WDFY3"
                     /gene_synonym="ALFY; BCHS; MCPH18; ZFYVE25"
                     /note="major polyA site"
ORIGIN      
        1 agacagccag cgggaggtgg agaaagcagg aggaggagga ggattaaaga tggccaccaa
       61 cagctgcggg aaacggcaac aacccctcac tttccgggat ggtccctgcg ggtcggcccg
      121 gccttgatgg agagaagaaa cccgaggagc gccgaggctg aggcggcggc ggcggggacc
      181 cagcgaggac gaggacgcgg cggagcaggg acgggggcag gagaagggaa aggcggcggc
      241 gtcgctgccc ctgctgccta gcaccgctgc ctggcccggc ggaccggttc ccatacctcg
      301 cggccgcaga atcgagctcg ggccccggcc cccggcccgc ggcgcggggc tcccgggccc
      361 cgccgcggac gtcgcgccgg tcgccccttc cccgtagccc gtgcgccctc ggcgcggagc
      421 cccggcccgc cgcggtcccg tctcctgggc ctgtcccgcc cgcgccctcc gccggccctc
      481 aggtataata cttctccacg tctgcttcag gaagaaagtg cctgccattc ttatcatttc
      541 taagcaggtt catgccagcc cagaacagag aatcagctgg agcccagatt tcaagttttg
      601 agtaaaatac cttcaagcga atgggcccta ttgtgctcac acattcagaa cctgttaccc
      661 aaggaattcc ctaaagaatt agaagtgcgt ctcaccaacc agccaagatg aacatggtga
      721 agaggatcat ggggcggccg aggcaggagg agtgcagccc acaagacaac gccttaggac
      781 tgatgcacct ccgccggctc ttcacggagt tgtgccatcc tccccggcac atgactcaga
      841 aggaacaaga agagaaactg tatatgatgc tgccagtgtt taacagggtt tttggaaatg
      901 ctccgccgaa tacaatgaca gaaaaatttt ctgatcttct gcagttcaca acacaagtct
      961 cacgactaat ggtgacagaa attcgaagga gagcatcaaa caaatccaca gaggctgcaa
     1021 gtcgggccat agttcagttc ctagagatta atcagagtga agaagccagt agaggctgga
     1081 tgcttctaac gacaattaat ttgttagctt cctctggtca gaaaaccgtg gactgcatga
     1141 caacaatgtc agtgccttcc accctggtta aatgtttata tctgtttttt gaccttccac
     1201 atgtgcctga ggcagttgga ggtgcacaga atgagctacc tctagcagaa cgtcgaggac
     1261 tactccagaa agtttttgta cagatcttag tgaaactgtg cagttttgtt tcccctgcgg
     1321 aggagctggc tcagaaagat gatctccagc ttctattcag tgcaataacc tcttggtgcc
     1381 ctccctataa cctgccttgg agaaagagtg ctggagaagt cctcatgacc atatctcgtc
     1441 atggtcttag tgtcaatgta gtgaagtata ttcatgagaa agagtgttta tctacatgtg
     1501 ttcagaatat gcagcaatca gatgacctgt ctcccctaga aattgtcgaa atgtttgctg
     1561 ggctttcttg tttcctcaaa gattccagcg atgtttccca aacacttctg gatgattttc
     1621 ggatatggca aggatataat tttctttgtg atctcttgct tagattggaa caagcaaaag
     1681 aggcagaatc caaagatgcc ttgaaagatc tggttaatct gataacttcc ctaacaacat
     1741 atggtgtcag tgaactaaaa ccagctggta ttaccacagg ggcacccttt ttattgcctg
     1801 gatttgcagt acctcagcct gcaggcaaag gtcacagtgt gagaaacgtc caggcctttg
     1861 cagttcttca gaatgcattt ttaaaagcaa aaaccagctt ccttgcccaa atcatccttg
     1921 atgctatcac aaatatttac atggctgaca atgccaatta cttcatccta gagtcacagc
