LOCUS       NM_012478               1859 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens WW domain binding protein 2 (WBP2), transcript variant
            1, mRNA.
ACCESSION   NM_012478
VERSION     NM_012478.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1859)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 1859)
  AUTHORS   Lim,Y.X., Lin,H., Chu,T. and Lim,Y.P.
  TITLE     WBP2 promotes BTRC mRNA stability to drive migration and invasion
            in triple-negative breast cancer via NF-kappaB activation
  JOURNAL   Mol Oncol 16 (2), 422-446 (2022)
   PUBMED   34197030
  REMARK    GeneRIF: WBP2 promotes BTRC mRNA stability to drive migration and
            invasion in triple-negative breast cancer via NF-kappaB activation.
REFERENCE   3  (bases 1 to 1859)
  AUTHORS   Tabatabaeian,H., Lim,S.K., Chu,T., Seah,S.H. and Lim,Y.P.
  TITLE     WBP2 inhibits microRNA biogenesis via interaction with the
            microprocessor complex
  JOURNAL   Life Sci Alliance 4 (7), e202101038 (2021)
   PUBMED   34117091
  REMARK    GeneRIF: WBP2 inhibits microRNA biogenesis via interaction with the
            microprocessor complex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1859)
  AUTHORS   Han,Q., Rong,X., Lin,X., Zhang,X., Fan,C., Zhao,H. and Wang,E.
  TITLE     WBP2 negatively regulates the Hippo pathway by competitively
            binding to WWC3 with LATS1 to promote non-small cell lung cancer
            progression
  JOURNAL   Cell Death Dis 12 (4), 384 (2021)
   PUBMED   33837178
  REMARK    GeneRIF: WBP2 negatively regulates the Hippo pathway by
            competitively binding to WWC3 with LATS1 to promote non-small cell
            lung cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1859)
  AUTHORS   Zheng,Z., Li,Y., Fan,S., An,J., Luo,X., Liang,M., Zhu,F. and
            Huang,K.
  TITLE     WW domain-binding protein 2 overexpression prevents diet-induced
            liver steatosis and insulin resistance through AMPKbeta1
  JOURNAL   Cell Death Dis 12 (3), 228 (2021)
   PUBMED   33658485
  REMARK    GeneRIF: WW domain-binding protein 2 overexpression prevents
            diet-induced liver steatosis and insulin resistance through
            AMPKbeta1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1859)
  AUTHORS   Nitsch,R., Di Palma,T., Mascia,A. and Zannini,M.
  TITLE     WBP-2, a WW domain binding protein, interacts with the
            thyroid-specific transcription factor Pax8
  JOURNAL   Biochem J 377 (Pt 3), 553-560 (2004)
   PUBMED   14531730
REFERENCE   7  (bases 1 to 1859)
  AUTHORS   Jolliffe,C.N., Harvey,K.F., Haines,B.P., Parasivam,G. and Kumar,S.
  TITLE     Identification of multiple proteins expressed in murine embryos as
            binding partners for the WW domains of the ubiquitin-protein ligase
            Nedd4
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 557-565 (2000)
   PUBMED   11042109
REFERENCE   8  (bases 1 to 1859)
  AUTHORS   Chen,H.I., Einbond,A., Kwak,S.J., Linn,H., Koepf,E., Peterson,S.,
            Kelly,J.W. and Sudol,M.
  TITLE     Characterization of the WW domain of human yes-associated protein
            and its polyproline-containing ligands
  JOURNAL   J Biol Chem 272 (27), 17070-17077 (1997)
   PUBMED   9202023
REFERENCE   9  (bases 1 to 1859)
  AUTHORS   Pirozzi,G., McConnell,S.J., Uveges,A.J., Carter,J.M., Sparks,A.B.,
            Kay,B.K. and Fowlkes,D.M.
  TITLE     Identification of novel human WW domain-containing proteins by
            cloning of ligand targets
  JOURNAL   J Biol Chem 272 (23), 14611-14616 (1997)
   PUBMED   9169421
REFERENCE   10 (bases 1 to 1859)
  AUTHORS   Chen,H.I. and Sudol,M.
  TITLE     The WW domain of Yes-associated protein binds a proline-rich ligand
            that differs from the consensus established for Src homology
            3-binding modules
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7819-7823 (1995)
   PUBMED   7644498
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA278794.1 and BC010616.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012478.3.
