LOCUS       NP_036610                261 aa            linear   PRI 28-APR-2025
DEFINITION  WW domain-binding protein 2 isoform 1 [Homo sapiens].
ACCESSION   NP_036610
VERSION     NP_036610.2
DBSOURCE    REFSEQ: accession NM_012478.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 261)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (residues 1 to 261)
  AUTHORS   Lim,Y.X., Lin,H., Chu,T. and Lim,Y.P.
  TITLE     WBP2 promotes BTRC mRNA stability to drive migration and invasion
            in triple-negative breast cancer via NF-kappaB activation
  JOURNAL   Mol Oncol 16 (2), 422-446 (2022)
   PUBMED   34197030
  REMARK    GeneRIF: WBP2 promotes BTRC mRNA stability to drive migration and
            invasion in triple-negative breast cancer via NF-kappaB activation.
REFERENCE   3  (residues 1 to 261)
  AUTHORS   Tabatabaeian,H., Lim,S.K., Chu,T., Seah,S.H. and Lim,Y.P.
  TITLE     WBP2 inhibits microRNA biogenesis via interaction with the
            microprocessor complex
  JOURNAL   Life Sci Alliance 4 (7), e202101038 (2021)
   PUBMED   34117091
  REMARK    GeneRIF: WBP2 inhibits microRNA biogenesis via interaction with the
            microprocessor complex.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 261)
  AUTHORS   Han,Q., Rong,X., Lin,X., Zhang,X., Fan,C., Zhao,H. and Wang,E.
  TITLE     WBP2 negatively regulates the Hippo pathway by competitively
            binding to WWC3 with LATS1 to promote non-small cell lung cancer
            progression
  JOURNAL   Cell Death Dis 12 (4), 384 (2021)
   PUBMED   33837178
  REMARK    GeneRIF: WBP2 negatively regulates the Hippo pathway by
            competitively binding to WWC3 with LATS1 to promote non-small cell
            lung cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 261)
  AUTHORS   Zheng,Z., Li,Y., Fan,S., An,J., Luo,X., Liang,M., Zhu,F. and
            Huang,K.
  TITLE     WW domain-binding protein 2 overexpression prevents diet-induced
            liver steatosis and insulin resistance through AMPKbeta1
  JOURNAL   Cell Death Dis 12 (3), 228 (2021)
   PUBMED   33658485
  REMARK    GeneRIF: WW domain-binding protein 2 overexpression prevents
            diet-induced liver steatosis and insulin resistance through
            AMPKbeta1.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 261)
  AUTHORS   Nitsch,R., Di Palma,T., Mascia,A. and Zannini,M.
  TITLE     WBP-2, a WW domain binding protein, interacts with the
            thyroid-specific transcription factor Pax8
  JOURNAL   Biochem J 377 (Pt 3), 553-560 (2004)
   PUBMED   14531730
REFERENCE   7  (residues 1 to 261)
  AUTHORS   Jolliffe,C.N., Harvey,K.F., Haines,B.P., Parasivam,G. and Kumar,S.
  TITLE     Identification of multiple proteins expressed in murine embryos as
            binding partners for the WW domains of the ubiquitin-protein ligase
            Nedd4
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 557-565 (2000)
   PUBMED   11042109
REFERENCE   8  (residues 1 to 261)
  AUTHORS   Chen,H.I., Einbond,A., Kwak,S.J., Linn,H., Koepf,E., Peterson,S.,
            Kelly,J.W. and Sudol,M.
  TITLE     Characterization of the WW domain of human yes-associated protein
            and its polyproline-containing ligands
  JOURNAL   J Biol Chem 272 (27), 17070-17077 (1997)
   PUBMED   9202023
REFERENCE   9  (residues 1 to 261)
  AUTHORS   Pirozzi,G., McConnell,S.J., Uveges,A.J., Carter,J.M., Sparks,A.B.,
            Kay,B.K. and Fowlkes,D.M.
  TITLE     Identification of novel human WW domain-containing proteins by
            cloning of ligand targets
  JOURNAL   J Biol Chem 272 (23), 14611-14616 (1997)
   PUBMED   9169421
REFERENCE   10 (residues 1 to 261)
  AUTHORS   Chen,H.I. and Sudol,M.
  TITLE     The WW domain of Yes-associated protein binds a proline-rich ligand
            that differs from the consensus established for Src homology
            3-binding modules
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7819-7823 (1995)
   PUBMED   7644498
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA278794.1 and BC010616.1.
            
            On Oct 30, 2002 this sequence version replaced NP_036610.1.
            
            Summary: The globular WW domain is composed of 38 to 40
            semiconserved amino acids shared by proteins of diverse functions
            including structural, regulatory, and signaling proteins. The
            domain is involved in mediating protein-protein interactions
            through the binding of polyproline ligands. This gene encodes a WW
            domain binding protein that is a transcriptional coactivator of
            estrogen receptor alpha and progesterone receptor. Defects in this
            gene have been associated with hearing impairment. [provided by
            RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1 and 3 both encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010616.1, AK057881.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254806.8/ ENSP00000254806.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..261
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     Protein         1..261
                     /product="WW domain-binding protein 2 isoform 1"
                     /calculated_mol_wt=27956
     Region          30..131
                     /region_name="PH-GRAM_WBP2"
                     /note="WW binding protein 2 (WB2) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13214"
                     /db_xref="CDD:275401"
     Site            192
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by YES and SRC.
                     /evidence=ECO:0000269|PubMed:21642474; propagated from
                     UniProtKB/Swiss-Prot (Q969T9.1)"
     Region          196..261
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q969T9.1)"
     Region          196..200
                     /region_name="PPxY motif 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q969T9.1)"
     Site            231
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by YES and SRC.
                     /evidence=ECO:0000269|PubMed:21642474; propagated from
                     UniProtKB/Swiss-Prot (Q969T9.1)"
     Region          248..252
                     /region_name="PPxY motif 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q969T9.1)"
     CDS             1..261
                     /gene="WBP2"
                     /gene_synonym="DFNB107; GRAMD6; WBP-2"
                     /coded_by="NM_012478.4:39..824"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS11731.1"
                     /db_xref="GeneID:23558"
                     /db_xref="HGNC:HGNC:12738"
                     /db_xref="MIM:606962"
ORIGIN      
        1 malnknhseg ggvivnntes ilmsydhvel tfndmknvpe afkgtkkgtv yltpyrvifl
       61 skgkdamqsf mmpfylmkdc eikqpvfgan yikgtvkaea gggwegsasy kltftaggai
      121 efgqrmlqva sqasrgevps gaygysymps gayvypppva ngmypcppgy pypppppefy
      181 pgppmmdgam gyvqpppppy pgpmeppvsg pdvpstpaae akaaeaaasa yynpgnphnv
      241 ymptsqpppp pyyppedkkt q
//