     1981 acacattgtc acagtttgca gagaagattt ctaaactccc agaagtacaa aacaaatact
     2041 ttgagatgct ggagtttgtt gtttttagct taaattatat accttgtaaa gaacttatta
     2101 gtgtcagtat cctcttaaaa tctagctctt cttatcactg tagcattatt gcaatgaaaa
     2161 cacttcttaa gtttacaaga catgactaca tatttaaaga cgtgttcagg gaggttggcc
     2221 ttttggaggt catggtaaac cttttgcata aatatgctgc cctgttgaag gatccaactc
     2281 aggcactaaa tgaacaaggg gactcaagaa ataatagttc agttgaagac caaaaacacc
     2341 tggctttatt ggttatggag accttgacag tgcttcttca aggatcaaac acaaatgcag
     2401 gaatttttcg agaatttgga ggtgcaagat gtgcacataa tatagtaaag taccctcaat
     2461 gccggcagca tgccttgatg actatccaac agctggtgct ctccccaaat ggggacgatg
     2521 acatgggcac tctcctgggg ctaatgcatt cagccccacc gacggaattg cagttgaaga
     2581 ctgatatttt aagggccctc ctgtcggtcc ttcgagaaag ccatcgttca agaacagttt
     2641 ttaggaaagt tggaggattt gtgtacatta catccttgct cgttgctatg gaaagatctt
     2701 tgagctgtcc acccaagaat ggctgggaga aagtgaacca gaatcaagtg tttgaacttc
     2761 ttcacactgt gttctgcacg ttgactgcag caatgcgcta tgagccagcc aactctcatt
     2821 tcttcaaaac agagattcag tatgagaagt tggcagatgc tgttcgattt cttggctgct
     2881 tctcagacct aagaaaaata agcgccatga atgtcttccc ctcaaataca cagccatttc
     2941 aaagactttt agaggaagat gtaatctcaa tagaatcagt gtcacccacg ttacggcact
     3001 gcagtaaact ttttatttat ctttacaaag tagccacaga ttcttttgac agtcgtgcag
     3061 aacagatccc tccttgcctg acaagtgagt cttctctccc ctctccttgg ggtacaccag
     3121 ctttgtccag gaaaaggcat gcatatcatt ctgtttcaac tccccctgtt taccctccta
     3181 aaaatgttgc cgacctgaaa ctacatgtga caacttcatc tctgcagagt tctgatgcag
     3241 tcatcattca tcctggagcc atgcttgcca tgctggacct actggcctct gttgggtcag
     3301 tgacacagcc agaacatgct ttggatcttc aacttgccgt ggcaaatatt ttacaatccc
     3361 tggtgcacac agaaaggaac cagcaagtca tgtgtgaagc tggtcttcat gcacgactgc
     3421 tgcagaggtg cagtgctgca ttggctgatg aggaccactc actgcacccg cccctgcagc
     3481 ggatgtttga acgattagcc tctcaggctc tggaacccat ggtgttgagg gagtttttac
     3541 gtttggcaag tcctttaaat tgtggtgcct gggacaaaaa actgctaaaa caatataggg
     3601 tccacaaacc aagttcactg agttatgaac cagaaatgag aagtagtatg atcacatctc
     3661 tggaaggtct gggtactgat aatgttttta gcttacatga agataaccat taccggataa
     3721 gcaagagcct ggtaaaatct gcggaaggaa gtactgtacc cctgaccagg gtgaagtgtc
     3781 tggtctccat gacaacccca catgacatca gacttcatgg gtcatcagtt actccagctt
     3841 ttgttgaatt tgacacatca cttgaagggt ttggatgtct ttttttgccc agtttggccc
     3901 ctcataatgc tcctacaaat aataccgtca caacaggtct tattgatggg gctgtggtca
     3961 gtggcattgg ttctggtgaa agattcttcc ctcctccctc cggcttaagt tactctagct
     4021 ggttttgtat tgaacatttt agttctcctc caaataacca ccctgtcaga cttcttactg
