LOCUS       NM_052950               9369 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens WD repeat and FYVE domain containing 2 (WDFY2), mRNA.
ACCESSION   NM_052950
VERSION     NM_052950.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9369)
  AUTHORS   Yang,Z., Liu,F., Bai,J., Ye,Z., Yin,J., Peng,T., Shan,H., Yu,Y.,
            Zhou,P. and Li,R.
  TITLE     Circ_0115118 regulates endometrial functions through the
            miR-138-1-3p/WDFY2 axis in patients with PCOSdagger
  JOURNAL   Biol Reprod 108 (5), 744-757 (2023)
   PUBMED   36780172
  REMARK    GeneRIF: Circ_0115118 regulates endometrial functions through the
            miR-138-1-3p/WDFY2 axis in patients with PCOSdagger.
REFERENCE   2  (bases 1 to 9369)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 9369)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 9369)
  AUTHORS   Monti,P., Ciribilli,Y., Foggetti,G., Menichini,P., Bisio,A.,
            Cappato,S., Inga,A., Divizia,M.T., Lerone,M., Bocciardi,R. and
            Fronza,G.
  TITLE     P63 modulates the expression of the WDFY2 gene which is implicated
            in cancer regulation and limb development
  JOURNAL   Biosci Rep 39 (12) (2019)
   PUBMED   31789342
  REMARK    GeneRIF: P63 modulates the expression of the WDFY2 gene which is
            implicated in cancer regulation and limb development.
REFERENCE   5  (bases 1 to 9369)
  AUTHORS   Sneeggen,M., Pedersen,N.M., Campsteijn,C., Haugsten,E.M.,
            Stenmark,H. and Schink,K.O.
  TITLE     WDFY2 restrains matrix metalloproteinase secretion and cell
            invasion by controlling VAMP3-dependent recycling
  JOURNAL   Nat Commun 10 (1), 2850 (2019)
   PUBMED   31253801
  REMARK    GeneRIF: WDFY2 regulates exocytosis of MT1-MMP by controlling
            endosomal sorting of the v-SNARE VAMP3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9369)
  AUTHORS   Kannan,K., Coarfa,C., Rajapakshe,K., Hawkins,S.M., Matzuk,M.M.,
            Milosavljevic,A. and Yen,L.
  TITLE     CDKN2D-WDFY2 is a cancer-specific fusion gene recurrent in
            high-grade serous ovarian carcinoma
  JOURNAL   PLoS Genet 10 (3), e1004216 (2014)
   PUBMED   24675677
  REMARK    GeneRIF: CDKN2D-WDFY2 fusion could be an important molecular
            signature for understanding and classifying sub-lineages among
            heterogeneous high-grade serous ovarian carcinomas.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 9369)
  AUTHORS   Fritzius,T. and Moelling,K.
  TITLE     Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes
            adipogenesis
  JOURNAL   EMBO J 27 (9), 1399-1410 (2008)
   PUBMED   18388859
REFERENCE   8  (bases 1 to 9369)
  AUTHORS   Fritzius,T., Frey,A.D., Schweneker,M., Mayer,D. and Moelling,K.
  TITLE     WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein
            kinase Czeta
  JOURNAL   FEBS J 274 (6), 1552-1566 (2007)
   PUBMED   17313651
  REMARK    GeneRIF: presence of ProF increases the PKCzeta-dependent
            phosphorylation of VAMP2 in vitro
REFERENCE   9  (bases 1 to 9369)
  AUTHORS   Fritzius,T., Burkard,G., Haas,E., Heinrich,J., Schweneker,M.,
            Bosse,M., Zimmermann,S., Frey,A.D., Caelers,A., Bachmann,A.S. and
            Moelling,K.
  TITLE     A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda
  JOURNAL   Biochem J 399 (1), 9-20 (2006)
   PUBMED   16792529
  REMARK    GeneRIF: The ProF protein partially co-localizes with EEA1 on
            vesicular structures and binds to the protein kinases Akt and
            PKCzeta/lambda (protein kinase Czeta/lambda) via its WD-repeat
            propeller.
