LOCUS       NM_007187               2388 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens WW domain binding protein 4 (WBP4), mRNA.
ACCESSION   NM_007187
VERSION     NM_007187.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2388)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2388)
  AUTHORS   Sticht,J., Bertazzon,M., Henning,L.M., Licha,J.R., Abualrous,E.T.
            and Freund,C.
  TITLE     FBP21's C-Terminal Domain Remains Dynamic When Wrapped around the
            c-Sec63 Unit of Brr2 Helicase
  JOURNAL   Biophys J 116 (3), 406-418 (2019)
   PUBMED   30558886
  REMARK    GeneRIF: FBP21's C-Terminal Domain Remains Dynamic When Wrapped
            around the c-Sec63 Unit of Brr2 Helicase
REFERENCE   3  (bases 1 to 2388)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   4  (bases 1 to 2388)
  AUTHORS   Henning,L.M., Santos,K.F., Sticht,J., Jehle,S., Lee,C.T.,
            Wittwer,M., Urlaub,H., Stelzl,U., Wahl,M.C. and Freund,C.
  TITLE     A new role for FBP21 as regulator of Brr2 helicase activity
  JOURNAL   Nucleic Acids Res 45 (13), 7922-7937 (2017)
   PUBMED   28838205
  REMARK    GeneRIF: Biochemical and biophysical analyses revealed that an
            intrinsically disordered region of FBP21 binds to an extended
            surface of the C-terminal Sec63 unit of Brr2. Additional contacts
            in the C-terminal helicase cassette are required for allosteric
            inhibition of Brr2 helicase activity.
REFERENCE   5  (bases 1 to 2388)
  AUTHORS   Yamazaki,K., Umeno,J., Takahashi,A., Hirano,A., Johnson,T.A.,
            Kumasaka,N., Morizono,T., Hosono,N., Kawaguchi,T., Takazoe,M.,
            Yamada,T., Suzuki,Y., Tanaka,H., Motoya,S., Hosokawa,M.,
            Arimura,Y., Shinomura,Y., Matsui,T., Matsumoto,T., Iida,M.,
            Tsunoda,T., Nakamura,Y., Kamatani,N. and Kubo,M.
  TITLE     A genome-wide association study identifies 2 susceptibility Loci
            for Crohn's disease in a Japanese population
  JOURNAL   Gastroenterology 144 (4), 781-788 (2013)
   PUBMED   23266558
REFERENCE   6  (bases 1 to 2388)
  AUTHORS   Ingham,R.J., Colwill,K., Howard,C., Dettwiler,S., Lim,C.S., Yu,J.,
            Hersi,K., Raaijmakers,J., Gish,G., Mbamalu,G., Taylor,L., Yeung,B.,
            Vassilovski,G., Amin,M., Chen,F., Matskova,L., Winberg,G.,
            Ernberg,I., Linding,R., O'donnell,P., Starostine,A., Keller,W.,
            Metalnikov,P., Stark,C. and Pawson,T.
  TITLE     WW domains provide a platform for the assembly of multiprotein
            networks
  JOURNAL   Mol Cell Biol 25 (16), 7092-7106 (2005)
   PUBMED   16055720
REFERENCE   7  (bases 1 to 2388)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   8  (bases 1 to 2388)
  AUTHORS   Bedford,M.T., Frankel,A., Yaffe,M.B., Clarke,S., Leder,P. and
            Richard,S.
  TITLE     Arginine methylation inhibits the binding of proline-rich ligands
            to Src homology 3, but not WW, domains
  JOURNAL   J Biol Chem 275 (21), 16030-16036 (2000)
   PUBMED   10748127
REFERENCE   9  (bases 1 to 2388)
  AUTHORS   Bedford,M.T., Reed,R. and Leder,P.
  TITLE     WW domain-mediated interactions reveal a spliceosome-associated
            protein that binds a third class of proline-rich motif: the proline
            glycine and methionine-rich motif
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10602-10607 (1998)
   PUBMED   9724750
REFERENCE   10 (bases 1 to 2388)
  AUTHORS   Chan,D.C., Bedford,M.T. and Leder,P.
