LOCUS       NM_152613               2255 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens WBP2 N-terminal like (WBP2NL), mRNA.
ACCESSION   NM_152613
VERSION     NM_152613.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2255)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2255)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2255)
  AUTHORS   Azad,N., Nazarian,H., Ghaffari Novin,M., Masteri Farahani,R.,
            Piryaei,A., Heidari,M.H. and Abdollahpour Alitappeh,M.
  TITLE     Oligoasthenoteratozoospermic (OAT) men display altered
            phospholipase C zeta (PLCzeta) localization and a lower percentage
            of sperm cells expressing PLCzeta and post-acrosomal sheath WW
            domain-binding protein (PAWP)
  JOURNAL   Bosn J Basic Med Sci 18 (2), 178-184 (2018)
   PUBMED   28954204
  REMARK    GeneRIF: PLCzeta and PAWP impairments may be one of the possible
            etiologies of decreased fertility in Oligoasthenoteratozoospermia
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2255)
  AUTHORS   Freour,T., Barragan,M., Torra-Massana,M., Ferrer-Vaquer,A. and
            Vassena,R.
  TITLE     Is there an association between PAWP/WBP2NL sequence, expression,
            and distribution in sperm cells and fertilization failures in ICSI
            cycles?
  JOURNAL   Mol Reprod Dev 85 (2), 163-170 (2018)
   PUBMED   29271520
  REMARK    GeneRIF: PAWP/WBP2NL was present in all samples, and no significant
            differences were detected between patients with fertilization
            failure and donors in sequence variants or mean protein expression,
            or in the proportion of PAWP/WBP2NL-positive sperm. In conclusion,
            no clear association between PAWP/WBP2NL protein expression in
            sperm and fertilization outcome in ICSI were observed from this
            cohort.
REFERENCE   5  (bases 1 to 2255)
  AUTHORS   Freour,T., Barragan,M., Ferrer-Vaquer,A., Rodriguez,A. and
            Vassena,R.
  TITLE     WBP2NL/PAWP mRNA and protein expression in sperm cells are not
            related to semen parameters, fertilization rate, or reproductive
            outcome
  JOURNAL   J Assist Reprod Genet 34 (6), 803-810 (2017)
   PUBMED   28444612
  REMARK    GeneRIF: Taken into account that WBP2NL/PAWP gene and protein
            levels and distribution did not correlate with fertilization rates,
            this study questions the interest of WBP2NL/PAWP protein and gene
            expression analysis in sperm cells as a prognostic factor for the
            outcome of ICSI cycles
REFERENCE   6  (bases 1 to 2255)
  AUTHORS   Aarabi,M., Balakier,H., Bashar,S., Moskovtsev,S.I., Sutovsky,P.,
            Librach,C.L. and Oko,R.
  TITLE     Sperm content of postacrosomal WW binding protein is related to
            fertilization outcomes in patients undergoing assisted reproductive
            technology
  JOURNAL   Fertil Steril 102 (2), 440-447 (2014)
   PUBMED   24907910
  REMARK    GeneRIF: Demonstrate significant correlations between sperm PAWP
            levels and both fertilization rates and normal embryonic
            development after intracytoplasmic sperm injection.
REFERENCE   7  (bases 1 to 2255)
  AUTHORS   Ji,Y., Schaid,D.J., Desta,Z., Kubo,M., Batzler,A.J., Snyder,K.,
            Mushiroda,T., Kamatani,N., Ogburn,E., Hall-Flavin,D., Flockhart,D.,
            Nakamura,Y., Mrazek,D.A. and Weinshilboum,R.M.
  TITLE     Citalopram and escitalopram plasma drug and metabolite
            concentrations: genome-wide associations
  JOURNAL   Br J Clin Pharmacol 78 (2), 373-383 (2014)
   PUBMED   24528284
REFERENCE   8  (bases 1 to 2255)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   9  (bases 1 to 2255)
  AUTHORS   Wu,A.T., Sutovsky,P., Manandhar,G., Xu,W., Katayama,M., Day,B.N.,
            Park,K.W., Yi,Y.J., Xi,Y.W., Prather,R.S. and Oko,R.
