LOCUS       NM_025203               3848 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens WD repeat and coiled coil containing (WDCP),
            transcript variant 1, mRNA.
ACCESSION   NM_025203
VERSION     NM_025203.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3848)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3848)
  AUTHORS   Xu,R., Xu,Y., Huo,W., Lv,Z., Yuan,J., Ning,S., Wang,Q., Hou,M.,
            Gao,G., Ji,J., Chen,J., Guo,R. and Xu,D.
  TITLE     Mitosis-specific MRN complex promotes a mitotic signaling cascade
            to regulate spindle dynamics and chromosome segregation
  JOURNAL   Proc Natl Acad Sci U S A 115 (43), E10079-E10088 (2018)
   PUBMED   30297404
REFERENCE   3  (bases 1 to 3848)
  AUTHORS   Yokoyama,N. and Miller,W.T.
  TITLE     Molecular characterization of WDCP, a novel fusion partner for the
            anaplastic lymphoma tyrosine kinase ALK
  JOURNAL   Biomed Rep 3 (1), 9-13 (2015)
   PUBMED   25469238
REFERENCE   4  (bases 1 to 3848)
  AUTHORS   Lipson,D., Capelletti,M., Yelensky,R., Otto,G., Parker,A.,
            Jarosz,M., Curran,J.A., Balasubramanian,S., Bloom,T., Brennan,K.W.,
            Donahue,A., Downing,S.R., Frampton,G.M., Garcia,L., Juhn,F.,
            Mitchell,K.C., White,E., White,J., Zwirko,Z., Peretz,T.,
            Nechushtan,H., Soussan-Gutman,L., Kim,J., Sasaki,H., Kim,H.R.,
            Park,S.I., Ercan,D., Sheehan,C.E., Ross,J.S., Cronin,M.T.,
            Janne,P.A. and Stephens,P.J.
  TITLE     Identification of new ALK and RET gene fusions from colorectal and
            lung cancer biopsies
  JOURNAL   Nat Med 18 (3), 382-384 (2012)
   PUBMED   22327622
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3848)
  AUTHORS   Lowe,J.K., Maller,J.B., Pe'er,I., Neale,B.M., Salit,J., Kenny,E.E.,
            Shea,J.L., Burkhardt,R., Smith,J.G., Ji,W., Noel,M., Foo,J.N.,
            Blundell,M.L., Skilling,V., Garcia,L., Sullivan,M.L., Lee,H.E.,
            Labek,A., Ferdowsian,H., Auerbach,S.B., Lifton,R.P.,
            Newton-Cheh,C., Breslow,J.L., Stoffel,M., Daly,M.J., Altshuler,D.M.
            and Friedman,J.M.
  TITLE     Genome-wide association studies in an isolated founder population
            from the Pacific Island of Kosrae
  JOURNAL   PLoS Genet 5 (2), e1000365 (2009)
   PUBMED   19197348
REFERENCE   6  (bases 1 to 3848)
  AUTHORS   Scott,M.P., Zappacosta,F., Kim,E.Y., Annan,R.S. and Miller,W.T.
  TITLE     Identification of novel SH3 domain ligands for the Src family
            kinase Hck. Wiskott-Aldrich syndrome protein (WASP),
            WASP-interacting protein (WIP), and ELMO1
  JOURNAL   J Biol Chem 277 (31), 28238-28246 (2002)
   PUBMED   12029088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB292134.1, AK025598.1, CX756689.1 and BC035698.2.