  TITLE     Formin binding proteins bear WWP/WW domains that bind proline-rich
            peptides and functionally resemble SH3 domains
  JOURNAL   EMBO J 15 (5), 1045-1054 (1996)
   PUBMED   8605874
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD742574.1, BC108310.1 and
            BF513662.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007187.4.
            
            Summary: This gene encodes WW domain-containing binding protein 4.
            The WW domain represents a small and compact globular structure
            that interacts with proline-rich ligands. This encoded protein is a
            general spliceosomal protein that may play a role in cross-intron
            bridging of U1 and U2 snRNPs in the spliceosomal complex A.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.194068.1,
                                           SRR1803613.267376.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379487.5/ ENSP00000368801.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                CD742574.1         462-512             c
            52-2382             BC108310.1         1-2331
            2383-2388           BF513662.1         21-26               c
FEATURES             Location/Qualifiers
     source          1..2388
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.11"
     gene            1..2388
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /note="WW domain binding protein 4"
                     /db_xref="GeneID:11193"
                     /db_xref="HGNC:HGNC:12739"
                     /db_xref="MIM:604981"
     exon            1..167
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1296
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /note="formin binding protein 21; domain-containing
                     binding protein 4; WW domain-containing binding protein 4;
                     WBP-4"
                     /codon_start=1
                     /product="WW domain-binding protein 4"
                     /protein_id="NP_009118.1"
                     /db_xref="CCDS:CCDS9375.1"
                     /db_xref="GeneID:11193"
                     /db_xref="HGNC:HGNC:12739"
                     /db_xref="MIM:604981"
                     /translation="MADYWKSQPKKFCDYCKCWIADNRPSVEFHERGKNHKENVAKRI
                     SEIKQKSLDKAKEEEKASKEFAAMEAAALKAYQEDLKRLGLESEILEPSITPVTSTIP
                     PTSTSNQQKEKKEKKKRKKDPSKGRWVEGITSEGYHYYYDLISGASQWEKPEGFQGDL
                     KKTAVKTVWVEGLSEDGFTYYYNTETGESRWEKPDDFIPHTSDLPSSKVNENSLGTLD
                     ESKSSDSHSDSDGEQEAEEGGVSTETEKPKIKFKEKNKNSDGGSDPETQKEKSIQKQN
                     SLGSNEEKSKTLKKSNPYGEWQEIKQEVESHEEVDLELPSTENEYVSTSEADGGGEPK
                     VVFKEKTVTSLGVMADGVAPVFKKRRTENGKSRNLRQRGDDQ"
     exon            168..240
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /inference="alignment:Splign:2.1.0"
     exon            241..303
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /inference="alignment:Splign:2.1.0"
     exon            304..427
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /inference="alignment:Splign:2.1.0"
     exon            428..604
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /inference="alignment:Splign:2.1.0"
     exon            605..651
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /inference="alignment:Splign:2.1.0"
     exon            652..727
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /inference="alignment:Splign:2.1.0"
     exon            728..921
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1085