REFERENCE   10 (bases 1 to 9369)
  AUTHORS   Hayakawa,A., Leonard,D., Murphy,S., Hayes,S., Soto,M., Fogarty,K.,
            Standley,C., Bellve,K., Lambright,D., Mello,C. and Corvera,S.
  TITLE     The WD40 and FYVE domain containing protein 2 defines a class of
            early endosomes necessary for endocytosis
  JOURNAL   Proc Natl Acad Sci U S A 103 (32), 11928-11933 (2006)
   PUBMED   16873553
  REMARK    GeneRIF: WDFY2, the WD40 and FYVE domain containing protein 2, has
            roles in endocytosis
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA124107.1, BC014004.2 and
            AL136525.17.
            
            On Nov 22, 2018 this sequence version replaced NM_052950.3.
            
            Summary: This gene encodes a protein that contains two WD domains
            and an FYVE zinc finger region. The function of this gene is
            unknown. An alternatively spliced transcript variant of this gene
            may exist. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.11536.1,
                                           SRR1803611.69395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298125.7/ ENSP00000298125.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                DA124107.1         115-160
            47-1659             BC014004.2         1-1613
            1660-3695           AL136525.17        134276-136311
            3696-9369           AL136525.17        136312-141985
FEATURES             Location/Qualifiers
     source          1..9369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.3"
     gene            1..9369
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /note="WD repeat and FYVE domain containing 2"
                     /db_xref="GeneID:115825"
                     /db_xref="HGNC:HGNC:20482"
                     /db_xref="MIM:610418"
     exon            1..363
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1429
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /note="WD40 and FYVE domain containing 2; propeller-FYVE
                     protein; WD40- and FYVE domain-containing protein 2; zinc
                     finger FYVE domain-containing protein 22"
                     /codon_start=1
                     /product="WD repeat and FYVE domain-containing protein 2"
                     /protein_id="NP_443182.1"
                     /db_xref="CCDS:CCDS9429.1"
                     /db_xref="GeneID:115825"
                     /db_xref="HGNC:HGNC:20482"
                     /db_xref="MIM:610418"
                     /translation="MAAEIQPKPLTRKPILLQRMEGSQEVVNMAVIVPKEEGVISVSE
                     DRTVRVWLKRDSGQYWPSVYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYN
                     KMTPVKNYQAHQSRVTMILFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASG
                     LQFDVETRHVFIGDHSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGS
                     SDHSVIMWDIGGRKGTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVVWNMDVERQ
                     ETPEWLDSDSCQKCDQPFFWNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPL
                     MGFEFEVRVCDSCHEAITDEERAPTATFHDSKHNIVHVHFDATRGWLLTSGTDKVIKL
                     WDMTPVVS"
     exon            364..431