            
            On Nov 22, 2018 this sequence version replaced NM_025203.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.15389.1,
                                           SRR1803612.10856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267750 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295148.9/ ENSP00000295148.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                DB292134.1         38-75
            39-1775             AK025598.1         1-1737
            1776-2486           CX756689.1         19-729
            2487-3848           BC035698.2         2337-3698
FEATURES             Location/Qualifiers
     source          1..3848
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..3848
                     /gene="WDCP"
                     /gene_synonym="C2orf44; MMAP; PP384"
                     /note="WD repeat and coiled coil containing"
                     /db_xref="GeneID:80304"
                     /db_xref="HGNC:HGNC:26157"
                     /db_xref="MIM:616234"
     exon            1..78
                     /gene="WDCP"
                     /gene_synonym="C2orf44; MMAP; PP384"
                     /inference="alignment:Splign:2.1.0"
     exon            79..1914
                     /gene="WDCP"
                     /gene_synonym="C2orf44; MMAP; PP384"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2262
                     /gene="WDCP"
                     /gene_synonym="C2orf44; MMAP; PP384"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein C2orf44; WD repeat and
                     coiled-coil-containing protein C2orf44"
                     /codon_start=1
                     /product="WD repeat and coiled-coil-containing protein
                     isoform 1"
                     /protein_id="NP_079479.1"
                     /db_xref="CCDS:CCDS1705.1"
                     /db_xref="GeneID:80304"
                     /db_xref="HGNC:HGNC:26157"
                     /db_xref="MIM:616234"
                     /translation="MELGKGKLLRTGLNALHQAVHPIHGLAWTDGNQVVLTDLRLHSG
                     EVKFGDSKVIGQFECVCGLSWAPPVADDTPVLLAVQHEKHVTVWQLCPSPMESSKWLT
                     SQTCEIRGSLPILPQGCVWHPKCAILTVLTAQDVSIFPNVHSDDSQVKADINTQGRIH
                     CACWTQDGLRLVVAVGSSLHSYIWDSAQKTLHRCSSCLVFDVDSHVCSITATVDSQVA
                     IATELPLDKICGLNASETFNIPPNSKDMTPYALPVIGEVRSMDKEATDSETNSEVSVS
                     SSYLEPLDLTHIHFNQHKSEGNSLICLRKKDYLTGTGQDSSHLVLVTFKKAVTMTRKV
                     TIPGILVPDLIAFNLKAHVVAVASNTCNIILIYSVIPSSVPNIQQIRLENTERPKGIC
                     FLTDQLLLILVGKQKLTDTTFLPSSKSDQYAISLIVREIMLEEEPSITSGESQTTYST
                     FSAPLNKANRKKLIESLSPDFCHQNKGLLLTVNTSSQNGRPGRTLIKEIQSPLSSICD
                     GSIALDAEPVTQPASLPRHSSTPDHTSTLEPPRLPQRKNLQSEKETYQLSKEVEILSR
                     NLVEMQRCLSELTNRLHNGKKSSSVYPLSQDLPYVHIIYQKPYYLGPVVEKRAVLLCD
                     GKLRLSTVQQTFGLSLIEMLHDSHWILLSADSEGFIPLTFTATQEIIIRDGSLSRSDV
                     FRDSFSHSPGAVSSLKVFTGLAAPSLDTTGCCNHVDGMA"
     exon            1915..2032
                     /gene="WDCP"
                     /gene_synonym="C2orf44; MMAP; PP384"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..3848
                     /gene="WDCP"
                     /gene_synonym="C2orf44; MMAP; PP384"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3829..3834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDCP"
                     /gene_synonym="C2orf44; MMAP; PP384"
                     /note="hexamer: AATAAA"
     polyA_site      3848
                     /gene="WDCP"
                     /gene_synonym="C2orf44; MMAP; PP384"
                     /note="major polyA site"
ORIGIN      
        1 agaacttctt atgtgcggcg gcgtgatgtt gggcggccac agagagattg gtgtttttgt
       61 gaggcagtga gacctaaggt aacctttatc aaaaggatgg agttgggaaa aggaaaacta
      121 ctcaggactg gactgaatgc gttgcatcaa gcagtgcatc cgatccatgg ccttgcctgg
      181 accgatggga atcaagttgt cctaactgat ttgcggcttc acagtggaga ggtcaagttt
      241 ggggactcca aagtcattgg acagtttgaa tgtgtctgtg ggttgtcctg ggccccacct
      301 gttgcagatg atacacctgt tctactcgct gtccagcatg agaagcatgt cactgtgtgg
      361 cagctgtgtc ccagccctat ggagtcaagc aaatggctga cgtctcagac ttgtgagatt
      421 agaggatcac tacctatcct tccccagggc tgtgtgtggc acccaaaatg tgctattctg