  TITLE     PAWP, a sperm-specific WW domain-binding protein, promotes meiotic
            resumption and pronuclear development during fertilization
  JOURNAL   J Biol Chem 282 (16), 12164-12175 (2007)
   PUBMED   17289678
REFERENCE   10 (bases 1 to 2255)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC022546.1, AK128138.1 and Z99716.4.
            
            On Nov 23, 2018 this sequence version replaced NM_152613.2.
            
            Summary: WBP2NL is a sperm-specific WW domain-binding protein that
            promotes meiotic resumption and pronuclear development during
            oocyte fertilization (Wu et al., 2007 [PubMed 17289678]).[supplied
            by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022546.1, SRR1660803.12835.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328823.13/ ENSP00000332983.9
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-392               BC022546.1         1-392
            393-1042            AK128138.1         456-1105
            1043-1420           BC022546.1         1043-1420
            1421-1421           Z99716.4           170881-170881
            1422-2255           BC022546.1         1422-2255
FEATURES             Location/Qualifiers
     source          1..2255
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..2255
                     /gene="WBP2NL"
                     /gene_synonym="GRAMD7; PAWP"
                     /note="WBP2 N-terminal like"
                     /db_xref="GeneID:164684"
                     /db_xref="HGNC:HGNC:28389"
                     /db_xref="MIM:610981"
     exon            1..93
                     /gene="WBP2NL"
                     /gene_synonym="GRAMD7; PAWP"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..961
                     /gene="WBP2NL"
                     /gene_synonym="GRAMD7; PAWP"
                     /note="WW domain-binding protein 2-like"
                     /codon_start=1
                     /product="postacrosomal sheath WW domain-binding protein"
                     /protein_id="NP_689826.2"
                     /db_xref="CCDS:CCDS14029.1"
                     /db_xref="GeneID:164684"
                     /db_xref="HGNC:HGNC:28389"
                     /db_xref="MIM:610981"
                     /translation="MAVNQSHTENRRGALIPNGESLLKRSPNVELSFPQRSEGSNVFS
                     GRKTGTLFLTSYRVIFITSCSISDPMLSFMMPFDLMTNLTVEQPVFAANFIKGTIQAA
                     PYGGWEGQATFKLVFRNGDAIEFAQLMVKAASAAARGFPLRTLNDWFSSMGIYVITGE
                     GNMCTPQMPCSVIVYGAPPAGYGAPPPGYGAPPAGYGAQPVGNEGPPVGYRASPVRYG
                     APPLGYGAPPAGYGAPPLGYGAPPLGYGTPPLGYGAPPLGYGAPPAGNEGPPAGYRAS
                     PAGSGARPQESTAAQAPENEASLPSASSSQVHS"
     exon            94..202
                     /gene="WBP2NL"
                     /gene_synonym="GRAMD7; PAWP"
                     /inference="alignment:Splign:2.1.0"
     exon            203..344
                     /gene="WBP2NL"
                     /gene_synonym="GRAMD7; PAWP"
                     /inference="alignment:Splign:2.1.0"
     exon            345..437
                     /gene="WBP2NL"
                     /gene_synonym="GRAMD7; PAWP"
                     /inference="alignment:Splign:2.1.0"
     exon            438..545
                     /gene="WBP2NL"
                     /gene_synonym="GRAMD7; PAWP"
                     /inference="alignment:Splign:2.1.0"