     4081 ttgtgcgccg agcaaattct tctgagcaac attacgtgtg ccttgcaata gttctatcag
     4141 caaaagaccg atctctgatt gtttccacca aagaggaact cctccaaaat tatgttgatg
     4201 attttagtga agagtcctca ttttatgaaa ttctcccatg ctgtgctcgc tttcgatgtg
     4261 gagagcttat cattgaggga cagtggcatc atttggtcct ggtaatgagc aaaggcatgt
     4321 tgaaaaacag tactgcagcc ctttatattg atggacagct tgttaacact gtaaagcttc
     4381 attatgtcca cagtactcca gggggttcag gttcggcaaa tccaccagtg gtgagcacgg
     4441 tctatgccta cattggtact ccacctgccc aacgccaaat tgcctcattg gtttggcgcc
     4501 tgggacccac acattttcta gaagaagttt taccttcttc aaatgttact accatttatg
     4561 aacttggacc aaattatgtt ggaagctttc aggctgtatg tatgccatgt aaagatgcaa
     4621 aatccgaagg ggtggtgcca tcccctgtgt cattagtacc agaggagaaa gtgtcatttg
     4681 gcctctatgc actctctgtg tcgtctctaa cagtggcaag aatccggaaa gtgtataaca
     4741 aattggatag caaagccatt gctaagcagt taggcatttc ctcacatgag aatgccactc
     4801 ctgtgaagtt gatacacaat tcagcaggac atcttaatgg atctgcacgg acaattgggg
     4861 ccgctctgat tggatacttg ggagtaagaa catttgtccc taagcctgtt gccactactt
     4921 tgcagtacgt tggtggagct gcagccatcc tgggcctggt ggccatggcc tctgatgtgg
     4981 aagggttata tgcagcagtc aaggccctgg tttgtgtggt caagagtaac ccactagcca
     5041 gcaaagaaat ggaaagaatc aagggctacc agttgctggc aatgttgctt aagaagaaac
     5101 gttcccttct taacagccac atcctccatc taactttttc tttggtggga actgttgata
     5161 gtggacatga gacctccatt attccaaatt caactgcttt ccaggacctc ctctgtgatt
     5221 ttgaagtctg gctccatgca ccatatgaac ttcatctttc cttatttgaa cactttattg
     5281 aactgctcac agagtccagt gaagcctcaa agaatgccaa attaatgaga gaattccagt
     5341 taatcccaaa gctgctcctg actcttcgag atatgtcttt atcccagcct actattgctg
     5401 ctattagtaa tgtcctgagc ttcttactgc aaggttttcc tagcagcaat gatctgctca
     5461 gatttgggca gtttatttct tctactttgc caacctttgc ggtttgtgag aaatttgtag
     5521 taatggaaat aaataatgaa gagaagcttg acactggaac tgaagaggag tttggaggtc
     5581 ttgtatcagc taatcttata cttttgagga acagacttct ggatatcttg ctaaaactaa
     5641 tttatacatc taaagaaaag acaagcatta atttgcaagc ttgtgaagaa ctggtgaaga
     5701 cactgggttt tgactggatc atgatgttta tggaggaaca cttacattcc accacagtta
     5761 cagcagccat gaggattctt gttgtcctac taagtaatca gtctattctc atcaagttta
     5821 aagaaggact cagtggtgga ggatggcttg aacagacaga ttctgtctta actaataaga
     5881 ttggaactgt attaggattc aacgtgggca gaagtgctgg tgggagatcg acggtcaggg
     5941 agattaaccg agatgcttgt cattttcctg gttttccagt ccttcagtca ttccttccta
     6001 aacacactaa tgtccctgcc ctctattttc tcctcatggc cttgtttctg cagcagccag
     6061 ttagtgagct gcctgagaac ctgcaggtca gtgtgcctgt catcagctgc cggagtaagc
     6121 agggttgcca gtttgatttg gattccattt ggacattcat ctttggagtt cctgcctcca