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..2388
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1431..1436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /note="hexamer: AATAAA"
     polyA_site      1453
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /note="major polyA site"
     regulatory      2365..2370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /note="hexamer: ATTAAA"
     polyA_site      2388
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /note="major polyA site"
ORIGIN      
        1 gtagttggga acagcggaac gctggtcccg gggactgagt aaggtgtctg gatcggaggg
       61 aggttcgggt gggcatcggg cggctggaag agctcgactc gtcccgctgg gaaagcgcga
      121 gtctgagtgg aaccctggac gacttgcaga gcggctggcg cagtcatggc ggactactgg
      181 aagtcacagc caaagaaatt ctgtgattac tgcaagtgct ggatagcaga caataggcct
      241 agtgttgaat ttcatgaaag aggaaagaat cataaggaaa atgtggcaaa aaggatcagt
      301 gagattaaac agaaaagcct ggataaggca aaggaagaag aaaaggcatc aaaggagttt
      361 gctgcaatgg aggcagctgc cctgaaagca taccaagagg atttgaaaag acttggctta
      421 gagtcagaaa ttttggagcc aagcataaca ccagtaacca gcactatccc acctacctcg
      481 acatcaaatc aacagaaaga aaagaaagaa aagaagaaaa gaaaaaaaga tccttcaaag
      541 ggcagatggg tagaaggcat aacctctgag ggttaccatt actattatga tcttatctca
      601 ggagcatctc agtgggagaa acctgaagga tttcaaggag acttaaaaaa gacagcagtg
      661 aagaccgttt gggtagaagg tttaagtgaa gatggtttta cctattacta taatacagaa
      721 acaggagaat ccagatggga gaaacctgat gatttcattc cacacactag tgatctgcct
      781 tctagtaagg tcaatgaaaa ttcacttggc accctagatg aatccaaatc atcagattcg
      841 catagtgatt ctgatgggga acaggaagca gaagaaggag gggtctctac agagacagaa
      901 aagccaaaaa taaagtttaa ggaaaaaaat aaaaatagtg atggaggaag tgacccagaa
      961 acacagaaag aaaaaagtat tcagaaacag aattcattag gttcaaatga agaaaaatcg
     1021 aaaactctta agaaatcaaa cccatatgga gaatggcaag aaattaaaca agaggttgag
     1081 tctcatgagg aggtagattt ggaacttcca agcactgaaa atgagtatgt atcaacttca
     1141 gaagctgatg gtggcggaga acccaaagtg gtatttaaag aaaaaacagt cacttctctt
     1201 ggagttatgg cagatggagt ggccccagtc ttcaaaaaga gaagaactga aaatggaaaa
     1261 tctagaaatt taaggcaacg aggtgatgat caatagttgc aggagagctt tttgtacatg
     1321 cttttaggac agaatggaga cttatacacc caaagtttat ctgtgtttgt ttgtaagtat
     1381 tatgatgcta aaaatttaga tttattctaa atgtatttga tgtgaattaa aataaatatt
     1441 ttttcatgtg aaatttattt tggttcctaa aatggaagcc taccacattg cattgtaata
     1501 cagtgtatta tgttcagtgt ctaaaaactg ctaattaagt cataatttaa gatgctatgt
     1561 atctgttatt taaaacatgg agaaacaggg cctttattcc attcatattc ataagagcat
     1621 atttatcctg cattgaaaat gcattacttt tgcacattga tattaactgt tgtccaacaa
     1681 ataagtatcg gagtacgtga gaatattccc agcccagtga tgatttggtt ctgaggctga
     1741 tgtgagaaag ctgatgtaaa aaatgtatgc atattggctt accttactca atttaaagtc
     1801 aaaagccaac agccaggagc agctcaggta cttcagatgt gcttaatatg gagtgaaaac
     1861 tggaccagag gtggaaagat gtatttgccc cagttcactt caaagcagca aacgttgttt
     1921 aagcatttta gtttgaacca ggcattgtgt taggaatcca gggataaaga tgaatgaaat
     1981 gtatttctgt tcttcaggag ttcacattct agcatatgcc ttttttcccc cagtcatgca
     2041 ctctttttag cagtcttata tgtactagaa aagatttttt aaagtttatt taaagctgtg
     2101 tagatgaagg cttgatctaa aatagtataa ggtctccagc ttcagtaaaa gtttttagtg
     2161 tttacttaaa ttagtaattt ctcactttct gtctggttaa aatgtcttaa aaagtagaat
     2221 tttcttcttt aatccgttta gtagttacct cccttttact tttcaaattc acaaaattac
     2281 atttctcata aattgtatag tatttaactt ataatagtta atatttgtct ttttaagatg
     2341 actgtacatg taagaaaaaa gcttattaaa aacttgatca aagaataa
//
