LOCUS       NM_020830               4607 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens WD repeat and FYVE domain containing 1 (WDFY1), mRNA.
ACCESSION   NM_020830 NM_178350
VERSION     NM_020830.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4607)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4607)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 4607)
  AUTHORS   Dutta,S., Roy,S., Polavaram,N.S., Baretton,G.B., Muders,M.H.,
            Batra,S. and Datta,K.
  TITLE     NRP2 transcriptionally regulates its downstream effector WDFY1
  JOURNAL   Sci Rep 6, 23588 (2016)
   PUBMED   27026195
  REMARK    GeneRIF: NRP2 inhibits WDFY1 transcription by preventing the
            nuclear localization of a transcription factor, Fetal
            ALZ50-reactive clone 1 (FAC1).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4607)
  AUTHORS   Hu,Y.H., Zhang,Y., Jiang,L.Q., Wang,S., Lei,C.Q., Sun,M.S.,
            Shu,H.B. and Liu,Y.
  TITLE     WDFY1 mediates TLR3/4 signaling by recruiting TRIF
  JOURNAL   EMBO Rep 16 (4), 447-455 (2015)
   PUBMED   25736436
  REMARK    GeneRIF: WDFY1 mediates TLR3/TLR4 signaling by recruiting TRIF.
REFERENCE   5  (bases 1 to 4607)
  AUTHORS   Chang,W.C., Chen,Y.C., Lee,K.M. and Tarn,W.Y.
  TITLE     Alternative splicing and bioinformatic analysis of human U12-type
            introns
  JOURNAL   Nucleic Acids Res 35 (6), 1833-1841 (2007)
   PUBMED   17332017
REFERENCE   6  (bases 1 to 4607)
  AUTHORS   Ridley,S.H., Ktistakis,N., Davidson,K., Anderson,K.E., Manifava,M.,
            Ellson,C.D., Lipp,P., Bootman,M., Coadwell,J., Nazarian,A.,
            Erdjument-Bromage,H., Tempst,P., Cooper,M.A., Thuring,J.W.,
            Lim,Z.Y., Holmes,A.B., Stephens,L.R. and Hawkins,P.T.
  TITLE     FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct
            functions in the endosomal and Golgi compartments
  JOURNAL   J Cell Sci 114 (Pt 22), 3991-4000 (2001)
   PUBMED   11739631
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ310568.1, AC073641.3,
            AK023415.1, AK022888.1 and BU682241.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020830.4.
            
            Summary: The protein encoded by this gene is a phosphatidylinositol
            3-phosphate binding protein, which contains a FYVE zinc finger
            domain and multiple WD-40 repeat domains. When exogenously
            expressed, it localizes to early endosomes. Mutagenesis analysis
            demonstrates that this endosomal localization is mediated by the
            FYVE domain. [provided by RefSeq, Jan 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065934.1, SRR1660807.218551.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233055.9/ ENSP00000233055.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1298              AJ310568.1         40-1337
            1299-1299           AC073641.3         23661-23661         c
            1300-1782           AJ310568.1         1339-1821
            1783-2632           AK023415.1         1629-2478
            2633-2678           AK022888.1         2609-2654
            2679-2679           AC073641.3         22281-22281         c
            2680-2760           AK022888.1         2656-2736
            2761-2761           AC073641.3         22199-22199         c
            2762-2777           AK022888.1         2738-2753
            2778-2778           AC073641.3         22182-22182         c
            2779-2868           AK022888.1         2755-2844
            2869-2869           AC073641.3         22091-22091         c
            2870-3966           AK022888.1         2846-3942
            3967-3967           AC073641.3         20993-20993         c
            3968-4570           AK022888.1         3944-4546
            4571-4607           BU682241.1         24-60               c
FEATURES             Location/Qualifiers
     source          1..4607
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.1"
     gene            1..4607
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
                     /note="WD repeat and FYVE domain containing 1"
                     /db_xref="GeneID:57590"
                     /db_xref="HGNC:HGNC:20451"