     6181 gcggaactgt ggtctcttct atccataacg tatgcacaga agctgttttt ttattattgg
     6241 gaatgctccg cagcatgctg acttcacctt ggcaatcaga agaagaggga tcttggctcc
     6301 gagaatatcc tgtgaccctg atgcagttct tcagatattt gtatcacaac gtgccagacc
     6361 ttgcctccat gtggatgagc cctgacttcc tgtgtgcatt agcagccacc gtcttcccct
     6421 tcaatattcg cccttactca gagatggtga ctgaccttga tgatgaagtt ggatctccag
     6481 cagaagagtt taaagcgttt gcagcagaca cagggatgaa caggagccaa tcagagtact
     6541 gcaatgtggg caccaagaca tatctgacca atcacccggc taaaaagttc gtttttgact
     6601 tcatgcgggt cttaatcata gacaacctct gtctcactcc tgccagcaag caaactccac
     6661 taattgatct tttgttggag gcttcccctg aaaggtctac aagaactcag caaaaagaat
     6721 ttcaaactta cattttggat agcgtgatgg accatttgct tgcagctgat gtgttattag
     6781 gggaagatgc atctctgcct attaccagtg gaggaagcta ccaggtattg gtgaacaatg
     6841 tgttttattt cacacagcgt gtggtggaca agctttggca aggcatgttc aacaaagaat
     6901 ctaaacttct tatagatttt ataattcaac taattgcaca gtcaaagaga agatcacagg
     6961 gattgtcact ggatgcagtg tatcattgcc tcaataggac catcttgtac cagttctcac
     7021 gggcacacaa aaccgttcct cagcaagtag ctctgcttga ttcactcagg gtcctcactg
     7081 taaacagaaa cttgatcctg ggacctggga accatgacca agaattcatt agctgtctgg
     7141 cccactgctt gataaatcta catgttggaa gcaacgtgga tggatttgga ctggaagcag
     7201 aagcccgcat gaccacatgg cacattatga tcccctcgga cattgaacca gatggtagtt
     7261 acagccaaga tattagtgaa gggcgtcagc ttctcataaa agctgtcaac agagtttgga
     7321 ctgaactgat acatagtaag aaacaagtct tagaggaact tttcaaagta actctacctg
     7381 tgaatgaaag gggccacgtg gacatagcta cagcaaggcc actcattgaa gaagctgccc
     7441 tgaagtgctg gcagaatcat ttggcccatg aaaagaaatg cataagtcga ggagaagctt
     7501 tagcgcccac cacacagtcc aaattatccc gtgtcagcag tggctttggt ctttccaagt
     7561 taacaggatc aagaaggaat cgaaaagaaa gtggtcttaa taaacacagt ctttccaccc
     7621 aggagatttc gcagtggatg tttactcaca ttgctgttgt tcgtgactta gtagatacac
     7681 aatataaaga atatcaggag cgtcagcaga atgccctgaa gtacgtgaca gaagagtggt
     7741 gtcagatcga gtgcgagctg ttgagggagc gggggctgtg gggccctccc atcggctccc
     7801 acctcgacaa gtggatgctg gagatgacag aagggccctg caggatgagg aaaaagatgg
     7861 tgcgaaatga tatgttttat aaccattacc cttacgtgcc agaaactgag caagagacaa
     7921 atgtggcgtc tgagatccca agtaaacagc ctgagacacc cgatgatatt cctcaaaaga
     7981 aacctgctcg atatagaaga gccgtaagtt atgacagtaa agagtactac atgcgactgg
     8041 cctctggcaa tcccgccatt gtccaagacg ccattgtgga gagttcagaa ggtgaagctg
     8101 ctcagcaaga accagagcat ggggaagaca ctattgctaa agtcaaaggt ttggtcaagc
     8161 ctcctctaaa acgctcccga tctgcacctg atggaggaga tgaggagaac caggagcagc
     8221 tacaagacca gattgctgag ggcagctcca tagaagagga ggagaaaaca gataatgcta