            
            Summary: The globular WW domain is composed of 38 to 40
            semiconserved amino acids shared by proteins of diverse functions
            including structural, regulatory, and signaling proteins. The
            domain is involved in mediating protein-protein interactions
            through the binding of polyproline ligands. This gene encodes a WW
            domain binding protein that is a transcriptional coactivator of
            estrogen receptor alpha and progesterone receptor. Defects in this
            gene have been associated with hearing impairment. [provided by
            RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1 and 3 both encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010616.1, AK057881.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254806.8/ ENSP00000254806.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA278794.1         86-87
            3-1859              BC010616.1         1-1857
FEATURES             Location/Qualifiers
     source          1..1859
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1859
                     /gene="WBP2"
                     /gene_synonym="DFNB107; GRAMD6; WBP-2"
                     /note="WW domain binding protein 2"
                     /db_xref="GeneID:23558"
                     /db_xref="HGNC:HGNC:12738"
                     /db_xref="MIM:606962"
     exon            1..97
                     /gene="WBP2"
                     /gene_synonym="DFNB107; GRAMD6; WBP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..824
                     /gene="WBP2"
                     /gene_synonym="DFNB107; GRAMD6; WBP-2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="WW domain-binding protein 2 isoform 1"
                     /protein_id="NP_036610.2"
                     /db_xref="CCDS:CCDS11731.1"
                     /db_xref="GeneID:23558"
                     /db_xref="HGNC:HGNC:12738"
                     /db_xref="MIM:606962"
                     /translation="MALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKG
                     TKKGTVYLTPYRVIFLSKGKDAMQSFMMPFYLMKDCEIKQPVFGANYIKGTVKAEAGG
                     GWEGSASYKLTFTAGGAIEFGQRMLQVASQASRGEVPSGAYGYSYMPSGAYVYPPPVA
                     NGMYPCPPGYPYPPPPPEFYPGPPMMDGAMGYVQPPPPPYPGPMEPPVSGPDVPSTPA
                     AEAKAAEAAASAYYNPGNPHNVYMPTSQPPPPPYYPPEDKKTQ"
     exon            98..206
                     /gene="WBP2"
                     /gene_synonym="DFNB107; GRAMD6; WBP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            207..342
                     /gene="WBP2"
                     /gene_synonym="DFNB107; GRAMD6; WBP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..435
                     /gene="WBP2"
                     /gene_synonym="DFNB107; GRAMD6; WBP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            436..570
                     /gene="WBP2"
                     /gene_synonym="DFNB107; GRAMD6; WBP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            571..693
                     /gene="WBP2"
                     /gene_synonym="DFNB107; GRAMD6; WBP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            694..770
                     /gene="WBP2"
                     /gene_synonym="DFNB107; GRAMD6; WBP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            771..1859
                     /gene="WBP2"
                     /gene_synonym="DFNB107; GRAMD6; WBP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1793..1798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WBP2"
                     /gene_synonym="DFNB107; GRAMD6; WBP-2"
                     /note="hexamer: AATAAA"
     polyA_site      1815
                     /gene="WBP2"
                     /gene_synonym="DFNB107; GRAMD6; WBP-2"
                     /note="major polyA site"
     regulatory      1839..1844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WBP2"
                     /gene_synonym="DFNB107; GRAMD6; WBP-2"
                     /note="hexamer: AGTAAA"
     polyA_site      1859
                     /gene="WBP2"
                     /gene_synonym="DFNB107; GRAMD6; WBP-2"
                     /note="major polyA site"
ORIGIN      
        1 attgcgtttt gagtctcggg acccctgttg gagagactat ggcgctcaac aagaatcact
       61 cggagggcgg cggagtgatc gtcaataaca ccgagagcat cctaatgtcc tatgatcacg
      121 tggaactcac attcaatgac atgaagaacg tgccagaagc cttcaaaggg accaagaaag
      181 gcactgtcta ccttacccct taccgggtca tctttctgtc caagggcaag gatgccatgc
      241 agtccttcat gatgccattt tatctcatga aagactgtga gatcaagcag cccgtatttg
      301 gtgcaaacta catcaaggga acagtgaagg cggaagcggg aggtggctgg gaaggctctg
      361 cttcctacaa gttgactttc acggcagggg gcgccattga gttcggacag cggatgctcc
      421 aggtggcatc tcaagcctcc agaggtgaag tccccagtgg agcctatggc tactcttaca
      481 tgcccagcgg ggcctatgtc tatcccccgc cagtcgccaa tggaatgtac ccctgccctc
      541 ctggctaccc ctatccaccg cccccacctg agttctatcc aggacccccc atgatggacg
      601 gggccatggg atacgtgcag cccccaccac cgccctaccc tgggcccatg gaacctccgg
      661 tcagcggccc cgatgtcccc tccactcctg cagccgaagc caaggccgca gaagcagccg
      721 ccagcgccta ttacaaccca ggcaatcctc acaacgtcta catgcccacg agccagccgc
      781 cgccacctcc ctactaccca ccggaagata agaagaccca gtaggccctc ctgcctccct
      841 gcctcccacc ctcatctctc taccctaccc ctcccatcgg ggctgtgctg gggcttgggg
      901 aggggagggg gcgccttgtt ctccctccag gtctgatcat aaacaattac caggaactag
      961 cattgtggga cattagggcc cccggcctcg ggagaggtgc cgcccagctt cccatgccag
     1021 cccggagccc acagtgctgc ccagcgtacc tccctcaccg tctggggctc ttctgggagc
     1081 acggagcatc ccctgttcct gtttcactct cagcttctcc cctcgaaggg actctctggc
     1141 cacctcctcc accgcagtcc agctccctca gtctggcacc cactgctaca ctcagcctca
     1201 tgagccactt cagaccagcc aggtgtcttc ccgggccctg ccagaccctg ctcacattcc
     1261 ctctgctggt ctgtgctggt ctcagaaggc caccgcgccc gcattccact cagccagggt
     1321 ccagctgcag cccccgccac ccttccttcc cttccctgtc ctgggtcatg ttgttgccac
     1381 cctgtgtgac ttttgaagct gtaaaatgag cttccagggc ttgggtggcg tcggggcagg
     1441 gccgccgagg ctgggaggaa gcccttctgc cttttgctgg tgtttctgga atttgctttc
     1501 cctcacctct cacttccttc tagaaggagc ttcctgactg gaaccagaga atgcatgtct
     1561 gtccacttgg tggctgctgg gtggggccgg gaacaagggc ccctgaccct gtgtgctggc
     1621 cgggacctgc caccagcccc ccagcctgct tcttcccctt aagctttgtg cccctggatg
     1681 cgctaacatt cactcttgtt tgtccctgga ctggccatga agtgaggaga tggttattta
     1741 aagagaattc cctatttatt tgacaaaaaa tccagttaat atattaatgt gaaataaacc
     1801 ctgtttgcac ctcgatttgt ttgctgaaaa tgtgaaatag taaaaatgaa ataactgga
//