                     /db_xref="MIM:618080"
     exon            1..188
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1284
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
                     /note="phosphoinositide-binding protein SR1; WD40- and
                     FYVE domain-containing protein 1; zinc finger FYVE
                     domain-containing protein 17; FYVE domain-containing
                     protein localized to endosomes 1"
                     /codon_start=1
                     /product="WD repeat and FYVE domain-containing protein 1"
                     /protein_id="NP_065881.1"
                     /db_xref="CCDS:CCDS33387.1"
                     /db_xref="GeneID:57590"
                     /db_xref="HGNC:HGNC:20451"
                     /db_xref="MIM:618080"
                     /translation="MAAEIHSRPQSSRPVLLSKIEGHQDAVTAALLIPKEDGVITASE
                     DRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFN
                     KMNFIKTYPAHQNRVSAIIFSLATEWVISTGHDKCVSWMCTRSGNMLGRHFFTSWASC
                     LQYDFDTQYAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSVACLWWDPIQRLLFSGA
                     SDNSIIMWDIGGRKGRTLLLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNMDVSRE
                     EAPQWLESDSCQKCEQPFFWNIKQMWDTKTLGLRQHHCRKCGQAVCGKCSSKRSSYPV
                     MGFEFQVRVCDSCYDSIKDEDRTSLATFHEGKHNISHMSMDIARGLMVTCGTDRIVKI
                     WDMTPVVGCSLATGFSPH"
     exon            189..256
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            257..330
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            331..385
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            386..536
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            537..649
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            650..776
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            777..882
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            883..984
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1115
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1224
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..4607
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4570
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
     regulatory      4585..4590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
                     /note="hexamer: AATAAA"
     polyA_site      4607
                     /gene="WDFY1"
                     /gene_synonym="FENS-1; FENS1; WDF1; ZFYVE17"
                     /note="major polyA site"
ORIGIN      
        1 gtcagctgat gggctgcctg ccgaggaggc cgcagcagtc gccgcgcgaa catggcggcc
       61 gaaatccact ccaggccgca gagcagccgc ccggtgctgc tgagcaagat cgaggggcac
      121 caggacgccg tcacggccgc gctgctcatc cccaaggagg acggcgtgat cacggccagc
      181 gaggacagaa ccatccgggt atggctgaaa agagacagtg gtcaatactg gcccagcatt
      241 taccacacaa tggcctctcc ttgctctgct atggcttacc atcatgacag cagacggata
      301 tttgtgggcc aggataatgg agctgtaatg gaatttcacg tttctgaaga ttttaataaa
      361 atgaacttta tcaagaccta cccagctcat cagaaccggg tgtctgcgat tatcttcagc
      421 ttggccacag agtgggtgat cagtaccggc cacgacaagt gtgtgagctg gatgtgcacg
      481 cggagcggga acatgctcgg gaggcacttc ttcacgtcct gggcttcgtg tctgcaatat
      541 gactttgaca ctcagtatgc tttcgttggt gattattctg ggcagatcac cctgctgaag
      601 cttgaacaga acacgtgttc agtcatcaca accctcaaag gacatgaagg tagtgtcgcc
      661 tgcctctggt gggaccctat tcagcggtta ctcttctcag gagcatctga caacagcatc
      721 atcatgtggg acatcggagg aaggaaaggc cggacgctgt tacttcaggg ccatcatgac
      781 aaggtgcagt cgctgtgcta ccttcagctc accaggcagc tcgtctcctg ttcctcggac
      841 ggcggaattg cagtgtggaa catggatgtt agcagagaag aggctcctca gtggttggaa
      901 agtgattctt gtcagaaatg tgagcagcca tttttctgga acataaagca gatgtgggac
      961 accaagacgc tggggctaag acaacatcac tgcaggaaat gcgggcaggc tgtctgcggg
     1021 aagtgcagca gcaagcgctc aagttaccca gtcatgggct tcgagttcca agtccgggtt
     1081 tgtgattctt gttacgactc catcaaagat gaagatcgga cttctctagc gacctttcat
     1141 gaaggaaaac ataacatttc ccacatgtcc atggacattg ccaggggact gatggtgacc
     1201 tgtgggaccg accgcattgt aaagatctgg gacatgacac ctgtggtggg ctgcagtctg