     8281 ccttactgcg cctgttagag gaaggagaaa agatccaaca catgtaccgc tgtgctcgag
     8341 tccagggcct agataccagt gaggggctcc ttctttttgg taaagagcat ttttatgtga
     8401 ttgatggatt taccatgaca gcaaccaggg aaataagaga tattgaaacc ttacctccaa
     8461 atatgcatga gcctattatt cctagaggag ccaggcaagg ccctagtcaa ctcaagagaa
     8521 catgcagcat ttttgcatat gaagatatca aggaagttca taaaaggaga tatctcctgc
     8581 agcctattgc tgtggaagtt ttctctggag atggacggaa ttacctcctt gcttttcaga
     8641 aaggaatcag aaacaaagtc tatcaaaggt ttttggctgt agtgccatct ctaacggaca
     8701 gttcagaatc tgtatctggg caacgaccaa acacgagtgt ggagcaggga tctgggttac
     8761 ttagcacttt ggttggagag aagtctgtga ctcagagatg ggagagaggt gaaatcagca
     8821 acttccaata tttgatgcat ttgaacactt tggctggcag atcatataat gatctcatgc
     8881 agtatcctgt cttcccctgg atccttgcag attatgactc agaggaggtg gatcttacta
     8941 atcccaagac gtttagaaac ctggctaagc caatgggagc acaaacagat gaacgattag
     9001 ctcagtataa gaagcggtat aaagactggg aggatcctaa tggagaaact cctgcatacc
     9061 actatgggac ccactattca tctgcaatga ttgtggcctc ataccttgta aggatggagc
     9121 ctttcacaca gatattctta aggctacagg gtggccactt tgacctggct gaccggatgt
     9181 ttcacagtgt gcgcgaggcc tggtattcag cgtcaaagca caatatggca gatgtaaaag
     9241 aacttatccc agagttcttt tatttaccag aattcctgtt caattccaac aactttgatc
     9301 taggctgtaa acaaaatggc accaagcttg gagatgttat ccttccaccc tgggcaaaag
     9361 gggacccacg agaattcatc agagtccatc gtgaggcttt ggagtgtgat tacgtgagtg
     9421 cccatctaca tgagtggatt gacttaatct tcggttataa acagcaaggc cctgctgcag
     9481 tagaagctgt aaatgtcttc catcatcttt tttatgaggg tcaagtggat atctacaaca
     9541 tcaatgaccc actaaaggag acagccacaa ttgggttcat taataacttc ggtcagatcc
     9601 ctaaacagtt atttaaaaaa cctcatccac caaagcgagt gagaagtcga ctcaatggag
     9661 acaatgcagg aatctctgtc ctaccaggat ctacaagtga caagatcttt tttcatcatc
     9721 tagacaactt gaggccttct ctaacacctg taaaagaact caaagaacct gtaggacaaa
     9781 tcgtatgtac agataaaggt attcttgcgg tggaacagaa taaggttctt atcccaccaa
     9841 cctggaataa aacttttgct tggggctatg cagacctcag ttgcagactg ggaacctatg
     9901 agtcagacaa ggccatgact gtttatgaat gcttgtctga gtggggccag attctctgtg
     9961 caatctgccc caaccccaag ctggtcatca cgggtggaac aagcacggtt gtgtgtgtgt
    10021 gggagatggg cacctccaaa gaaaaggcca agaccgtcac cctcaaacag gccttactgg
    10081 gccacactga taccgtcacc tgcgccacag catcattagc ctatcacata attgtcagtg
    10141 ggtcccgtga tcgaacctgt atcatttggg atttgaacaa actgtcattt ctaacccagc
    10201 ttcgagggca tcgagctcca gtttctgctc tttgtatcaa tgaattaaca ggggacattg
    10261 tgtcctgcgc tggcacatat atccatgtgt ggagcatcaa tgggaaccct atcgtgagtg
    10321 tcaacacgtt cacaggtagg agccagcaga tcatctgctg ctgcatgtcg gagatgaacg