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            432..505
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            506..560
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            561..711
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            712..824
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            825..951
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1057
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1159
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1290
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1399
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..9369
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8432..8437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /note="hexamer: AATAAA"
     polyA_site      8453
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /note="major polyA site"
     regulatory      9347..9352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /note="hexamer: ATTAAA"
     polyA_site      9369
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
ORIGIN      
        1 gtagtggcgc cggcttgcat cccaggtcgt ggcggttttg gtgcctgaag cagggagcgc
       61 ggagtcgttc ccgagagagg cggccaggct atgctcgccg gtttccggcg ttccgctccg
      121 gccagccaga gtctctgtct caacctgtgt ccgtgctcca gcagtctcct cagcccggcc
      181 ccgcggcgcg gttggcggcg gcgccccagg cgcgccccct cctccgatgg cggcggagat
      241 ccagcccaag cctctgaccc gcaagccgat cctgctgcag cggatggagg ggtcccagga
      301 ggtggtgaat atggccgtga tcgtgcccaa agaggagggc gtcatcagcg tctccgagga
      361 caggacagtt cgtgtttggt taaagagaga cagtggacag tattggccaa gcgtatacca
      421 tgcaatgcct tctccatgtt catgcatgtc ttttaacccg gaaacaagaa gactgtccat
      481 aggtctagac aatggtacaa tctcagagtt tatattgtca gaagattata acaagatgac
      541 tcctgtgaaa aactatcaag cgcatcagag cagagtgacg atgatcctgt ttgtcctgga
      601 gctggagtgg gtgctgagca caggacagga caagcaattt gcctggcact gctctgagag
      661 tgggcagcgc ctgggaggtt atcggaccag tgctgtggcc tcaggcctgc aatttgatgt
      721 tgaaacccgg catgtgttta tcggtgacca ctcaggccaa gtaacaatcc tcaaactgga
      781 gcaagaaaac tgcaccctgg tcacaacatt cagaggacac acaggtgggg tgaccgctct
      841 ctgttgggac ccagtccagc gggtgttgtt ctcaggcagt tcagatcact ctgtcatcat
      901 gtgggacatc ggtgggagaa aaggaacagc catcgagctc caaggacaca acgacagagt
      961 ccaggccctc tcctatgcac agcacacgcg acaattgatc tcctgtggcg gtgatggtgg
     1021 gattgtcgtc tggaacatgg acgtggagag gcaggagacc cctgaatggt tggacagtga
     1081 ttcctgccaa aagtgtgatc agcctttctt ctggaacttc aagcaaatgt gggacagtaa
     1141 gaaaattggt ctaagacagc accactgccg caagtgtggg aaggccgtct gtggcaagtg
     1201 cagctccaag cgctcctcca tccccctgat gggcttcgag tttgaagtga gggtctgtga
     1261 cagctgccac gaggccatca cagatgaaga acgtgcaccc acagccacct tccatgacag
     1321 taaacataac attgtgcatg tgcatttcga tgcaaccaga ggatggttac tgacttctgg
     1381 aactgacaag gttattaagt tgtgggatat gaccccagtc gtgtcttgat gactctccca
     1441 ggaatcagaa agatagtatt tactaaagaa acggttgttt taacccaaat cattaccaga
     1501 gtggtaaagc agacatgtga gaagtaagaa agaaactaaa gaccctgaat gaatttgcag
     1561 attacccatg tgcacagtgg ggacctggcc agtgagcact cgcaagggga ctcttccaac
     1621 ttgttcatac aatataaaag aagctatttt tttaacaaat ggtttataca gtctggctgt