     1261 gcgactgggt tttctccgca ctgatctgag agctgggcgg cgtccacacc taagaacagc
     1321 agctccacca aatgaagtcc ctctcacgca gctccacagc gctgtctcgt gaatggacag
     1381 tagccactta caaacaaatc aacattttta aaaagaaaat gtaaaggtgt gttttggggc
     1441 atttgtggaa cttacccatg gggactaata tggaaaaggt ctgtccatag tggttccctg
     1501 aagactggaa ttacttcagc aaaacttccc catgaacagc taatgtgtag tgaaagaatg
     1561 agctagcaaa tgagttttag cggggacaaa aaatcaaaca aaaaagtgaa tgcttagaac
     1621 cttctcaaag cagtcacaag tacagacact tcacttagcc tagggggcct tccagggttc
     1681 ttgtggctgt tgtcagagca ggagctgggg gagggaagac ttgttctctc tttcttgagg
     1741 ggtggcatta ggaacttacg aaaccagaga cctttcccta tgacttggca gtatgtgaat
     1801 atcctctaca cttagttatt gataaacttc ttaaagagat ctgttatttt caggtagtgc
     1861 cataatctgc acttagcatt ggcttgcttc agttgtttct cttcccagcc agtatgccac
     1921 aggtgaactt tcggggttgt cattaagtaa gttgtgaaat ttctgtaata acaaaggcag
     1981 tccgcattct tccctttccc ccaaattcct agggcaaaac ttttttatgg tgctgttaac
     2041 atgggagtca cacaagccgc ctgacttttt ctcattgcca ttagtaatga ctgatggaaa
     2101 acccagccac cactgtgatg cgaaatgatc agtctgttgc ctgaaacagc ccagtcctct
     2161 taactgaaac agcattctac ttcttgttcc aagatgagcc tctgcaatat tctggcaatt
     2221 taatataccc cctacaaaag cactccacag cttttacact attttgactt tgagttataa
     2281 ctagtattat tcatgttttc ataaaaagaa gttagtgacc cagagctata atcatccatc
     2341 aagtcttcca caataattcc caactcataa attgctttcc taacaactag caaaagctat
     2401 tgttcataat ggcatttcta aagcttttgg gcactgtgta ccaggatgag gaagagaaga
     2461 aatgaggagc ctgtctttta atattccagt atttgtgtgt ttgatttttt ttgacaacag
     2521 tacatatatc tatttctcta gggatatgga agtaagtgga gaagggccta cctttttaaa
     2581 ggacaaatat aaaaatagca acagtatctt tgctaatctt actaatagat attgattaaa
     2641 aaaaaaaaac ctcagtactg catcactgtg ttgggatcat accaggacaa tagggtcatt
     2701 ccatatgata aaactaaagg actaaatttg ttttataatg atgtcttaga gggactgaaa
     2761 ggtttaagga ggcgatcaaa ctaaaatgtc ttaatggctg tgtgacacac gtaaggaaag
     2821 gaaagggggt cacgcacatc atgtactgga atgatctgca ttaaacatag acttgtcttc
     2881 agaaataaga ctgaagggtt ttgttgttcc ttagagtttt cgtgttacat cacctaaaga
     2941 gatttctttt aaaaactttc tagactcttt gcaaaatgta tattactaac atagtttgga
     3001 agaaaaattg agtagtggta agttttgttc aagcacaatg ttgaatgtta agcttcctgt
     3061 attaatttta gttcagttaa tggttcagcc catacaaagg tgctatccta gggattttat
     3121 gaattcctga aaggaaaata gaatatgatc aattccttgc cctgtggaag agtgcagaac
     3181 tgtggttttg ttttcctttg acttctgtaa aatgtgaccg tttgacatct gtggtagatt
     3241 gaacggaata tcacagctgc tgagtttact ccatagcttt caaacctttt ttattttaag
     3301 aaattcttga aaaaccctat gttccatggg aacataaagt tattatagtg cctcctaagg
     3361 ggttaatata aatcaaggag gaagtttata tttaaggaag aattggagtg acgtatctta
     3421 gaaaaggaaa ggctgatgtt tccatatagc ttgctctcca ccaggcctat catttttctt
     3481 tttagagaca aacgtgacag gctagtcttg tctctctcat atgctaggta gcaaatgggg
     3541 tgatattttt atagaagtgg gcaaaaatta ttttctcaat tttactgagt aggcacagaa
     3601 gaaaagtaca gataggctga tggttattgc cttattttga ctgcatttct cttaaatgga
     3661 tcatttaaat tagttcttca agtaacagtt tactggttgt tccattcctg aatatgcagg
     3721 ctaatttgta cagataggga ttaaggaata cagactatta gagaagatcc ttatatttac
     3781 atctagtata tatgtggtaa ggaaatgccg attcttcatt ataaacaagt tttaaaattg
     3841 ttctttctta gttcaaatga tagcaatacc cctatagcat taggtagaaa caaattattc
     3901 attacatcgt aaatctcttt actatgtcct agctctgtcc tgctacctaa aggatataaa
     3961 gaaatactat tgctctagaa tgtattactt tgttctccca tgaaagaatt cagtttgtta
     4021 gtacctatat ttttaaactg gtgaaactga cccaaatatg taataaatac catagtagct
     4081 cagacccaag gagatatttt tctaaaatca gttttcgtta aagtacttct acttccgtta
     4141 ttggatatgg tatctcctaa agtgtaaaaa aaatctgtta ctatatagtg ataaaccatc
     4201 tgctcatcgt aagtgtaagg cttaacaaat aagtaataca tgctatattt attcaagtgt
     4261 ctattgctta attgttaatt gtgagcagat ttattgaatg cctattctat tttctgcagt
     4321 ttacaataca ataactcttt gagtaagttg aagtttaatt gtgcaacaaa tttgtattag
     4381 agtacaattt aaagtgtttt tctctatagc cttttttgac tggggaagca aggggtaatg
     4441 ttaattagta cactttgttc ttgtactagc tatgtttcta taagatatgg tgccctgtgt
     4501 atcccagaga tgctagaaaa ctgttctttg ctcctatttg tgggttctgt ttttgtgggt
     4561 tttttttttt gagaaaatgt acacaataaa acattccttg cttgtta
//