    10381 aatgggacac gcagaacgtc atagtgacag gacactcaga tggagtggtt cggttttgga
    10441 gaatggaatt tttgcaagtt cctgaaacac cagctcctga gcctgctgaa gtcctagaaa
    10501 tgcaggaaga ctgtccagaa gcacaaatag ggcaggaagc ccaagacgag gacagcagtg
    10561 attcagaagc agatgagcag agcatcagcc aggaccctaa ggacactcca agccaaccca
    10621 gcagcaccag ccacaggccc cgggcagcct cctgccgcgc aacagccgcc tggtgtactg
    10681 acagtggctc tgacgactcc agacgctggt ccgaccagct cagtctagat gagaaagacg
    10741 gcttcatatt tgtgaactat tcagagggcc agaccagagc ccatctgcag ggccccctta
    10801 gccaccccca ccccaatccc attgaggtgc ggaattacag cagattgaaa cctgggtacc
    10861 gatgggaacg gcagctggtg ttcaggagta agctgactat gcacacagcc tttgatcgaa
    10921 aggacaatgc acacccagct gaggtcactg ccttgggcat ctccaaggat cacagtagga
    10981 tcctcgttgg tgacagtcga ggccgagttt tcagctggtc tgtgagtgac cagccaggcc
    11041 gttctgctgc tgatcactgg gtgaaggatg aaggtggtga cagctgctca ggctgctcgg
    11101 tgaggttttc actcacagaa agacgacacc attgcaggaa ctgtggtcag ctcttctgcc
    11161 agaagtgcag tcgctttcaa tctgaaatca aacgcttgaa aatctcatcc ccggtgcgtg
    11221 tttgtcagaa ctgttattat aacttacagc atgagagagg ttcagaagat gggcctcgaa
    11281 attgttgaag attcaacaag ctgagtggag accatggtct gtagacccct tcccgattct
    11341 cctgtcccag cttggaaggc attgaaaaca gtctccgttt acacatctct tcataccacg
    11401 tgtttgaagt gttaaaattc aaagggatca ttgaataaaa cgggtgtaga gtacaggaat
    11461 ggggcagacg cgattcaggt gaacagcaca agaagaatat gaggtggttc ctaggagcaa
    11521 cactttcgac ctccagttct ccctgatgac agtagctgtc tccaagagaa aaatcctcac
    11581 ttattaactc tcttttcttg catctcattt ttatagagct actcatcctt atttggaaaa
    11641 accaacaaca aaaaaggctt ttagaaaatg gttgtaaatc tgacttcttt gcaagtaact
    11701 atgtatattg taaatagata taaaaggcct tttttctaaa taaggactta actgcctgta
    11761 acatgaaact tcaaactaaa ccactaactc aatgaactac ttatggtttg tctgacatcc
    11821 ctcacttacc aattaattat aaatatgttt ttttaaatcc ccaaagacat tatctgtggt
    11881 ctttttttcc tttcaagctc agcctgtgtg cctgatgtca tttctttcaa gttgcccaca
    11941 gtatctccac ttaaactagg ctagtaacca aaataatgtg gaccttcttt aggaaacagt
    12001 gtgggagaat aggagtccag ccgtaagata aactggaaat atttgggcgt cttgtacctg
    12061 gctacgcacc acctcagtgt tgttcctaca taaacagggc cccttttaaa cttgtatgtg
    12121 gactgctgtt tggtcaaaga ataccttctt agcattgcag aaaggtggtc agatgaccag
    12181 tgtagtgcag gaaacagccc tgtctcaact aatggaaata tatttgcatg taacccaaaa
    12241 ttagcttatc ttgcatagaa cataataagt atgtgtcttt ggtgacacta atgttctact
    12301 atagcttatt ttcaaacaag gggtaaaaaa aggaaagaaa gaagtgtaca gaattaacat
    12361 ataaactttg ttgtaaaact gaatcatgtc agaactgctt aaaattaacc tttaccattt
    12421 aatgtcatct acctgaaaac agtgagattt atactgtatc aatgtctatt tttttgtttt