     1681 gctgcattgt tttgagtgta ccgaaaaatc tgtgtggggt gtttaatttt tatacttttc
     1741 aacaccccat tttacttgtt gctttgtcag agaaataagg gaggtatcta ctcagagtat
     1801 tttggtcatt atactttctg tgtttacttc aacatgtgtc acgtggccag cggctttttc
     1861 ttctcttccc tctgcaccta cctgcacctt ctctgccttt cctggagggg atgtatttat
     1921 gttatttatt cccagtgttt ctgctttcat gtcctcctca gtggagagat ttggaaactc
     1981 atcatgtgga ttcaccagcc agctgctgga attgcctgaa gagcgatttg tttgtaatgt
     2041 ctgcctcatt cacgttctta tgaagtagaa aagactgtgt ttctgcctca gttgcctctg
     2101 tctttcccac attaaaaaaa aaaatgctgt gagaaagctg ctcccaacca tggttatcac
     2161 agaagtagat tattttaact cagagcttca acgatcagtg cctggatcat ttagaattca
     2221 gttggagcct cctgagcctc ttgttttagc ttttttgacg cagctctccc tcactcgtaa
     2281 caatgaaaac aaatgacaca cacacaaaat cctacatcag cggccctcaa ccttgttggc
     2341 agcagggacc ggtttcaaaa tgaaactgtt ccacctcgga tcagcaggca ttagcttctc
     2401 ataaggagca cgcaacctaa atccctcgca tgcgcagttc acaatagagt ttctgctcct
     2461 gtgagaatct gacgccaccg ctgatctgat gggaggcgga gcccaggcag taacacttgc
     2521 ttgcccactg ctcacgtctg atgggtgccc ccattcctca caggctatgg accagtaccc
     2581 atctgcagcc cagggttggg gacccccacc atacatgctc tgaaaataag tgtctttaag
     2641 ttgtgttttt ctgtgtgaca tcatctctga acttgaacat gttcattacg gcaagattgt
     2701 aatcctgctg tattcctcgc cctctgtatt ctatcccttt aaaaactaga tatttaaaca
     2761 ttttatccta atgtgtttca tcagaacact ttgcacactt tcttactaaa acggtatgtg
     2821 ggtggtccga gacagaatgg tacctacagt gcaggctatg tttctgtggg aatggaaaag
     2881 aggactttag aaagtgaacc tgaagaactc ttatttctaa gggaatccag tcaagcttga
     2941 gaaaatgaaa tattcttgtg tgtagtgatt cagctcagga tattgaagtc ccttttaaaa
     3001 atcttatttt cacctgtaaa aatagaataa aaattaatgg caagcctgcg ccaggtgcct
     3061 gcccctccta agcactttac acgcacagct cattcaacct cacgtgtcgg gagcatcagg
     3121 gagctcacca gtctcttgag gatcacaggc caattgcttg tccttcccga cccaagcccc
     3181 accccacagt gtcttgctct cttctgattt tacaggtttt ttggcagtaa tacacatggg
     3241 agtgaaattg aaatcctccc tattattttc cctcttttcc tggaaagccg ttttttgccc
     3301 tcacaatcat tcattacttc tctaactagg gggaagtact acaagctgtc ctcaggtact
     3361 gcccctacgt gtgtttccct gggatggggc cttgctagag gtgattctgc tgccccagca
     3421 ttgggaagca ggaccagtgc atgtgcccca tgcagccacg gtacatggaa gctgtcactt
     3481 gagccatcag accggctcag cccatgtgac cggagctctg aagaggcaca cacgcatgcc
     3541 ccgcacaggc tgttagcact tgtcgcctcg ctgccctggt ccagactacc cttgcttgcg
     3601 tcagtcaaaa ctgttgtaac tactttgagt cttttctgca tgattgctct ttgagagaac
     3661 tttaacaagg gaattaaatt taaaatattc aaatatctat tttgtagttt attactagaa
     3721 gctgcagcca cttactaagt tgtatgtaat ataggactgt gtgttggaaa tgagtaatag
     3781 agctgaatca ctccattttc ccttcctaaa ctttgagctt ggcctgccgg cagagagagg
     3841 aacacagtat tagggcagca aaggcccagg cgcccagcaa gcctgtatgg gttctgagat
     3901 gggtctagat gcgttcagac ctcattcggg aagcagagtg tccccgtcag atcacatatg
     3961 tcctctacag tcgctctggc ctgtgacctt gcacgccact ctaccttctc cctcccagcc
     4021 cacagagcca ctcagaggct gaagccactt cacagcccac tggtgttgag aatcatcatc
     4081 agaaaaccag atatgtcaag gtatccattg ctctttcctt ttctctcatc tgtgtgggtg
     4141 cttgaatttg gtgaaatgcg tttagcaaac caactgtgtg tttgtaatac tgtgaattct
     4201 tgcgttttgc attaagtgtc tcccccattt ttgtaatttg tagagaaata tgtgctggtg