      481 actgtgttga ctgctcagga tgtctccatt ttccctaatg ttcactctga tgattcccag
      541 gtaaaggcag acatcaacac ccagggccgc attcactgtg catgttggac ccaggatggc
      601 ctgaggctgg tggtggcagt aggcagcagc ctgcattctt atatttggga cagcgctcag
      661 aagactcttc acaggtgctc ctcctgcctg gtgtttgatg tggacagcca cgtctgctcc
      721 atcacagcaa ctgtggactc acaggttgct atagctactg agcttccatt ggataagatc
      781 tgtggcttaa atgcatctga aacctttaat atcccaccta acagtaaaga catgactccg
      841 tatgctttac cagttattgg tgaagtacgc tctatggata aagaggcaac tgattctgaa
      901 acaaattctg aagtatcagt ttcttcttcc tatttagaac ctctggatct aactcacata
      961 catttcaatc aacataagtc tgagggtaat tctcttattt gtctaagaaa aaaggactac
     1021 ttgacaggaa ctggccaaga ttcttcacat ttggtccttg tgacctttaa gaaggcagtt
     1081 accatgacga gaaaagtcac tattccaggc attctggttc ctgatctgat agcatttaat
     1141 cttaaagccc acgtagtggc agtggcttcc aacacttgta atataatttt gatctactct
     1201 gtcattccat cttcagtccc aaacatccag caaattcgat tagagaacac tgaaagacca
     1261 aaagggatat gtttcttgac agaccaacta ttactaattt tggtaggaaa acaaaaactc
     1321 actgatacaa catttcttcc ttcttcaaag tctgatcagt atgccattag cttgattgtt
     1381 agagaaataa tgttggaaga agaaccttca ataacatcag gtgaaagcca gactacctac
     1441 tctactttca gtgctccgtt aaataaagca aatagaaaaa agttaattga aagtctttcc
     1501 ccagattttt gtcaccaaaa caaagggctg ttgctgacag ttaataccag tagtcagaat
     1561 ggaaggcctg gaagaacact tattaaagaa atccagagtc ctctgtctag tatctgtgat
     1621 ggctccatag ctctagatgc tgagcctgtt acccagccag catcgctgcc cagacacagc
     1681 agcacaccag accacaccag cacactggag cctcctcgtt tgcctcaaag aaagaactta
     1741 caaagtgaaa aggaaactta tcagctgtct aaggaagtgg aaattttatc taggaacctg
     1801 gttgaaatgc aacggtgtct ttctgaactt acaaaccgtc tgcataatgg gaagaaatcc
     1861 tcttcagtgt atccactctc tcaagatctt ccttatgttc acatcattta ccagaaacct
     1921 tattatctag gtcctgttgt tgaaaaaaga gcggtgcttc tctgtgatgg taaactaagg
     1981 ctcagtacag ttcagcagac ttttggcctt tctctcattg aaatgctaca tgattcccac
     2041 tggattcttc tctctgctga cagtgagggc tttatcccgt taaccttcac agccacacag
     2101 gaaataatca taagagatgg cagcctgtcc aggtcagatg tcttcagaga ctctttttct
     2161 cacagtccag gtgctgtttc ttctcttaaa gtctttacag gccttgctgc ccccagttta
     2221 gataccactg gctgttgtaa ccatgtagat ggcatggctt gatatctgca gtgtccttgc
     2281 tgtgtagctc ttcagatgag accattacaa acaaggcctg cttgacactg gacactcgcc
     2341 aatgagactc ccactgcact caggcgaagc gcttgccatg gtcggctctc ctggtttccc
     2401 cctgtttccc ctgagctgag gctcgctgct gtgtagcaga gctcagtctt tattagatgg
     2461 ctccgaaagt ggtgtttatg tattcatgac tgtgtggttt tgactaaggg cagaattctc
     2521 agaacaaaac aatattatgg tgccatatgg atggtgtttt atggtttctc tgaggctttg
     2581 tgtcccttgt ccaaagctgc attgaagctg tcttaggagc acttaaaaga taccttggca
     2641 ttgttatagg tctttttctt ggcttcaaga ggaggttgag gagtctgctg gggggcatgt
     2701 gctctagcat attaacctca aaccagcaag aattagcaga gctccaagga ggaccagaga
     2761 cccactggct tctgctctca ggaacaggaa gtggctctga tgttgcctgg acctcccaga
     2821 atttaaacca aaccctcttg cttccttaac aaattctggc tgacgaaggt ccaggtactc
     2881 ttaaaaactg gccctgggaa aattttgaat gaaatttcaa gggaatttgt cccctctggg
     2941 ttccacttga ggttgtgccg atgctgctac cacactgtcg agcccaggta agtcctactg
     3001 caggattttg tgctgtggcc actcatgagt gtccctgaaa taactttttt tttttttaaa
     3061 tccagttttg ggatcacgca actttcctat ttttctccca gtagtcagct cccttagtta
     3121 acttgtcact ttaatttgat atttttattt tctctccttt taagtcttag agaccagcag
     3181 agaatctgtg agagaaagta tttcaggaag ttagaaattc aaccgaatct gaggtagtcc
     3241 taaaaagtgc cattttgttt cacttatggg ctaaagtacc agcttagtca ggtaagagcc
     3301 ctgacccact tcagatggta acaccacttc tcactgcctt cagatggaat cacagatttc
     3361 agtcacggcg cataacaaat tgatcagtga gtggctaggc atctgcagat aaattgtttc
     3421 agccatagaa gctccattag cacatatgct tccttttccc cccttccttt aaaatcatct
     3481 ggaaagaaac tattttgtgc ccttggggac tcctgtctgt ctgttacagt ttaccaagat
     3541 ggagctgggt taggaaagaa gtgagggccc attttgtggt tcaagtgcac tagacagctg
     3601 ctggggtagg aagcacaggc aatgtctgta atcagctgtg ggagagcagt gactgagaac
     3661 agtctgaggc ctggctccac ttggaagtat ctggggtgcg atgaaatcac aattatcttg
     3721 aagcctaaag agggaactac aagactgtta actaagatca atgtgggcac ctaaaagggt
     3781 atgttaaaat caccatttct caggtcaaaa tactgtgaat aagtcttcaa taaaatcact
     3841 aatggtta
//