    12481 tgctatgaat ataattacag tattttaata tttagttatt taatttgttc tactagttgg
    12541 atacagaaca cacaaatcca gggggattaa agctggaagg ggctaagaga ttagtttaca
    12601 gagaaaaggc ttggtggtgg gattttttta aatgtgtgtt atgtacatat atatatatat
    12661 ataatatata ttaaaaatga aacaattaat ctagatttta acattttcag aaacttagtg
    12721 ataacattat gaacaattct aaaagccctg tgatttgaaa aatatagaat cattaatggc
    12781 ccaagatagg ccttcacacc ttcacaggtg cgaaaggaaa ggccttcaca ccctcacaga
    12841 ggcatcatgc aaaggacagc ggctttggct tttccaattt tccatcttta ggccctggtg
    12901 agaggcacac ttatgcacta aaatgcacat atatgcacat gcattcaaaa ataggcattt
    12961 ggtacaatgg tgatcttgta cctgatgggc tgaaaccagc ttaagaacaa atttgttctt
    13021 cctgatatga taactaggtc tccaagagaa aatagaaagg ctgctttagt gccttacgct
    13081 tactaaattt aaatctttat ttacctgggt ttgagcctac agtctattta tgattacata
    13141 tcaaaattga ttaaaacact tccatttcta aaagttcaaa tatacttgtt aataaaagga
    13201 ttatcggcat taatacttta atttaaagaa aagttgtgtt ctgttttcct ttctgtgtct
    13261 tactcccccc acactctccc tcccccatca ccatcttcaa ttctaataaa taatgctgat
    13321 gttcaacagt tgcagaaatt gtgctattat gtaactgtgg gccttgcccc tgtctggccc
    13381 tctagatgat ttgtagcagt gttattctac actttttaaa agaagcgtcc tccttttgtc
    13441 catgaatcat gtttacccca tacccagtgg cagaggtgtt ctttaaagac ttgaatatat
    13501 gaatgtgtgt gtgtagttac ttaaaggtta ttcctctttg taataggaaa ctatatggga
    13561 tgaacacttt taaactttcc gacacaactt ccattactaa ctttctaaca gaacttccat
    13621 aactagaagg tggaaaccaa aaccctcatg gtagtatttc ctctggcagc tggtgctgtg
    13681 ggcaactgtt ttgttcaatc gggtttcttt tctttttgcc tctaatgcag aaatcaacag
    13741 aatcactcac acatacaagt acactcacat acataaacta attatttctc tggatatctt
    13801 tctgtgttcc atgtaaattt atttaccaac atctattgtc aacatgtaca tctaccttag
    13861 tatggtctgc attctttttc tgagagtacc tcatagggct cctgcctgat ctttgtagtt
    13921 tgttcattca tccatccacc tgttcatttg ttcatccatg tattctaaca tttctatgta
    13981 gtgtgcaact ctaatgtcat gcttttgaag aagagaatag ctgcccatag cagccatccg
    14041 tctggataat agcaaaacac tctagataag ttattttgca ctttcttatg tataaagttg
    14101 gtagaaactt atttttgctt tgtatcattt aaatacattt tgttttggta aatgaactgt
    14161 gtataaaata tttatgccgt taaaactgtt tttagaaagt atttttaatt tcagcaagtt
    14221 tggttacttg ttgcatgact cttaacacag ctgacttttt gtgtcagtgc aatgtatatt
    14281 ttttgtcctg ttattaactt gtaagcccta gtaatggcca attatttgta cagcaacaga
    14341 agtaaattga agatactggc taagactgga ttgattgtgg acttttatac tatattgcag
    14401 aaaccaatat ctgtttcttg gtggttatgt aaaagacctg aagaattact atctagtgtg
    14461 cagtctgtga tatctgaatg ttcattgtat atttgtctct gatgcaaaaa ggtagagtaa
    14521 cacaattaca atacatgatt aaatgcaata gtccaggta
//