     4261 ttgggtgtct tccaagcatt ttatggaaat ggaggctcca ttccttagga gtaaaagctg
     4321 gcgccagcac ttggctcttg ttctgtctag gtgaactctc ataattcttg ttttaccctg
     4381 ttggatttgc actttacata tatttttgct ctattactta aacatatagc agcttttaca
     4441 aataatgcct aacatgcctg cgctgagaaa gtggcagatc tacacatatc atacgcagag
     4501 ttgttctcta cctgatgggg caaaaccaac cacatgttct tggttcctcc aaacgaatga
     4561 cattacttga cattactgcc tgagtgtatc ttcacaatag caaaatggtt tgagattaag
     4621 catttggaat cttatgtcat tttgtatggg gtcaatccac cataacgtgt ttctcatttg
     4681 gttttaatta tttccagaaa tcataaagtc acaaaactgg aagggatctt cagagatcta
     4741 gagtgtttca agcagaaaac acattagtta tacagggcag ttagatatgg ctgagatgta
     4801 aacaagagaa tctaaaagaa tgttcaagga atagctgttt ttgaacatta cttagtaatg
     4861 gcatgagtgg gaggagagac tttcagcacc ttgagacagg gcgctctctg gaaccagctt
     4921 tgttcctctt atcgaaagca tatatgacag tttttttggc tccggccctg tggtggggga
     4981 ggtaattatt gccttcatcc acataaattc cttcctatac attcccctca gaccacccca
     5041 gaggcaaaac tgaaatggaa atccagtggc acttaaaatt caccctgccc cgtttggctg
     5101 cgattcccag gcttacagca ctgcccttat ggaatatcac attttcattt tctgagattc
     5161 attttataaa agtaaaggcc aggtgccatg gctcacacct ataatctgaa cactttggga
     5221 ggacaaggtg ggaggattgc tgagcccagg agttcaagac cagcctgggc cacacagcaa
     5281 gatcctgtca ctaccaaaaa ttcaaaactt agttgggtgt ggtggcacac acctgtattc
     5341 ccagctactc aggaagctga ggcgggagga tcactcgagc ccaggaattc aaggatgcag
     5401 tgagctatga ttgcactact gcagtccagc ctgggcagca gagcaaggcc ctgaataaat
     5461 aaacaaaagt ataatttatt tttgcctgat attaatcact tcttaaggcc caaatttttg
     5521 tttttaagca aaaggatagc tctaagtgtg ggttgcagtt actggacata aatattcact
     5581 aaatgagatt cctttggtta tggctgttca tagaatttta attctatgtc agtgttcttg
     5641 ttcactaaga tatttcgaag tgagagaaag cattttacca atacattctt attttttctc
     5701 ctttaaaata atattgaatt tttcctggta cgaagacaga tatttattaa cttgattgga
     5761 aaacacagaa attaagatca tgttgaacac tgagttatct agatgatccc tgagatttga
     5821 atgttcatgt caaccgtgtt gagcgctcac cagccaccag gctttaggca ctggcagtgc
     5881 aaggtgtctg aggcccattc tcaggctggg cagaggtcac acagtgagta aatgggtctt
     5941 ttcagtgcaa tgtggttatg atagaggcat gccagggtgc cactaaccca gcaggtgtgg
     6001 caggaggggc ttcacagagg aaagggactt tgagctcagt gttaaaggat gaggagtgag
     6061 tcataagggg gaaaaatgga aatgactttc caggcttcag aaacagcata aacaaacaaa
     6121 ggcctgagag ctggagtcag tgtggtgtgt ccagggatca caagtgggct ggagctgccg
     6181 gagaacagcc aagtggctca gctgccatcc cagaattgag ctcgtcacta tcagatgctg
     6241 ctgctccctg gcctcagagg aaagcagcac acagctcacc acgaggggtt tccccagagg
     6301 ctcctcctgc agccaatgct actattagtt tatattataa tagtatcagt ttctttttct
     6361 ttggaaatcc ctagaactgt taactgaagg tgactcaggg taactaattc tggatctttg
     6421 ggtgcacagc ctctcactgg agtctgagag gaggaggtgg agactatcag tgcacggccc
     6481 gcaaccagga aggactccca gactaacgcc aaaggtgtgt tgggctcagc tgctccactg
     6541 tggaaaagga aagccctggc cctgtggcag gagaggattg ttctagtcaa gtgtggcgtt
     6601 gcacggacag gcggtgccga gtgtttgggt gcagacacag gcagctgctg ccctccactt
     6661 cctgctcttg caagtcacag atgattccag tacaatgtgg gaggtcctcc ttacaggggc
     6721 acttgcaaca ggaaggcaga gagtttcgtc aattcaggta caggtctgtc tgggagacct
     6781 ggccctgtgg aggcaggaac accgtgcagg ggcatggcag cgcctgtctt tgctatcaca