     exon            546..2255
                     /gene="WBP2NL"
                     /gene_synonym="GRAMD7; PAWP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2233..2238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WBP2NL"
                     /gene_synonym="GRAMD7; PAWP"
                     /note="hexamer: AATAAA"
     polyA_site      2255
                     /gene="WBP2NL"
                     /gene_synonym="GRAMD7; PAWP"
                     /note="major polyA site"
ORIGIN      
        1 atctacgggg cggcaggagg cccgaagcaa gatggcggtg aatcagagcc acaccgagaa
       61 ccgccgcgga gccctcatcc ctaacggtga aagtctcttg aagcggtctc cgaatgtgga
      121 gctctccttc ccacagcgat cagaaggctc aaatgtcttt agtggtagaa agacaggaac
      181 attgtttctc acttcatacc gggtgatttt cataacttca tgctccatca gtgatcccat
      241 gttgtctttt atgatgccat ttgatctgat gacgaacctc actgttgaac aaccagtatt
      301 tgctgcaaac ttcattaagg gaactattca ggcagctcca tatggtggct gggaaggaca
      361 agctactttt aaattagtct tcagaaatgg agatgccatt gaatttgccc agttgatggt
      421 gaaagctgcc tctgctgctg cccgaggatt tccacttaga accttaaatg actggttcag
      481 ctctatggga atttatgtaa ttactgggga agggaatatg tgcactccac agatgccttg
      541 ttcagttatt gtctatggag ccccacctgc aggatatgga gccccacctc ccggatacgg
      601 agccccacct gcaggatatg gagcccaacc cgtaggaaat gaaggcccgc ctgtgggata
      661 cagagcctca cctgtgcgat atggagcccc acctcttgga tacggagccc cacctgcagg
      721 atatggagcc ccacctctag gatatggagc cccacctctt ggatatggaa ccccacctct
      781 cggatatgga gccccacctc tcggatatgg agccccacct gcaggaaatg aaggcccgcc
      841 tgcgggatac agagcctcac ctgctggatc aggagccagg cctcaggaat ctacagcagc
      901 ccaggctcct gaaaacgagg cttctcttcc ctctgcctcc tcttctcagg tccattctta
      961 accttctaag atgtaaacct tgaagactca ccaagcaaag aggtacccta aaattgaagt
     1021 caggataagg aggacgactc aggtatgtga tcacaggctt ctcgcaggta gttgttccac
     1081 cctttggaag ggcaatctta tgggggaagg tgaaacttta cttctgtgcc tagattttag
     1141 aagcagaatc aactcttaaa tagctggcta aaggaagaat accattgtgg ggctaattcc
     1201 ccagtaattt ggttgacatt gggttgcatt tttaaacata actttttcca cactcgcatt
     1261 caaggttcct gtcttcccat cctcattcaa gaaacattta ttatgctccg tttgctaggc
     1321 actaagatgc gtgctaaaaa cgtcatgttg aacacttagt tgtttgagaa agctaaattt
     1381 tcaatagtaa gagtgttata aattacggtg gatccacaaa atggagtatt atacacctgt
     1441 tgaaaactat gtctagaggt agagaaagcc ttctttgagg agaccaaaac caacaaataa
     1501 aagcatgata aattgactat atcaaaattt aaaacttctc tatgacagaa gttaaaagat
     1561 aggcaacaga ataggaaaaa gtgattttca acatatatat taatttatag tcagaatacg
     1621 tgaataacta caaatcaatt ctccccaaaa tgacagaaat atgaattgcc gaataaccaa
     1681 ggcaatagca tggccagaaa acgtttgaaa agatgttcag cttgactagt gttagggaaa
     1741 tgcaacctga gatgagaaaa catttttatc tccaaagatt tacaaatatt aaaactcttg
     1801 atatggcact ttcacatttt aaaatatgcc tgcgagaaaa cttgcatgtg tgcacaaaga
     1861 tgcatgtggg aagatttcat tatattcatt gtttctaaca gcacaaaatt agaaataacc
     1921 tatatgtcca ttaataggaa atatatgaat aggctatggt atgcccatac tacgtatgca
     1981 gaaatttcta agacttgttg ataaggagaa aagcaagttg tagggagcat atactatagt
     2041 gattttcagc ctcatcagac tgaatgcccc attttataac aaatatttat attttataac
     2101 aaacgtttat atttgtatat ttataacaaa tattttgtaa tgtctccttc acttcaatga
     2161 agtttgtaga taattgcata tgattccaca ccatttcaac caaaattaat aggccataaa
     2221 tgtgatagag gaaataaaag gagtttgtag taaaa
//