     6841 tcatttgcct tttccttgta ggacccaaag atctatgtcc aaaacttagt ccagaaacat
     6901 ctgcattcct gtttaaactt cagctcagtt tcttaaccaa gaaccacgtc aaccctccag
     6961 ggttgtggtt tgtatttttg cctttaagca ttatctcctt tccaccaaga agcctactta
     7021 ggtttaacac atgaaagcag tgtctaaaaa ttagatcggt cctaaattgg aatgggatgt
     7081 cttccttgca tgtcccatac cagggaattt ttttaacaca cagtgtagag cctttgccag
     7141 agatgttgaa agggagatta aaggcttgag ggatgaattt gatcatcatt cttaaagtcc
     7201 cttccaatcc tgtgattctc tgattccctg agtctcgttt attattggac atgcctagcc
     7261 catcaccagt gacctgcccg catattgctg gcttcccttg gataacggag agcctatcac
     7321 cacatgcctt tgttgtcttc catcatatca agtgagttgc tttctggact ttttccatct
     7381 agagcctgct aggtttggtt ttgagaaaag atggtgaagt ttcttttcat gagtttgtag
     7441 ggcaaaaaaa attcttttta aagatggtaa gggtggaaat taatcatggt accatctcat
     7501 taaaaataga tacctcaaaa tgtttacctt tacaagtcaa gaagagtatc tgactttctt
     7561 ggaagtgtca agaattgcag gttggctgaa aagttagatt gagaatctga ccttgttact
     7621 tatgattctt ttttcccttg gttctcgggg atgcatgaga aggtgagctg tcactcacaa
     7681 aaaaagggaa aatgatttga aaaatgtttc acatatacac tttttatcat tttagtggat
     7741 ggcagcctta cgtcagtagt atatgccact atgaagtatg gccaaaaccc tagcgtcact
     7801 tgtaaccatt gtactcttat ggatttgtgt cttacaccat ttgccttgct ttttaaatga
     7861 ctttgttttt caaggtgctg tcattttgca aaaggaaatc tttatatgaa atgtacaaaa
     7921 accgttacta actggacaac agggaaggtg ctggccccac attagtgcct gcccaccgct
     7981 ctacttctaa ccagggacac ggatcttcca ttctctacat ccaccggact gcagcccaag
     8041 tctggacctg gctgcagtgg gcatattacc gtatggatat ctttttcttt ctttttttaa
     8101 agtgaggaga ttcttcaggg ggtcaggctg agaatgtaat aagcctgaca ttggaacaga
     8161 tttctcccgt gtggtctagc tggacccctc cggcatttgc cacactccct gccagtcctg
     8221 acattgactt cctgaatgtg attaggtggt aatgagcaag aatttcctag gatattgaaa
     8281 catctgtatc caggccccca atcaaatgct gctgaatatt gtgaatgttt ttactccgct
     8341 cactttccca ctgtgctttc ctctaaccaa aatatacgtg tagccattac caatgtacaa
     8401 ctctcaatgc ggagttgccg ccacggttta aaataaatct ctgtgaaaac ctttctgcag
     8461 ctatggtccc atcacggtta catgtggcca cgcacacacc gacaaccttg ctgtgctgtt
     8521 tagccctgtg ggttctgtcc agttggtggg agggggaggt tccagaccac tccacctgct
     8581 gtctagatgc cagggagagc tgctgtttgg aggtgaagat gagccctgtt caccacagtc
     8641 taagcacagc acacgggctc aagccatgga gcccttttcc ttcatcatgt aagtcagctt
     8701 tttcttgtgc ttagtaaact tttccagtga ggagaaatga cttcggggca aacactgcca
     8761 gggaaagcct catttaaaac ttgtgaggtt cattttatgg agaagaaaaa taggtgcaaa
     8821 ggcaccaagt gacctgcatg ctatggaatc accgttgagg gggtggctgg gttgccccgt
     8881 cctggtgctg ccagcacagc gtcgcccaca cccagcattg ctgaggccca tcatcctcct
     8941 gcagaaaagg aggcatgcag ttaaatggag ctggtgcttg cttgatagcg cctccttttg
     9001 tcagaaagac gctgatgttt caggctggca cacccagaaa aatcccttcc ttgtggtcct
     9061 tggctgatga tgagccctgg atcagagtgt ctccaggacc actgagaagc tgcagccgtc
     9121 tgggttttcc tctgctatgg gggatgagtt acgtttattc caccatggac accaagaatg
     9181 tatgtagatg tattctaaat ctgctcattg gttttattac aacttttcct ggagtcacta
     9241 agaggtaaaa tggtgtaaat tagaggtttt atcaaagtgt agtaccagaa tgccagatgc
     9301 attactgaag ccactcctaa tcttaagcaa atgtaaacta ggcctcatta aattgtttgt
     9361 gtaaatatg
//
